{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:04:52Z","timestamp":1791950692437,"version":"4.3.4"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s43032-019-00034-3","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T18:03:43Z","timestamp":1583863423000},"page":"1047-1057","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Quercetin Prevents Lipopolysaccharide-Induced Experimental Preterm Labor in Mice and Increases Offspring Survival Rate"],"prefix":"10.1007","volume":"27","author":[{"given":"Xinxiu","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaozhen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingrui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weishe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,10]]},"reference":[{"issue":"9832","key":"34_CR1","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/S0140-6736(12)60560-1","volume":"379","author":"L Liu","year":"2012","unstructured":"Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012;379(9832):2151\u201361.","journal-title":"Lancet."},{"issue":"3","key":"34_CR2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ijgo.2014.06.018","volume":"127","author":"L Zou","year":"2014","unstructured":"Zou L, Wang X, Ruan Y, Li G, Chen Y, Zhang W. Preterm birth and neonatal mortality in China in 2011. Int J Gynecol Obstet. 2014;127(3):243\u20137.","journal-title":"Int J Gynecol Obstet"},{"issue":"9832","key":"34_CR3","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/S0140-6736(12)60560-1","volume":"379","author":"L Liu","year":"2012","unstructured":"Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012;379(9832):2151\u201361.","journal-title":"Lancet."},{"issue":"Suppl 3","key":"34_CR4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1471-0528.2006.01120.x","volume":"113","author":"R Romero","year":"2006","unstructured":"Romero R, Espinoza J, Kusanovic JP, et al. The preterm parturition syndrome. BJOG. 2006;113(Suppl 3):17\u201342.","journal-title":"BJOG."},{"issue":"6198","key":"34_CR5","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.1251816","volume":"345","author":"R Romero","year":"2014","unstructured":"Romero R, Dey SK, Fisher SJ. Preterm labor: one syndrome, many causes. Science. 2014;345(6198):760\u20135.","journal-title":"Science."},{"issue":"9606","key":"34_CR6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","volume":"371","author":"RL Goldenberg","year":"2008","unstructured":"Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008;371(9606):75\u201384.","journal-title":"Lancet."},{"key":"34_CR7","doi-asserted-by":"crossref","unstructured":"Kemp MW. Preterm birth, intrauterine infection, and fetal inflammation. Front Immunol. 2014;5.","DOI":"10.3389\/fimmu.2014.00574"},{"issue":"6","key":"34_CR8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1095\/biolreprod.116.143289","volume":"95","author":"LF Edey","year":"2016","unstructured":"Edey LF, O'Dea KP, Herbert BR, Hua R, Waddington SN, MacIntyre D, et al. The local and systemic immune response to intrauterine LPS in the prepartum mouse. Biol Reprod. 2016;95(6):125.","journal-title":"Biol Reprod"},{"issue":"5","key":"34_CR9","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1096\/fj.13-247783","volume":"28","author":"DA MacIntyre","year":"2014","unstructured":"MacIntyre DA, Lee YS, Migale R, Herbert BR, Waddington SN, Peebles D, et al. Activator protein 1 is a key terminal mediator of inflammation-induced preterm labor in mice. FASEB J. 2014;28(5):2358\u201368.","journal-title":"FASEB J"},{"issue":"1","key":"34_CR10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1095\/biolreprod.110.085746","volume":"84","author":"WS Zhang","year":"2011","unstructured":"Zhang WS, Xie QS, Wu XH, Liang QH. Neuromedin B and its receptor induce labor onset and are associated with the RELA (NFKB P65)\/IL6 pathway in pregnant mice. Biol Reprod. 2011;84(1):113\u20137.","journal-title":"Biol Reprod"},{"issue":"5","key":"34_CR11","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1095\/biolreprod.111.095984","volume":"86","author":"WS Zhang","year":"2012","unstructured":"Zhang WS, Fei KL, Wu MT, Wu XH, Liang QH. Neuromedin B and its receptor influence the activity of myometrial primary cells in vitro through regulation of Il6 expression via the Rela\/p65 pathway in mice. Biol Reprod. 