{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T08:33:54Z","timestamp":1759826034315},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s43032-019-00002-x","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T19:03:47Z","timestamp":1581707027000},"page":"100-109","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Trisomy 21 is Associated with Caspase-2 Upregulation in Cytotrophoblasts at the Maternal-Fetal Interface"],"prefix":"10.1007","volume":"27","author":[{"given":"Daisy","family":"Leon-Martinez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua F.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara","family":"Zdravkovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Genbacev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Gormley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Mcmaster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan J.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Bianco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,1]]},"reference":[{"key":"2_CR1","unstructured":"Birth Defects: Data & Statistics in the United States. 2014. http:\/\/www.cdc.gov\/NCBDDD\/birthdefects\/data.html."},{"issue":"3","key":"2_CR2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1086\/520000","volume":"81","author":"E A\u00eft Yahya-Graison","year":"2007","unstructured":"A\u00eft Yahya-Graison E, Aubert J, Dauphinot L, Rivals I, Prieur M, Golfier G, et al. Classification of human chromosome 21 gene-expression variations in Down syndrome: impact on disease phenotypes. Am J Hum Genet. 2007;81(3):475\u201391.","journal-title":"Am J Hum Genet."},{"issue":"3","key":"2_CR3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.5966\/sctm.2012-0117","volume":"2","author":"JA Briggs","year":"2013","unstructured":"Briggs JA, Mason EA, Ovchinnikov DA, Wells CA, Wolvetang EJ. Concise review: new paradigms for Down syndrome research using induced pluripotent stem cells: tackling complex human genetic disease. Stem Cells Transl Med. 2013;2(3):175\u201384.","journal-title":"Stem Cells Transl Med."},{"issue":"3","key":"2_CR4","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1371\/journal.pgen.0020050","volume":"2","author":"RJ Roper","year":"2006","unstructured":"Roper RJ, Reeves RH. Understanding the basis for Down syndrome phenotypes. PLoS Genet. 2006;2(3):e50.","journal-title":"PLoS Genet"},{"issue":"9311","key":"2_CR5","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0140-6736(02)08092-3","volume":"359","author":"Q Yang","year":"2002","unstructured":"Yang Q, Rasmussen SA, Friedman JM. Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study. Lancet. 2002;359(9311):1019\u201325.","journal-title":"Lancet."},{"issue":"5","key":"2_CR6","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1097\/01.AOG.0000215560.86673.22","volume":"107","author":"K Bianco","year":"2006","unstructured":"Bianco K, Caughey AB, Shaffer BL, Davis R, Norton ME. History of miscarriage and increased incidence of fetal aneuploidy in subsequent pregnancy. Obstet Gynecol. 2006;107(5):1098\u2013102.","journal-title":"Obstet Gynecol."},{"issue":"8","key":"2_CR7","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/pd.1970110814","volume":"11","author":"AS Breed","year":"1991","unstructured":"Breed AS, Mantingh A, Vosters R, Beekhuis JR, Van Lith JM, Anders GJ. Follow-up and pregnancy outcome after a diagnosis of mosaicism in CVS. Prenat Diagn. 1991;11(8):577\u201380.","journal-title":"Prenat Diagn."},{"issue":"3","key":"2_CR8","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1097\/GRF.0b013e3181ee2793","volume":"53","author":"RJ Wapner","year":"2010","unstructured":"Wapner RJ. Genetics of stillbirth. Clin Obstet Gynecol. 2010;53(3):628\u201334.","journal-title":"Clin Obstet Gynecol."