{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:17:59Z","timestamp":1790198279605,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1C1B6003"],"award-info":[{"award-number":["2018R1C1B6003"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1C1C100787211"],"award-info":[{"award-number":["2020R1C1C100787211"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endometrial angiogenesis plays crucial roles in determining the endometrial receptivity. Defects in endometrial receptivity often cause repeated implantation failure, which is one of the major unmet needs for infertility and contributes a major barrier to the assisted reproductive technology. Despite the numerous extensive research work, there are currently no effective evidence-based treatments to prevent or cure this condition. As a non-invasive treatment strategy, botulinum toxin A (BoTA) was administered into one side of mouse uterine horns, and saline was infused into the other side of horns for the control. Impact of BoTA was assessed in the endometrium at 3 or 8 days after infusion. We demonstrated that BoTA administration enhances the capacity of endothelial cell tube formation and sprouting. The intrauterine BoTA administration significantly induced endometrial angiogenesis displaying increased numbers of vessel formation and expression levels of related marker genes. Moreover, BoTA intrauterine application promoted the endometrial receptivity, and the rates of embryo implantation were improved with BoTA treatment with no morphologically retarded embryos. Intrauterine BoTA treatment has a beneficial effect on vascular reconstruction of functional endometrium prior to embryo implantation by increasing endometrial blood flow near the uterine cavity suggesting BoTA treatment as a potential therapeutic strategy for patients who are suffering from repeated implantation failure with the problems with endometrial receptivity.<\/jats:p>","DOI":"10.1007\/s43032-021-00496-4","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T12:03:16Z","timestamp":1614600196000},"page":"1671-1687","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Non-invasive Intrauterine Administration of Botulinum Toxin A Enhances Endometrial Angiogenesis and Improves the Rates of Embryo Implantation"],"prefix":"10.1007","volume":"28","author":[{"given":"Hwa Seon","family":"Koo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Ji","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon-Hwa","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungho","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwijae","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danbi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Woo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0771-9515","authenticated-orcid":false,"given":"Youn-Jung","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"issue":"4","key":"496_CR1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/s1043-2760(01)00379-4","volume":"12","author":"SK Smith","year":"2001","unstructured":"Smith SK. Regulation of angiogenesis in the endometrium. Trends Endocrinol Metab. 2001;12(4):147\u201351. https:\/\/doi.org\/10.1016\/s1043-2760(01)00379-4.","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"496_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1053\/plac.2000.0588","volume":"22","author":"DM Sherer","year":"2001","unstructured":"Sherer DM, Abulafia O. Angiogenesis during implantation, and placental and early embryonic development. Placenta. 2001;22(1):1\u201313. https:\/\/doi.org\/10.1053\/plac.2000.0588.","journal-title":"Placenta."