{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:08:57Z","timestamp":1787162937237,"version":"build-2736575974"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s43032-021-00467-9","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T14:35:40Z","timestamp":1612276540000},"page":"341-356","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Folate Levels and Pregnancy Rate in Women Undergoing Assisted Reproductive Techniques: a Systematic Review and Meta-analysis"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3112-3161","authenticated-orcid":false,"given":"Alessio","family":"Paffoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Reschini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania A.","family":"Noli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Vigan\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Parazzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgardo","family":"Somigliana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"467_CR1","unstructured":"Eurocat, Prevalence Charts and Tables Available online: https:\/\/eu-rd-platform.jrc.ec.europa.eu\/eurocat\/eurocat-data\/prevalence_en (accessed on 26 March 2020)."},{"key":"467_CR2","unstructured":"Data & Statistics on Birth Defects Available online: https:\/\/www.cdc.gov\/ncbddd\/birthdefects\/data.html (accessed on 24 March 2020)."},{"key":"467_CR3","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1159\/000499698","volume":"74","author":"I Cetin","year":"2019","unstructured":"Cetin I, B\u00fchling K, Demir C, Kortam A, Prescott SL, Yamashiro Y, et al. Impact of micronutrient status during pregnancy on early nutrition programming. Ann Nutr Metab. 2019;74:269\u201378. https:\/\/doi.org\/10.1159\/000499698.","journal-title":"Ann Nutr Metab"},{"key":"467_CR4","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.rbmo.2011.03.002","volume":"22","author":"M Laanpere","year":"2011","unstructured":"Laanpere M, Altm\u00e4e S, Kaart T, Stavreus-Evers A, Nilsson TK, Salumets A. Folate-metabolizing gene variants and pregnancy outcome of IVF. Reprod BioMed Online. 2011;22:603\u201314.","journal-title":"Reprod BioMed Online"},{"key":"467_CR5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1159\/000365794","volume":"65","author":"F Parisi","year":"2014","unstructured":"Parisi F, Laoreti A, Cetin I. Multiple Micronutrient Needs in Pregnancy in Industrialized Countries. Ann Nutr Metab. 2014;65:13\u201321.","journal-title":"Ann Nutr Metab"},{"key":"467_CR6","unstructured":"WHO Library Cataloguing-in-Publication Data Neonatal and Perinatal Mortality: Country, Regional and Global Estimates; WHO Press, World Health Organization: Geneva, Switzerland, 2006;"},{"key":"467_CR7","doi-asserted-by":"crossref","unstructured":"Kramer, M.S. Maternal Nutrition and Adverse Pregnancy Outcomes: Lessons from Epidemiology. In The impact of maternal nutrition on the offspring Nestl\u00e8 nutrition workshop series: Pediatric Program 2005;1\u201315.","DOI":"10.1159\/000082589"},{"key":"467_CR8","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1136\/bmj.318.7183.570","volume":"318","author":"KP West","year":"1999","unstructured":"West KP, Katz J, Khatry SK, Leclerq SC, Pradhan EK, Shrestha C. SR; PB, D.; SM, C.; P, P.; R.P. Double blind, cluster randomised trial of low dose supplementation with vitamin A or beta carotene on mortality related to pregnancy in Nepal. Bmj. 1999;318:570\u20135.","journal-title":"Bmj"},{"key":"467_CR9","doi-asserted-by":"crossref","unstructured":"Altman, D.; Carroli, G.; Duley, L.; Farrell, B.; Moodley, J.; Neilson, J.; Smith, D.; Magpie Trial