{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T19:01:17Z","timestamp":1766516477190},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s43032-020-00162-1","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T16:02:41Z","timestamp":1581350561000},"page":"1455-1464","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Evidence that Melatonin Increases Inhibin Beta-A and Follistatin Gene Expression in Ovaries of Pinealectomized Rats"],"prefix":"10.1007","volume":"27","author":[{"given":"Carla C.","family":"Maganhin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C\u00e2ndida P.","family":"Baracat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1tia C.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isadora Braga","family":"Seganfredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla Maganhin","family":"Luquetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"dos Santos Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Aparecida Ferraz","family":"Carbonel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"de Jesus Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Cipolla-Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoel Jo\u00e3o Batista Castello","family":"Gir\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund C.","family":"Baracat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Soares-Jr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,10]]},"reference":[{"key":"162_CR1","doi-asserted-by":"crossref","unstructured":"Reiter RJ, Reiter RJ, Tamura H, Tan DX, Xu XY. Melatonin and the circadian system: contributions to successful female reproduction. Fertil Steril. 2014;102:321\u20138.","DOI":"10.1016\/j.fertnstert.2014.06.014"},{"key":"162_CR2","first-page":"115","volume":"17","author":"JM Soares Jr","year":"2003","unstructured":"Soares JM Jr, Sim\u00f5es MJ, Oshima CT, Mora OA, De Lima GR, Baracat EC. Pinealectomy changes rat ovarian interstitial cell morphology and decreases progesterone receptor expression. GynecolEndocrinol. 2003;17:115\u201323.","journal-title":"GynecolEndocrinol."},{"key":"162_CR3","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.fertnstert.2014.04.006","volume":"102","author":"CC Maganhin","year":"2014","unstructured":"Maganhin CC, Sim\u00f5es RS, Fuchs LF, Sasso GR, Sim\u00f5es MJ, Baracat EC, et al. Melatonin influences on steroidogenic gene expression in the ovary of pinealectomized rats. F Fertil Steril. 2014;102:291\u20138.","journal-title":"F Fertil Steril"},{"key":"162_CR4","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/j.fertnstert.2007.03.050","volume":"89","author":"EL Dair","year":"2008","unstructured":"Dair EL, Simoes RS, Sim\u00f5es MJ, Romeu LR, Oliveira-Filho RM, Haidar MA, et al. Effects of melatonin on the endometrial morphology and embryo implantation in rats. Fertil Steril. 2008;89:1299\u2013305.","journal-title":"Fertil Steril"},{"key":"162_CR5","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1016\/j.fertnstert.2010.04.042","volume":"95","author":"LR Romeu","year":"2011","unstructured":"Romeu LR, da Motta EL, Maganhin CC, Oshima CT, Fonseca MC, Barrueco KF, et al. Effects of melatonin on histomorphology and on the expression of steroid receptors, VEGF, and PCNA in ovaries of pinealectomized female rats. Fertil Steril. 2011;95:1379\u201384.","journal-title":"Fertil Steril"},{"issue":"2","key":"162_CR6","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1385\/ENDO:27:2:101","volume":"27","author":"ML Dubocovich","year":"2005","unstructured":"Dubocovich ML, Markowska M. Functional MT1 and MT2 melatonin receptors in mammals. Endocrine. 2005;27(2):101\u201310.","journal-title":"Endocrine."