{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:37:54Z","timestamp":1777480674997,"version":"3.51.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Fundaci\u00f3n Gonzalo Rio Arronte","award":["S.633"],"award-info":[{"award-number":["S.633"]}]},{"DOI":"10.13039\/501100010567","name":"SECTEI","doi-asserted-by":"crossref","award":["SECTEI\/253\/2019"],"award-info":[{"award-number":["SECTEI\/253\/2019"]}],"id":[{"id":"10.13039\/501100010567","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100011999","name":"Fundaci\u00f3n Mexicana para la Salud","doi-asserted-by":"publisher","award":["Proyecto Interinstitucional"],"award-info":[{"award-number":["Proyecto Interinstitucional"]}],"id":[{"id":"10.13039\/100011999","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1007\/s43032-022-01007-9","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T18:14:36Z","timestamp":1657217676000},"page":"221-232","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cervicovaginal Cytokines to Predict the Onset of Normal and Preterm Labor: a Pseudo-longitudinal Study"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0935-1491","authenticated-orcid":false,"given":"Daniel Eduardo","family":"Sandoval-Colin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7503-7591","authenticated-orcid":false,"given":"Myrna Souraye","family":"Godines-Enriquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9087-8017","authenticated-orcid":false,"given":"Aurora","family":"Espejel-N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9621-1002","authenticated-orcid":false,"given":"Jes\u00fas Jorge","family":"Beltr\u00e1n-Montoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2434-6474","authenticated-orcid":false,"given":"Denisse Alejandra","family":"Picazo-Mendoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"de la Cerda-\u00c1ngeles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3093-937X","authenticated-orcid":false,"given":"Omar Yaxmehen","family":"Bello-Chavolla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9016-6626","authenticated-orcid":false,"given":"Noem\u00ed","family":"Meraz-Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1012-2760","authenticated-orcid":false,"given":"Erika","family":"Chavira-Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7137-4200","authenticated-orcid":false,"given":"Felipe","family":"Vadillo-Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"1007_CR1","doi-asserted-by":"publisher","first-page":"4513","DOI":"10.12659\/MSM.917298","volume":"25","author":"T Li","year":"2019","unstructured":"Li T, Yi T, Zhao J, Zhao X, He X. Combined proinflammatory biomarkers have better predictive value for term labor than single markers. Med Sci Monit. 2019;25:4513\u201320.","journal-title":"Med Sci Monit"},{"key":"1007_CR2","doi-asserted-by":"publisher","first-page":"223.e1","DOI":"10.1016\/j.ajog.2011.01.002","volume":"204","author":"ER Unal","year":"2011","unstructured":"Unal ER, Cierny JT, Roedner C, Newman R, Goetzl L. Maternal inflammation in spontaneous term labor. Am J Obstet Gynecol. 2011;204:223.e1-223.e5.","journal-title":"Am J Obstet Gynecol"},{"key":"1007_CR3","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/aji.12074","volume":"69","author":"N Gomez-Lopez","year":"2013","unstructured":"Gomez-Lopez N, Vega-Sanchez R, Castillo-Castrejon M, Romero R, Cubeiro-Arreola K, Vadillo-Ortega F. Evidence for a role for the adaptive immune response in human term parturition. Am J Reprod Immunol. 2013;69:212\u201330.","journal-title":"Am J Reprod Immunol"},{"key":"1007_CR4","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/cmi.2014.46","volume":"11","author":"N Gomez-Lopez","year":"2014","unstructured":"Gomez-Lopez N, StLouis D, Lehr MA, Sanchez-Rodriguez EN, Arenas-Hernandez M. Immune cells in term and preterm labor. Cell Mol Immunol. 