{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:23:39Z","timestamp":1776381819123,"version":"3.51.2"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1007\/s43032-019-00039-y","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T17:04:25Z","timestamp":1580749465000},"page":"477-487","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Intermittent Hypoxia Impairs Trophoblast Cell Viability by Triggering the Endoplasmic Reticulum Stress Pathway"],"prefix":"10.1007","volume":"27","author":[{"given":"Wei","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Lin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanli","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengnan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"issue":"3","key":"39_CR1","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0002-9440(10)61778-6","volume":"159","author":"TH Hung","year":"2001","unstructured":"Hung TH, Skepper JN, Burton GJ. In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnancies. Am J Pathol. 2001;159(3):1031\u201343.","journal-title":"Am J Pathol"},{"issue":"2","key":"39_CR2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3122\/jabfm.2009.02.080057","volume":"22","author":"C Venkata","year":"2009","unstructured":"Venkata C, Venkateshiah SB. Sleep-disordered breathing during pregnancy. J Am Board Fam Med. 2009;22(2):158\u201368.","journal-title":"J Am Board Fam Med"},{"issue":"3","key":"39_CR3","doi-asserted-by":"crossref","first-page":"261 e261","DOI":"10.1016\/j.ajog.2009.10.867","volume":"202","author":"JM Louis","year":"2010","unstructured":"Louis JM, Auckley D, Sokol RJ, Mercer BM. Maternal and neonatal morbidities associated with obstructive sleep apnea complicating pregnancy. Am J Obstet Gynecol. 2010;202(3):261 e261\u20135.","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"39_CR4","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s11325-014-0946-4","volume":"18","author":"XX Ding","year":"2014","unstructured":"Ding XX, Wu YL, Xu SJ, Zhang SF, Jia XM, Zhu RP, et al. A systematic review and quantitative assessment of sleep-disordered breathing during pregnancy and perinatal outcomes. Sleep Breath. 2014;18(4):703\u201313.","journal-title":"Sleep Breath"},{"issue":"6","key":"39_CR5","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/jmwh.12141","volume":"58","author":"JG Hensley","year":"2013","unstructured":"Hensley JG. Common sleep disorders: management strategies and pregnancy outcomes. J Midwifery Womens Health. 2013;58(6):716.","journal-title":"J Midwifery Womens Health"},{"key":"39_CR6","first-page":"285","volume":"131","author":"KA Champagne","year":"2010","unstructured":"Champagne KA, Kimoff RJ, Barriga PC, Schwartzman K. Sleep disordered breathing in women of childbearing age & during pregnancy. Indian J Med Res. 2010;131:285\u2013301.","journal-title":"Indian J Med Res"},{"issue":"1","key":"39_CR7","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijgo.2006.01.004","volume":"93","author":"C Domingo","year":"2006","unstructured":"Domingo C, Latorre E, Mirapeix RM, Abad J. Snoring, obstructive sleep apnea syndrome, and pregnancy. Int J Gynaecol Obstet. 2006;93(1):57\u20139.","journal-title":"Int J Gynaecol Obstet"},{"issue":"8","key":"39_CR8","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1097\/00007611-199808000-00013","volume":"91","author":"DF Lewis","year":"1998","unstructured":"Lewis DF, Chesson AL, Edwards MS, Weeks JW, Adair CD. Obstructive sleep apnea during pregnancy resulting in pulmonary hypertension. South Med J. 1998;91(8):761\u20132.","journal-title":"South Med J"},{"issue":"5","key":"39_CR9","first-page":"543","volume":"108","author":"KA Brain","year":"2001","unstructured":"Brain KA, Thornton JG, Sarkar A, Johnson AO. Obstructive sleep apnoea and fetal death: successful treatment with continuous positive airway pressure. BJOG. 2001;108(5):543\u20134.","journal-title":"BJOG."},{"issue":"7)","key":"39_CR10","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/sleep\/27.7.1405","volume":"27","author":"GW Pien","year":"2004","unstructured":"Pien GW, Schwab RJ. Sleep disorders during pregnancy. Sleep. 