},{"issue":"9","key":"2_CR9","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/pd.1970070904","volume":"7","author":"MH Bogart","year":"1987","unstructured":"Bogart MH, Pandian MR, Jones OW. Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalities. Prenat Diagn. 1987;7(9):623\u201330.","journal-title":"Prenat Diagn."},{"issue":"7","key":"2_CR10","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1056\/NEJM199908123410701","volume":"341","author":"NJ Wald","year":"1999","unstructured":"Wald NJ, Watt HC, Hackshaw AK. Integrated screening for Down's syndrome on the basis of tests performed during the first and second trimesters. N Engl J Med. 1999;341(7):461\u20137.","journal-title":"N Engl J Med."},{"issue":"Suppl","key":"2_CR11","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/j.placenta.2011.11.007","volume":"33","author":"G Pidoux","year":"2012","unstructured":"Pidoux G, Gerbaud P, Cocquebert M, et al. Review: Human trophoblast fusion and differentiation: lessons from trisomy 21 placenta. Placenta. 2012;33(Suppl):S81\u20136.","journal-title":"Placenta."},{"issue":"11","key":"2_CR12","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1210\/en.2007-0589","volume":"148","author":"G Pidoux","year":"2007","unstructured":"Pidoux G, Gerbaud P, Marpeau O, Guibourdenche J, Ferreira F, Badet J, et al. Human placental development is impaired by abnormal human chorionic gonadotropin signaling in trisomy 21 pregnancies. Endocrinology. 2007;148(11):5403\u201313.","journal-title":"Endocrinology."},{"issue":"7","key":"2_CR13","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1053\/plac.2000.0553","volume":"21","author":"L Roberts","year":"2000","unstructured":"Roberts L, Sebire NJ, Fowler D, Nicolaides KH. Histomorphological features of chorionic villi at 10-14 weeks of gestation in trisomic and chromosomally normal pregnancies. Placenta. 2000;21(7):678\u201383.","journal-title":"Placenta."},{"issue":"4","key":"2_CR14","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1159\/000264470","volume":"12","author":"F Qureshi","year":"1997","unstructured":"Qureshi F, Jacques SM, Johnson MP, Hume RF Jr, Kramer RL, Yaron Y, et al. Trisomy 21 placentas: histopathological and immunohistochemical findings using proliferating cell nuclear antigen. Fetal Diagn Ther. 1997;12(4):210\u20135.","journal-title":"Fetal Diagn Ther."},{"issue":"4","key":"2_CR15","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/ajmg.a.30254","volume":"130","author":"A Wright","year":"2004","unstructured":"Wright A, Zhou Y, Weier JF, et al. Trisomy 21 is associated with variable defects in cytotrophoblast differentiation along the invasive pathway. Am J Med Genet A. 2004;130(4):354\u201364.","journal-title":"Am J Med Genet A."},{"issue":"9","key":"2_CR16","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/pd.4862","volume":"36","author":"K Bianco","year":"2016","unstructured":"Bianco K, Gormley M, Farrell J, Zhou Y, Oliverio O, Tilden H, et al. Placental transcriptomes in the common aneuploidies reveal critical regions on the trisomic chromosomes and genome-wide effects. Prenat Diagn. 2016;36(9):812\u201322.","journal-title":"Prenat Diagn."},{"issue":"9","key":"2_CR17","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.placenta.2008.07.003","volume":"29","author":"AE Heazell","year":"2008","unstructured":"Heazell AE, Crocker IP. Live and let die - regulation of villous trophoblast apoptosis in normal and abnormal pregnancies. Placenta. 2008;29(9):772\u201383.","journal-title":"Placenta."},{"issue":"12","key":"2_CR18","first-page":"1687","volume":"79","author":"B Huppertz","year":"1999","unstructured":"Huppertz B, Frank HG, Reister F, Kingdom J, Korr H, Kaufmann P. Apoptosis cascade progresses during turnover of human trophoblast: analysis of villous cytotrophoblast and syncytial fragments in vitro. Lab Invest. 