2014;11:571\u201381.","journal-title":"Cell Mol Immunol"},{"key":"1007_CR5","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1093\/humupd\/dmw022","volume":"22","author":"R Menon","year":"2016","unstructured":"Menon R, Bonney EA, Condon J, Mesiano S, Taylor RN. Novel concepts on pregnancy clocks and alarms: redundancy and synergy in human parturition. Hum Reprod Update. 2016;22:535\u201360.","journal-title":"Hum Reprod Update"},{"key":"1007_CR6","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1095\/biolreprod66.2.445","volume":"66","author":"A Young","year":"2002","unstructured":"Young A, Thomson AJ, Ledingham M, Jordan F, Greer IA, Norman JE. Immunolocalization of proinflammatory cytokines in myometrium, cervix, and fetal membranes during human parturition at term. Biol Reprod. 2002;66:445\u20139.","journal-title":"Biol Reprod"},{"key":"1007_CR7","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1093\/molehr\/gag001","volume":"9","author":"I Osman","year":"2003","unstructured":"Osman I, Young A, Ledingham MA, et al. Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term. Mol Hum Reprod. 2003;9:41\u20135.","journal-title":"Mol Hum Reprod"},{"issue":"11","key":"1007_CR8","doi-asserted-by":"publisher","first-page":"2757","DOI":"10.4049\/jimmunol.1900901","volume":"203","author":"N Gomez-Lopez","year":"2019","unstructured":"Gomez-Lopez N, Motomura K, Miller D, Garcia-Flores V, Galaz J, Romero R. Inflammasomes: their role in normal and complicated pregnancies. J Immunol. 2019;203(11):2757\u201369.","journal-title":"J Immunol"},{"issue":"9","key":"1007_CR9","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1093\/molehr\/gaaa054","volume":"26","author":"K Motomura","year":"2020","unstructured":"Motomura K, Romero R, Garc\u00eda-Flores V, et al. The alarmin interleukin-1\u03b1 causes preterm birth through the NLRP3 inflammasome. Mol Hum Reprod. 2020;26(9):712\u201326.","journal-title":"Mol Hum Reprod"},{"issue":"5","key":"1007_CR10","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1093\/biolre\/ioy261","volume":"100","author":"J Faro","year":"2019","unstructured":"Faro J, Romero R, Schwenkel G, et al. Intra-amniotic inflammation induces preterm birth by activating the NLRP3 inflammasome. Biol Reprod. 2019;100(5):1290\u2013305.","journal-title":"Biol Reprod"},{"key":"1007_CR11","doi-asserted-by":"publisher","unstructured":"Kim SA, Park KH, Lee SM, Kim YM, Hong S. Inflammatory proteins in the amniotic fluid, plasma, and cervicovaginal fluid for the prediction of intra-amniotic infection\/inflammation and imminent preterm birth in preterm labor. Am J Perinatol. 2020.https:\/\/doi.org\/10.1055\/s-0040-1718575","DOI":"10.1055\/s-0040-1718575"},{"key":"1007_CR12","first-page":"1","volume":"7","author":"J Stranik","year":"2021","unstructured":"Stranik J, Kacerovsky M, Andrys C, et al. Intra-amniotic infection and sterile intra-amniotic inflammation are associated with elevated concentrations of cervical fluid interleukin-6 in women with spontaneous preterm labor with intact membranes. J Matern Fetal Neonatal Med. 2021;7:1\u20139.","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"3","key":"1007_CR13","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1177\/1933719112451794","volume":"20","author":"JW Park","year":"2013","unstructured":"Park JW, Park KH, Lee SY. Noninvasive prediction of intra-amniotic infection and\/or inflammation in women with preterm labor: various cytokines in cervicovaginal fluid. Reprod Sci. 2013;20(3):262\u20138.","journal-title":"Reprod Sci"},{"issue":"2 Pt 1","key":"1007_CR14","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1097\/AOG.0b013e3181ae6a08","volume":"114","author":"RM Holst","year":"2009","unstructured":"Holst RM, Hagberg H, Wennerholm UB, et al. Prediction of spontaneous preterm delivery in women with preterm labor: analysis of multiple proteins in amniotic and cervical fluids. Obstet Gynecol. 