2012;86(5):154 1-7.","journal-title":"Biol Reprod"},{"issue":"3","key":"34_CR12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3390\/nu8030167","volume":"8","author":"Y Li","year":"2016","unstructured":"Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, et al. Quercetin, Inflammation and Immunity. Nutrients. 2016;8(3):167.","journal-title":"Nutrients"},{"key":"34_CR13","doi-asserted-by":"crossref","unstructured":"Ekinci AF, Gulcin I, Karagoz B, Soslu R. Quercetin protects rat skeletal muscle from ischemia reperfusion injury. J Enzyme Inhib Med Chem. 2016;31(sup2):162\u2013166.","DOI":"10.1080\/14756366.2016.1193735"},{"key":"34_CR14","doi-asserted-by":"crossref","unstructured":"Leiherer A, Stoemmer K, Muendlein A, et al. Quercetin impacts expression of metabolism- and obesity-associated genes in SGBS adipocytes. Nutrients. 2016;8(5).","DOI":"10.3390\/nu8050282"},{"key":"34_CR15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.fct.2017.03.048","volume":"105","author":"L Xiao","year":"2017","unstructured":"Xiao L, Liu L, Guo X, Zhang S, Wang J, Zhou F, et al. Quercetin attenuates high fat diet-induced atherosclerosis in apolipoprotein E knockout mice: a critical role of NADPH oxidase. Food Chem Toxicol. 2017;105:22\u201333.","journal-title":"Food Chem Toxicol"},{"key":"34_CR16","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jnutbio.2015.09.016","volume":"27","author":"C Carrasco-Pozo","year":"2016","unstructured":"Carrasco-Pozo C, Castillo RL, Beltran C, et al. Molecular mechanisms of gastrointestinal protection by quercetin against indomethacin-induced damage: role of NF-kappaB and Nrf2. J Nutr Biochem. 2016;27:289\u201398.","journal-title":"J Nutr Biochem"},{"issue":"11","key":"34_CR17","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/pros.23536","volume":"78","author":"LQ Meng","year":"2018","unstructured":"Meng LQ, Yang FY, Wang MS, Shi BK, Chen DX, Chen D, et al. Quercetin protects against chronic prostatitis in rat model through NF-kappaB and MAPK signaling pathways. Prostate. 2018;78(11):790\u2013800.","journal-title":"Prostate."},{"issue":"2","key":"34_CR18","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.siny.2015.12.008","volume":"21","author":"HCG Nadeau","year":"2016","unstructured":"Nadeau HCG, Subramaniam A, Andrews WW. Infection and preterm birth. Semin Fetal Neonatal Med. 2016;21(2):100\u20135.","journal-title":"Semin Fetal Neonatal Med"},{"issue":"9","key":"34_CR19","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1016\/j.ajpath.2015.05.015","volume":"185","author":"R Migale","year":"2015","unstructured":"Migale R, Herbert BR, Lee YS, Sykes L, Waddington SN, Peebles D, et al. Specific lipopolysaccharide serotypes induce differential maternal and neonatal inflammatory responses in a murine model of preterm labor. Am J Pathol. 2015;185(9):2390\u2013401.","journal-title":"Am J Pathol"},{"issue":"1","key":"34_CR20","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/jcmm.13335","volume":"22","author":"L Nadeem","year":"2018","unstructured":"Nadeem L, Farine T, Dorogin A, Matysiak-Zablocki E, Shynlova O, Lye S. Differential expression of myometrial AP-1 proteins during gestation and labour. J Cell Mol Med. 2018;22(1):452\u201371.","journal-title":"J Cell Mol Med"},{"issue":"3","key":"34_CR21","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/biolre\/iox180","volume":"98","author":"AR Willcockson","year":"2018","unstructured":"Willcockson AR, Nandu T, Liu CL, Nallasamy S, Kraus WL, Mahendroo M. Transcriptome signature identifies distinct cervical pathways induced in lipopolysaccharide-mediated preterm birth. Biol Reprod. 2018;98(3):408\u201321.","journal-title":"Biol Reprod"},{"issue":"11","key":"34_CR22","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.3390\/ijms18112497","volume":"18","author":"M Lee","year":"2017","unstructured":"Lee M, Yun S, Lee H, Yang J. Quercetin mitigates inflammatory responses induced by vascular endothelial growth factor in mouse retinal photoreceptor cells through suppression of nuclear factor kappa B. Int J Mol Sci. 2017;18(11):2497.","journal-title":"Int J Mol Sci"},{"key":"34_CR23","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.intimp.2017.03.029","volume":"47","author":"R Wang","year":"2017","unstructured":"Wang R, Zhang H, Wang Y, Song F, Yuan Y. Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-\u043aB\/I\u043aB\u03b1, p38 MAPK, and Bcl-2\/Bax signaling. Int Immunopharmacol. 2017;47:126\u201333.","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"34_CR24","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/ptr.6268","volume":"33","author":"T Li","year":"2019","unstructured":"Li T, Li F, Liu X, Liu J, Li D. Synergistic anti-inflammatory effects of quercetin and catechin via inhibiting activation of TLR4-MyD88-mediated NF-\u03baB and MAPK signaling pathways. Phytother Res. 2019;33(3):756\u201367.","journal-title":"Phytother Res"},{"key":"34_CR25","doi-asserted-by":"crossref","unstructured":"Koyama Y, Kaidzu S, Kim YC, et al. Suppression of light-induced retinal degeneration by quercetin via the AP-1 pathway in rats. Antioxidants (Basel). 2019;8(4).","DOI":"10.3390\/antiox8040079"},{"issue":"4","key":"34_CR26","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.phrs.2010.06.003","volume":"62","author":"SR Panicker","year":"2010","unstructured":"Panicker SR, Sreenivas P, Babu MS, Karunagaran D, Kartha CC. Quercetin attenuates monocyte chemoattractant protein-1 gene expression in glucose primed aortic endothelial cells through NF-\u03baB and AP-1. Pharmacol Res. 2010;62(4):328\u201336.","journal-title":"Pharmacol Res"},{"issue":"38","key":"34_CR27","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000012494","volume":"97","author":"Q Peng","year":"2018","unstructured":"Peng Q, Liu Y, Dong M, Xu F, Huang J, Chen J, et al. Interaction between NF-\u03baB and AP-1 and their intracellular localization at labor in human late pregnant myometrial cells in vivo and in vitro. Medicine. 2018;97(38):e12494.","journal-title":"Medicine."},{"issue":"5","key":"34_CR28","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1007\/s00011-007-6172-9","volume":"56","author":"YD Min","year":"2007","unstructured":"Min YD, Choi CH, Bark H, Son HY, Park HH, Lee S, et al. Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-\u03baB and p38 MAPK in HMC-1 human mast cell line. Inflamm Res. 2007;56(5):210\u20135.","journal-title":"Inflamm Res"},{"issue":"1","key":"34_CR29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4155\/fmc-2016-0186","volume":"9","author":"G Carullo","year":"2017","unstructured":"Carullo G, Cappello AR, Frattaruolo L, Badolato M, Armentano B, Aiello F. Quercetin and derivatives: useful tools in inflammation and pain management. Future Med Chem. 2017;9(1):79\u201393.","journal-title":"Future Med Chem"},{"issue":"9606","key":"34_CR30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","volume":"371","author":"RL Goldenberg","year":"2008","unstructured":"Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008;371(9606):75\u201384.","journal-title":"Lancet."},{"key":"34_CR31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.intimp.2017.06.031","volume":"50","author":"N Yin","year":"2017","unstructured":"Yin N, Wang H, Zhang H, Ge H, Tan B, Yuan Y, et al. IL-27 induces a pro-inflammatory response in human fetal membranes mediating preterm birth. Int Immunopharmacol. 2017;50:361\u20139.","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"34_CR32","doi-asserted-by":"crossref","first-page":"e12685","DOI":"10.1111\/aji.12685","volume":"78","author":"R Romero","year":"2017","unstructured":"Romero R, Chaemsaithong P, Chaiyasit N, et al. CXCL10 and IL-6: markers of two different forms of intra-amniotic inflammation in preterm labor. Am J Reprod Immunol. 2017;78(1):e12685.","journal-title":"Am J Reprod Immunol"},{"key":"34_CR33","doi-asserted-by":"crossref","first-page":"126","DOI":"10.4103\/2277-9175.133243","volume":"3","author":"Z Shahshahan","year":"2014","unstructured":"Shahshahan Z, Hashemi L. Maternal serum cytokines in the prediction of preterm labor and response to tocolytic therapy in preterm labor women. Adv Biomed Res. 2014;3:126.","journal-title":"Adv Biomed Res"},{"issue":"3","key":"34_CR34","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ajpath.2015.11.004","volume":"186","author":"A Toda","year":"2016","unstructured":"Toda A, Sawada K, Fujikawa T, Wakabayashi A, Nakamura K, Sawada I, et al. Targeting inhibitor of \u03baB kinase \u03b2 prevents inflammation-induced preterm delivery by inhibiting IL-6 production from amniotic cells. Am J Pathol. 