1999;79(12):1687\u2013702.","journal-title":"Lab Invest."},{"issue":"7","key":"2_CR19","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1210\/er.2005-0003","volume":"26","author":"SL Straszewski-Chavez","year":"2005","unstructured":"Straszewski-Chavez SL, Abrahams VM, Mor G. The role of apoptosis in the regulation of trophoblast survival and differentiation during pregnancy. Endocr Rev. 2005;26(7):877\u201397.","journal-title":"Endocr Rev."},{"issue":"2","key":"2_CR20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.placenta.2007.11.002","volume":"29","author":"AE Heazell","year":"2008","unstructured":"Heazell AE, Lacey HA, Jones CJ, Huppertz B, Baker PN, Crocker IP. Effects of oxygen on cell turnover and expression of regulators of apoptosis in human placental trophoblast. Placenta. 2008;29(2):175\u201386.","journal-title":"Placenta."},{"issue":"4","key":"2_CR21","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.placenta.2008.01.013","volume":"29","author":"SD Klugman","year":"2008","unstructured":"Klugman SD, Gross SJ, Liang J, Livne K, Gross B, Khabele D, et al. Expression of keratin 8 and TNF-related apoptosis-I inducing ligand (TRAIL) in Down syndrome placentas. Placenta. 2008;29(4):382\u20134.","journal-title":"Placenta."},{"issue":"1","key":"2_CR22","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/mrd.20729","volume":"75","author":"M Langbein","year":"2008","unstructured":"Langbein M, Strick R, Strissel PL, Vogt N, Parsch H, Beckmann MW, et al. Impaired cytotrophoblast cell-cell fusion is associated with reduced syncytin and increased apoptosis in patients with placental dysfunction. Mol Reprod Dev. 2008;75(1):175\u201383.","journal-title":"Mol Reprod Dev."},{"issue":"3","key":"2_CR23","first-page":"163","volume":"28","author":"D Tamiolakis","year":"2001","unstructured":"Tamiolakis D, Papadopoulos N, Manavis J, Alexiadis G, Karamanidis D, Kotini A, et al. Differential expression of Bcl-2 proto-oncogene in the trophoblast from embryos with Down's syndrome and those after spontaneous abortion. Clin Exp Obstet Gynecol. 2001;28(3):163\u20137.","journal-title":"Clin Exp Obstet Gynecol."},{"issue":"4","key":"2_CR24","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/ajmg.a.30254","volume":"130A","author":"A Wright","year":"2004","unstructured":"Wright A, Zhou Y, Weier JF, Caceres E, Kapidzic M, Tabata T, et al. Trisomy 21 is associated with variable defects in cytotrophoblast differentiation along the invasive pathway. Am J Med Genet A. 2004;130A(4):354\u201364.","journal-title":"Am J Med Genet A."},{"issue":"6","key":"2_CR25","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/S0002-9378(97)70081-4","volume":"177","author":"SC Smith","year":"1997","unstructured":"Smith SC, Baker PN, Symonds EM. Increased placental apoptosis in intrauterine growth restriction. Am J Obstet Gynecol. 1997;177(6):1395\u2013401.","journal-title":"Am J Obstet Gynecol."},{"issue":"4","key":"2_CR26","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1159\/000320289","volume":"71","author":"S Tomas","year":"2011","unstructured":"Tomas S, Prusac IK, Roje D, Tadin I. Trophoblast apoptosis in placentas from pregnancies complicated by preeclampsia. Gynecol Obstet Investig. 2011;71(4):250\u20135.","journal-title":"Gynecol Obstet Investig."},{"issue":"2","key":"2_CR27","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s00404-005-0028-8","volume":"273","author":"HM Tanir","year":"2005","unstructured":"Tanir HM, Sener T, Artan S, Kaytaz B, Sahin-Mutlu F, Ozen ME. Programmed cell death (apoptosis) in placentas from normal pregnancy and pregnancy complicated by term (t) and preterm (p) premature rupture of membranes (PROM). Arch Gynecol Obstet. 