},{"issue":"3","key":"496_CR3","doi-asserted-by":"publisher","first-page":"773","DOI":"10.3892\/etm.2015.2181","volume":"9","author":"X Gong","year":"2015","unstructured":"Gong X, Tong Q, Chen Z, Zhang Y, Xu C, Jin Z. Microvascular density and vascular endothelial growth factor and osteopontin expression during the implantation window in a controlled ovarian hyperstimulation rat model. Exp Ther Med. 2015;9(3):773\u20139. https:\/\/doi.org\/10.3892\/etm.2015.2181.","journal-title":"Exp Ther Med"},{"issue":"8","key":"496_CR4","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1097\/00006254-200008000-00024","volume":"55","author":"E Geva","year":"2000","unstructured":"Geva E, Jaffe RB. Role of angiopoietins in reproductive tract angiogenesis. Obstet Gynecol Surv. 2000;55(8):511\u20139. https:\/\/doi.org\/10.1097\/00006254-200008000-00024.","journal-title":"Obstet Gynecol Surv"},{"issue":"1","key":"496_CR5","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/s0146-0005(00)80062-2","volume":"24","author":"RB Jaffe","year":"2000","unstructured":"Jaffe RB. Importance of angiogenesis in reproductive physiology. Semin Perinatol. 2000;24(1):79\u201381. https:\/\/doi.org\/10.1016\/s0146-0005(00)80062-2.","journal-title":"Semin Perinatol"},{"issue":"5","key":"496_CR6","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1093\/humupd\/4.5.509","volume":"4","author":"SK Smith","year":"1998","unstructured":"Smith SK. Angiogenesis, vascular endothelial growth factor and the endometrium. Hum Reprod Update. 1998;4(5):509\u201319. https:\/\/doi.org\/10.1093\/humupd\/4.5.509.","journal-title":"Hum Reprod Update"},{"issue":"8","key":"496_CR7","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1093\/humrep\/16.8.1557","volume":"16","author":"JW Maas","year":"2001","unstructured":"Maas JW, Groothuis PG, Dunselman GA, de Goeij AF, Struyker Boudier HA, Evers JL. Endometrial angiogenesis throughout the human menstrual cycle. Hum Reprod. 2001;16(8):1557\u201361. https:\/\/doi.org\/10.1093\/humrep\/16.8.1557.","journal-title":"Hum Reprod"},{"issue":"3","key":"496_CR8","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1210\/er.2003-0020","volume":"25","author":"SK Dey","year":"2004","unstructured":"Dey SK, Lim H, Das SK, Reese J, Paria BC, Daikoku T, et al. Molecular cues to implantation. Endocr Rev. 2004;25(3):341\u201373. https:\/\/doi.org\/10.1210\/er.2003-0020.","journal-title":"Endocr Rev"},{"key":"496_CR9","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/s0083-6729(08)60999-1","volume":"31","author":"A Psychoyos","year":"1973","unstructured":"Psychoyos A. Hormonal control of ovoimplantation. Vitam Horm. 1973;31:201\u201356. https:\/\/doi.org\/10.1016\/s0083-6729(08)60999-1.","journal-title":"Vitam Horm"},{"issue":"5","key":"496_CR10","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1093\/humupd\/4.5.465","volume":"4","author":"S Tabibzadeh","year":"1998","unstructured":"Tabibzadeh S. Molecular control of the implantation window. Hum Reprod Update. 1998;4(5):465\u201371. https:\/\/doi.org\/10.1093\/humupd\/4.5.465.","journal-title":"Hum Reprod Update"},{"key":"496_CR11","doi-asserted-by":"publisher","unstructured":"Chen X, Man GCW, Liu Y, Wu F, Huang J, Li TC, et al. Physiological and pathological angiogenesis in endometrium at the time of embryo implantation. Am J Reprod Immunol. 2017;78(2). https:\/\/doi.org\/10.1111\/aji.12693.","DOI":"10.1111\/aji.12693"},{"issue":"1","key":"496_CR12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1093\/humupd\/2.1.57","volume":"2","author":"PA Rogers","year":"1996","unstructured":"Rogers PA. Structure and function of endometrial blood vessels. Hum Reprod Update. 