2004;27(7)):1405\u201317.","journal-title":"Sleep"},{"issue":"11","key":"39_CR11","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1080\/00016340701662183","volume":"86","author":"G Koken","year":"2007","unstructured":"Koken G, Sahin FK, Cosar E, et al. Oxidative stress markers in pregnant women who snore and fetal outcome: a case control study. Acta Obstet Gynecol Scand. 2007;86(11):1317\u201321.","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"4","key":"39_CR12","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1183\/09031936.00021810","volume":"36","author":"G Bourjeily","year":"2010","unstructured":"Bourjeily G, Raker CA, Chalhoub M, Miller MA. Pregnancy and fetal outcomes of symptoms of sleep-disordered breathing. Eur Respir J. 2010;36(4):849\u201355.","journal-title":"Eur Respir J"},{"issue":"5","key":"39_CR13","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1097\/EDE.0b013e31822546fd","volume":"22","author":"K Micheli","year":"2011","unstructured":"Micheli K, Komninos I, Bagkeris E, Roumeliotaki T, Koutis A, Kogevinas M, et al. Sleep patterns in late pregnancy and risk of preterm birth and fetal growth restriction. Epidemiology. 2011;22(5):738\u201344.","journal-title":"Epidemiology."},{"issue":"2","key":"39_CR14","first-page":"136 e131","volume":"206","author":"YH Chen","year":"2012","unstructured":"Chen YH, Kang JH, Lin CC, Wang IT, Keller JJ, Lin HC. Obstructive sleep apnea and the risk of adverse pregnancy outcomes. Am J Obstet Gynecol. 2012;206(2):136 e131\u20135.","journal-title":"Am J Obstet Gynecol"},{"key":"39_CR15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1472-6874-10-17","volume":"10","author":"C Qiu","year":"2010","unstructured":"Qiu C, Enquobahrie D, Frederick IO, Abetew D, Williams MA. Glucose intolerance and gestational diabetes risk in relation to sleep duration and snoring during pregnancy: a pilot study. BMC Womens Health. 2010;10:17.","journal-title":"BMC Womens Health"},{"issue":"2","key":"39_CR16","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1164\/ajrccm\/144.2.461","volume":"144","author":"M Charbonneau","year":"1991","unstructured":"Charbonneau M, Falcone T, Cosio MG, Levy RD. Obstructive sleep apnea during pregnancy. Therapy and implications for fetal health. Am Rev Respir Dis. 1991;144(2):461\u20133.","journal-title":"Am Rev Respir Dis"},{"issue":"10","key":"39_CR17","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1210\/jc.2013-2348","volume":"98","author":"S Reutrakul","year":"2013","unstructured":"Reutrakul S, Zaidi N, Wroblewski K, Kay HH, Ismail M, Ehrmann DA, et al. Interactions between pregnancy, obstructive sleep apnea, and gestational diabetes mellitus. J Clin Endocrinol Metab. 2013;98(10):4195\u2013202.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"39_CR18","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1183\/09031936.00122607","volume":"33","author":"K Champagne","year":"2009","unstructured":"Champagne K, Schwartzman K, Opatrny L, Barriga P, Morin L, Mallozzi A, et al. Obstructive sleep apnoea and its association with gestational hypertension. Eur Respir J. 2009;33(3):559\u201365.","journal-title":"Eur Respir J"},{"issue":"3 Pt 2","key":"39_CR19","first-page":"453","volume":"74","author":"J Kowall","year":"1989","unstructured":"Kowall J, Clark G, Nino-Murcia G, Powell N. Precipitation of obstructive sleep apnea during pregnancy. Obstet Gynecol. 1989;74(3 Pt 2):453\u20135.","journal-title":"Obstet Gynecol"},{"issue":"2","key":"39_CR20","first-page":"151","volume":"5","author":"M Conti","year":"1988","unstructured":"Conti M, Izzo V, Muggiasca ML, Tiengo M. Sleep apnoea syndrome in pregnancy: a case report. Eur J Anaesthesiol. 1988;5(2):151\u20134.","journal-title":"Eur J Anaesthesiol"},{"issue":"8","key":"39_CR21","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/00006254-199608000-00024","volume":"51","author":"LA Lefcourt","year":"1996","unstructured":"Lefcourt LA, Rodis JF. Obstructive sleep apnea in pregnancy. Obstet Gynecol Surv. 1996;51(8):503\u20136.","journal-title":"Obstet Gynecol Surv"},{"issue":"5 Pt 1","key":"39_CR22","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/S0002-9378(12)90747-4","volume":"165","author":"DM Sherer","year":"1991","unstructured":"Sherer DM, Caverly CB, Abramowicz JS. Severe obstructive sleep apnea and associated snoring documented during external tocography. Am J Obstet Gynecol. 