{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T01:16:56Z","timestamp":1784596616010,"version":"3.55.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T00:00:00Z","timestamp":1636675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T00:00:00Z","timestamp":1636675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["no. 81471521"],"award-info":[{"award-number":["no. 81471521"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s43032-021-00671-7","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T15:03:16Z","timestamp":1636729396000},"page":"173-183","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["FoxO1 Regulates Neuropeptide Y and Pro-opiomelanocortin in the Hypothalamus of Rat Offspring Small for Gestational Age"],"prefix":"10.1007","volume":"29","author":[{"given":"Lifang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6593-8732","authenticated-orcid":false,"given":"Qingyun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,12]]},"reference":[{"key":"671_CR1","unstructured":"Slancheva B, Mumdzhiev H. Small for gestational age newborns--definition, etiology and neonatal treatment.\u00a0Akush Ginekol (Sofiia) 13. 2013;52(2):25\u201332."},{"issue":"12","key":"671_CR2","first-page":"1785","volume":"47","author":"Z Hu","year":"2018","unstructured":"Hu Z, Tang L, Xu HL. Maternal vitamin D deficiency and the risk of small for gestational age: a meta-analysis. Iran J Public Health. 2018;47(12):1785\u201395.","journal-title":"Iran J Public Health"},{"issue":"8","key":"671_CR3","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.jgyn.2013.09.013","volume":"42","author":"A Gaudineau","year":"2013","unstructured":"Gaudineau A. Prevalence, risk factors, maternal and fetal morbidity and mortality of intrauterine growth restriction and small-for-gestational age. J Gynecol Obstet Biol Reprod (Paris). 2013;42(8):895\u2013910. https:\/\/doi.org\/10.1016\/j.jgyn.2013.09.013.","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"issue":"12","key":"671_CR4","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/ncpneph0344","volume":"2","author":"DJ Barker","year":"2006","unstructured":"Barker DJ, Bagby SP, Hanson MA. Mechanisms of disease: in utero programming in the pathogenesis of hypertension. Nat Clin Pract Nephrol. 2006;2(12):700\u20137. https:\/\/doi.org\/10.1038\/ncpneph0344.","journal-title":"Nat Clin Pract Nephrol"},{"key":"671_CR5","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.brainres.2014.09.031","volume":"1589","author":"M Desai","year":"2014","unstructured":"Desai M, Li T, Han G, Ross MG. Programmed hyperphagia secondary to increased hypothalamic SIRT1. Brain Res. 2014;1589:26\u201336. https:\/\/doi.org\/10.1016\/j.brainres.2014.09.031.","journal-title":"Brain Res"},{"issue":"4","key":"671_CR6","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1177\/1933719111424448","volume":"19","author":"T Fukami","year":"2012","unstructured":"Fukami T, Sun X, Li T, Desai M, Ross MG. Mechanism of programmed obesity in intrauterine fetal growth restricted offspring: paradoxically enhanced appetite stimulation in fed and fasting states. Reprod Sci. 2012;19(4):423\u201330. https:\/\/doi.org\/10.1177\/1933719111424448.","journal-title":"Reprod Sci"},{"issue":"3","key":"671_CR7","doi-asserted-by":"publisher","first-page":"R813","DOI":"10.1152\/ajpregu.00201.2009","volume":"297","author":"B Coupe","year":"2009","unstructured":"Coupe B, Grit I, Darmaun D, Parnet P. The timing of \u201ccatch-up growth\u201d affects metabolism and appetite regulation in male rats born with intrauterine growth restriction. Am J Physiol Regul Integr Comp Physiol. 2009;297(3):R813\u201324. https:\/\/doi.org\/10.1152\/ajpregu.00201.2009.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"671_CR8","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1210\/en.2007-1263","volume":"149","author":"F Delahaye","year":"2008","unstructured":"Delahaye F, Breton C, Risold PY, Enache M, Dutriez-Casteloot I, Laborie C, et al. Maternal perinatal undernutrition drastically reduces postnatal leptin surge and affects the development of arcuate nucleus proopiomelanocortin neurons in neonatal male rat pups. Endocrinology. 