{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:29:42Z","timestamp":1791286182487,"version":"4.1.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s43032-021-00473-x","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T10:35:56Z","timestamp":1613039756000},"page":"357-365","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Frequency of MED12 Mutation in Relation to Tumor and Patient\u2019s Clinical Characteristics: a Meta-analysis"],"prefix":"10.1007","volume":"29","author":[{"given":"Chao","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9956-736X","authenticated-orcid":false,"given":"William","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Dong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Jiao","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Xiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Bin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"473_CR1","doi-asserted-by":"publisher","first-page":"16043","DOI":"10.1038\/nrdp.2016.43","volume":"2","author":"EA Stewart","year":"2016","unstructured":"Stewart EA, Laughlin-Tommaso SK, Catherino WH, Lalitkumar S, Gupta D, Vollenhoven B. Uterine fibroids. Nat Rev Dis Primers. 2016;2:16043.","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"473_CR2","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.fertnstert.2018.10.022","volume":"111","author":"H Ferrero","year":"2019","unstructured":"Ferrero H. Growth disparities in uterine leiomyomas associated with MED12 mutation. Fertil Steril. 2019;111(1):58\u20139.","journal-title":"Fertil Steril"},{"issue":"4","key":"473_CR3","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1097\/GCO.0000000000000185","volume":"27","author":"MB Moravek","year":"2015","unstructured":"Moravek MB, Bulun SE. Endocrinology of uterine fibroids: steroid hormones, stem cells, and genetic contribution. Curr Opin Obstet Gynecol. 2015;27(4):276\u201383.","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"5","key":"473_CR4","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1055\/s-0033-1348896","volume":"31","author":"WH Catherino","year":"2013","unstructured":"Catherino WH, Eltoukhi HM, Al-Hendy A. Racial and ethnic differences in the pathogenesis and clinical manifestations of uterine leiomyoma. Semin Reprod Med. 2013;31(5):370\u20139.","journal-title":"Semin Reprod Med"},{"key":"473_CR5","doi-asserted-by":"crossref","unstructured":"N. Chabbert-buffet, D. Ph, N. Esber, M. Sc, P. Bouchard, and M. D, \u201cFibroid growth and medical options for treatment,\u201d Fertil Steril, vol. 102, no. 3, pp. 630\u2013639, 2014.","DOI":"10.1016\/j.fertnstert.2014.07.1238"},{"issue":"4","key":"473_CR6","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.bpobgyn.2008.01.014","volume":"22","author":"EER Othman","year":"2008","unstructured":"Othman EER, Al-Hendy A. Molecular genetics and racial disparities of uterine leiomyomas. Best Pract Res Clin Obstet Gynaecol. 2008;22(4):589\u2013601.","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"473_CR7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.bpobgyn.2017.09.004","volume":"46","author":"D Pavone","year":"2018","unstructured":"Pavone D, Clemenza S, Sorbi F, Fambrini M, Petraglia F. Epidemiology and risk factors of uterine fibroids. Best Pract Res Clin Obstet Gynaecol. 2018;46:3\u201311.","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"1","key":"473_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12943-017-0672-1","volume":"16","author":"N M\u00e4kinen","year":"2017","unstructured":"M\u00e4kinen N, K\u00e4mpj\u00e4rvi K, Frizzell N, B\u00fctzow R, Vahteristo P. Characterization of MED12, HMGA2, and FH alterations reveals molecular variability in uterine smooth muscle tumors. Mol Cancer. 2017;16(1):1\u20138.","journal-title":"Mol Cancer"},{"issue":"3","key":"473_CR9","doi-asserted-by":"publisher","first-page":"211.e1","DOI":"10.1016\/j.ajog.2011.12.002","volume":"206","author":"ER Cardozo","year":"2012","unstructured":"Cardozo ER, Clark AD, Banks NK, Henne MB, Stegmann BJ, Segars JH. The estimated annual cost of uterine leiomyomata in the United States. Am J Obstet Gynecol. 