1991;165(5 Pt 1):1300\u20131.","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"39_CR23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ijgo.2013.01.013","volume":"121","author":"JT Owusu","year":"2013","unstructured":"Owusu JT, Anderson FJ, Coleman J, Oppong S, Seffah JD, Aikins A, et al. Association of maternal sleep practices with pre-eclampsia, low birth weight, and stillbirth among Ghanaian women. Int J Gynaecol Obstet. 2013;121(3):261\u20135.","journal-title":"Int J Gynaecol Obstet"},{"issue":"8","key":"39_CR24","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.3109\/14767058.2011.629255","volume":"25","author":"R Tauman","year":"2012","unstructured":"Tauman R, Sivan Y, Katsav S, Greenfeld M, Many A. Maternal snoring during pregnancy is not associated with fetal growth restriction. J Matern Fetal Neonatal Med. 2012;25(8):1283\u20136.","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"2","key":"39_CR25","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0028-2243(78)90131-4","volume":"8","author":"SJ Joel-Cohen","year":"1978","unstructured":"Joel-Cohen SJ, Schoenfeld A. Fetal response to periodic sleep apnea: a new syndrome in obstetrics. Eur J Obstet Gynecol Reprod Biol. 1978;8(2):77\u201381.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"7","key":"39_CR26","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1080\/00016340701281919","volume":"86","author":"D Perez-Chada","year":"2007","unstructured":"Perez-Chada D, Videla AJ, O'Flaherty ME, et al. Snoring, witnessed sleep apnoeas and pregnancy-induced hypertension. Acta Obstet Gynecol Scand. 2007;86(7):788\u201392.","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"2","key":"39_CR27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00404-009-1327-2","volume":"283","author":"A Ayrim","year":"2011","unstructured":"Ayrim A, Keskin EA, Ozol D, Onaran Y, Yiidirim Z, Kafali H. Influence of self-reported snoring and witnessed sleep apnea on gestational hypertension and fetal outcome in pregnancy. Arch Gynecol Obstet. 2011;283(2):195\u20139.","journal-title":"Arch Gynecol Obstet"},{"issue":"6","key":"39_CR28","doi-asserted-by":"crossref","first-page":"487 e481","DOI":"10.1016\/j.ajog.2012.08.034","volume":"207","author":"LM O'Brien","year":"2012","unstructured":"O'Brien LM, Bullough AS, Owusu JT, et al. Pregnancy-onset habitual snoring, gestational hypertension, and preeclampsia: prospective cohort study. Am J Obstet Gynecol. 2012;207(6):487 e481\u20139.","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"39_CR29","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1515\/jpm-2014-0052","volume":"43","author":"G Bourjeily","year":"2015","unstructured":"Bourjeily G, Curran P, Butterfield K, Maredia H, Carpenter M, Lambert-Messerlian G. Placenta-secreted circulating markers in pregnant women with obstructive sleep apnea. J Perinat Med. 2015;43(1):81\u20137.","journal-title":"J Perinat Med"},{"issue":"2","key":"39_CR30","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.mehy.2009.03.007","volume":"73","author":"R Jerath","year":"2009","unstructured":"Jerath R, Barnes VA, Fadel HE. Mechanism of development of pre-eclampsia linking breathing disorders to endothelial dysfunction. Med Hypotheses. 