1996;2(1):57\u201362. https:\/\/doi.org\/10.1093\/humupd\/2.1.57.","journal-title":"Hum Reprod Update"},{"key":"496_CR13","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3389\/fendo.2019.00061","volume":"10","author":"H Kim","year":"2019","unstructured":"Kim H, Shin JE, Koo HS, Kwon H, Choi DH, Kim JH. Effect of autologous platelet-rich plasma treatment on refractory thin endometrium during the frozen embryo transfer cycle: a pilot study. Front Endocrinol (Lausanne). 2019;10:61. https:\/\/doi.org\/10.3389\/fendo.2019.00061.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"496_CR14","doi-asserted-by":"publisher","unstructured":"Xie Y, Zhang T, Tian Z, Zhang J, Wang W, Zhang H, et al. Efficacy of intrauterine perfusion of granulocyte colony-stimulating factor (G-CSF) for infertile women with thin endometrium: a systematic review and meta-analysis. Am J Reprod Immunol. 2017;78(2). https:\/\/doi.org\/10.1111\/aji.12701.","DOI":"10.1111\/aji.12701"},{"issue":"4","key":"496_CR15","doi-asserted-by":"publisher","first-page":"293","DOI":"10.2174\/1574888X14666181205120110","volume":"14","author":"X Zhu","year":"2019","unstructured":"Zhu X, Peault B, Yan G, Sun H, Hu Y, Ding L. Stem cells and endometrial regeneration: from basic research to clinical trial. Curr Stem Cell Res Ther. 2019;14(4):293\u2013304. https:\/\/doi.org\/10.2174\/1574888X14666181205120110.","journal-title":"Curr Stem Cell Res Ther"},{"issue":"1","key":"496_CR16","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s12958-016-0197-2","volume":"14","author":"J Zhao","year":"2016","unstructured":"Zhao J, Xu B, Xie S, Zhang Q, Li YP. Whether G-CSF administration has beneficial effect on the outcome after assisted reproductive technology? A systematic review and meta-analysis. Reprod Biol Endocrinol. 2016;14(1):62. https:\/\/doi.org\/10.1186\/s12958-016-0197-2.","journal-title":"Reprod Biol Endocrinol"},{"issue":"3","key":"496_CR17","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018848","volume":"99","author":"J Du","year":"2020","unstructured":"Du J, Lu H, Yu X, Lu Z, Mi L, Zhang X. Efficacy and safety of platelet-rich plasma for the treatment of thin endometrium: a protocol for systematic review and meta-analysis. Medicine (Baltimore). 2020;99(3):e18848. https:\/\/doi.org\/10.1097\/MD.0000000000018848.","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"496_CR18","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s40902-019-0226-0","volume":"41","author":"KH Kwon","year":"2019","unstructured":"Kwon KH, Shin KS, Yeon SH, Kwon DG. Application of botulinum toxin in maxillofacial field: Part III. Ancillary treatment for maxillofacial surgery and summary. Maxillofac Plast Reconstr Surg. 2019;41(1):45. https:\/\/doi.org\/10.1186\/s40902-019-0226-0.","journal-title":"Maxillofac Plast Reconstr Surg"},{"issue":"5","key":"496_CR19","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1097\/PRS.0000000000002119","volume":"137","author":"H Sundaram","year":"2016","unstructured":"Sundaram H, Liew S, Signorini M, Vieira Braz A, Fagien S, Swift A, et al. Global Aesthetics Consensus: hyaluronic acid fillers and botulinum toxin type A-recommendations for combined treatment and optimizing outcomes in diverse patient populations. Plast Reconstr Surg. 2016;137(5):1410\u201323. https:\/\/doi.org\/10.1097\/PRS.0000000000002119.","journal-title":"Plast Reconstr Surg"},{"issue":"10","key":"496_CR20","doi-asserted-by":"publisher","first-page":"913","DOI":"10.3390\/toxins4100913","volume":"4","author":"S Chen","year":"2012","unstructured":"Chen S. Clinical uses of botulinum neurotoxins: current indications, limitations and future developments. Toxins (Basel). 