2012;206(3):211.e1\u20139.","journal-title":"Am J Obstet Gynecol"},{"key":"473_CR10","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.bpobgyn.2015.12.001","volume":"34","author":"LI Zepiridis","year":"2016","unstructured":"Zepiridis LI, Grimbizis GF, Tarlatzis BC. Infertility and uterine fibroids. Best Pract Res Clin Obstet Gynaecol. 2016;34:66\u201373.","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"473_CR11","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.bpobgyn.2015.11.017","volume":"34","author":"F Parazzini","year":"2016","unstructured":"Parazzini F, Tozzi L, Bianchi S. Pregnancy outcome and uterine fibroids. Best Pract Res Clin Obstet Gynaecol. 2016;34:74\u201384.","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"4","key":"473_CR12","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.ajog.2007.12.039","volume":"198","author":"PC Klatsky","year":"2008","unstructured":"Klatsky PC, Tran ND, Caughey AB, Fujimoto VY. Fibroids and reproductive outcomes: a systematic literature review from conception to delivery. Am J Obstet Gynecol. 2008;198(4):357\u201366.","journal-title":"Am J Obstet Gynecol"},{"issue":"7","key":"473_CR13","doi-asserted-by":"publisher","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman D, The PRISMA Group. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med. 2009;6(7):e1000097.","journal-title":"PLoS Med"},{"key":"473_CR14","unstructured":"Wells GA et al. \u201cThe Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. .,\u201d The Ottawa Hospital Research Institute, 2013. [Online]. Available: http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp. [Accessed: 25-Feb-2019]."},{"key":"473_CR15","unstructured":"The Cochrane Collaboration, \u201cReview Manager (RevMan) [Computer program]. Version 5.3.5. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration.\u201d The, 2014."},{"issue":"1","key":"473_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2288-9-80","volume":"9","author":"BC Wallace","year":"2009","unstructured":"Wallace BC, Schmid CH, Lau J, Trikalinos TA. Meta-Analyst: software for meta-analysis of binary, continuous and diagnostic data. BMC Med Res Methodol. 2009;9(1):1\u201312.","journal-title":"BMC Med Res Methodol"},{"issue":"7","key":"473_CR17","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.7863\/ultra.33.7.1217","volume":"33","author":"M Moshesh","year":"2017","unstructured":"Moshesh M, Peddada SD, Cooper T, Baird D. Intra-observer variation in fibroid size measurements: estimated effects on assessing fibroid growth. J Ultrasound Med. 2017;33(7):1217\u201312224.","journal-title":"J Ultrasound Med"},{"issue":"7414","key":"473_CR18","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"J Higgins","year":"2003","unstructured":"Higgins J, Thompson S, Deeks J, Altman D. Measuring inconsistency in meta-analyses. Br Med J. 2003;327(7414):557\u201360.","journal-title":"Br Med J"},{"issue":"6","key":"473_CR19","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.3892\/ol.2015.3118","volume":"9","author":"J Ye","year":"2015","unstructured":"Ye J, Wang H, Chen Y-B, Yuan D-L, Zhang L-X, Liu L. MED12 mutation in patients with hysteromyoma. Oncol Lett. 2015;9(6):2771\u20134.","journal-title":"Oncol Lett"},{"issue":"3","key":"473_CR20","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1136\/jclinpath-2016-203976","volume":"70","author":"LK Dzhemlikhanova","year":"2017","unstructured":"Dzhemlikhanova LK, Efimova OA, Osinovskaya NS, Parfenyev SE, Niauri DA, Sultanov IY, et al. Catechol-O-methyltransferase Val158Met polymorphism is associated with increased risk of multiple uterine leiomyomas either positive or negative for MED12 exon 2 mutations. J Clin Pathol. 2017;70(3):233\u20136.","journal-title":"J Clin Pathol"},{"issue":"3","key":"473_CR21","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.ygyno.2018.07.007","volume":"150","author":"LJ Galindo","year":"2018","unstructured":"Galindo LJ, Hern\u00e1ndez-Beeftink T, Salas A, Jung Y, Reyes R, de Oca FM, et al. HMGA2 and MED12 alterations frequently co-occur in uterine leiomyomas. Gynecol Oncol. 