2005;273(2):98\u2013103.","journal-title":"Arch Gynecol Obstet."},{"issue":"3","key":"2_CR28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1600-0897.2010.00837.x","volume":"64","author":"AN Sharp","year":"2010","unstructured":"Sharp AN, Heazell AE, Crocker IP, Mor G. Placental apoptosis in health and disease. Am J Reprod Immunol. 2010;64(3):159\u201369.","journal-title":"Am J Reprod Immunol."},{"issue":"8","key":"2_CR29","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/cdd.2012.36","volume":"19","author":"L Dorstyn","year":"2012","unstructured":"Dorstyn L, Puccini J, Wilson CH, Shalini S, Nicola M, Moore S, et al. Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability. Cell Death Differ. 2012;19(8):1288\u201398.","journal-title":"Cell Death Differ."},{"issue":"7","key":"2_CR30","doi-asserted-by":"crossref","first-page":"e67033","DOI":"10.1371\/journal.pone.0067033","volume":"8","author":"C Han","year":"2013","unstructured":"Han C, Zhao R, Kroger J, Qu M, Wani AA, Wang QE. Caspase-2 short isoform interacts with membrane-associated cytoskeleton proteins to inhibit apoptosis. PLoS One. 2013;8(7):e67033.","journal-title":"PLoS One."},{"issue":"12","key":"2_CR31","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/nrc2745","volume":"9","author":"S Kumar","year":"2009","unstructured":"Kumar S. Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more? Nat Rev Cancer. 2009;9(12):897\u2013903.","journal-title":"Nat Rev Cancer."},{"issue":"8","key":"2_CR32","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/cdd.2012.13","volume":"19","author":"S Shalini","year":"2012","unstructured":"Shalini S, Dorstyn L, Wilson C, Puccini J, Ho L, Kumar S. Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice. Cell Death Differ. 2012;19(8):1370\u201380.","journal-title":"Cell Death Differ."},{"issue":"3","key":"2_CR33","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1172\/JCI116316","volume":"91","author":"Y Zhou","year":"1993","unstructured":"Zhou Y, Damsky CH, Chiu K, Roberts JM, Fisher SJ. Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblasts. J Clin Invest. 1993;91(3):950\u201360.","journal-title":"J Clin Invest."},{"issue":"3","key":"2_CR34","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00441-007-0428-0","volume":"329","author":"Y Zhou","year":"2007","unstructured":"Zhou Y, Bianco K, Huang L, Nien JK, McMaster M, Romero R, et al. Comparative analysis of maternal-fetal interface in preeclampsia and preterm labor. Cell Tissue Res. 2007;329(3):559\u201369.","journal-title":"Cell Tissue Res."},{"issue":"1","key":"2_CR35","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1172\/JCI115565","volume":"89","author":"CH Damsky","year":"1992","unstructured":"Damsky CH, Fitzgerald ML, Fisher SJ. Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo. J Clin Invest. 1992;89(1):210\u201322.","journal-title":"J Clin Invest."},{"issue":"4","key":"2_CR36","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0002-9440(10)62567-9","volume":"160","author":"Y Zhou","year":"2002","unstructured":"Zhou Y, McMaster M, Woo K, Janatpour M, Perry J, Karpanen T, et al. Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Pathol. 2002;160(4):1405\u201323.","journal-title":"Am J Pathol."},{"key":"2_CR37","doi-asserted-by":"crossref","unstructured":"Bianco K, Gormley M, Tilden H, McMaster M, Fisher S. Genomic profiles in common aneuploidies: a combination of dose effect and whole genome misregulation. In. Vol 208, Issue 1, Supplement. American Journal of Obstetrics and Gynecology 2013:S30.","DOI":"10.1016\/j.ajog.2012.10.224"},{"issue":"1","key":"2_CR38","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.canlet.2009.11.008","volume":"292","author":"M Bataller","year":"2010","unstructured":"Bataller M, M\u00e9ndez C, Salas JA, Portugal J. Cellular response and activation of apoptosis by mithramycin SK in p21(WAF1)-deficient HCT116 human colon carcinoma cells. Cancer Lett. 2010;292(1):80\u201390.","journal-title":"Cancer Lett."