2009;73(2):163\u20136.","journal-title":"Med Hypotheses"},{"issue":"6","key":"39_CR31","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/jp.2012.14","volume":"32","author":"AM Fung","year":"2012","unstructured":"Fung AM, Wilson DL, Barnes M, Walker SP. Obstructive sleep apnea and pregnancy: the effect on perinatal outcomes. J Perinatol Jun. 2012;32(6):399\u2013406.","journal-title":"J Perinatol Jun"},{"issue":"4","key":"39_CR32","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1183\/09031936.01.00053501","volume":"18","author":"G Connolly","year":"2001","unstructured":"Connolly G, Razak AR, Hayanga A, Russell A, McKenna P, McNicholas WT. Inspiratory flow limitation during sleep in pre-eclampsia: comparison with normal pregnant and nonpregnant women. Eur Respir J. 2001;18(4):672\u20136.","journal-title":"Eur Respir J"},{"issue":"2","key":"39_CR33","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1006\/excr.1993.1139","volume":"206","author":"CH Graham","year":"1993","unstructured":"Graham CH, Hawley TS, Hawley RG, MacDougall J, Kerbel RS, Khoo N, et al. Establishment and characterization of first trimester human trophoblast cells with extended lifespan. Exp Cell Res. 1993;206(2):204\u201311.","journal-title":"Exp Cell Res"},{"issue":"6","key":"39_CR34","doi-asserted-by":"crossref","first-page":"4321","DOI":"10.1074\/jbc.M407706200","volume":"280","author":"G Yuan","year":"2005","unstructured":"Yuan G, Nanduri J, Bhasker CR, Semenza GL, Prabhakar NR. Ca2+\/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia. J Biol Chem. 2005;280(6):4321\u20138.","journal-title":"J Biol Chem"},{"key":"39_CR35","doi-asserted-by":"crossref","unstructured":"Chang WL, Liu YW, Dang YL, et al. PLAC8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration. Development. 2018;145(2).","DOI":"10.1242\/dev.148932"},{"issue":"4","key":"39_CR36","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1530\/REP-14-0052","volume":"148","author":"WL Chang","year":"2014","unstructured":"Chang WL, Yang Q, Zhang H, et al. Role of placenta-specific protein 1 in trophoblast invasion and migration. Reproduction. 2014;148(4):343\u201352.","journal-title":"Reproduction"},{"key":"39_CR37","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1477-7827-10-49","volume":"10","author":"A Agarwal","year":"2012","unstructured":"Agarwal A, Aponte-Mellado A, Premkumar BJ, Shaman A, Gupta S. The effects of oxidative stress on female reproduction: a review. Reprod Biol Endocrinol. 2012;10:49.","journal-title":"Reprod Biol Endocrinol"},{"issue":"1","key":"39_CR38","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0143-4004(03)00183-8","volume":"25","author":"MT Coughlan","year":"2004","unstructured":"Coughlan MT, Vervaart PP, Permezel M, Georgiou HM, Rice GE. Altered placental oxidative stress status in gestational diabetes mellitus. Placenta. 2004;25(1):78\u201384.","journal-title":"Placenta."},{"issue":"10","key":"39_CR39","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/j.biocel.2010.06.001","volume":"42","author":"KH Al-Gubory","year":"2010","unstructured":"Al-Gubory KH, Fowler PA, Garrel C. The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes. Int J Biochem Cell Biol. 2010;42(10):1634\u201350.","journal-title":"Int J Biochem Cell Biol"},{"issue":"6","key":"39_CR40","first-page":"483","volume":"34","author":"X Xie","year":"2005","unstructured":"Xie X, He J, Dong MY. Current advances in etiology and pathophysiology of preeclampsia. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2005;34(6):483\u20137.","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"issue":"2","key":"39_CR41","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1213\/ANE.0000000000001048","volume":"122","author":"J Wu","year":"2016","unstructured":"Wu J, Stefaniak J, Hafner C, et al. Intermittent hypoxia causes inflammation and injury to human adult cardiac myocytes. Anesth Analg. 2016;122(2):373\u201380.","journal-title":"Anesth Analg"},{"issue":"4","key":"39_CR42","volume":"9","author":"W Ding","year":"2014","unstructured":"Ding W, Zhang X, Huang H, Ding N, Zhang S, Hutchinson SZ, et al. Adiponectin protects rat myocardium against chronic intermittent hypoxia-induced injury via inhibition of endoplasmic reticulum stress. PLoS One. 2014;9(4):e94545.","journal-title":"PLoS One"},{"key":"39_CR43","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.expneurol.2014.04.029","volume":"257","author":"XH Cai","year":"2014","unstructured":"Cai XH, Li XC, Jin SW, Liang DS, Wen ZW, Cao HC, et al. Endoplasmic reticulum stress plays critical role in brain damage after chronic intermittent hypoxia in growing rats. Exp Neurol. 