{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:21:32Z","timestamp":1789687292876,"version":"4.0.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81473378"],"award-info":[{"award-number":["81473378"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s43032-021-00692-2","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T11:03:01Z","timestamp":1626433381000},"page":"3431-3439","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Ginsenoside Rg2 Ameliorates Brain Injury After Intracerebral Hemorrhage in a Rat Model of Preeclampsia"],"prefix":"10.1007","volume":"28","author":[{"given":"Liying","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijie","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangcong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4295-5908","authenticated-orcid":false,"given":"Tian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayuan","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"issue":"1","key":"692_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejogrb.2013.05.005","volume":"170","author":"E Abalos","year":"2013","unstructured":"Abalos E, Cuesta C, Grosso AL, Chou D, Say L. Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol. 2013;170(1):1\u20137.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"3","key":"692_CR2","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1053\/j.semperi.2009.02.010","volume":"33","author":"L Duley","year":"2009","unstructured":"Duley L. The global impact of pre-eclampsia and eclampsia. Semin Perinatol. 2009;33(3):130\u20137.","journal-title":"Semin Perinatol"},{"issue":"3","key":"692_CR3","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1056\/NEJMoa0706475","volume":"359","author":"D Moster","year":"2008","unstructured":"Moster D, Lie RT, Markestad T. Long-term medical and social consequences of preterm birth. N Engl J Med. 2008;359(3):262\u201373.","journal-title":"N Engl J Med"},{"issue":"2","key":"692_CR4","doi-asserted-by":"publisher","first-page":"e003497","DOI":"10.1161\/CIRCOUTCOMES.116.003497","volume":"10","author":"P Wu","year":"2017","unstructured":"Wu P, Haththotuwa R, Kwok CS, Babu A, Kotronias RA, Rushton C, et al. Preeclampsia and future cardiovascular health: a systematic review and meta-analysis. Circ Cardiovasc Qual Outcomes. 2017;10(2):e003497.","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"7","key":"692_CR5","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1177\/1747493017723271","volume":"12","author":"RH Swartz","year":"2017","unstructured":"Swartz RH, Cayley ML, Foley N, Ladhani NNN, Leffert L, Bushnell C, et al. The incidence of pregnancy-related stroke: a systematic review and meta-analysis. Int J Stroke. 2017;12(7):687\u201397.","journal-title":"Int J Stroke"},{"issue":"6","key":"692_CR6","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1055\/s-0037-1608940","volume":"37","author":"CM Sells","year":"2017","unstructured":"Sells CM, Feske SK. Stroke in pregnancy. Semin Neurol. 2017;37(6):669\u201378.","journal-title":"Semin Neurol"},{"issue":"6","key":"692_CR7","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1097\/GCO.0000000000000024","volume":"25","author":"F Crovetto","year":"2013","unstructured":"Crovetto F, Somigliana E, Peguero A, Figueras F. Stroke during pregnancy and pre-eclampsia. Curr Opin Obstet Gynecol. 2013;25(6):425\u201332.","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"3","key":"692_CR8","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s10143-007-0074-8","volume":"30","author":"L Marshman","year":"2007","unstructured":"Marshman L, Aspoas A, Rai M, Chawda S. The implications of ISAT and ISUIA for the management of cerebral aneurysms during pregnancy. Neurosurg Rev. 2007;30(3):177\u201380.","journal-title":"Neurosurg Rev"},{"issue":"3","key":"692_CR9","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.jgr.2018.10.002","volume":"43","author":"J Lee","year":"2019","unstructured":"Lee J, Park K, Cho I. Panax ginseng: a candidate herbal medicine for autoimmune disease. J Ginseng Res. 2019;43(3):342\u20138.","journal-title":"J Ginseng Res"},{"key":"692_CR10","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.ijbiomac.2019.03.229","volume":"33","author":"B Zhao","year":"2019","unstructured":"Zhao B, Lv C, Lu J. Natural occurring polysaccharides from Panax ginseng C. A. Meyer: A review of isolation, structures, and bioactivities. Int J Biol Macromol. 2019;33:324\u201336.","journal-title":"Int J Biol Macromol"},{"issue":"8","key":"692_CR11","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/s002280050674","volume":"55","author":"B Vogler","year":"1999","unstructured":"Vogler B, Pittler M, Ernst E. The efficacy of ginseng. A systematic review of randomized clinical trials. Eur J Clin Pharmacol. 