Collaboration Group. Do Women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. Lancet Lond. Engl. 2002, 359, 1877\u20131890, doi:10.1016\/s0140-6736(02)08778-0.","DOI":"10.1016\/S0140-6736(02)08778-0"},{"key":"467_CR10","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/S0140-6736(99)80010-5","volume":"354","author":"LC Chappell","year":"1999","unstructured":"Chappell LC, Seed PT, Briley AL, Kelly FJ, Lee R, Hunt BJ, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet Lond Engl. 1999;354:810\u20136. https:\/\/doi.org\/10.1016\/S0140-6736(99)80010-5.","journal-title":"Lancet Lond Engl"},{"key":"467_CR11","doi-asserted-by":"publisher","first-page":"1832","DOI":"10.1056\/NEJM199212243272602","volume":"327","author":"AE Czeizel","year":"1992","unstructured":"Czeizel AE, Dud\u00e1s I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med. 1992;327:1832\u20135.","journal-title":"N Engl J Med"},{"key":"467_CR12","doi-asserted-by":"crossref","unstructured":"Li K, Wahlqvist M. Nutrition, L.D. One-carbon metabolism and neural tube defects: a review. Nutrients. 2016;8.","DOI":"10.3390\/nu8110741"},{"key":"467_CR13","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1093\/humrep\/dew066","volume":"31","author":"E Somigliana","year":"2016","unstructured":"Somigliana E, Paffoni A, Busnelli A, Filippi F, Pagliardini L, Vigano P, et al. Age-related infertility and unexplained infertility: an intricate clinical dilemma. Hum Reprod. 2016;31:1390\u20136.","journal-title":"Hum Reprod"},{"key":"467_CR14","doi-asserted-by":"crossref","unstructured":"Dugdale AE. Predicting iron and folate deficiency anaemias from standard blood testing: the mechanism and implications for clinical medicine and public health in developing countries. Theor Biol Med Model. 2006.","DOI":"10.1186\/1742-4682-3-34"},{"key":"467_CR15","doi-asserted-by":"publisher","unstructured":"Tinelli C, Di Pino A, Ficulle E, Marcelli S, Feligioni M. Hyperhomocysteinemia as a risk factor and potential nutraceutical target for certain pathologies. Front Nutr. 2019;6. https:\/\/doi.org\/10.3389\/fnut.2019.00049.","DOI":"10.3389\/fnut.2019.00049"},{"key":"467_CR16","doi-asserted-by":"crossref","unstructured":"Joshi, R.; Adhikari, S.; Patro, B.S.; Chattopadhyay, S.; Mukherjee, T. Free radical scavenging behavior of folic acid: evidence for possible antioxidant activity. Free Radic Biol Med 2001, 15;30(12):1390\u20139.","DOI":"10.1016\/S0891-5849(01)00543-3"},{"issue":"Suppl 1","key":"467_CR17","doi-asserted-by":"publisher","first-page":"S37","DOI":"10.1079\/bjn2001338","volume":"86","author":"CP Wild","year":"2001","unstructured":"Wild CP, Andersson C, O\u2019Brien NM, Wilson L, Woods JA. A critical evaluation of the application of biomarkers in epidemiological studies on diet and health. Br J Nutr. 2001;86(Suppl 1):S37\u201353. https:\/\/doi.org\/10.1079\/bjn2001338.","journal-title":"Br J Nutr"},{"key":"467_CR18","doi-asserted-by":"crossref","unstructured":"Steegers-Theunissen RP, Steegers EA, Thomas CM, Hollanders HM, Peereboom-Stegeman JH, Trijbels FJ, et al. Study on the presence of homocysteine in ovarian follicular fluid. Fertil Steril. 1993.","DOI":"10.1016\/S0015-0282(16)56401-2"},{"key":"467_CR19","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1016\/j.fertnstert.2007.06.036","volume":"89","author":"JC Boxmeer","year":"2008","unstructured":"Boxmeer JC, Brouns RM, Lindemans J, Steegers EAP, Martini E, Macklon NS, et al. Preconception folic acid treatment affects the microenvironment of the maturing oocyte in humans. Fertil Steril. 