2016;186(3):616\u201329.","journal-title":"Am J Pathol"},{"issue":"3","key":"34_CR35","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1177\/1099800404271900","volume":"6","author":"L Farina","year":"2005","unstructured":"Farina L, Winkelman C. A review of the role of proinflammatory cytokines in labor and noninfectious preterm labor. Biol Res Nurs. 2005;6(3):230\u20138.","journal-title":"Biol Res Nurs"},{"issue":"3","key":"34_CR36","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1034\/j.1600-0897.2001.d01-6.x","volume":"46","author":"U Friebe-Hoffmann","year":"2001","unstructured":"Friebe-Hoffmann U, Chiao JP, Rauk PN. Effect of IL-1beta and IL-6 on oxytocin secretion in human uterine smooth muscle cells. Am J Reprod Immunol. 2001;46(3):226\u201331.","journal-title":"Am J Reprod Immunol"},{"issue":"2\u20133","key":"34_CR37","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ejphar.2008.03.008","volume":"585","author":"AW Boots","year":"2008","unstructured":"Boots AW, Haenen GRMM, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. 2008;585(2\u20133):325\u201337.","journal-title":"Eur J Pharmacol"},{"issue":"5\u20136","key":"34_CR38","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S0006-2952(02)01153-X","volume":"64","author":"I Rahman","year":"2002","unstructured":"Rahman I. Oxidative stress, transcription factors and chromatin remodelling in lung inflammation. Biochem Pharmacol. 2002;64(5\u20136):935\u201342.","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"34_CR39","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/jcp.25637","volume":"232","author":"W Lim","year":"2017","unstructured":"Lim W, Yang C, Park S, Bazer FW, Song G. Inhibitory effects of quercetin on progression of human choriocarcinoma cells are mediated through PI3K\/AKT and MAPK signal transduction cascades. J Cell Physiol. 2017;232(6):1428\u201340.","journal-title":"J Cell Physiol"},{"issue":"2\u20133","key":"34_CR40","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.tox.2011.10.017","volume":"290","author":"K Vanhees","year":"2011","unstructured":"Vanhees K, Godschalk RW, Sanders A, van Waalwijk Van Doorn-Khosrovani SB, van Schooten FJ. Maternal quercetin intake during pregnancy results in an adapted iron homeostasis at adulthood. Toxicology. 2011;290(2\u20133):350\u20138.","journal-title":"Toxicology."},{"issue":"12","key":"34_CR41","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1089\/jmf.2014.3293","volume":"18","author":"H Shahzad","year":"2015","unstructured":"Shahzad H, Giribabu N, Sekaran M, Salleh N. Quercetin induces dose-dependent differential morphological and proliferative changes in rat uteri in the presence and in the absence of estrogen. J Med Food. 2015;18(12):1307\u201316.","journal-title":"J Med Food"},{"issue":"9","key":"34_CR42","first-page":"5484","volume":"7","author":"H Shahzad","year":"2014","unstructured":"Shahzad H, Giribabu N, Muniandy S, Salleh N. Quercetin induces morphological and proliferative changes of rat's uteri under estrogen and progesterone influences. Int J Clin Exp Pathol. 2014;7(9):5484.","journal-title":"Int J Clin Exp Pathol"},{"key":"34_CR43","first-page":"1","volume":"2014","author":"L Xu","year":"2014","unstructured":"Xu L, Sun L, Lu L, et al. Effects of quercetin on CYP450 and cytokines in Aroclor 1254 injured endometrial cells of the pregnant rats. Biomed Res Int. 2014;2014:1\u20137.","journal-title":"Biomed Res Int"},{"issue":"6","key":"34_CR44","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0254-6272(17)30008-0","volume":"36","author":"X Wang","year":"2016","unstructured":"Wang X, Yan Y, Yang L, Li M, Zhong X. Effect of quercetin on the expression of Bcl-2\/Bax apoptotic proteins in endometrial cells of lipopolysaccharide-induced-abortion. J Tradit Chin Med. 2016;36(6):737\u201342.","journal-title":"J Tradit Chin Med"},{"issue":"3","key":"34_CR45","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3390\/nu8030167","volume":"8","author":"Y Li","year":"2016","unstructured":"Li Y, Yao J, Han C, et al. Quercetin, Inflammation and Immunity. Nutrients. 