},{"key":"162_CR7","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1159\/000084897","volume":"8","author":"MI Masana","year":"2005","unstructured":"Masana MI, Soares JM Jr, Dubocovich ML. 17Beta-estradiol modulates hMT1 melatonin receptor function. Neuroendocrinology. 2005;8:87\u201395.","journal-title":"Neuroendocrinology"},{"key":"162_CR8","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1080\/07420520500263193","volume":"22","author":"JF Walters","year":"2005","unstructured":"Walters JF, Hampton SM, Ferns GA, Skene DJ. Effect of menopause on melatonin and alertness rhythms investigated in constant routine conditions. Chronobiol Int. 2005;22:859\u201372.","journal-title":"Chronobiol Int"},{"key":"162_CR9","doi-asserted-by":"crossref","unstructured":"Findlay JK. An update on the roles of inhibin, activin, and follistatin as local regulators of folliculogenesis1 biol. Reprod. 1993; 48(1): 15\u201323.","DOI":"10.1095\/biolreprod48.1.15"},{"issue":"6","key":"162_CR10","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1210\/endo.140.6.6788","volume":"140","author":"GM Lanuza","year":"1999","unstructured":"Lanuza GM, Groome NP, Bara\u00f1ao JL, Campo S. Dimeric inhibin A and B production are differentially regulated by hormones and local factors in rat granulosa cells. Endocrinol. 1999;140(6):2549\u201354.","journal-title":"Endocrinol."},{"key":"162_CR11","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1111\/j.1471-0528.2007.01624.x","volume":"115","author":"A Prakash","year":"2008","unstructured":"Prakash A, Tuckerman E, Laird S, Ola B, Li TC, Ledger WL. A preliminary study comparing the endometrial expression of inhibin, activin and follistatin in women with a history of implantation failure after IVF treatment and a control group. BJOG. 2008;115:532\u20136 discussion 536-7.","journal-title":"BJOG."},{"key":"162_CR12","doi-asserted-by":"publisher","first-page":"e0129643","DOI":"10.1371\/journal.pone.0129643","volume":"10","author":"Z Wang","year":"2015","unstructured":"Wang Z, Niu W, Wang Y, Teng Z, Wen J, Xia G, et al. Follistatin288 regulates germ cell cyst breakdown and primordial follicle assembly in the mouse ovary. PLoS One. 2015;10:e0129643.","journal-title":"PLoS One"},{"key":"162_CR13","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.rbmo.2012.10.007","volume":"26","author":"MK Kim","year":"2013","unstructured":"Kim MK, Park EA, Kim HJ, Choi WY, Cho JH, Lee WS, et al. Does supplementation of in-vitro culture medium with melatonin improve IVF outcome in PCOS? Reprod Biomed Online. 2013;26:22\u20139.","journal-title":"Reprod Biomed Online"},{"key":"162_CR14","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.ejogrb.2012.10.006","volume":"166","author":"CC Maganhin","year":"2013","unstructured":"Maganhin CC, Fuchs LF, Sim\u00f5es RS, Oliveira-Filho RM, de Jesus SM, Baracat EC, et al. Effects of melatonin on ovarian follicles. Eur J Obstet Gynecol Reprod Biol. 2013;166:178\u201384.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"162_CR15","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1210\/endo-75-2-238","volume":"75","author":"EW Chu","year":"1964","unstructured":"Chu EW, Wurtman RJ, Axelrod J. An inhibitory effect of melatonin on the estrous phase of the estrous cycle of the rodent. Endocrinology. 1964;75:238\u201342.","journal-title":"Endocrinology."},{"key":"162_CR16","doi-asserted-by":"crossref","unstructured":"Dardes RC, Baracat EC, Sim\u00f5es MJ. Modulation of estrous cycle and LH, FSH and melatonin levels by pinealectomy and sham-pinealectomy in female rats. ProgNeuropsychopharmacolBiol Psychiatry. 