2008;149(2):470\u20135. https:\/\/doi.org\/10.1210\/en.2007-1263.","journal-title":"Endocrinology."},{"key":"671_CR9","volume-title":"The rat brain in stereotaxic coordinates","author":"G Paxinos","year":"2004","unstructured":"Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 5th ed. San Diego: Academic Press; 2004.","edition":"5"},{"issue":"2","key":"671_CR10","doi-asserted-by":"publisher","first-page":"T25","DOI":"10.1530\/JOE-13-0398","volume":"220","author":"M Schneeberger","year":"2014","unstructured":"Schneeberger M, Gomis R, Claret M. Hypothalamic and brainstem neuronal circuits controlling homeostatic energy balance. J Endocrinol. 2014;220(2):T25\u201346. https:\/\/doi.org\/10.1530\/JOE-13-0398.","journal-title":"J Endocrinol"},{"issue":"6","key":"671_CR11","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1007\/s11427-018-9371-4","volume":"62","author":"S Wen","year":"2019","unstructured":"Wen S, Wang C, Gong M, Zhou L. An overview of energy and metabolic regulation. Sci China Life Sci. 2019;62(6):771\u201390. https:\/\/doi.org\/10.1007\/s11427-018-9371-4.","journal-title":"Sci China Life Sci"},{"issue":"4","key":"671_CR12","doi-asserted-by":"publisher","first-page":"229","DOI":"10.5483\/bmbrep.2015.48.4.272","volume":"48","author":"JW Sohn","year":"2015","unstructured":"Sohn JW. Network of hypothalamic neurons that control appetite. BMB Rep. 2015;48(4):229\u201333. https:\/\/doi.org\/10.5483\/bmbrep.2015.48.4.272.","journal-title":"BMB Rep"},{"key":"671_CR13","doi-asserted-by":"publisher","unstructured":"Simpson KA, Martin NM, Bloom SR. Hypothalamic regulation of food intake and clinical therapeutic applications. Arq Bras Endocrinol Metab.\u00a02009;53(2):120\u20138. https:\/\/doi.org\/10.1590\/s0004-27302009000200002.","DOI":"10.1590\/s0004-27302009000200002"},{"issue":"7","key":"671_CR14","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1177\/1933719108316982","volume":"15","author":"J Yousheng","year":"2008","unstructured":"Yousheng J, Nguyen T, Desai M, Ross MG. Programmed alterations in hypothalamic neuronal orexigenic responses to ghrelin following gestational nutrient restriction. Reprod Sci. 2008;15(7):702\u20139. https:\/\/doi.org\/10.1177\/1933719108316982.","journal-title":"Reprod Sci"},{"issue":"4","key":"671_CR15","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1177\/1933719107303983","volume":"14","author":"M Desai","year":"2007","unstructured":"Desai M, Gayle D, Han G, Ross MG. Programmed hyperphagia due to reduced anorexigenic mechanisms in intrauterine growth-restricted offspring. Reprod Sci. 2007;14(4):329\u201337. https:\/\/doi.org\/10.1177\/1933719107303983.","journal-title":"Reprod Sci"},{"issue":"7","key":"671_CR16","doi-asserted-by":"publisher","first-page":"3617","DOI":"10.1210\/en.2007-1388","volume":"149","author":"F Remmers","year":"2008","unstructured":"Remmers F, Verhagen LA, Adan RA. Delemarre-van de Waal HA. Hypothalamic neuropeptide expression of juvenile and middle-aged rats after early postnatal food restriction. Endocrinology. 2008;149(7):3617\u201325. https:\/\/doi.org\/10.1210\/en.2007-1388.","journal-title":"Endocrinology."},{"issue":"1-2","key":"671_CR17","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.abb.2012.07.017","volume":"534","author":"SH Ro","year":"2013","unstructured":"Ro SH, Liu D, Yeo H, Paik JH. FoxOs in neural stem cell fate decision. Arch Biochem Biophys. 2013;534(1-2):55\u201363. https:\/\/doi.org\/10.1016\/j.abb.2012.07.017.","journal-title":"Arch Biochem Biophys"},{"key":"671_CR18","doi-asserted-by":"publisher","first-page":"569392","DOI":"10.1155\/2015\/569392","volume":"2015","author":"K Maiese","year":"2015","unstructured":"Maiese K. FoxO proteins in the nervous system. Anal Cell Pathol. 2015;2015:569392\u201315. https:\/\/doi.org\/10.1155\/2015\/569392.","journal-title":"Anal Cell Pathol"},{"issue":"5","key":"671_CR19","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.stem.2009.09.013","volume":"5","author":"JH Paik","year":"2009","unstructured":"Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS, et al. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell. 2009;5(5):540\u201353. https:\/\/doi.org\/10.1016\/j.stem.2009.09.013.","journal-title":"Cell Stem Cell"},{"issue":"8","key":"671_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002857","volume":"8","author":"SH Hong","year":"2012","unstructured":"Hong SH, Lee KS, Kwak SJ, Kim AK, Bai H, Jung MS, et al. Minibrain\/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF\/NPY pathway in Drosophila and mammals. PLoS Genet. 2012;8(8):e1002857. https:\/\/doi.org\/10.1371\/journal.pgen.1002857.","journal-title":"PLoS Genet"},{"issue":"2","key":"671_CR21","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1210\/en.2011-1635","volume":"153","author":"HJ Kim","year":"2012","unstructured":"Kim HJ, Kobayashi M, Sasaki T, Kikuchi O, Amano K, Kitazumi T, et al. Overexpression of FoxO1 in the hypothalamus and pancreas causes obesity and glucose intolerance. Endocrinology. 2012;153(2):659\u201371. https:\/\/doi.org\/10.1210\/en.2011-1635.","journal-title":"Endocrinology."},{"issue":"5","key":"671_CR22","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.2337\/db13-0651","volume":"63","author":"G Heinrich","year":"2014","unstructured":"Heinrich G, Meece K, Wardlaw SL, Accili D. Preserved energy balance in mice lacking FoxO1 in neurons of Nkx2.1 lineage reveals functional heterogeneity of FoxO1 signaling within the hypothalamus. Diabetes. 2014;63(5):1572\u201382. https:\/\/doi.org\/10.2337\/db13-0651.","journal-title":"Diabetes."},{"issue":"12","key":"671_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008322","volume":"4","author":"I Cakir","year":"2009","unstructured":"Cakir I, Perello M, Lansari O, Messier NJ, Vaslet CA, Nillni EA. Hypothalamic Sirt1 regulates food intake in a rodent model system. PLoS One. 2009;4(12):e8322. https:\/\/doi.org\/10.1371\/journal.pone.0008322.","journal-title":"PLoS One"},{"key":"671_CR24","doi-asserted-by":"publisher","first-page":"429","DOI":"10.3389\/fncel.2019.00429","volume":"13","author":"Y Yang","year":"2019","unstructured":"Yang Y, Zhang K, Chen X, Wang J, Lei X, Zhong J, et al. SVCT2 Promotes Neural Stem\/Progenitor Cells Migration Through Activating CDC42 After Ischemic Stroke. Front Cell Neurosci. 2019;13:429. https:\/\/doi.org\/10.3389\/fncel.2019.00429.","journal-title":"Front Cell Neurosci"},{"key":"671_CR25","doi-asserted-by":"publisher","first-page":"110324","DOI":"10.1016\/j.colsurfb.2019.06.054","volume":"182","author":"M Tang","year":"2019","unstructured":"Tang M, Li J, He L, Guo R, Yan X, Li D, et al. Transcriptomic profiling of neural stem cell differentiation on graphene substrates. Colloids Surf B: Biointerfaces. 2019;182:110324. https:\/\/doi.org\/10.1016\/j.colsurfb.2019.06.054.","journal-title":"Colloids Surf B: Biointerfaces"},{"issue":"8","key":"671_CR26","doi-asserted-by":"publisher","first-page":"3192","DOI":"10.1210\/en.2010-1217","volume":"152","author":"M Desai","year":"2011","unstructured":"Desai M, Li T, Ross MG. Fetal hypothalamic neuroprogenitor cell culture: preferential differentiation paths induced by leptin and insulin. Endocrinology. 2011;152(8):3192\u2013201. https:\/\/doi.org\/10.1210\/en.2010-1217.","journal-title":"Endocrinology."},{"issue":"8","key":"671_CR27","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1002\/jnr.21631","volume":"86","author":"RI Erickson","year":"2008","unstructured":"Erickson RI, Paucar AA, Jackson RL, Visnyei K, Kornblum H. Roles of insulin and transferrin in neural progenitor survival and proliferation. J Neurosci Res. 2008;86(8):1884\u201394. https:\/\/doi.org\/10.1002\/jnr.21631.","journal-title":"J Neurosci Res"},{"issue":"1","key":"671_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004213","volume":"4","author":"TK Kelly","year":"2009","unstructured":"Kelly TK, Karsten SL, Geschwind DH, Kornblum HI. Cell lineage and regional identity of cultured spinal cord neural stem cells and comparison to