2018;150(3):562\u20138.","journal-title":"Gynecol Oncol"},{"issue":"10","key":"473_CR22","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1038\/modpathol.2016.107","volume":"29","author":"B Liegl-Atzwanger","year":"2016","unstructured":"Liegl-Atzwanger B, Heitzer E, Flicker K, M\u00fcller S, Ulz P, Saglam O, et al. Exploring chromosomal abnormalities and genetic changes in uterine smooth muscle tumors. Mod Pathol. 2016;29(10):1262\u201377.","journal-title":"Mod Pathol"},{"issue":"11","key":"473_CR23","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1093\/molehr\/gay037","volume":"24","author":"J Mello","year":"2018","unstructured":"Mello J, et al. MicroRNAs involved in the HMGA2 deregulation and its co-occurrence with MED12 mutation in uterine leiomyoma. Mol Hum Reprod. 2018;24(11):256\u2013563.","journal-title":"Mol Hum Reprod"},{"issue":"8","key":"473_CR24","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1038\/modpathol.2013.243","volume":"27","author":"E Bertsch","year":"2014","unstructured":"Bertsch E, Qiang W, Zhang Q, Espona-Fiedler M, Druschitz S, Liu Y, et al. MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma. Mod Pathol. 2014;27(8):1144\u201353.","journal-title":"Mod Pathol"},{"issue":"12","key":"473_CR25","doi-asserted-by":"publisher","first-page":"966","DOI":"10.18632\/oncotarget.370","volume":"2","author":"N M\u00e4kinen","year":"2011","unstructured":"M\u00e4kinen N, Heinonen H-R, Moore S, Tomlinson IPM, van der Spuy ZM, Aaltonen LA. MED12 exon 2 mutations are common in uterine leiomyomas from South African patients. Oncotarget. 2011;2(12):966\u20139.","journal-title":"Oncotarget"},{"issue":"2","key":"473_CR26","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s00438-014-0938-x","volume":"290","author":"SK Halder","year":"2014","unstructured":"Halder SK, Laknaur A, Miller J, Layman LC, Diamond M, Al-Hendy A. Novel MED12 gene somatic mutations in women from the Southern United States with symptomatic uterine fibroids. Mol Gen Genomics. 2014;290(2):505\u201311.","journal-title":"Mol Gen Genomics"},{"issue":"4","key":"473_CR27","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1111\/his.12039","volume":"62","author":"A Matsubara","year":"2013","unstructured":"Matsubara A, Sekine S, Yoshida M, Yoshida A, Taniguchi H, Kushima R, et al. Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours. Histopathology. 2013;62(4):657\u201361.","journal-title":"Histopathology"},{"issue":"2","key":"473_CR28","doi-asserted-by":"publisher","first-page":"124","DOI":"10.7150\/ijms.21856","volume":"15","author":"M Lee","year":"2018","unstructured":"Lee M, Cheon K, Chae B, Hwang H, Kim HK, Chung YJ, et al. Analysis of MED12 mutation in multiple uterine leiomyomas in south Korean patients. Int J Med Sci. 2018;15(2):124\u20138.","journal-title":"Int J Med Sci"},{"key":"473_CR29","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1002\/gcc.22029","volume":"52","author":"DN Markowski","year":"2013","unstructured":"Markowski DN, Huhle S, Nimzyk R, Stenman G, Loning T, Bullerdiek J. MED12 mutations occurring in benign and malignant mammalian smooth muscle tumors. Genes Chromosom Cancer. 2013;52:297\u2013304.","journal-title":"Genes Chromosom Cancer"},{"issue":"6","key":"473_CR30","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/ijc.27610","volume":"131","author":"EM Je","year":"2012","unstructured":"Je EM, Kim MR, Min KO, Yoo NJ, Lee SH. Mutational analysis of MED12 exon 2 in uterine leiomyoma and other common tumors. Int J Cancer. 2012;131(6):3\u20136.","journal-title":"Int J Cancer"},{"issue":"6053","key":"473_CR31","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1126\/science.1208930","volume":"334","author":"N M\u00e4kinen","year":"2011","unstructured":"M\u00e4kinen N, et al. MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas. Science (80- ). 