2008;89:1766\u201370. https:\/\/doi.org\/10.1016\/j.fertnstert.2007.06.036.","journal-title":"Fertil Steril"},{"key":"467_CR20","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.plabm.2015.03.005","volume":"1","author":"G Singh","year":"2015","unstructured":"Singh G, Hamdan H, Singh V. Clinical utility of serum folate measurement in tertiary care patients: argument for revising reference range for serum folate from 3.0 ng\/ml to 13.0 ng\/ml. Pr Lab Med. 2015;1:35\u201341. https:\/\/doi.org\/10.1016\/j.plabm.2015.03.005.","journal-title":"Pr Lab Med"},{"key":"467_CR21","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1159\/000046683","volume":"44","author":"IA Brouwer","year":"2000","unstructured":"Brouwer IA, van Rooij IA, van Dusseldorp M, Thomas CM, Blom HJ, Hautvast JG, et al. Homocysteine-lowering effect of 500 microg folic acid every other day versus 250 microg\/day. Ann Nutr Metab. 2000;44:194\u20137. https:\/\/doi.org\/10.1159\/000046683.","journal-title":"Ann Nutr Metab"},{"key":"467_CR22","doi-asserted-by":"crossref","unstructured":"Jacques, P.F.; Selhub, J.; Bostom, A.G.; Wilson, P.W.; Rosenberg, I.H. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med 1999, 13;340(19):1449-54.","DOI":"10.1056\/NEJM199905133401901"},{"key":"467_CR23","unstructured":"WHO | Serum and red blood cell folate concentrations for assessing folate status in populations Available online: http:\/\/www.who.int\/nutrition\/publications\/micronutrients\/indicators_serum_RBC_folate\/en\/ (accessed on 24 December 2020)."},{"key":"467_CR24","volume-title":"Lancet","author":"Group, M.R.C.V.S.R","year":"1991","unstructured":"Group, M.R.C.V.S.R. Lancet. Results of the Medical Research Council Vitamin Study: Prevention of Neural Tube Defects; 1991."},{"key":"467_CR25","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1001\/jama.1995.03530210052030","volume":"274","author":"LE Daly","year":"1995","unstructured":"Daly LE, Kirke PN, Molloy A, Weir DG, Scott JM. Folate levels and neural tube defects. Implications for prevention. JAMA. 1995;274:1698\u2013702.","journal-title":"JAMA"},{"key":"467_CR26","unstructured":"WHO guideline: optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects. In; World Health Organization: Geneva, Switzerland, 2015."},{"key":"467_CR27","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1093\/ajcn\/nqz027","volume":"109","author":"M-Y Chen","year":"2019","unstructured":"Chen M-Y, Rose CE, Qi YP, Williams JL, Yeung LF, Berry RJ, et al. Defining the plasma folate concentration associated with the red blood cell folate concentration threshold for optimal neural tube defects prevention: a population-based, randomized trial of folic acid supplementation. Am J Clin Nutr. 2019;109:1452\u201361. https:\/\/doi.org\/10.1093\/ajcn\/nqz027.","journal-title":"Am J Clin Nutr"},{"key":"467_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089354","volume":"9","author":"JP Bestwick","year":"2014","unstructured":"Bestwick JP, Huttly WJ, Morris JK, Wald NJ. Prevention of neural tube defects: a cross-sectional study of the uptake of folic acid supplementation in nearly half a million women. PLoS One. 2014;9:e89354. https:\/\/doi.org\/10.1371\/journal.pone.0089354.","journal-title":"PLoS One"},{"key":"467_CR29","doi-asserted-by":"crossref","unstructured":"Ren, A.G. Prevention of neural tube defects with folic acid: the Chinese experience. World J Clin Pediatr 2015, 2015;4(3):41\u201344, doi:10.5409\/wjcp.v4.i3.41.","DOI":"10.5409\/wjcp.v4.i3.41"},{"key":"467_CR30","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/nure.12003","volume":"71","author":"ML Blumfield","year":"2013","unstructured":"Blumfield