2009;114(2 Pt 1):268\u201377.","journal-title":"Obstet Gynecol"},{"issue":"6","key":"1007_CR15","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1111\/j.0001-6349.2005.00708.x","volume":"84","author":"RM Holst","year":"2005","unstructured":"Holst RM, Mattsby-Baltzer I, Wennerholm UB, et al. Interleukin-6 and interleukin-8 in cervical fluid in a population of Swedish women in preterm labor: relationship to microbial invasion of the amniotic fluid, intra-amniotic inflammation, and preterm delivery. Acta Obstet Gynecol Scand. 2005;84(6):551\u20137.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"1007_CR16","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.bpobgyn.2020.03.001","volume":"67","author":"E Abalos","year":"2020","unstructured":"Abalos E, Chamillard M, D\u00edaz V, Pasquale J, Souza JP. Progression of the first stage of spontaneous labour. Best Pract Res Clin Obstet Gynaecol. 2020;67:19\u201332.","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"1007_CR17","unstructured":"Harrell FEJ, Slaughter JC. Biostatistics for biomedical research. Power. 2015;1\u2013158."},{"key":"1007_CR18","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/0090-6980(89)90028-2","volume":"37","author":"R Romero","year":"1989","unstructured":"Romero R, Durum S, Dinarello CA, Oyarzun E, Hobbins JC, Mitchell MD. Interleukin-1 stimulates prostaglandin biosynthesis by human amnion. Prostaglandins. 1989;37:13\u201322.","journal-title":"Prostaglandins"},{"key":"1007_CR19","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/j.1600-0897.1993.tb00601.x","volume":"30","author":"F Hertelendy","year":"1993","unstructured":"Hertelendy F, Romero R, Molnar M, Todd H, Baldassare JJ. Cytokine-initiated signal transduction in human myometrial cells. Am J Reprod Immunol. 1993;30:49\u201357.","journal-title":"Am J Reprod Immunol"},{"key":"1007_CR20","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/S0002-9378(99)70562-4","volume":"181","author":"AR Belt","year":"1999","unstructured":"Belt AR, Baldassare JJ, Molna\u00b4r M, Romero R, Hertelendy F. The nuclear transcription factor NF-kappaB mediates interleukin-1 beta-induced expression of cyclooxygenase-2 in human myometrial cells. Am J Obstet Gynecol. 1999;181:359\u201366.","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"1007_CR21","doi-asserted-by":"publisher","first-page":"R101","DOI":"10.1530\/JOE-16-0157","volume":"231","author":"SP Sivarajasingam","year":"2016","unstructured":"Sivarajasingam SP, Imami N, Johnson MR. Myometrial cytokines and their role in the onset of labour. J Endocrinol. 2016;231(3):R101\u201319.","journal-title":"J Endocrinol"},{"issue":"Suppl 1","key":"1007_CR22","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1471-0528.2005.00579.x","volume":"112","author":"F Vadillo-Ortega","year":"2005","unstructured":"Vadillo-Ortega F, Estrada-Guti\u00e9rrez G. Role of matrix metalloproteinases in preterm labour. BJOG. 2005;112(Suppl 1):19\u201322.","journal-title":"BJOG"},{"key":"1007_CR23","doi-asserted-by":"publisher","first-page":"125.e1","DOI":"10.1016\/j.ajog.2013.11.032","volume":"210","author":"CA Combs","year":"2014","unstructured":"Combs CA, Gravett M, Garite TJ, et al. Amniotic fluid infection, inflammation, and colonization in preterm labor with intact membranes. Am J Obstet Gynecol. 2014;210:125.e1-125.e15.","journal-title":"Am J Obstet Gynecol"},{"key":"1007_CR24","doi-asserted-by":"publisher","first-page":"604.e1","DOI":"10.1016\/j.ajog.2017.02.035","volume":"216","author":"KJ Oh","year":"2017","unstructured":"Oh KJ, Kim SM, Hong JS, et al. Twenty-four percent of patients with clinical chorioamnionitis in preterm gestations have no evidence of either culture-proven intraamniotic infection or intraamniotic inflammation. Am J Obstet Gynecol. 