2000 ;24:441\u2013453.","DOI":"10.1016\/S0278-5846(99)00110-4"},{"key":"162_CR17","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1124\/jpet.103.049916","volume":"306","author":"JM Soares Jr","year":"2003","unstructured":"Soares JM Jr, Masana MI, Er\u015fahin C, Dubocovich ML. Functional melatonin receptors in rat ovaries at various stages of the estrous cycle. J Pharmacol Exp Ther. 2003;306:694\u2013702.","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"162_CR18","doi-asserted-by":"publisher","first-page":"404","DOI":"10.7150\/ijbs.27912","volume":"15","author":"X Wang","year":"2019","unstructured":"Wang X, Meng K, He Y, Wang H, Zhang Y, Quan F. Melatonin stimulates STAR expression and progesterone production via activation of the PI3K\/AKT pathway in bovine theca cells. Int J Biol Sci. 2019;15(2):404\u201315.","journal-title":"Int J Biol Sci"},{"key":"162_CR19","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.theriogenology.2018.05.042","volume":"118","author":"H Wang","year":"2018","unstructured":"Wang H, Pu Y, Luo L, Li Y, Zhang Y, Cao Z. Membrane receptor-independent inhibitory effect of melatonin on androgen production in porcine theca cells. Theriogenology. 2018;118:63\u201371.","journal-title":"Theriogenology."},{"issue":"4","key":"162_CR20","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1071\/RD17203","volume":"30","author":"T Feng","year":"2018","unstructured":"Feng T, Schutz LF, Morrell BC, Perego MC, Spicer LJ. Effect of melatonin on bovine theca cells in vitro. Reprod Fertil Dev. 2018;30(4):643\u201350.","journal-title":"Reprod Fertil Dev"},{"key":"162_CR21","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.fertnstert.2013.04.016","volume":"100","author":"YD Hoang","year":"2013","unstructured":"Hoang YD, McTavish KJ, Chang RJ, Shimasaki S. Paracrine regulation of theca androgen production by granulosa cells in the ovary. Fertil Steril. 2013;100:561\u20137.","journal-title":"Fertil Steril"},{"key":"162_CR22","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.anireprosci.2014.03.017","volume":"147","author":"WC Yang","year":"2014","unstructured":"Yang WC, Tang KQ, Fu CZ, Riaz H, Zhang Q, Zan LS. Melatonin regulates the development and function of bovine Sertoli cells via its receptors MT1 and MT2. Anim Reprod Sci. 2014;147:10\u20136.","journal-title":"Anim Reprod Sci"},{"key":"162_CR23","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1126\/science.94.2449.545-a","volume":"94","author":"E Shorr","year":"1941","unstructured":"Shorr E. A new technique for staining vaginal smears. A single differential stain. Science. 1941;94:545\u20136.","journal-title":"Science."},{"key":"162_CR24","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.1600-079X.1993.tb00494.x","volume":"14","author":"A Lewi\u0144ski","year":"1993","unstructured":"Lewi\u0144ski A, Szymczykiewicz P, Sewerynek E, Wajs E. Effects of pinealectomy and melatonin administration on certain indices of ovarian hyperplasia and\/or hypertrophy in rats with both ovaries intact or after unilateral ovariectomy. J Pineal Res. 1993;14:117\u201327.","journal-title":"J Pineal Res"},{"key":"162_CR25","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/1477-7827-9-108","volume":"9","author":"LG Chuffa","year":"2011","unstructured":"Chuffa LG, Seiva FR, F\u00e1varo WJ, Teixeira GR, Amorim JP, Mendes LO, et al. Melatonin reduces LH, 17 beta-estradiol and induces differential regulation of sex steroid receptors in reproductive tissues during rat ovulation. Reprod Biol Endocrinol. 2011;9:108.","journal-title":"Reprod Biol Endocrinol"},{"issue":"7","key":"162_CR26","doi-asserted-by":"publisher","first-page":"RESEARCH0034","DOI":"10.1186\/gb-2002-3-7-research0034","volume":"3","author":"J Vandesompele","year":"2002","unstructured":"Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002;3(7):RESEARCH0034.","journal-title":"Genome Biol"},{"key":"162_CR27","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212delta deltaC(T)) method. Methods. 