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We observed that (1) there was a significant inhibition of vascular reactivity to PE in LP, 3\u00a0days and 2\u00a0weeks PP vessels that returned to pre-pregnancy levels at 4 and 12\u00a0weeks PP; (2) inhibition of NO production in PP vessels restored PE-induced constriction to pre-pregnancy levels; (3) vasodilator responses to ACh were similar at all PP periods; (4) LP and early PP was associated with a persistent increase in arterial distensibility that correlates with a PP-induced reduction in wall collagen, and regressed to pre-conception levels at 12\u00a0weeks PP; (5) vessels from non-nursing PP mice demonstrated an increased PE reactivity, diminished responses to ACh, and reduced distensibility compared to breastfeeding mice. These studies provide a timeframe for mesenteric artery adaptations that occur during pregnancy and extend to the PP period, but which may be modified by PP events.<\/jats:p>","DOI":"10.1007\/s43032-020-00402-4","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T23:03:44Z","timestamp":1610060624000},"page":"1200-1215","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Kinetics of Postpartum Mesenteric Artery Structure and Function Relative to Pregnancy and Lactation in Mice"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9662-3306","authenticated-orcid":false,"given":"Natalia I.","family":"Gokina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca I.","family":"Fairchild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor E.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirtika","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Bonney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"issue":"1","key":"402_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/s0146-0005(00)80047-6","volume":"24","author":"KL Thornburg","year":"2000","unstructured":"Thornburg KL, Jacobson SL, Giraud GD, Morton MJ. 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