1999;55(8):567\u201375.","journal-title":"Eur J Clin Pharmacol"},{"key":"692_CR12","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.brainresbull.2017.08.009","volume":"134","author":"Y Ren","year":"2017","unstructured":"Ren Y, Wang JL, Zhang X, Wang H, Ye Y, Song L, et al. Antidepressant-like effects of ginsenoside Rg2 in a chronic mild stress model of depression. Brain Res Bull. 2017;134:211\u20139.","journal-title":"Brain Res Bull"},{"issue":"3","key":"692_CR13","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.jep.2007.10.026","volume":"115","author":"G Zhang","year":"2008","unstructured":"Zhang G, Liu A, Zhou Y, San X, Jin T, Jin Y. Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia. J Ethnopharmacol. 2008;115(3):441\u20138.","journal-title":"J Ethnopharmacol"},{"key":"692_CR14","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.psychres.2018.12.034","volume":"279","author":"Z Gao","year":"2019","unstructured":"Gao Z, Ju R, Luo M, Wu S, Zhang W. The anxiolytic-like effects of ginsenoside Rg2 on an animal model of PTSD. Psychiatry Res. 2019;279:130\u20137.","journal-title":"Psychiatry Res"},{"key":"692_CR15","doi-asserted-by":"crossref","unstructured":"Li B, Zhang Y, Li H, Shen H, Wang Y, Li X, et al. Miro1 Regulates neuronal mitochondrial transport and distribution to alleviate neuronal damage in secondary brain injury after intracerebral hemorrhage in rats. Cell Mol Neurobiol. 2020; 41(4):795\u2013812.","DOI":"10.1007\/s10571-020-00887-2"},{"issue":"4","key":"692_CR16","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1161\/01.STR.26.4.627","volume":"26","author":"J Garcia","year":"1995","unstructured":"Garcia J, Wagner S, Liu K, Hu X. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke. 1995;26(4):627\u201334.","journal-title":"Stroke"},{"issue":"12","key":"692_CR17","doi-asserted-by":"publisher","first-page":"11768","DOI":"10.18632\/aging.103342","volume":"12","author":"Z Zeng","year":"2020","unstructured":"Zeng Z, Gong X, Hu Z. L-3-n-butylphthalide attenuates inflammation response and brain edema in rat intracerebral hemorrhage model. Aging. 2020;12(12):11768\u201380.","journal-title":"Aging."},{"issue":"1","key":"692_CR18","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12974-017-1039-7","volume":"15","author":"T Wang","year":"2018","unstructured":"Wang T, Nowrangi D, Yu L, Lu T, Tang J, Han B, et al. Activation of dopamine D1 receptor decreased NLRP3-mediated inflammation in intracerebral hemorrhage mice. J Neuroinflammation. 2018;15(1):2.","journal-title":"J Neuroinflammation"},{"issue":"1","key":"692_CR19","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"O Lowry","year":"1951","unstructured":"Lowry O, Rosebrough N, Farr A, Randall R. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193(1):265\u201375.","journal-title":"J Biol Chem"},{"key":"692_CR20","doi-asserted-by":"publisher","first-page":"108969","DOI":"10.1016\/j.biopha.2019.108969","volume":"116","author":"S Yang","year":"2019","unstructured":"Yang S, Song L, Shi X, Zhao N, Ma Y. Ameliorative effects of pre-eclampsia by quercetin supplement to aspirin in a rat model induced by L-NAME. Biomed Pharmacother. 2019;116:108969.","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"692_CR21","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1177\/1358863X20919798","volume":"25","author":"J Zuo","year":"2020","unstructured":"Zuo J, Jiang Z. Melatonin attenuates hypertension and oxidative stress in a rat model of L-NAME-induced gestational hypertension. Vasc Med. 2020;25(4):295\u2013301.","journal-title":"Vasc Med"},{"key":"692_CR22","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jphotobiol.2019.03.013","volume":"194","author":"S Lu","year":"2019","unstructured":"Lu S, Lin Q, Li Y, Jiang X. Synthesis of Nomega-nitro-l-arginine methyl ester modified reduced graphene oxide nanosheets and their protective action on experimental preeclampsia in mice. J Photochem Photobiol B. 2019;194:183\u20137.","journal-title":"J Photochem Photobiol B"},{"key":"692_CR23","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.placenta.2020.06.015","volume":"99","author":"Y Li","year":"2020","unstructured":"Li Y, Yang N, Wang B, Niu X, Cai W, Li Y, et al. Effect and mechanism of prophylactic use of tadalafil during pregnancy on l-NAME-induced preeclampsia-like rats. Placenta. 2020;99:35\u201344.","journal-title":"Placenta."},{"issue":"2","key":"692_CR24","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1080\/10641963.2017.1339073","volume":"40","author":"T Amaral","year":"2018","unstructured":"Amaral T, Ognibene D, Carvalho L, Rocha A, Costa C, Moura R, et al. Differential responses of mesenteric arterial bed to vasoactive substances in L-NAME-induced preeclampsia: Role of oxidative stress and endothelial dysfunction. Clin Exp Hypertens. 