2001;25:402\u20138.","journal-title":"Methods."},{"key":"162_CR28","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3892\/mmr_000000249","volume":"3","author":"LF Barrezueta","year":"2010","unstructured":"Barrezueta LF, Oshima CT, Lima FO, De Oliveira Costa H, Gomes TS, Neto RA, et al. The intrinsic apoptotic signaling pathway in gastric adenocarcinomas of Brazilian patients: immunoexpression of the Bcl-2 family (Bcl-2, Bcl-x, Bak, Bax, Bad) determined by tissue microarray analysis. Mol Med Rep. 2010;3:261\u20137.","journal-title":"Mol Med Rep"},{"key":"162_CR29","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1262\/jrd.2014-158","volume":"61","author":"M M'baye","year":"2015","unstructured":"M'baye M, Hua G, Khan HA, Yang L. RNAi-mediated knockdown of INHBB increases apoptosis and inhibits steroidogenesis in mouse granulosa cells. J Reprod Dev. 2015;61:391\u20137.","journal-title":"J Reprod Dev"},{"key":"162_CR30","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1590\/S0104-42302010000600024","volume":"56","author":"S Ferreira Cda","year":"2010","unstructured":"Ferreira Cda S, Maganhin CC, Sim\u00f5es Rdos S, Gir\u00e3o MJ, Baracat EC, Soares JM Jr. Melatonin: cell death modulator. Rev Assoc Med Bras (1992). 2010;56:715\u20138.","journal-title":"Rev Assoc Med Bras (1992)"},{"issue":"4","key":"162_CR31","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1080\/10495398.2016.1184675","volume":"27","author":"Q Zhou","year":"2016","unstructured":"Zhou Q, Wan M, Wei Q, Song Q, Xiong L, Huo J, et al. Expression, regulation, and functional characterization of FST gene in porcine granulosa cells. Anim Biotechnol. 2016;27(4):295\u2013302.","journal-title":"Anim Biotechnol"},{"key":"162_CR32","doi-asserted-by":"publisher","first-page":"3313","DOI":"10.1210\/endo-128-6-3313","volume":"128","author":"M Shimonaka","year":"1991","unstructured":"Shimonaka M, Inouye S, Shimasaki S, Ling N. Follistatin binds to both activin and inhibin through the common subunit. Endocrinology. 1991;128:3313\u20135.","journal-title":"Endocrinology."},{"key":"162_CR33","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1006\/frne.1998.0169","volume":"19","author":"DJ Phillips","year":"1998","unstructured":"Phillips DJ, de Kretser DM. Follistatin: a multifunctional regulatory protein. Front Neuroendocrinol. 1998;19:287\u2013322.","journal-title":"Front Neuroendocrinol"},{"key":"162_CR34","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1210\/endo-119-6-2711","volume":"119","author":"TA Bicsak","year":"1986","unstructured":"Bicsak TA, Tucker EM, Cappel S, Vaughan J, Rivier J, Vale W, et al. Hormonal regulation of granulosa cell inhibin biosynthesis. Endocrinology. 1986;119:2711\u20139.","journal-title":"Endocrinology."},{"key":"162_CR35","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1749-6632.1993.tb43850.x","volume":"687","author":"SG Hillier","year":"1993","unstructured":"Hillier SG, Mir\u00f3 F. Inhibin, activin, and follistatin. Potential roles in ovarian physiology. Ann N Y Acad Sci. 1993;687:29\u201338.","journal-title":"Ann N Y Acad Sci"},{"key":"162_CR36","doi-asserted-by":"publisher","first-page":"E1922","DOI":"10.1210\/jc.2014-1223","volume":"99","author":"HM Chang","year":"2014","unstructured":"Chang HM, Cheng JC, Klausen C, Taylor EL, Leung PC. Effects of recombinant activins on steroidogenesis in human granulosa-lutein cells. J ClinEndocrinolMetab. 2014;99:E1922\u201332.","journal-title":"J ClinEndocrinolMetab"},{"key":"162_CR37","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.mce.2011.01.014","volume":"335","author":"S Kazutaka","year":"2011","unstructured":"Kazutaka S, Winnall WR, Muir JA, Hedger MP. Regulation of Sertoli cell activin A and inhibin B by tumour necrosis factor \u03b1 and interleukin 1\u03b1: interaction with follicle-stimulating hormone\/adenosine 3\u2032,5\u2032-cyclic phosphate signalling. Mol Cell Endocrinol. 