2011;334(6053):252\u20135.","journal-title":"Science (80- )"},{"issue":"1","key":"473_CR32","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3892\/ol.2017.6120","volume":"14","author":"J Wu","year":"2017","unstructured":"Wu J, Zou Y, Luo Y, Guo JB, Liu FY, Zhou JY, et al. Prevalence and clinical significance of mediator complex subunit 12 mutations in 362 Han Chinese samples with uterine leiomyoma. Oncol Lett. 2017;14(1):47\u201354.","journal-title":"Oncol Lett"},{"issue":"6","key":"473_CR33","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1097\/PGP.0000000000000255","volume":"35","author":"NS Osinovskaya","year":"2016","unstructured":"Osinovskaya NS, Malysheva OV, Shved NY, Ivashchenko TE, Sultanov IY, Efimova OA, et al. Frequency and spectrum of MED12 exon 2 mutations in multiple versus solitary uterine leiomyomas from Russian patients. Int J Gynecol Pathol. 2016;35(6):509\u201315.","journal-title":"Int J Gynecol Pathol"},{"issue":"2","key":"473_CR34","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1007\/s13277-015-3943-8","volume":"37","author":"S Sadeghi","year":"2016","unstructured":"Sadeghi S, Khorrami M, Amin-Beidokhti M, Abbasi M, Kamalian Z, Irani S, et al. The study of MED12 gene mutations in uterine leiomyomas from Iranian patients. Tumor Biol. 2016;37(2):1567\u201371.","journal-title":"Tumor Biol"},{"issue":"8","key":"473_CR35","first-page":"2441","volume":"5","author":"S Shahbazi","year":"2015","unstructured":"Shahbazi S, Fatahi N, Amini-Moghaddam S. Somatic mutational analysis of MED12 exon 2 in uterine leiomyomas of Iranian women. Am J Cancer Res. 2015;5(8):2441\u20136.","journal-title":"Am J Cancer Res"},{"issue":"3","key":"473_CR36","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1089\/gtmb.2014.0273","volume":"19","author":"H Wang","year":"2015","unstructured":"Wang H, Ye J, Qian H, Zhou R, Jiang J, Ye L. High-resolution melting analysis of MED12 mutations in uterine leiomyomas in Chinese patients. Genet Test Mol Biomarkers. 2015;19(3):162\u20136.","journal-title":"Genet Test Mol Biomarkers"},{"key":"473_CR37","doi-asserted-by":"crossref","unstructured":"Ajabnoor GMA et al. \u201cExpanded somatic mutation spectrum of MED12 gene in uterine leiomyomas of Saudi Arabian women,\u201d Front Genet, vol. 9, 2018.","DOI":"10.3389\/fgene.2018.00552"},{"key":"473_CR38","doi-asserted-by":"crossref","unstructured":"McGuire MM, Yatsenko A, Hoffner L, Jones M, Surti U, and Rajkovic A \u201cWhole exome sequencing in a random sample of north American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas,\u201d PLoS One, vol. 7, no. 3, 2012.","DOI":"10.1371\/journal.pone.0033251"},{"issue":"12","key":"473_CR39","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1134\/S1022795413120089","volume":"49","author":"NS Osinovskaya","year":"2013","unstructured":"Osinovskaya NS, Ivashchenko TE, Dolinskii AK, Sultanov IY, Ghimbovschi S, Hoffman E, et al. MED12 gene mutations in women with uterine myoma. Russ J Genet. 2013;49(12):1245\u20139.","journal-title":"Russ J Genet"},{"issue":"4","key":"473_CR40","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/j.fertnstert.2014.06.040","volume":"102","author":"HR Heinonen","year":"2014","unstructured":"Heinonen HR, Sarvilinna NS, Sj\u00f6berg J, K\u00e4mpj\u00e4rvi K, Pitk\u00e4nen E, Vahteristo P, et al. MED12 mutation frequency in unselected sporadic uterine leiomyomas. Fertil Steril. 2014;102(4):1137\u201342.","journal-title":"Fertil Steril"},{"key":"473_CR41","first-page":"1","volume":"222\u2013223","author":"MA Hayden","year":"2018","unstructured":"Hayden MA, et al. Clinical, pathologic, cytogenetic, and molecular profiling in self-identified black women with uterine leiomyomata. Cancer Gene Ther. 2018;222\u2013223:1\u20138.","journal-title":"Cancer Gene Ther"},{"issue":"12","key":"473_CR42","first-page":"1099","volume":"7","author":"AR Ahmadi","year":"2015","unstructured":"Ahmadi AR, Porrahim H, Moghadasi H, Najafi N, Rakhshan A. MED12 exon 2 mutations in uterine leiomyoma\u2019s in women patients of Tehran Province of Iran. J Pharm Sci Res. 2015;7(12):1099\u2013102.","journal-title":"J Pharm Sci Res"},{"issue":"1","key":"473_CR43","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1038\/s41598-017-01199-0","volume":"7","author":"H-R Heinonen","year":"2017","unstructured":"Heinonen H-R, et al. Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas. Sci Rep. 2017;7(1):1015.","journal-title":"Sci Rep"},{"key":"473_CR44","doi-asserted-by":"crossref","unstructured":"Ajabnoor GMA et al. \u201cExpanded somatic mutation spectrum of MED12 gene in uterine leiomyomas of Saudi Arabian women,\u201d Front Genet, vol. 9, no. December, pp. 1\u201313, 2018.","DOI":"10.3389\/fgene.2018.00552"},{"key":"473_CR45","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1056\/NEJMoa1302736","volume":"369","author":"M Mehine","year":"2013","unstructured":"Mehine M, Kaasinen E, M\u00e4kinen N, Katainen R, K\u00e4mpj\u00e4rvi K, Pitk\u00e4nen E, et al. Characterization of uterine leiomyomas by whole-genome sequencing. N Engl J Med. 2013;369:43\u201353.","journal-title":"N Engl J Med"},{"key":"473_CR46","doi-asserted-by":"crossref","unstructured":"Liu S, Yin P, Kujawa SA, Coon JS, Okeigwe I, Bulun SE \u201cProgesterone receptor integrates the effects of mutated MED12 and altered DNA methylation to stimulate RANKL expression and stem cell proliferation in uterine leiomyoma,\u201d Oncogene, 2018.","DOI":"10.1038\/s41388-018-0612-6"},{"issue":"7","key":"473_CR47","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1002\/ijc.27424","volume":"131","author":"DN Markowski","year":"2012","unstructured":"Markowski DN, Bartnitzke S, L\u00f6ning T, Drieschner N, Helmke BM, Bullerdiek J. MED12 mutations in uterine fibroids-their relationship to cytogenetic subgroups. Int J Cancer. 2012;131(7):1528\u201336.","journal-title":"Int J Cancer"},{"issue":"5","key":"473_CR48","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1093\/humupd\/dmv030","volume":"21","author":"AE Commandeur","year":"2015","unstructured":"Commandeur AE, Styer AK, Teixeira JM. Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth. Hum Reprod Update. 2015;21(5):593\u2013615.","journal-title":"Hum Reprod Update"},{"issue":"3","key":"473_CR49","first-page":"592","volume":"158","author":"A Al-Hendy","year":"2016","unstructured":"Al-Hendy A, Laknaur A, Diamond MP, Ismail N, Boyer TG, Halder SK. Silencing Med12 gene reduces proliferation of human leiomyoma cells mediated via Wnt\/\u03b2-catenin signaling pathway. Endocrinology. 2016;158(3):592\u2013603.","journal-title":"Endocrinology"},{"issue":"4","key":"473_CR50","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1093\/ajcp\/94.4.435","volume":"94","author":"SF Cramer","year":"1990","unstructured":"Cramer SF, Patel A. The frequency of uterine leiomyomas. Am J Clin Pathol. 1990;94(4):435\u20138.","journal-title":"Am J Clin Pathol"},{"key":"473_CR51","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.fertnstert.2013.03.007","volume":"100","author":"MS Islam","year":"2013","unstructured":"Islam MS, Protic O, Stortoni P, Grechi G, Lamanna P, Petraglia F, et al. Complex networks of multiple factors in the pathogenesis of uterine leiomyoma. Fertil Steril. Jul. 2013;100:178\u201393.","journal-title":"Fertil Steril"},{"issue":"7","key":"473_CR52","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1530\/ERC-18-0184","volume":"25","author":"VA Serna","year":"2018","unstructured":"Serna VA, Wu X, Qiang W, Thomas J, Blumenfeld ML, Kurita T. Cellular kinetics of MED12-mutant uterine leiomyoma growth and regression in vivo. Endocr Relat Cancer. 2018;25(7):747\u201359.","journal-title":"Endocr Relat Cancer"},{"issue":"1","key":"473_CR53","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1067\/mob.2003.99","volume":"188","author":"DD Baird","year":"2003","unstructured":"Baird DD, Dunson DB, Hill MC, Cousins D, Schectman JM. High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet Gynecol. 