},{"issue":"24","key":"2_CR39","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1038\/sj.onc.1211005","volume":"27","author":"LH Ho","year":"2008","unstructured":"Ho LH, Read SH, Dorstyn L, Lambrusco L, Kumar S. Caspase-2 is required for cell death induced by cytoskeletal disruption. Oncogene. 2008;27(24):3393\u2013404.","journal-title":"Oncogene."},{"issue":"1","key":"2_CR40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1042\/BJ20130556","volume":"455","author":"YY Jean","year":"2013","unstructured":"Jean YY, Ribe EM, Pero ME, et al. Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death. Biochem J. 2013;455(1):15\u201325.","journal-title":"Biochem J."},{"key":"2_CR41","doi-asserted-by":"crossref","first-page":"e940","DOI":"10.1038\/cddis.2013.463","volume":"4","author":"H Vakifahmetoglu-Norberg","year":"2013","unstructured":"Vakifahmetoglu-Norberg H, Norberg E, Perdomo AB, et al. Caspase-2 promotes cytoskeleton protein degradation during apoptotic cell death. Cell Death Dis. 2013;4:e940.","journal-title":"Cell Death Dis."},{"issue":"6","key":"2_CR42","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1124\/mol.63.6.1437","volume":"63","author":"S Ceruti","year":"2003","unstructured":"Ceruti S, Beltrami E, Matarrese P, Mazzola A, Cattabeni F, Malorni W, et al. A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2\u2032-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells. Mol Pharmacol. 2003;63(6):1437\u201347.","journal-title":"Mol Pharmacol."},{"issue":"9","key":"2_CR43","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1182\/blood.V92.9.3090","volume":"92","author":"Z Estrov","year":"1998","unstructured":"Estrov Z, Thall PF, Talpaz M, Estey EH, Kantarjian HM, Andreeff M, et al. Caspase 2 and caspase 3 protein levels as predictors of survival in acute myelogenous leukemia. Blood. 1998;92(9):3090\u20137.","journal-title":"Blood."},{"issue":"9","key":"2_CR44","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1210\/jcem.82.9.4360","volume":"82","author":"AM Bamberger","year":"1997","unstructured":"Bamberger AM, Schulte HM, Thuneke I, Erdmann I, Bamberger CM, ASA SL. Expression of the apoptosis-inducing Fas ligand (FasL) in human first and third trimester placenta and choriocarcinoma cells. J Clin Endocrinol Metab. 1997;82(9):3173\u20135.","journal-title":"J Clin Endocrinol Metab."},{"key":"2_CR45","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0065-2776(08)60672-0","volume":"57","author":"S Nagata","year":"1994","unstructured":"Nagata S. Fas and Fas ligand: a death factor and its receptor. Adv Immunol. 1994;57:129\u201344.","journal-title":"Adv Immunol."},{"issue":"1","key":"2_CR46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/pd.2409","volume":"30","author":"WP Robinson","year":"2010","unstructured":"Robinson WP, Pe\u00f1aherrera MS, Jiang R, et al. Assessing the role of placental trisomy in preeclampsia and intrauterine growth restriction. Prenat Diagn. 2010;30(1):1\u20138.","journal-title":"Prenat Diagn."},{"issue":"1","key":"2_CR47","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1210\/en.2008-0990","volume":"150","author":"VD Winn","year":"2008","unstructured":"Winn VD, Gormley M, Paquet AC, et al. Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. Endocrinology. 2008;150(1):452\u201362.","journal-title":"Endocrinology"},{"key":"2_CR48","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.placenta.2018.03.005","volume":"65","author":"RL Hannibal","year":"2018","unstructured":"Hannibal RL, Cardoso-Moreira M, Chetty SP, Lau J, Qi Z, Gonzalez-Maldonado E, et al. Investigating human placentation and pregnancy using first trimester chorionic villi. Placenta. 