2014;257:148\u201356.","journal-title":"Exp Neurol"},{"issue":"2","key":"39_CR44","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.toxlet.2014.03.011","volume":"227","author":"S Zhou","year":"2014","unstructured":"Zhou S, Yin X, Zheng Y, et al. Metallothionein prevents intermittent hypoxia-induced cardiac endoplasmic reticulum stress and cell death likely via activation of Akt signaling pathway in mice. Toxicol Lett. 2014;227(2):113\u201323.","journal-title":"Toxicol Lett"},{"issue":"3","key":"39_CR45","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.3892\/etm.2017.4804","volume":"14","author":"Y Hou","year":"2017","unstructured":"Hou Y, Yang H, Cui Z, Tai X, Chu Y, Guo X. Tauroursodeoxycholic acid attenuates endoplasmic reticulum stress and protects the liver from chronic intermittent hypoxia induced injury. Exp Ther Med. 2017;14(3):2461\u20138.","journal-title":"Exp Ther Med"},{"issue":"4","key":"39_CR46","first-page":"R1274","volume":"295","author":"J Jun","year":"2008","unstructured":"Jun J, Savransky V, Nanayakkara A, et al. Intermittent hypoxia has organ-specific effects on oxidative stress. Am J Phys Regul Integr Comp Phys. 2008;295(4):R1274\u201381.","journal-title":"Am J Phys Regul Integr Comp Phys"},{"issue":"4","key":"39_CR47","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jhep.2010.11.005","volume":"54","author":"H Malhi","year":"2011","unstructured":"Malhi H, Kaufman RJ. Endoplasmic reticulum stress in liver disease. J Hepatol Apr. 2011;54(4):795\u2013809.","journal-title":"J Hepatol Apr"},{"key":"39_CR48","doi-asserted-by":"crossref","first-page":"879419","DOI":"10.1155\/2012\/879419","volume":"2012","author":"DP da Rosa","year":"2012","unstructured":"da Rosa DP, Forgiarini LF, Baronio D, Feijo CA, Martinez D, Marroni NP. Simulating sleep apnea by exposure to intermittent hypoxia induces inflammation in the lung and liver. Mediat Inflamm. 2012;2012:879419.","journal-title":"Mediat Inflamm"},{"issue":"3","key":"39_CR49","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s11325-010-0370-3","volume":"15","author":"SZ Feng","year":"2011","unstructured":"Feng SZ, Tian JL, Zhang Q, Wang H, Sun N, Zhang Y, et al. An experimental research on chronic intermittent hypoxia leading to liver injury. Sleep Breath. 2011;15(3):493\u2013502.","journal-title":"Sleep Breath"},{"issue":"9","key":"39_CR50","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1089\/ars.2014.6122","volume":"23","author":"LH Xu","year":"2015","unstructured":"Xu LH, Xie H, Shi ZH, et al. Critical role of endoplasmic reticulum stress in chronic intermittent hypoxia-induced deficits in synaptic plasticity and long-term memory. Antioxid Redox Signal. 2015;23(9):695\u2013710.","journal-title":"Antioxid Redox Signal"},{"issue":"4","key":"39_CR51","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/path.4678","volume":"238","author":"M Mizuuchi","year":"2016","unstructured":"Mizuuchi M, Cindrova-Davies T, Olovsson M, Charnock-Jones DS, Burton GJ, Yung HW. Placental endoplasmic reticulum stress negatively regulates transcription of placental growth factor via ATF4 and ATF6beta: implications for the pathophysiology of human pregnancy complications. J Pathol Mar. 2016;238(4):550\u201361.","journal-title":"J Pathol Mar"},{"issue":"5728","key":"39_CR52","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1126\/science.1111726","volume":"308","author":"CW Redman","year":"2005","unstructured":"Redman CW, Sargent IL. Latest advances in understanding preeclampsia. Science. 2005;308(5728):1592\u20134.","journal-title":"Science"},{"issue":"7","key":"39_CR53","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1172\/JCI66966","volume":"123","author":"Y Zhou","year":"2013","unstructured":"Zhou Y, Gormley MJ, Hunkapiller NM, Kapidzic M, Stolyarov Y, Feng V, et al. Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsia. J Clin Invest. 2013;123(7):2862\u201372.","journal-title":"J Clin Invest"},{"key":"39_CR54","doi-asserted-by":"crossref","unstructured":"Caniggia I, Winter JL. Adriana and Luisa Castellucci Award lecture 2001. Hypoxia inducible factor-1: oxygen regulation of trophoblast differentiation in normal and pre-eclamptic pregnancies--a review. Placenta. 