ML, Hure AJ, Macdonald-Wicks L, Smith R, Collins CE. A systematic review and meta-analysis of micronutrient intakes during pregnancy in developed countries. Nutr Rev. 2013;71:118\u201332. https:\/\/doi.org\/10.1111\/nure.12003.","journal-title":"Nutr Rev"},{"key":"467_CR31","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1093\/humrep\/dep009","volume":"24","author":"JC Boxmeer","year":"2009","unstructured":"Boxmeer JC, Macklon NS, Lindemans J, Beckers NGM, Eijkemans MJC, Laven JSE, et al. IVF outcomes are associated with biomarkers of the homocysteine pathway in monofollicular fluid. Hum Reprod. 2009;24:1059\u201366. https:\/\/doi.org\/10.1093\/humrep\/dep009.","journal-title":"Hum Reprod"},{"key":"467_CR32","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1097\/AOG.0000000000000477","volume":"124","author":"AJ Gaskins","year":"2014","unstructured":"Gaskins AJ, Afeiche MC, Wright DL, Toth TL, Williams PL, Gillman MW, et al. Dietary folate and reproductive success among women undergoing assisted reproduction. Obstet Gynecol. 2014;124:801\u20139.","journal-title":"Obstet Gynecol"},{"key":"467_CR33","doi-asserted-by":"publisher","first-page":"943","DOI":"10.3945\/ajcn.115.112185","volume":"102","author":"AJ Gaskins","year":"2015","unstructured":"Gaskins AJ, Chiu Y-H, Williams PL, Ford JB, Toth TL, Hauser R, et al. Association between serum folate and vitamin b-12 and outcomes of assisted reproductive technologies. Am J Clin Nutr. 2015;102:943\u201350.","journal-title":"Am J Clin Nutr"},{"key":"467_CR34","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/S0140-6736(06)68651-0","volume":"367","author":"P Haggarty","year":"2006","unstructured":"Haggarty P, Mccallum H, Mcbain H, Andrews K, Duthie S, Mcneill G, et al. Effect of B vitamins and genetics on success of in-vitro fertilisation: prospective cohort study. Lancet. 2006;367:1513\u20139.","journal-title":"Lancet"},{"key":"467_CR35","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.rbmo.2014.01.017","volume":"28","author":"T Murto","year":"2014","unstructured":"Murto T, Skoog Svanberg A, Yngve A, Nilsson TK, Altm\u00e4e S, W\u00e5nggren K, et al. Folic acid supplementation and IVF pregnancy outcome in women with unexplained infertility. Reprod BioMed Online. 2014;28:766\u201372.","journal-title":"Reprod BioMed Online"},{"key":"467_CR36","doi-asserted-by":"crossref","unstructured":"George, L.; Mills, J.L.; Johansson, A.L.; Nordmark, A.; Olander, B.; Granath, F.; Cnattingius, S. Plasma folate levels and risk of spontaneous abortion. JAMA 2002, 16;288(15):1867-73.","DOI":"10.1001\/jama.288.15.1867"},{"key":"467_CR37","doi-asserted-by":"crossref","unstructured":"Hasan, R.; Olshan, A.F.; Herring, A.H.; Savitz, D.A.; Siega-Riz, A.M.; Hartmann, K.E. Self-reported vitamin supplementation in early pregnancy and risk of miscarriage. Am J Epidemiol 2009, 1;169(11):1312-8, doi:10.1093\/aje\/kwp050.","DOI":"10.1093\/aje\/kwp050"},{"key":"467_CR38","doi-asserted-by":"publisher","unstructured":"M\u00e9n\u00e9zo Y, Lichtblau I, Elder K. New insights into human pre-implantation metabolism in vivo and in vitro. J Assist Reprod Genet. 2013. https:\/\/doi.org\/10.1007\/s10815-013-9953-9.","DOI":"10.1007\/s10815-013-9953-9"},{"key":"467_CR39","doi-asserted-by":"crossref","unstructured":"Wirsching, J.; Gra\u00dfmann, S.; Eichelmann, F.; Harms, L.M.; Schenk, M.; Barth, E.; Berndzen, A.; Olalekan, M.; Sarmini, L.; Zuberer, H.; et al. Development and reliability assessment of a new quality appraisal tool for cross-sectional studies using biomarker data (BIOCROSS. BMC Med Res Methodol 2018, 6;18(1):122, doi:10.1186\/s12874-018-0583-x.","DOI":"10.1186\/s12874-018-0583-x"},{"key":"467_CR40","doi-asserted-by":"publisher","unstructured":"Wan X, Wang W, Liu J, Tong T. Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range. BMC Med Res Methodol. 2014. https:\/\/doi.org\/10.1186\/1471-2288-14-135.","DOI":"10.1186\/1471-2288-14-135"},{"key":"467_CR41","doi-asserted-by":"crossref","unstructured":"Walter SD, Yao X. Effect sizes can be calculated for studies reporting ranges for outcome variables in systematic reviews. J Clin Epidemiol. 2007.","DOI":"10.1016\/j.jclinepi.2006.11.003"},{"key":"467_CR42","unstructured":"The Jamovi Project. Available Online: Https:\/\/Www.Jamovi.Org (Accessed on 20 March 2020) 2019."},{"key":"467_CR43","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1093\/humrep\/den292","volume":"23","author":"JC Boxmeer","year":"2008","unstructured":"Boxmeer JC, Steegers-Theunissen RPM, Lindemans J, Wildhagen MF, Martini E, Steegers EAP, et al. Homocysteine metabolism in the pre-ovulatory follicle during ovarian stimulation. Hum Reprod Oxf Engl. 2008;23:2570\u20136. https:\/\/doi.org\/10.1093\/humrep\/den292.","journal-title":"Hum Reprod Oxf Engl"},{"key":"467_CR44","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/aogs.12522","volume":"94","author":"T Murto","year":"2015","unstructured":"Murto T, Kallak TK, Hoas A, Altm\u00e4e S, Salumets A, Nilsson TK, et al. Folic acid supplementation and methylenetetrahydrofolate reductase (MTHFR) gene variations in relation to in vitro fertilization pregnancy outcome. Acta Obstet Gynecol Scand. 2015;94:65\u201371.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"467_CR45","doi-asserted-by":"publisher","unstructured":"Paffoni A, Castiglioni M, Ferrari S, La Vecchia I, Ferraris Fusarini C, Bettinardi N, et al. Homocysteine pathway and in vitro fertilization outcome. Reprod Toxicol. 2018. https:\/\/doi.org\/10.1016\/j.reprotox.2017.12.003.","DOI":"10.1016\/j.reprotox.2017.12.003."},{"key":"467_CR46","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1080\/13625187.2016.1263292","volume":"22","author":"I La Vecchia","year":"2017","unstructured":"La Vecchia I, Paffoni A, Castiglioni M, Ferrari S, Bortolus R, Fusarini CF, et al. Folate, homocysteine and selected vitamins and minerals status in infertile women. Eur J Contracept Reprod Health Care. 2017;22:70\u20135. https:\/\/doi.org\/10.1080\/13625187.2016.1263292.","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"467_CR47","doi-asserted-by":"crossref","unstructured":"Roopnarinesingh R, Jackson B, Osman Z, Harrison R, Mayne P. Homocysteine in assisted reproduction: does oestradiol influence homocysteine levels? J Obstet Gynaecol. 2006.","DOI":"10.1080\/01443610500378764"},{"key":"467_CR48","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.fertnstert.2009.02.025","volume":"94","author":"S Altm\u00e4e","year":"2010","unstructured":"Altm\u00e4e S, Stavreus-Evers A, Ruiz JR, Laanpere M, Syv\u00e4nen T, Yngve A, et al. Variations in folate pathway genes are associated with unexplained female infertility. Fertil Steril. 2010;94:130\u20137. https:\/\/doi.org\/10.1016\/j.fertnstert.2009.02.025.","journal-title":"Fertil Steril"},{"key":"467_CR49","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1159\/000493138","volume":"84","author":"N Rogenhofer","year":"2019","unstructured":"Rogenhofer N, Mischitz D, Mann C, Gluderer J, von Sch\u00f6nfeldt V, Jeschke U, et al. Correlation of vitamin D3 (calcitriol) serum concentrations with vitamin b12 and folic acid in women undergoing in vitro fertilisation\/intracytoplasmatic sperm injection. Gynecol Obstet Investig. 