2017;216:604.e1-604.e11.","journal-title":"Am J Obstet Gynecol"},{"key":"1007_CR25","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1111\/aji.12296","volume":"72","author":"R Romero","year":"2014","unstructured":"Romero R, Miranda J, Chaiworapongsa T, et al. Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Reprod Immunol. 2014;72:458\u201374.","journal-title":"Am J Reprod Immunol"},{"issue":"1","key":"1007_CR26","doi-asserted-by":"publisher","first-page":"104.e1","DOI":"10.1016\/j.ajog.2008.08.032","volume":"200","author":"S Bollapragada","year":"2009","unstructured":"Bollapragada S, Youssef R, Jordan F, Greer I, Norman J, Nelson S. Term labor is associated with a core inflammatory response in human fetal membranes, myometrium, and cervix. Am J Obstet Gynecol. 2009;200(1):104.e1-11.","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"1007_CR27","doi-asserted-by":"publisher","first-page":"375.e1","DOI":"10.1016\/j.ajog.2008.06.040","volume":"199","author":"HS Seong","year":"2008","unstructured":"Seong HS, Lee SE, Kang JH, Romero R, Yoon BH. The frequency of microbial invasion of the amniotic cavity and histologic chorioamnionitis in women at term with intact membranes in the presence or absence of labor. Am J Obstet Gynecol. 2008;199(4):375.e1-5.","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"1007_CR28","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1080\/14767058.2017.1297404","volume":"31","author":"F Lucaroni","year":"2018","unstructured":"Lucaroni F, Morciano L, Rizzo G, et al. Biomarkers for predicting spontaneous preterm birth: an umbrella systematic review. J Matern Fetal Neonatal Med. 2018;31(6):726\u201334.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"1007_CR29","first-page":"4309485","volume":"2017","author":"RN Monastero","year":"2017","unstructured":"Monastero RN, Pentyala S. Cytokines as biomarkers and their respective clinical cutoff levels. Int J Inflam. 2017;2017:4309485.","journal-title":"Int J Inflam"},{"issue":"9","key":"1007_CR30","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1111\/j.1471-0528.2011.02923.x","volume":"118","author":"A Conde-Agudelo","year":"2011","unstructured":"Conde-Agudelo A, Papageorghiou AT, Kennedy SH, Villar J. Novel biomarkers for the prediction of the spontaneous preterm birth phenotype: a systematic review and meta-analysis. BJOG. 2011;118(9):1042\u201354.","journal-title":"BJOG"},{"key":"1007_CR31","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.placenta.2020.05.007","volume":"98","author":"RF Lamont","year":"2020","unstructured":"Lamont RF, Richardson LS, Boniface JJ, et al. Commentary on a combined approach to the problem of developing biomarkers for the prediction of spontaneous preterm labor that leads to preterm birth. Placenta. 2020;98:13\u201323.","journal-title":"Placenta"},{"key":"1007_CR32","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists\u2019 Committee on Practice Bulletins\u2014Obstetrics. Prediction and prevention of spontaneous preterm birth: ACOG practice bulletin, number 234. Obstet Gynecol 2021;138(2):e65.","DOI":"10.1097\/AOG.0000000000004479"},{"key":"1007_CR33","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/1043-4666(91)90037-E","volume":"3","author":"U Santhanam","year":"1991","unstructured":"Santhanam U, Avila C, Romero R, et al. Cytokines in normal and abnormal parturition: elevated amniotic fluid interleukin-6 levels in women with premature rupture of membranes associated with intrauterine infection. Cytokine. 1991;3:155\u201363.","journal-title":"Cytokine"},{"key":"1007_CR34","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1177\/1933719111415548","volume":"18","author":"R Menon","year":"2011","unstructured":"Menon R, Torloni MR, Voltolini C, et al. Biomarkers of spontaneous preterm birth: an overview of the literature in the last four decades. Reprod Sci. 2011;18:1046\u201370.","journal-title":"Reprod Sci"},{"issue":"2","key":"1007_CR35","doi-asserted-by":"publisher","first-page":"e95","DOI":"10.1097\/AOG.0000000000002236","volume":"130","author":"Committee Opinion No","year":"2017","unstructured":"Committee Opinion No. 712: Intrapartum management of intraamniotic infection. Obstet Gynecol. 