2011;335:195\u2013203.","journal-title":"Mol Cell Endocrinol"},{"issue":"107","key":"162_CR38","doi-asserted-by":"crossref","first-page":"pe39","DOI":"10.1126\/stke.2001.107.pe39","volume":"2001","author":"MI Masana","year":"2001","unstructured":"Masana MI, Dubocovich ML. Melatonin receptor signaling: finding the path through the dark. Sci STKE. 2001;2001(107):pe39.","journal-title":"Sci STKE"},{"issue":"2","key":"162_CR39","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1677\/joe.0.1670289","volume":"167","author":"T V\u00e4nttinen","year":"2000","unstructured":"V\u00e4nttinen T, Liu J, Liu J, Hyd\u00e9n-Granskog C, Parviainen M, Penttil\u00e4 I, et al. Regulation of immunoreactiveinhibin A and B secretion in cultured human granulosa-luteal cells by gonadotropins, activin A and insulin-like growth factor type-1 receptor. J Endocrinol. 2000;167(2):289\u201394.","journal-title":"J Endocrinol"},{"key":"162_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0303-7207(96)03842-7","volume":"121","author":"T Tuuri","year":"1996","unstructured":"Tuuri T, Er\u00e4maa M, Van Schaik RH, Ritvos O. Differential regulation of inhibin\/activin alpha- and beta A-subunit and follistin mRNAs by cyclic AMP and phorbol ester in cultured human granulosa-luteal cells. Mol Cell Endocrinol. 1996;121:1\u201310.","journal-title":"Mol Cell Endocrinol"},{"key":"162_CR41","doi-asserted-by":"publisher","first-page":"3308","DOI":"10.1210\/en.2008-1668","volume":"150","author":"PR Manna","year":"2009","unstructured":"Manna PR, Huhtaniemi IT, Stocco DM. Mechanisms of protein kinase C signaling in the modulation of 3\u2032,5\u2032-cyclic adenosine monophosphate-mediated steroidogenesis in mouse gonadal cells. Endocrinology. 2009;150:3308\u201317.","journal-title":"Endocrinology."},{"issue":"4","key":"162_CR42","first-page":"274","volume":"26","author":"MA Emanuele","year":"2002","unstructured":"Emanuele MA, Wezeman F, Emanuele NV. Alcohol\u2019s effects on female reproductive function. Alcohol Res Health. 2002;26(4):274\u201381.","journal-title":"Alcohol Res Health"},{"issue":"6","key":"162_CR43","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1177\/1933719116670307","volume":"24","author":"DA Ram\u00edrez","year":"2017","unstructured":"Ram\u00edrez DA, Vieyra E, Gonz\u00e1lez AI, Mor\u00e1n C, Dom\u00ednguez R, Morales-Ledesma L. Both the suprachiasmatic nucleus and the superior ovarian nerve contribute to the processes of ovulation and steroid hormone secretion on proestrus. Reprod Sci. 2017;24(6):844\u201355.","journal-title":"Reprod Sci"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-020-00162-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s43032-020-00162-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-020-00162-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T05:05:11Z","timestamp":1665810311000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s43032-020-00162-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,10]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["162"],"URL":"https:\/\/doi.org\/10.1007\/s43032-020-00162-1","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,10]]},"assertion":[{"value":"23 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This project was approved by the Institutional Research Committee at Federal University of S\u00e3o Paulo (0233\/06), in accordance with the National Institutes of Health (NIH) Guidelines Regarding Animal Experimentation and with the ethical principles recommended by the Brazilian Committee on Animal Experimentation (COBEA, Brazil).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}}]}}