2012;4(10):913\u201339. https:\/\/doi.org\/10.3390\/toxins4100913.","journal-title":"Toxins (Basel)"},{"issue":"2","key":"496_CR21","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1177\/1090820X11434506","volume":"32","author":"MA Doft","year":"2012","unstructured":"Doft MA, Hardy KL, Ascherman JA. Treatment of hyperhidrosis with botulinum toxin. Aesthet Surg J. 2012;32(2):238\u201344. https:\/\/doi.org\/10.1177\/1090820X11434506.","journal-title":"Aesthet Surg J"},{"issue":"2","key":"496_CR22","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1177\/1756285616677005","volume":"10","author":"CM Escher","year":"2017","unstructured":"Escher CM, Paracka L, Dressler D, Kollewe K. Botulinum toxin in the management of chronic migraine: clinical evidence and experience. Ther Adv Neurol Disord. 2017;10(2):127\u201335. https:\/\/doi.org\/10.1177\/1756285616677005.","journal-title":"Ther Adv Neurol Disord"},{"key":"496_CR23","doi-asserted-by":"publisher","unstructured":"Hsieh PF, Chiu HC, Chen KC, Chang CH, Chou EC. Botulinum toxin A for the treatment of overactive bladder. Toxins (Basel). 2016;8(3). https:\/\/doi.org\/10.3390\/toxins8030059.","DOI":"10.3390\/toxins8030059"},{"issue":"1","key":"496_CR24","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1097\/SAP.0000000000001054","volume":"79","author":"RG Aru","year":"2017","unstructured":"Aru RG, Songcharoen SJ, Seals SR, Arnold PB, Hester RL. Microcirculatory effects of botulinum toxin A in the rat: acute and chronic vasodilation. Ann Plast Surg. 2017;79(1):82\u20135. https:\/\/doi.org\/10.1097\/SAP.0000000000001054.","journal-title":"Ann Plast Surg"},{"issue":"6","key":"496_CR25","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1097\/SAP.0000000000000435","volume":"76","author":"TH Park","year":"2016","unstructured":"Park TH, Lee SH, Park YJ, Lee YS, Rah DK, Kim SY. Presurgical botulinum toxin A treatment increases angiogenesis by hypoxia-inducible factor-1alpha\/vascular endothelial growth factor and subsequent superiorly based transverse rectus abdominis myocutaneous flap survival in a rat model. Ann Plast Surg. 2016;76(6):723\u20138. https:\/\/doi.org\/10.1097\/SAP.0000000000000435.","journal-title":"Ann Plast Surg"},{"issue":"8","key":"496_CR26","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000000852","volume":"4","author":"A Gugerell","year":"2016","unstructured":"Gugerell A, Kober J, Schmid M, Buchberger E, Kamolz LP, Keck M. Botulinum toxin A: dose-dependent effect on reepithelialization and angiogenesis. Plast Reconstr Surg Glob Open. 2016;4(8):e837. https:\/\/doi.org\/10.1097\/GOX.0000000000000852.","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"4","key":"496_CR27","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1242\/jcs.164004","volume":"128","author":"YJ Kang","year":"2015","unstructured":"Kang YJ, Lees M, Matthews LC, Kimber SJ, Forbes K, Aplin JD. MiR-145 suppresses embryo-epithelial juxtacrine communication at implantation by modulating maternal IGF1R. J Cell Sci. 2015;128(4):804\u201314. https:\/\/doi.org\/10.1242\/jcs.164004.","journal-title":"J Cell Sci"},{"key":"496_CR28","doi-asserted-by":"publisher","unstructured":"Chung M, Ahn J, Son K, Kim S, Jeon NL. Biomimetic model of tumor microenvironment on microfluidic platform. Adv Healthc Mater. 2017;6(15). https:\/\/doi.org\/10.1002\/adhm.201700196.","DOI":"10.1002\/adhm.201700196"},{"issue":"4","key":"496_CR29","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1093\/humrep\/det433","volume":"29","author":"YJ Kang","year":"2014","unstructured":"Kang YJ, Forbes K, Carver J, Aplin JD. The role of the osteopontin-integrin alphavbeta3 interaction at implantation: functional analysis using three different in vitro models. Hum Reprod. 