2002;(23 Suppl A):S47\u201357.","DOI":"10.1053\/plac.2002.0815"},{"issue":"1","key":"39_CR55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.102.014977","volume":"69","author":"P Kaufmann","year":"2003","unstructured":"Kaufmann P, Black S, Huppertz B. Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol Reprod. 2003;69(1):1\u20137.","journal-title":"Biol Reprod"},{"issue":"1","key":"39_CR56","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0002-9440(10)65123-1","volume":"155","author":"E DiFederico","year":"1999","unstructured":"DiFederico E, Genbacev O, Fisher SJ. Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall. Am J Pathol. 1999;155(1):293\u2013301.","journal-title":"Am J Pathol"},{"issue":"2","key":"39_CR57","first-page":"271","volume":"96","author":"AD Allaire","year":"2000","unstructured":"Allaire AD, Ballenger KA, Wells SR, McMahon MJ, Lessey BA. Placental apoptosis in preeclampsia. Obstet Gynecol. Aug 2000;96(2):271\u20136.","journal-title":"Obstet Gynecol"},{"issue":"4","key":"39_CR58","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/bdrb.20051","volume":"74","author":"JL Zechel","year":"2005","unstructured":"Zechel JL, Gamboa JL, Peterson AG, Puchowicz MA, Selman WR, Lust WD. Neuronal migration is transiently delayed by prenatal exposure to intermittent hypoxia. Birth Defects Res B Dev Reprod Toxicol. 2005;74(4):287\u201399.","journal-title":"Birth Defects Res B Dev Reprod Toxicol"},{"issue":"12","key":"39_CR59","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1161\/01.RES.0000024411.22110.AA","volume":"90","author":"TH Hung","year":"2002","unstructured":"Hung TH, Skepper JN, Charnock-Jones DS, Burton GJ. Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia. Circ Res. 2002;90(12):1274\u201381.","journal-title":"Circ Res"},{"issue":"2","key":"39_CR60","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/humupd\/dml048","volume":"13","author":"C Ferretti","year":"2007","unstructured":"Ferretti C, Bruni L, Dangles-Marie V, Pecking AP, Bellet D. Molecular circuits shared by placental and cancer cells, and their implications in the proliferative, invasive and migratory capacities of trophoblasts. Hum Reprod Update. 2007;13(2):121\u201341.","journal-title":"Hum Reprod Update"},{"issue":"5","key":"39_CR61","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1164\/rccm.201310-1830OC","volume":"189","author":"I Almendros","year":"2014","unstructured":"Almendros I, Wang Y, Becker L, et al. Intermittent hypoxia-induced changes in tumor-associated macrophages and tumor malignancy in a mouse model of sleep apnea. Am J Respir Crit Care Med. 2014;189(5):593\u2013601.","journal-title":"Am J Respir Crit Care Med"}],"updated-by":[{"DOI":"10.1007\/s43032-020-00242-2","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000}}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-019-00039-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s43032-019-00039-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-019-00039-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T02:53:27Z","timestamp":1612234407000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s43032-019-00039-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["39"],"URL":"https:\/\/doi.org\/10.1007\/s43032-019-00039-y","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s43032-020-00242-2","asserted-by":"object"}]},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"28 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2020","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Affiliation 1 was incorrect in the original article and should have read: \ufffd\ufffd\ufffdDepartment of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.\ufffd\ufffd\ufffd","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The utilization of clinical samples followed the guidelines of the Ethics Committee of the Beijing Obstetrics and Gynecology Hospital; all clinical samples were collected from the Beijing Obstetrics and Gynecology Hospital. We obtained written informed consent for donating placentas from the pregnant women involved.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}