2019;84:128\u201335. https:\/\/doi.org\/10.1159\/000493138.","journal-title":"Gynecol Obstet Investig"},{"key":"467_CR50","doi-asserted-by":"publisher","unstructured":"Twigt JM, Hammiche F, Sinclair KD, Beckers NG, Visser JA, Lindemans J, et al. Preconception folic acid use modulates estradiol and follicular responses to ovarian stimulation. J Clin Endocrinol Metab. 2011. https:\/\/doi.org\/10.1210\/jc.2010-1282.","DOI":"10.1210\/jc.2010-1282"},{"key":"467_CR51","doi-asserted-by":"publisher","unstructured":"Vujkovic M, Vries JH, Lindemans J, Macklon NS, Spek PJ, Steegers EA, et al. The preconception mediterranean dietary pattern in couples undergoing in vitro fertilization\/intracytoplasmic sperm injection treatment increases the chance of pregnancy. Fertil Steril. 2010. https:\/\/doi.org\/10.1016\/j.fertnstert.2009.12.079.","DOI":"10.1016\/j.fertnstert.2009.12.079"},{"key":"467_CR52","doi-asserted-by":"publisher","unstructured":"Ponzano A, Tiboni GM. Folate serum levels in Italian women entering an in vitro fertilization program. Gynecol Endocrinol. 2017. https:\/\/doi.org\/10.1080\/09513590.2017.1334197.","DOI":"10.1080\/09513590.2017.1334197"},{"key":"467_CR53","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.1093\/humrep\/dep069","volume":"24","author":"B Berker","year":"2009","unstructured":"Berker B, Kaya C, Aytac R, Satiroglu H. Homocysteine concentrations in follicular fluid are associated with poor oocyte and embryo qualities in polycystic ovary syndrome patients undergoing assisted reproduction. Hum Reprod Oxf Engl. 2009;24:2293\u2013302. https:\/\/doi.org\/10.1093\/humrep\/dep069.","journal-title":"Hum Reprod Oxf Engl"},{"key":"467_CR54","unstructured":"Dhonukshe-Rutten RA, Vries JH, Bree A, Put N, Staveren WA, Groot LC. Dietary intake and status of folate and vitamin b12 and their association with homocysteine and cardiovascular disease in european populations. Eur J Clin Nutr. 2009."},{"key":"467_CR55","doi-asserted-by":"crossref","unstructured":"Dietrich M, Brown CJ, Block G. The effect of folate fortification of cereal-grain products on blood folate status, dietary folate intake, and dietary folate sources among adult non-supplement users in the United States. J Am Coll Nutr. 2005.","DOI":"10.1080\/07315724.2005.10719474"},{"key":"467_CR56","first-page":"808","volume":"51","author":"Centers for Disease Control and Prevention","year":"2002","unstructured":"Centers for Disease Control and Prevention. (CDC) folate status in women of childbearing age, by race\/ethnicity--United States, 1999-2000. MMWR Morb Mortal Wkly Rep. 2002;51:808\u201310.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"467_CR57","doi-asserted-by":"publisher","unstructured":"Pounis G, Di Castelnuovo AF, Lorgeril M, Krogh V, Siani A, Arnout J, et al. European Collaborative Group of the IMMIDIET Project. Folate intake and folate serum levels in men and women from two European populations: the IMMIDIET project. Nutrition. 2014. https:\/\/doi.org\/10.1016\/j.nut.2013.11.014.","DOI":"10.1016\/j.nut.2013.11.014."},{"key":"467_CR58","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1007\/s00394-011-0281-5","volume":"51","author":"ST Kaehler","year":"2012","unstructured":"Kaehler ST, Baumgartner H, Jeske M, Anliker M, Schennach H, Marschang P, et al. A, G. Prevalence of hypovitaminosis D and folate deficiency in healthy young female austrian students in a health care profession. Eur J Nutr. 2012;51:1021\u201331.","journal-title":"Eur J Nutr"},{"key":"467_CR59","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1002\/bdra.23378","volume":"103","author":"SC Tinker","year":"2015","unstructured":"Tinker SC, Hamner HC, Qi YP, Crider KS. U.S. women of childbearing age who are at possible increased risk of a neural tube defect-affected pregnancy due to suboptimal red blood cell folate concentrations, National Health and Nutrition Examination Survey 2007 to 2012. Birth Defects Res Clin Mol Teratol. 