2014;29(4):739\u201349. https:\/\/doi.org\/10.1093\/humrep\/det433.","journal-title":"Hum Reprod"},{"issue":"2","key":"496_CR30","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1093\/humrep\/deg072","volume":"18","author":"J Carver","year":"2003","unstructured":"Carver J, Martin K, Spyropoulou I, Barlow D, Sargent I, Mardon H. An in-vitro model for stromal invasion during implantation of the human blastocyst. Hum Reprod. 2003;18(2):283\u201390. https:\/\/doi.org\/10.1093\/humrep\/deg072.","journal-title":"Hum Reprod"},{"key":"496_CR31","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3389\/fcell.2020.00105","volume":"8","author":"X Zhou","year":"2020","unstructured":"Zhou X, Xu B, Zhang D, Jiang X, Chang HM, Leung PCK, et al. Loss of CDYL Results in suppression of ctnnb1 and decreased endometrial receptivity. Front Cell Dev Biol. 2020;8:105. https:\/\/doi.org\/10.3389\/fcell.2020.00105.","journal-title":"Front Cell Dev Biol"},{"issue":"19","key":"496_CR32","doi-asserted-by":"publisher","first-page":"3864","DOI":"10.1093\/bioinformatics\/btz163","volume":"35","author":"B Mlecnik","year":"2019","unstructured":"Mlecnik B, Galon J, Bindea G. Automated exploration of gene ontology term and pathway networks with ClueGO-REST. Bioinformatics. 2019;35(19):3864\u20136. https:\/\/doi.org\/10.1093\/bioinformatics\/btz163.","journal-title":"Bioinformatics."},{"issue":"1","key":"496_CR33","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"W Huang da","year":"2009","unstructured":"Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44\u201357. https:\/\/doi.org\/10.1038\/nprot.2008.211.","journal-title":"Nat Protoc"},{"issue":"20","key":"496_CR34","doi-asserted-by":"publisher","first-page":"3796","DOI":"10.1242\/dev.137919","volume":"143","author":"M Shin","year":"2016","unstructured":"Shin M, Beane TJ, Quillien A, Male I, Zhu LJ, Lawson ND. Vegfa signals through ERK to promote angiogenesis, but not artery differentiation. Development. 2016;143(20):3796\u2013805. https:\/\/doi.org\/10.1242\/dev.137919.","journal-title":"Development."},{"issue":"10","key":"496_CR35","doi-asserted-by":"publisher","first-page":"e387","DOI":"10.1038\/emm.2017.151","volume":"49","author":"EY Zhang","year":"2017","unstructured":"Zhang EY, Gao B, Shi HL, Huang LF, Yang L, Wu XJ, et al. 20(S)-Protopanaxadiol enhances angiogenesis via HIF-1alpha-mediated VEGF secretion by activating p70S6 kinase and benefits wound healing in genetically diabetic mice. Exp Mol Med. 2017;49(10):e387. https:\/\/doi.org\/10.1038\/emm.2017.151.","journal-title":"Exp Mol Med"},{"issue":"1","key":"496_CR36","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1242\/jcs.175943","volume":"130","author":"JD Aplin","year":"2017","unstructured":"Aplin JD, Ruane PT. Embryo-epithelium interactions during implantation at a glance. J Cell Sci. 2017;130(1):15\u201322. https:\/\/doi.org\/10.1242\/jcs.175943.","journal-title":"J Cell Sci"},{"issue":"1","key":"496_CR37","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s10456-011-9251-z","volume":"15","author":"MJ Siemerink","year":"2012","unstructured":"Siemerink MJ, Klaassen I, Vogels IM, Griffioen AW, Van Noorden CJ, Schlingemann RO. CD34 marks angiogenic tip cells in human vascular endothelial cell cultures. Angiogenesis. 2012;15(1):151\u201363. https:\/\/doi.org\/10.1007\/s10456-011-9251-z.","journal-title":"Angiogenesis."},{"issue":"2","key":"496_CR38","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.tjog.2016.06.019","volume":"56","author":"M Rizov","year":"2017","unstructured":"Rizov M, Andreeva P, Dimova I. Molecular regulation and role of angiogenesis in reproduction. Taiwan J Obstet Gynecol. 