2018;65:65\u201375.","journal-title":"Placenta."},{"issue":"2","key":"2_CR49","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1083\/jcb.109.2.891","volume":"109","author":"SJ Fisher","year":"1989","unstructured":"Fisher SJ, Cui TY, Zhang L, Hartman L, Grahl K, Zhang GY, et al. Adhesive and degradative properties of human placental cytotrophoblast cells in vitro. J Cell Biol. 1989;109(2):891\u2013902.","journal-title":"J Cell Biol."},{"issue":"5","key":"2_CR50","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0955-0674(98)80043-4","volume":"10","author":"CH Damsky","year":"1998","unstructured":"Damsky CH, Fisher SJ. Trophoblast pseudo-vasculogenesis: faking it with endothelial adhesion receptors. Curr Opin Cell Biol. 1998;10(5):660\u20136.","journal-title":"Curr Opin Cell Biol."},{"issue":"12","key":"2_CR51","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1242\/dev.120.12.3657","volume":"120","author":"CH Damsky","year":"1994","unstructured":"Damsky CH, Librach C, Lim KH, Fitzgerald ML, McMaster M, Janatpour M, et al. Integrin switching regulates normal trophoblast invasion. Development. 1994;120(12):3657\u201366.","journal-title":"Development."},{"issue":"2","key":"2_CR52","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1083\/jcb.113.2.437","volume":"113","author":"CL Librach","year":"1991","unstructured":"Librach CL, Werb Z, Fitzgerald ML, Chiu K, Corwin NM, Esteves RA, et al. 92-kD type IV collagenase mediates invasion of human cytotrophoblasts. J Cell Biol. 1991;113(2):437\u201349.","journal-title":"J Cell Biol."},{"issue":"6","key":"2_CR53","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1172\/JCI200422991","volume":"114","author":"K Red-Horse","year":"2004","unstructured":"Red-Horse K, Zhou Y, Genbacev O, Prakobphol A, Foulk R, McMaster M, et al. Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. J Clin Invest. 2004;114(6):744\u201354.","journal-title":"J Clin Invest."},{"issue":"9","key":"2_CR54","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/stem.686","volume":"29","author":"O Genbacev","year":"2011","unstructured":"Genbacev O, Donne M, Kapidzic M, et al. Establishment of human trophoblast progenitor cell lines from the chorion. Stem Cells. 2011;29(9):1427\u201336.","journal-title":"Stem Cells."},{"issue":"1","key":"2_CR55","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1055\/s-0032-1331798","volume":"31","author":"O Genbacev","year":"2013","unstructured":"Genbacev O, Lamb JD, Prakobphol A, Donne M, McMaster MT, Fisher SJ. Human trophoblast progenitors: where do they reside? Semin Reprod Med. 2013;31(1):56\u201361.","journal-title":"Semin Reprod Med."},{"issue":"7","key":"2_CR56","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1084\/jem.192.7.1035","volume":"192","author":"V Jesenberger","year":"2000","unstructured":"Jesenberger V, Procyk KJ, Yuan J, Reipert S, Baccarini M. Salmonella-induced caspase-2 activation in macrophages: a novel mechanism in pathogen-mediated apoptosis. J Exp Med. 2000;192(7):1035\u201346.","journal-title":"J Exp Med."},{"issue":"40","key":"2_CR57","doi-asserted-by":"crossref","first-page":"6743","DOI":"10.1038\/sj.onc.1207848","volume":"23","author":"K Schmelz","year":"2004","unstructured":"Schmelz K, Wieder T, Tamm I, M\u00fcller A, Essmann F, Geilen CC, et al. Tumor necrosis factor alpha sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-kappaB. Oncogene. 2004;23(40):6743\u201359.","journal-title":"Oncogene."},{"key":"2_CR58","doi-asserted-by":"crossref","unstructured":"Shalini S, Dorstyn L, Dawar S, Kumar S. Old, new and emerging functions of caspases. Cell Death Differ. 