2015;103:517\u201326.","journal-title":"Birth Defects Res Clin Mol Teratol"},{"key":"467_CR60","doi-asserted-by":"publisher","unstructured":"Gilfix BM. Utility of measuring serum or red blood cell folate in the era of folate fortification of flour. Clin Biochem. 2014. https:\/\/doi.org\/10.1016\/j.clinbiochem.2014.01.023.","DOI":"10.1016\/j.clinbiochem.2014.01.023"},{"issue":"10","key":"467_CR61","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1001\/jamainternmed.2014.3593","volume":"174","author":"J Theisen-Toupal","year":"2014","unstructured":"Theisen-Toupal J, Horowitz G, Breu A. Low yield of outpatient serum folate testing: eleven years of experience. JAMA Intern Med. 2014;174(10):1696\u20137. https:\/\/doi.org\/10.1001\/jamainternmed.2014.3593.","journal-title":"JAMA Intern Med"},{"key":"467_CR62","doi-asserted-by":"crossref","unstructured":"Ferraro, S.; Panzeri, A.; Panteghini, M. Tackling serum folate test in european countries within the health technology assessment paradigm: request appropriateness, assays and health outcomes. Clin Chem Lab Med 2017, 28;55(9):1262-1275, doi:10.1515\/cclm-2016-0804.","DOI":"10.1515\/cclm-2016-0804"},{"key":"467_CR63","doi-asserted-by":"publisher","first-page":"k724","DOI":"10.1136\/bmj.k724","volume":"360","author":"JL Mills","year":"2018","unstructured":"Mills JL, Molloy AM, Reynolds EH. Do the benefits of folic acid fortification outweigh the risk of masking vitamin b12 deficiency? BMJ. 2018;360:k724. https:\/\/doi.org\/10.1136\/bmj.k724.","journal-title":"BMJ"},{"key":"467_CR64","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1002\/ijc.20648","volume":"113","author":"MA Sanjoaquin","year":"2005","unstructured":"Sanjoaquin MA, Allen N, Couto E, Roddam AW, Key TJ. Folate intake and colorectal cancer risk: a meta-analytical approach. Int J Cancer. 2005;113:825\u20138. https:\/\/doi.org\/10.1002\/ijc.20648.","journal-title":"Int J Cancer"},{"key":"467_CR65","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1136\/bmj.329.7456.41","volume":"329","author":"GP Oakley","year":"2004","unstructured":"Oakley GP, Johnston RB. Balancing benefits and harms in public health prevention programmes mandated by governments. BMJ. 2004;329:41\u20133. https:\/\/doi.org\/10.1136\/bmj.329.7456.41.","journal-title":"BMJ"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-021-00467-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-021-00467-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-021-00467-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T06:56:10Z","timestamp":1671000970000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-021-00467-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,2]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["467"],"URL":"https:\/\/doi.org\/10.1007\/s43032-021-00467-9","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,2]]},"assertion":[{"value":"29 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}},{"value":"All authors have read and agreed to the published version of the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Original data are available from the corresponding Author upon reasonable request.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data Availability"}}]}}