2017;56(2):127\u201332. https:\/\/doi.org\/10.1016\/j.tjog.2016.06.019.","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"4","key":"496_CR39","doi-asserted-by":"publisher","first-page":"179","DOI":"10.5653\/cerm.2011.38.4.179","volume":"38","author":"DW Park","year":"2011","unstructured":"Park DW, Yang KM. Hormonal regulation of uterine chemokines and immune cells. Clin Exp Reprod Med. 2011;38(4):179\u201385. https:\/\/doi.org\/10.5653\/cerm.2011.38.4.179.","journal-title":"Clin Exp Reprod Med"},{"issue":"4","key":"496_CR40","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1002\/jum.14418","volume":"37","author":"HS Koo","year":"2018","unstructured":"Koo HS, Park CW, Cha SH, Yang KM. Serial evaluation of endometrial blood flow for prediction of pregnancy outcomes in patients who underwent controlled ovarian hyperstimulation and in vitro fertilization and embryo transfer. J Ultrasound Med. 2018;37(4):851\u20137. https:\/\/doi.org\/10.1002\/jum.14418.","journal-title":"J Ultrasound Med"},{"issue":"11","key":"496_CR41","doi-asserted-by":"publisher","first-page":"6355","DOI":"10.1073\/pnas.95.11.6355","volume":"95","author":"AM Babic","year":"1998","unstructured":"Babic AM, Kireeva ML, Kolesnikova TV, Lau LF. CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth. Proc Natl Acad Sci U S A. 1998;95(11):6355\u201360. https:\/\/doi.org\/10.1073\/pnas.95.11.6355.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"496_CR42","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3389\/fped.2015.00033","volume":"3","author":"T Hashimoto","year":"2015","unstructured":"Hashimoto T, Shibasaki F. Hypoxia-inducible factor as an angiogenic master switch. Front Pediatr. 2015;3:33. https:\/\/doi.org\/10.3389\/fped.2015.00033.","journal-title":"Front Pediatr"},{"issue":"1","key":"496_CR43","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.yjmcc.2006.04.021","volume":"41","author":"ER Popa","year":"2006","unstructured":"Popa ER, Harmsen MC, Tio RA, van der Strate BW, Brouwer LA, Schipper M, et al. Circulating CD34+ progenitor cells modulate host angiogenesis and inflammation in vivo. J Mol Cell Cardiol. 2006;41(1):86\u201396. https:\/\/doi.org\/10.1016\/j.yjmcc.2006.04.021.","journal-title":"J Mol Cell Cardiol"},{"issue":"8","key":"496_CR44","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/s41419-019-1757-0","volume":"10","author":"D Qi","year":"2019","unstructured":"Qi D, Wei M, Jiao S, Song Y, Wang X, Xie G, et al. Hypoxia inducible factor 1alpha in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment. Cell Death Dis. 2019;10(8):544. https:\/\/doi.org\/10.1038\/s41419-019-1757-0.","journal-title":"Cell Death Dis"},{"issue":"4","key":"496_CR45","doi-asserted-by":"publisher","first-page":"e25155","DOI":"10.4161\/jkst.25155","volume":"2","author":"P Suman","year":"2013","unstructured":"Suman P, Malhotra SS, Gupta SK. LIF-STAT signaling and trophoblast biology. JAKSTAT. 2013;2(4):e25155. https:\/\/doi.org\/10.4161\/jkst.25155.","journal-title":"JAKSTAT."},{"issue":"6","key":"496_CR46","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1530\/rep.1.01100","volume":"131","author":"LJ Xiao","year":"2006","unstructured":"Xiao LJ, Yuan JX, Song XX, Li YC, Hu ZY, Liu YX. Expression and regulation of stanniocalcin 1 and 2 in rat uterus during embryo implantation and decidualization. Reproduction. 2006;131(6):1137\u201349. https:\/\/doi.org\/10.1530\/rep.1.01100.","journal-title":"Reproduction."},{"issue":"4","key":"496_CR47","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.jhsa.2012.01.021","volume":"37","author":"AV Stone","year":"2012","unstructured":"Stone AV, Koman LA, Callahan MF, Eckman DM, Smith BP, Plate JF, et al. The effect of botulinum neurotoxin-A on blood flow in rats: a potential mechanism for treatment of Raynaud phenomenon. J Hand Surg [Am]. 