2014.","DOI":"10.1038\/cdd.2014.216"},{"issue":"3","key":"2_CR59","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.bbrc.2005.03.191","volume":"331","author":"B Zhivotovsky","year":"2005","unstructured":"Zhivotovsky B, Orrenius S. Caspase-2 function in response to DNA damage. Biochem Biophys Res Commun. 2005;331(3):859\u201367.","journal-title":"Biochem Biophys Res Commun."},{"issue":"1","key":"2_CR60","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/sj.cdd.4401186","volume":"10","author":"ME Peter","year":"2003","unstructured":"Peter ME, Krammer PH. The CD95(APO-1\/Fas) DISC and beyond. Cell Death Differ. 2003;10(1):26\u201335.","journal-title":"Cell Death Differ."},{"issue":"3","key":"2_CR61","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1046\/j.1432-1327.1998.2540439.x","volume":"254","author":"K Schulze-Osthoff","year":"1998","unstructured":"Schulze-Osthoff K, Ferrari D, Los M, Wesselborg S, Peter ME. Apoptosis signaling by death receptors. Eur J Biochem. 1998;254(3):439\u201359.","journal-title":"Eur J Biochem."},{"issue":"9","key":"2_CR62","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1177\/1933719113477488","volume":"20","author":"PC Banzato","year":"2013","unstructured":"Banzato PC, Daher S, Traina E, Torloni MR, Gueuvoghlanian-Silva BY, Puccini RF, et al. FAS and FAS-L genotype and expression in patients with recurrent pregnancy loss. Reprod Sci. 2013;20(9):1111\u20135.","journal-title":"Reprod Sci."},{"issue":"1","key":"2_CR63","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/mrd.10331","volume":"66","author":"HK Choi","year":"2003","unstructured":"Choi HK, Choi BC, Lee SH, Kim JW, Cha KY, Baek KH. Expression of angiogenesis- and apoptosis-related genes in chorionic villi derived from recurrent pregnancy loss patients. Mol Reprod Dev. 2003;66(1):24\u201331.","journal-title":"Mol Reprod Dev."},{"issue":"5","key":"2_CR64","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/humrep\/den031","volume":"23","author":"A Kaponis","year":"2008","unstructured":"Kaponis A, Skyrlas A, Zagorianakou N, et al. Coelomic cells show apoptosis via Fas\/FasL system: a comparative study between healthy human pregnancies and missed miscarriages. Hum Reprod. 2008;23(5):1159\u201369.","journal-title":"Hum Reprod."},{"issue":"6","key":"2_CR65","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1095\/biolreprod66.6.1853","volume":"66","author":"S Aschkenazi","year":"2002","unstructured":"Aschkenazi S, Straszewski S, Verwer KM, Foellmer H, Rutherford T, Mor G. Differential regulation and function of the Fas\/Fas ligand system in human trophoblast cells. Biol Reprod. 2002;66(6):1853\u201361.","journal-title":"Biol Reprod."},{"issue":"18","key":"2_CR66","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1038\/onc.2009.36","volume":"28","author":"M Olsson","year":"2009","unstructured":"Olsson M, Vakifahmetoglu H, Abruzzo PM, H\u00f6gstrand K, Grandien A, Zhivotovsky B. DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis. Oncogene. 2009;28(18):1949\u201359.","journal-title":"Oncogene."}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-019-00002-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s43032-019-00002-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-019-00002-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T17:02:16Z","timestamp":1665853336000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s43032-019-00002-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["2"],"URL":"https:\/\/doi.org\/10.1007\/s43032-019-00002-x","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"12 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest. Susan J. Fisher was a consultant for Verinata Health, Inc an Illumina Company. Katherine Bianco was a consultant for SeraCare Life Science Inc.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interests"}}]}}