2016;8(3):167.","journal-title":"Nutrients"},{"key":"34_CR46","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.fitote.2015.09.018","volume":"106","author":"G D'Andrea","year":"2015","unstructured":"D'Andrea G. Quercetin: a flavonol with multifaceted therapeutic applications? Fitoterapia. 2015;106:256\u201371.","journal-title":"Fitoterapia."},{"issue":"10","key":"34_CR47","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1093\/jn\/131.10.2648","volume":"131","author":"T Walle","year":"2001","unstructured":"Walle T, Walle UK, Halushka PV. Carbon dioxide is the major metabolite of quercetin in humans. J Nutr. 2001;131(10):2648\u201352.","journal-title":"J Nutr"},{"key":"34_CR48","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pnpbp.2014.05.007","volume":"54","author":"D Nieoczym","year":"2014","unstructured":"Nieoczym D, Soca\u0142a K, Raszewski G, Wla\u017a P. Effect of quercetin and rutin in some acute seizure models in mice. Prog Neuro-Psychopharmacol Biol Psychiatry. 2014;54:50\u20138.","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"11","key":"34_CR49","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1016\/j.fct.2007.05.015","volume":"45","author":"M Harwood","year":"2007","unstructured":"Harwood M, Danielewska-Nikiel B, Borzelleca JF, et al. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic\/carcinogenic properties. Food Chem Toxicol. 2007;45(11):2179\u2013205.","journal-title":"Food Chem Toxicol"},{"issue":"4","key":"34_CR50","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/bdd.605","volume":"29","author":"YJ Moon","year":"2008","unstructured":"Moon YJ, Wang L, DiCenzo R, Morris ME. Quercetin pharmacokinetics in humans. Biopharm Drug Dispos. 2008;29(4):205\u201317.","journal-title":"Biopharm Drug Dispos"},{"issue":"2","key":"34_CR51","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3181\/00379727-77-18746","volume":"77","author":"M Sullivan","year":"1951","unstructured":"Sullivan M, Follis RJ, Hilgartner M. Toxicology of podophyllin. Proc Soc Exp Biol Med. 1951;77(2):269\u201372.","journal-title":"Proc Soc Exp Biol Med"},{"issue":"1","key":"34_CR52","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0278-6915(82)80012-4","volume":"20","author":"CC Willhite","year":"1982","unstructured":"Willhite CC. Teratogenic potential of quercetin in the rat. Food Chem Toxicol. 1982;20(1):75\u20139.","journal-title":"Food Chem Toxicol"},{"issue":"4","key":"34_CR53","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jnutbio.2013.10.002","volume":"25","author":"S Wang","year":"2014","unstructured":"Wang S, Su R, Nie S, Sun M, Zhang J, Wu D, et al. Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals. J Nutr Biochem. 2014;25(4):363\u201376.","journal-title":"J Nutr Biochem"},{"issue":"4","key":"34_CR54","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.tiv.2009.02.004","volume":"23","author":"C Bovet","year":"2009","unstructured":"Bovet C, Plet B, Ruff M, Eiler S, Granger F, Panagiotidis A, et al. Towards high-throughput identification of endocrine disrupting compounds with mass spectrometry. Toxicol in Vitro. 2009;23(4):704\u20139.","journal-title":"Toxicol in Vitro"},{"key":"34_CR55","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.reprotox.2017.03.012","volume":"69","author":"H Shahzad","year":"2017","unstructured":"Shahzad H, Giribabu N, Karim K, Muniandy S, Kassim NM, Salleh N. Quercetin alters uterine fluid volume and aquaporin (AQP) subunits (AQP-1, 2, 5 & 7) expression in the uterus in the presence of sex-steroids in rats. Reprod Toxicol. 2017;69:276\u201385.","journal-title":"Reprod Toxicol"},{"issue":"2","key":"34_CR56","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1207\/S15327914NC382_13","volume":"38","author":"BM Collins-Burow","year":"2000","unstructured":"Collins-Burow BM, Burow ME, Duong BN, McLachlan JA. Estrogenic and antiestrogenic activities of flavonoid phytochemicals through estrogen receptor binding-dependent and -independent mechanisms. Nutr Cancer. 