brain-derived neural stem cells. PLoS One. 2009;4(1):e4213. https:\/\/doi.org\/10.1371\/journal.pone.0004213.","journal-title":"PLoS One"},{"key":"671_CR29","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.brainres.2010.12.080","volume":"1378","author":"M Desai","year":"2011","unstructured":"Desai M, Li T, Ross MG. Hypothalamic neurosphere progenitor cells in low birth-weight rat newborns: neurotrophic effects of leptin and insulin. Brain Res. 2011;1378:29\u201342. https:\/\/doi.org\/10.1016\/j.brainres.2010.12.080.","journal-title":"Brain Res"},{"key":"671_CR30","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12884-015-0440-4","volume":"15","author":"T Sebastian","year":"2015","unstructured":"Sebastian T, Yadav B, Jeyaseelan L, Vijayaselvi R, Jose R. Small for gestational age births among South Indian women: temporal trend and risk factors from 1996 to 2010. BMC Pregnancy Childbirth. 2015;15:7. https:\/\/doi.org\/10.1186\/s12884-015-0440-4.","journal-title":"BMC Pregnancy Childbirth"},{"issue":"8","key":"671_CR31","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1007\/s00018-013-1501-3","volume":"71","author":"K Achim","year":"2014","unstructured":"Achim K, Salminen M, Partanen J. Mechanisms regulating GABAergic neuron development. Cell Mol Life Sci : CMLS. 2014;71(8):1395\u2013415. https:\/\/doi.org\/10.1007\/s00018-013-1501-3.","journal-title":"Cell Mol Life Sci : CMLS"},{"key":"671_CR32","doi-asserted-by":"publisher","first-page":"2054783","DOI":"10.1155\/2019\/2054783","volume":"2019","author":"M Gaitanou","year":"2019","unstructured":"Gaitanou M, Segklia K, Matsas R. Cend1, a Story with many tales: from regulation of cell cycle progression\/exit of neural stem cells to brain structure and function. Stem Cells Int. 2019;2019:2054783\u201316. https:\/\/doi.org\/10.1155\/2019\/2054783.","journal-title":"Stem Cells Int"},{"issue":"3","key":"671_CR33","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1097\/GRF.0b013e318299c39d","volume":"56","author":"MG Ross","year":"2013","unstructured":"Ross MG, Desai M. Developmental programming of offspring obesity, adipogenesis, and appetite. Clin Obstet Gynecol. 2013;56(3):529\u201336. https:\/\/doi.org\/10.1097\/GRF.0b013e318299c39d.","journal-title":"Clin Obstet Gynecol"},{"key":"671_CR34","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1159\/000281143","volume":"65","author":"SG Bouret","year":"2010","unstructured":"Bouret SG. Leptin, nutrition, and the programming of hypothalamic feeding circuits. Nestle Nutr Workshop Ser Pediatr Program. 2010;65:25\u201335; discussion -9. https:\/\/doi.org\/10.1159\/000281143.","journal-title":"Nestle Nutr Workshop Ser Pediatr Program"},{"key":"671_CR35","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.yfrne.2015.07.002","volume":"39","author":"LM Zeltser","year":"2015","unstructured":"Zeltser LM. Developmental influences on circuits programming susceptibility to obesity. Front Neuroendocrinol. 2015;39:17\u201327. https:\/\/doi.org\/10.1016\/j.yfrne.2015.07.002.","journal-title":"Front Neuroendocrinol"},{"key":"671_CR36","doi-asserted-by":"publisher","unstructured":"Klein MO, MacKay H, Edwards A, Park SB, Kiss ACI, Felicio LF, et al. POMC and NPY mRNA expression during development is increased in rat offspring brain from mothers fed with a high fat diet.\u00a0Int. J. Devl Neuroscience. 2018;64:14\u201320. https:\/\/doi.org\/10.1016\/j.ijdevneu.2017.03.004.","DOI":"10.1016\/j.ijdevneu.2017.03.004"},{"key":"671_CR37","doi-asserted-by":"crossref","unstructured":"Bouret SG. Development of hypothalamic circuits that control food intake and energy balance. In: nd, Harris RBS, editors. Appetite and Food Intake: Central Control. Boca Raton (FL) 2017. p. 135-154.","DOI":"10.1201\/9781315120171-7"},{"issue":"6","key":"671_CR38","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1507\/endocrj.EJ16-0593","volume":"64","author":"T Iwasa","year":"2017","unstructured":"Iwasa T, Matsuzaki T, Yano K, Tungalagsuvd A, Munkhzaya M, Mayila Y, et al. The effects of prenatal undernutrition and a high-fat postnatal diet on central and peripheral orexigenic and anorexigenic factors in female rats. Endocr J. 2017;64(6):597\u2013604. https:\/\/doi.org\/10.1507\/endocrj.EJ16-0593.","journal-title":"Endocr J"},{"issue":"5667","key":"671_CR39","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1126\/science.1095004","volume":"304","author":"SG Bouret","year":"2004","unstructured":"Bouret SG, Draper SJ, Simerly RB. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science. 2004;304(5667):108\u201310. https:\/\/doi.org\/10.1126\/science.1095004.","journal-title":"Science."},{"issue":"5","key":"671_CR40","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1038\/nm1392","volume":"12","author":"T Kitamura","year":"2006","unstructured":"Kitamura T, Feng Y, Kitamura YI, Chua SC Jr, Xu AW, Barsh GS, et al. Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat Med. 2006;12(5):534\u201340. https:\/\/doi.org\/10.1038\/nm1392.","journal-title":"Nat Med"},{"issue":"7","key":"671_CR41","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/nn1731","volume":"9","author":"MS Kim","year":"2006","unstructured":"Kim MS, Pak YK, Jang PG, Namkoong C, Choi YS, Won JC, et al. Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis. Nat Neurosci. 2006;9(7):901\u20136. https:\/\/doi.org\/10.1038\/nn1731.","journal-title":"Nat Neurosci"},{"issue":"10","key":"671_CR42","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1038\/nm.2026","volume":"15","author":"L Plum","year":"2009","unstructured":"Plum L, Lin HV, Dutia R, Tanaka J, Aizawa KS, Matsumoto M, et al. The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nat Med. 2009;15(10):1195\u2013201. https:\/\/doi.org\/10.1038\/nm.2026.","journal-title":"Nat Med"},{"key":"671_CR43","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3389\/fendo.2019.00188","volume":"10","author":"B Fleiss","year":"2019","unstructured":"Fleiss B, Wong F, Brownfoot F, Shearer IK, Baud O, Walker DW, et al. Knowledge gaps and emerging research areas in intrauterine growth restriction-associated brain injury. Front Endocrinol (Lausanne). 2019;10:188. https:\/\/doi.org\/10.3389\/fendo.2019.00188.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"671_CR44","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3389\/fphys.2016.00040","volume":"7","author":"F Gaccioli","year":"2016","unstructured":"Gaccioli F, Lager S. Placental nutrient transport and intrauterine growth restriction. Front Physiol. 2016;7:40. https:\/\/doi.org\/10.3389\/fphys.2016.00040.","journal-title":"Front Physiol"},{"key":"671_CR45","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/jog.12206","volume":"40","author":"Q Shi","year":"2014","unstructured":"Shi Q, Wang J, Yan S, Zhao J, Li H. Expression of neuropeptide Y and pro-opiomelanocortin in hypothalamic arcuate nucleus in 17\u03b1-ethinyl estradiol-induced intrahepatic cholestasis pregnant rat offspring. J Obstet Gynaecol Res. 2014;40:445\u201352. https:\/\/doi.org\/10.1111\/jog.12206.","journal-title":"J Obstet Gynaecol Res"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-021-00671-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-021-00671-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-021-00671-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T18:31:41Z","timestamp":1639679501000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-021-00671-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,12]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["671"],"URL":"https:\/\/doi.org\/10.1007\/s43032-021-00671-7","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,12]]},"assertion":[{"value":"29 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experiments were approved by the animal research committee of the Capital University of Medicine in Beijing and conducted in accordance with the guidelines for laboratory animal care and use approved by the Capital Medical University[2017(26)].","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare that there is no conflict of interest.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}