2012;37(4):795\u2013802. https:\/\/doi.org\/10.1016\/j.jhsa.2012.01.021.","journal-title":"J Hand Surg [Am]"},{"issue":"5","key":"496_CR48","doi-asserted-by":"publisher","first-page":"482","DOI":"10.5144\/0256-4947.2013.482","volume":"33","author":"MM Al-Qattan","year":"2013","unstructured":"Al-Qattan MM, Al-Shanawani BN, Alshomer F. Botulinum toxin type A: implications in wound healing, facial cutaneous scarring, and cleft lip repair. Ann Saudi Med. 2013;33(5):482\u20138. https:\/\/doi.org\/10.5144\/0256-4947.2013.482.","journal-title":"Ann Saudi Med"},{"issue":"2","key":"496_CR49","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.bjps.2012.09.012","volume":"66","author":"M Ziade","year":"2013","unstructured":"Ziade M, Domergue S, Batifol D, Jreige R, Sebbane M, Goudot P, et al. Use of botulinum toxin type A to improve treatment of facial wounds: a prospective randomised study. J Plast Reconstr Aesthet Surg. 2013;66(2):209\u201314. https:\/\/doi.org\/10.1016\/j.bjps.2012.09.012.","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"3","key":"496_CR50","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1590\/s0034-70942009000300013","volume":"59","author":"OC Colhado","year":"2009","unstructured":"Colhado OC, Boeing M, Ortega LB. Botulinum toxin in pain treatment. Rev Bras Anestesiol. 2009;59(3):366\u201381. https:\/\/doi.org\/10.1590\/s0034-70942009000300013.","journal-title":"Rev Bras Anestesiol"},{"issue":"1","key":"496_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3344\/kjp.2011.24.1.1","volume":"24","author":"WS Sim","year":"2011","unstructured":"Sim WS. Application of botulinum toxin in pain management. Korean J Pain. 2011;24(1):1\u20136. https:\/\/doi.org\/10.3344\/kjp.2011.24.1.1.","journal-title":"Korean J Pain"},{"issue":"3","key":"496_CR52","doi-asserted-by":"publisher","first-page":"310e","DOI":"10.1097\/PRS.0000000000001544","volume":"136","author":"Y Guo","year":"2015","unstructured":"Guo Y, Lu Y, Liu T, Zhou Y, Yang P, Zhu J, et al. Efficacy and safety of botulinum toxin type A in the treatment of glabellar lines: a meta-analysis of randomized, placebo-controlled, double-blind trials. Plast Reconstr Surg. 2015;136(3):310e\u20138e. https:\/\/doi.org\/10.1097\/PRS.0000000000001544.","journal-title":"Plast Reconstr Surg"},{"issue":"7","key":"496_CR53","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1185\/030079904125003962","volume":"20","author":"M Naumann","year":"2004","unstructured":"Naumann M, Jankovic J. Safety of botulinum toxin type A: a systematic review and meta-analysis. Curr Med Res Opin. 2004;20(7):981\u201390. https:\/\/doi.org\/10.1185\/030079904125003962.","journal-title":"Curr Med Res Opin"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-021-00496-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-021-00496-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-021-00496-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T09:15:21Z","timestamp":1621847721000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-021-00496-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":53,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["496"],"URL":"https:\/\/doi.org\/10.1007\/s43032-021-00496-4","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,1]]},"assertion":[{"value":"28 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This experimental procedure and animal use protocol have been approved by the Animal Ethics Committee of the CHA University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}