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A total of 58 multidrug-resistant clinical isolates were analyzed using ERIC-PCR to assess clonal relatedness, and PCR followed by amplicon sequencing to detect resistance genes (\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM<\/jats:sub>\n                    ,\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>KPC<\/jats:sub>\n                    ,\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>GES<\/jats:sub>\n                    ,\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>VIM<\/jats:sub>\n                    , and\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>IMP<\/jats:sub>\n                    ).\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    was the most frequently identified species (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200928, 48.27%), followed by\n                    <jats:italic>Serratia marcescens<\/jats:italic>\n                    and\n                    <jats:italic>Proteus mirabilis<\/jats:italic>\n                    , among others. All seven\n                    <jats:italic>P. mirabilis<\/jats:italic>\n                    isolates were classified as XDR, as were six\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    and three\n                    <jats:italic>S. marcescens<\/jats:italic>\n                    isolates. Amikacin (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200946, 79.31% susceptible) and colistin (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200937, 97.37% susceptible) exhibited the highest susceptibility rates among all antimicrobials tested against the majority of isolates. ERIC-PCR revealed multiclonal dissemination and high genetic variability among the isolates. The\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>KPC<\/jats:sub>\n                    gene was the most prevalent (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200932, 55.17%), followed by\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM<\/jats:sub>\n                    (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200926, 44.83%). Among the\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM<\/jats:sub>\n                    allelic variants,\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM\u22121<\/jats:sub>\n                    (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200912, 46.15%) was the most common, followed by\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM\u22125<\/jats:sub>\n                    (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20097, 26.92%) and\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM\u221229<\/jats:sub>\n                    (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20091, 3.85%). This study reports the first detection in Brazil of\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM\u22125<\/jats:sub>\n                    in\n                    <jats:italic>Klebsiella aerogenes<\/jats:italic>\n                    ,\n                    <jats:italic>Citrobacter freundii<\/jats:italic>\n                    , and\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    , in addition to reporting the first identification of\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM\u221229<\/jats:sub>\n                    in\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    . Additionally, this study gives the first report in the Americas of\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM<\/jats:sub>\n                    in\n                    <jats:italic>Klebsiella ozaenae<\/jats:italic>\n                    . These findings highlight the substantial potential for mutation and interspecies dissemination of\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM<\/jats:sub>\n                    variants within the Enterobacterales order.\n                  <\/jats:p>","DOI":"10.1007\/s42770-026-02109-1","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:31:46Z","timestamp":1791826306000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Occurrence of blaNDM\u22125 and blaNDM\u221229 variants and genetic diversity among Enterobacterales in hospitalized patients in northeastern Brazil"],"prefix":"10.1007","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4916-4626","authenticated-orcid":false,"given":"Lamartine Rodrigues","family":"Martins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8780-3460","authenticated-orcid":false,"given":"\u00c9rica Maria","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4968-4680","authenticated-orcid":false,"given":"Maria Izabely Silva","family":"Pimentel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9650-7900","authenticated-orcid":false,"given":"Elizabeth Maria Bispo","family":"Beltr\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0277-108X","authenticated-orcid":false,"given":"Ana Catarina","family":"de Souza Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"2109_CR1","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00203-022-03051-0","volume":"204","author":"W Alves","year":"2022","unstructured":"Alves W, de O, Scavuzzi AML, Beltr\u00e3o EMB, Oliveira \u00c9M, Santos Vasconcelos CR, Rezende AM et al (2022) Occurrence of blaNDM-7 and association with blaKPC-2, blaCTX-M15, aac, aph, mph(A), catB3 and virulence genes in a clinical isolate of Klebsiella pneumoniae with different plasmids in Brazil. 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