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Glutamine consumption in the poor-quality embryos was significantly higher than that in the good-quality embryos (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). A significant increase in glutamine consumption was observed from aneuploid embryos compared with that from euploid embryos (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). The Pearson correlation coefficients between embryo quality and glutamine consumption, and between aneuploidy and glutamine consumption, were 0.430 and 0.757, respectively. The area under the ROC curve was 0.938 (95% CI: 0.902\u20130.975) for identifying aneuploidy. Animal experiments demonstrate that increased glutamine consumption may be a compensatory mechanism to mitigate oxidative stress. Our data suggest that glutamine consumption is associated with embryo quality and aneuploidy. Glutamine may serve as a molecular indicator for embryo assessment and aneuploidy testing.<\/jats:p>","DOI":"10.1007\/s43032-021-00812-y","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T22:02:18Z","timestamp":1643061738000},"page":"1721-1729","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Glutamine as a Potential Noninvasive Biomarker for Human Embryo Selection"],"prefix":"10.1007","volume":"29","author":[{"given":"Sui-Bing","family":"Miao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ru","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kao-Qi","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan-Yu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Chuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai-Ping","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Hua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"issue":"5","key":"812_CR1","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/j.fertnstert.2017.10.004","volume":"108","author":"T Sanchez","year":"2017","unstructured":"Sanchez T, Seidler EA, Gardner DK, Needleman D, Sakkas D. 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The procedures used in this study adhere to the tenets of the Declaration of Helsinki. Informed consent was obtained from all individual participants included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}