2003;188(1):100\u20137.","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"473_CR54","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/S0029-7844(97)00534-6","volume":"90","author":"LM Marshall","year":"1997","unstructured":"Marshall LM, Spiegelman D, Barbieri RL, Goldman MB, Manson JE, Colditz GA, et al. Variation in the incidence of uterine leiomyoma among premenopausal women by age and race. Obstet Gynecol. 1997;90(6):967\u201373.","journal-title":"Obstet Gynecol"},{"issue":"3","key":"473_CR55","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1097\/AOG.0b013e318197bbaf","volume":"113","author":"SK Laughlin","year":"2009","unstructured":"Laughlin SK, Baird DD, Savitz DA, Herring AH, Hartmann KE. Prevalence of uterine leiomyomas in the first trimester of pregnancy: an ultrasound-screening study. Obstet Gynecol. 2009;113(3):630\u20135.","journal-title":"Obstet Gynecol"},{"issue":"1","key":"473_CR56","first-page":"3","volume":"100","author":"DJ Dewaay","year":"2002","unstructured":"Dewaay DJ, Syrop CH, Nygaard IE, Davis WA, Van Voorhis BJ. Natural history of uterine polyps and leiomyomata. Obstet Gynecol. 2002;100(1):3\u20137.","journal-title":"Obstet Gynecol"},{"issue":"2","key":"473_CR57","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/aje\/kwh016","volume":"159","author":"LA Wise","year":"2004","unstructured":"Wise LA, Palmer JR, Harlow BL, Spiegelman D, Stewart EA, Adams-Campbell LL, et al. Reproductive factors, hormonal contraception, and risk of uterine leiomyomata in African-American women: a prospective study. Am J Epidemiol. 2004;159(2):113\u201323.","journal-title":"Am J Epidemiol"},{"issue":"10","key":"473_CR58","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1136\/jclinpath-2015-203590","volume":"69","author":"WJ Tan","year":"2016","unstructured":"Tan WJ, Chan JY, Thike AA, Lim JCT, Md Nasir ND, Tan JSY, et al. MED12 protein expression in breast fibroepithelial lesions: correlation with mutation status and oestrogen receptor expression. J Clin Pathol. 2016;69(10):858\u201365.","journal-title":"J Clin Pathol"},{"issue":"3","key":"473_CR59","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.fertnstert.2006.01.052","volume":"86","author":"A Al-Hendy","year":"2006","unstructured":"Al-Hendy A, Salama SA. Ethnic distribution of estrogen receptor-alpha polymorphism is associated with a higher prevalence of uterine leiomyomas in black Americans. Fertil Steril. 2006;86(3):686\u201393.","journal-title":"Fertil Steril"},{"issue":"2","key":"473_CR60","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s00438-014-0938-x","volume":"290","author":"SK Halder","year":"2015","unstructured":"Halder SK, Laknaur A, Miller J, Layman LC, Diamond M, Al-Hendy A. Novel MED12 gene somatic mutations in women from the Southern United States with symptomatic uterine fibroids. Mol Gen Genomics. 2015;290(2):505\u201311.","journal-title":"Mol Gen Genomics"},{"key":"473_CR61","doi-asserted-by":"crossref","unstructured":"Wise LA and Laughlin-Tommaso SK, Epidemiology of uterine fibroids \u2013 from menarche to menopause, vol. 59, no. 1. 2016.","DOI":"10.1097\/GRF.0000000000000164"},{"issue":"46","key":"473_CR62","first-page":"1","volume":"95","author":"YJ Tak","year":"2016","unstructured":"Tak YJ, et al. Association between uterine leiomyoma and metabolic syndrome in parous premenopausal women: a case-control study. Medicine (United States). 2016;95(46):1\u20137.","journal-title":"Medicine (United States)"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-021-00473-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-021-00473-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-021-00473-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T04:06:14Z","timestamp":1650254774000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-021-00473-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,10]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["473"],"URL":"https:\/\/doi.org\/10.1007\/s43032-021-00473-x","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,10]]},"assertion":[{"value":"3 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research Involving Human Participants and\/or Animals"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}