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Sci."],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During pregnancy, supply of nutrients and exposure of the mother to environmental factors can influence fetus phenotype, possibly modifying growth of fetal tissues and organs. Few studies inconsistently reported that fetuses exposed to an insufficient energy supply, as those born small for gestational age, may have a reduced volume of uterus and ovaries. A retrospective analysis was performed on ultrasound data performed between 2012 and 2018 in 69 young premenarchal girls, 5 to 9\u00a0years of age, attending our endocrine\u2013gynecologic clinic for a suspect of early puberty. Length of pregnancy and birthweight was also retrieved. When corrected for age, and presence of ovarian follicles, ovarian volume was positively (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.210; <jats:italic>p<\/jats:italic>\u2009=\u20090.001) related to percentiles of birthweight (beta coefficient 0.012; 95% CI, 0.002\u20130.021). Similarly, uterine volume was positively (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.237; <jats:italic>p<\/jats:italic>\u2009=\u20090.005) related to percentiles of birthweight (beta coefficient 0.067; 95% CI, 0.021\u20130.114). Ovarian (<jats:italic>p<\/jats:italic>\u2009=\u20090.034) and uterine (<jats:italic>p<\/jats:italic>\u2009=\u20090.014) volume was higher in the upper 3rd distribution of birthweight percentiles. In conclusion, development of ovarian and uterine volume increases progressively with the increase of birthweight percentiles. The data indicate an association between birthweight and the volume of uterus and ovary at 5\u20139\u00a0years of age.<\/jats:p>","DOI":"10.1007\/s43032-020-00351-y","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T20:02:41Z","timestamp":1602705761000},"page":"1347-1352","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Relation of Birthweight and Ovarian and Uterine Size Prior to Menarche"],"prefix":"10.1007","volume":"28","author":[{"given":"Nadia","family":"Parisi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0249-6284","authenticated-orcid":false,"given":"Alice","family":"Tassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Capodicasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjeza","family":"Xholli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2714-623X","authenticated-orcid":false,"given":"Angelo","family":"Cagnacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"key":"351_CR1","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1111\/j.1365-2796.2007.01809.x","volume":"261","author":"DJ Barker","year":"2007","unstructured":"Barker DJ. 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The study was approved by the Institutional review board of DAME (Department of Medicine, University of Udine) on 12th June 2019; approval number 29\/IRB_Cagnacci_2019.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Informed consent not required. The patient\u2019s identification data were kept separate from clinical data. Furthermore, the ability to identify patients will be maintained only until the final results are published anonymously and aggregate.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code Availability"}}]}}