2018;40(2):126\u201335.","journal-title":"Clin Exp Hypertens"},{"issue":"9","key":"692_CR25","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s11883-019-0798-2","volume":"21","author":"M Zambrano","year":"2019","unstructured":"Zambrano M, Miller E. Maternal stroke: an update. Curr Atheroscler Rep. 2019;21(9):33.","journal-title":"Curr Atheroscler Rep"},{"issue":"2","key":"692_CR26","first-page":"133","volume":"1","author":"A Betz","year":"1989","unstructured":"Betz A, Iannotti F, Hoff J. Brain edema: a classification based on blood-brain barrier integrity. Cerebrovasc Brain Metab Rev. 1989;1(2):133\u201354.","journal-title":"Cerebrovasc Brain Metab Rev"},{"issue":"12","key":"692_CR27","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/S0166-2236(00)02004-X","volume":"24","author":"J Huber","year":"2001","unstructured":"Huber J, Egleton R, Davis T. Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier. Trends Neurosci. 2001;24(12):719\u201325.","journal-title":"Trends Neurosci"},{"issue":"9","key":"692_CR28","doi-asserted-by":"publisher","first-page":"14372","DOI":"10.1002\/jcb.28693","volume":"120","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Deng H, Hu Y, Pan C, Wu G, Li Q, et al. Adipose-derived mesenchymal stem cells stereotactic transplantation alleviate brain edema from intracerebral hemorrhage. J Cell Biochem. 2019;120(9):14372\u201382.","journal-title":"J Cell Biochem"},{"issue":"1","key":"692_CR29","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S1474-4422(05)70283-0","volume":"5","author":"G Xi","year":"2006","unstructured":"Xi G, Keep R, Hoff J. Mechanisms of brain injury after intracerebral haemorrhage. Lancet Neurol. 2006;5(1):53\u201363.","journal-title":"Lancet Neurol"},{"issue":"1","key":"692_CR30","doi-asserted-by":"publisher","first-page":"29","DOI":"10.5853\/jos.2019.02236","volume":"22","author":"C Tschoe","year":"2020","unstructured":"Tschoe C, Bushnell CD, Duncan PW, Alexander-Miller MA, Wolfe SQ. Neuroinflammation after intracerebral hemorrhage and potential therapeutic targets. J Stroke. 2020;22(1):29\u201346.","journal-title":"J Stroke"},{"issue":"4","key":"692_CR31","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1002\/ana.22528","volume":"70","author":"LH Sansing","year":"2011","unstructured":"Sansing LH, Harris TH, Welsh FA, Kasner SE, Hunter CA, Kariko K. Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage. Ann Neurol. 2011;70(4):646\u201356.","journal-title":"Ann Neurol"},{"issue":"3","key":"692_CR32","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1111\/j.1471-4159.2006.04414.x","volume":"101","author":"X Zhao","year":"2007","unstructured":"Zhao X, Zhang Y, Strong R, Zhang J, Grotta J, Aronowski J. Distinct patterns of intracerebral hemorrhage-induced alterations in NF-\u03baB subunit, iNOS, and COX-2 expression. J Neurochem. 2007;101(3):652\u201363.","journal-title":"J Neurochem"},{"issue":"5","key":"692_CR33","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1038\/sj.jcbfm.9600403","volume":"27","author":"J Wang","year":"2007","unstructured":"Wang J, Dore S. Inflammation after intracerebral hemorrhage. J Cereb Blood Flow Metab. 2007;27(5):894\u2013908.","journal-title":"J Cereb Blood Flow Metab"},{"key":"692_CR34","first-page":"46","volume":"9","author":"S Lin","year":"2012","unstructured":"Lin S, Yin Q, Zhong Q, Lv FL, Zhou Y, Li JQ, et al. Heme activates TLR4-mediated inflammatory injury via MyD88\/TRIFsignaling pathway in intracerebral hemorrhage. J Neuroinflammation. 2012;9:46.","journal-title":"J Neuroinflammation"},{"issue":"2","key":"692_CR35","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1023\/A:1007074420772","volume":"20","author":"N Abbott","year":"2000","unstructured":"Abbott N. Inflammatory mediators and modulation of blood\u2013brain barrier permeability. Cell Mol Neurobiol. 2000;20(2):131\u201347.","journal-title":"Cell Mol Neurobiol"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-021-00692-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-021-00692-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-021-00692-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T14:46:39Z","timestamp":1636555599000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-021-00692-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,16]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["692"],"URL":"https:\/\/doi.org\/10.1007\/s43032-021-00692-2","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,16]]},"assertion":[{"value":"8 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experiments were approved by the Ethics Committee of Jilin University (JU19812) and were conducted according to the National Institutes of Health Guidelines for the Care and Use of Laboratory Animals (publication 86-23, revised in 1986).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"The funding agencies had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}