2017;130(2):e95\u2013101.","journal-title":"Obstet Gynecol"},{"issue":"3","key":"1007_CR36","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1097\/AOG.0000000000001246","volume":"127","author":"RD Higgins","year":"2016","unstructured":"Higgins RD, Saade G, Polin RA, et al. Chorioamnionitis workshop participants. Evaluation and management of women and newborns with a maternal diagnosis of chorioamnionitis: summary of a workshop. Obstet Gynecol. 2016;127(3):426\u201336.","journal-title":"Obstet Gynecol"},{"issue":"6","key":"1007_CR37","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1038\/s41591-019-0450-2","volume":"25","author":"JM Fettweis","year":"2019","unstructured":"Fettweis JM, Serrano MG, Brooks JP, et al. The vaginal microbiome and preterm birth. Nat Med. 2019;25(6):1012\u201321.","journal-title":"Nat Med"},{"issue":"8","key":"1007_CR38","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1471-2172-8-27","volume":"26","author":"B Genser","year":"2007","unstructured":"Genser B, Cooper PJ, Yazdanbakhsh M, Barreto ML, Rodrigues LC. A guide to modern statistical analysis of immunological data. BMC Immunol. 2007;26(8):27.","journal-title":"BMC Immunol"},{"issue":"10","key":"1007_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046423","volume":"7","author":"N Ballenberger","year":"2012","unstructured":"Ballenberger N, Lluis A, von Mutius E, Illi S, Schaub B. Novel statistical approaches for non-normal censored immunological data: analysis of cytokine and gene expression data. PLoS ONE. 2012;7(10): e46423.","journal-title":"PLoS ONE"},{"issue":"1","key":"1007_CR40","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1177\/1933719113492204","volume":"21","author":"YJ Heng","year":"2014","unstructured":"Heng YJ, Liong S, Permezel M, Rice GE, Di Quinzio MK, Georgiou HM. The interplay of the interleukin 1 system in pregnancy and labor. Reprod Sci. 2014;21(1):122\u201330.","journal-title":"Reprod Sci"},{"issue":"6","key":"1007_CR41","doi-asserted-by":"publisher","first-page":"656.e1","DOI":"10.1016\/j.ajog.2008.06.011","volume":"199","author":"YJ Heng","year":"2008","unstructured":"Heng YJ, Di Quinzio MK, Permezel M, Rice GE, Georgiou HM. Interleukin-1 receptor antagonist in human cervicovaginal fluid in term pregnancy and labor. Am J Obstet Gynecol. 2008;199(6):656.e1-7.","journal-title":"Am J Obstet Gynecol"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-022-01007-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-022-01007-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-022-01007-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T17:43:09Z","timestamp":1672767789000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-022-01007-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,7]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["1007"],"URL":"https:\/\/doi.org\/10.1007\/s43032-022-01007-9","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,7]]},"assertion":[{"value":"18 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Health Ministry institutional IRB (Register 2010\/010\/3117, 9 August 2017) and by the INMEGEN IRB (12\/2018\/I) in accordance with the Declaration of Helsinki and the Guideline for Good Clinical Practices. All participants signed informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"All authors agree to participate in this publication. This study does not include images or other personal or clinical details of participants that compromise anonymity. With their consent to participate, all patients have also signed a written consent to publish their data anonymously.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}