2000;38(2):229\u201344.","journal-title":"Nutr Cancer"},{"issue":"3","key":"34_CR57","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.semcdb.2007.05.003","volume":"18","author":"S Mesiano","year":"2007","unstructured":"Mesiano S, Welsh TN. Steroid hormone control of myometrial contractility and parturition. Semin Cell Dev Biol. 2007;18(3):321\u201331.","journal-title":"Semin Cell Dev Biol"},{"issue":"5","key":"34_CR58","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/humupd\/dmw022","volume":"22","author":"R Menon","year":"2016","unstructured":"Menon R, Bonney EA, Condon J, Mesiano S, Taylor RN. Novel concepts on pregnancy clocks and alarms: redundancy and synergy in human parturition. Hum Reprod Update. 2016;22(5):535\u201360.","journal-title":"Hum Reprod Update"},{"issue":"3","key":"34_CR59","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.semcdb.2007.05.002","volume":"18","author":"BA L\u00f3pez","year":"2007","unstructured":"L\u00f3pez BA. The regulation of uterine relaxation. Semin Cell Dev Biol. 2007;18(3):340\u20137.","journal-title":"Semin Cell Dev Biol"},{"issue":"2","key":"34_CR60","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1476-5381.1993.tb12832.x","volume":"108","author":"J Senior","year":"1993","unstructured":"Senior J, Marshall K, Sangha R, Clayton JK. In vitro characterization of prostanoid receptors on human myometrium at term pregnancy. Brit J Pharmacol. 1993;108(2):501\u20136.","journal-title":"Brit J Pharmacol"},{"issue":"3","key":"34_CR61","first-page":"E719","volume":"295","author":"S Hsia","year":"2008","unstructured":"Hsia S, Kuo Y, Chiang W, Wang PS. Effects of adlay hull extracts on uterine contraction and Ca2+ mobilization in the rat. Am J Physiol-Endoc M. 2008;295(3):E719\u201326.","journal-title":"Am J Physiol-Endoc M"},{"issue":"1","key":"34_CR62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/rep.0.1240001","volume":"124","author":"JR Challis","year":"2002","unstructured":"Challis JR, Sloboda DM, Alfaidy N, Lye SJ, Gibb W, Patel FA, et al. Prostaglandins and mechanisms of preterm birth. Reproduction. 2002;124(1):1\u201317.","journal-title":"Reproduction."},{"issue":"5","key":"34_CR63","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1056\/NEJMra050435","volume":"357","author":"HN Simhan","year":"2007","unstructured":"Simhan HN, Caritis SN. Prevention of preterm delivery. N Engl J Med. 2007;357(5):477\u201387.","journal-title":"N Engl J Med"},{"issue":"6","key":"34_CR64","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/molehr\/7.6.595","volume":"7","author":"M Sakai","year":"2001","unstructured":"Sakai M, Tanebe K, Sasaki Y, Momma K, Yoneda S, Saito S. Evaluation of the tocolytic effect of a selective cyclooxygenase-2 inhibitor in a mouse model of lipopolysaccharide-induced preterm delivery. Mol Hum Reprod. 2001;7(6):595\u2013602.","journal-title":"Mol Hum Reprod"},{"issue":"11","key":"34_CR65","doi-asserted-by":"crossref","first-page":"934","DOI":"10.2174\/1389201017666160630192037","volume":"17","author":"G Rezaeizadeh","year":"2016","unstructured":"Rezaeizadeh G, Hantoushzadeh S, Ghiasi S, Nikfar S, Abdollahi M. A systematic review of the uterine relaxant effect of herbal sources. Curr Pharm Biotechnol. 2016;17(11):934.","journal-title":"Curr Pharm Biotechnol"},{"issue":"5","key":"34_CR66","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.lfs.2003.06.039","volume":"74","author":"M Ajay","year":"2003","unstructured":"Ajay M, Gilani AH, Mustafa MR. Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sci. 2003;74(5):603\u201312.","journal-title":"Life Sci"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-019-00034-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s43032-019-00034-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-019-00034-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T00:17:59Z","timestamp":1615335479000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s43032-019-00034-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,10]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["34"],"URL":"https:\/\/doi.org\/10.1007\/s43032-019-00034-3","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,10]]},"assertion":[{"value":"26 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The author(s) declare(s) that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interests"}}]}}