{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:13:00Z","timestamp":1740147180646,"version":"3.37.3"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1007\/s43032-022-01057-z","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T01:03:28Z","timestamp":1661907808000},"page":"914-927","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Uroplakin 1a Knockout Mice Display Marginal Reduction in Fecundity, Decreased Bacterial Clearance Capacity, and Drastic Changes in the Testicular Transcriptome"],"prefix":"10.1007","volume":"30","author":[{"given":"Suresh Babu","family":"Munipalli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5431-2267","authenticated-orcid":false,"given":"Suresh","family":"Yenugu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"1057_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2148-14-13","volume":"14","author":"R Desalle","year":"2014","unstructured":"Desalle R, Chicote JU, Sun TT, Garcia-Espana A. Generation of divergent uroplakin tetraspanins and their partners during vertebrate evolution: identification of novel uroplakins. BMC Evol Biol. 2014;14:13.","journal-title":"BMC Evol Biol"},{"key":"1057_CR2","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.ympev.2006.04.023","volume":"41","author":"A Garcia-Espana","year":"2006","unstructured":"Garcia-Espana A, Chung PJ, Zhao X, Lee A, Pellicer A, Yu J, et al. Origin of the tetraspanin uroplakins and their co-evolution with associated proteins: implications for uroplakin structure and function. Mol Phylogenet Evol. 2006;41:355\u201367.","journal-title":"Mol Phylogenet Evol"},{"key":"1057_CR3","doi-asserted-by":"publisher","first-page":"13716","DOI":"10.1016\/S0021-9258(17)36889-8","volume":"269","author":"XR Wu","year":"1994","unstructured":"Wu XR, Lin JH, Walz T, Haner M, Yu J, Aebi U, et al. Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins. J Biol Chem. 1994;269:13716\u201324.","journal-title":"J Biol Chem"},{"key":"1057_CR4","doi-asserted-by":"publisher","first-page":"3937","DOI":"10.1091\/mbc.e05-02-0136","volume":"16","author":"CC Hu","year":"2005","unstructured":"Hu CC, Liang FX, Zhou G, Tu L, Tang CH, Zhou J, et al. Assembly of urothelial plaques: tetraspanin function in membrane protein trafficking. Mol Biol Cell. 2005;16:3937\u201350.","journal-title":"Mol Biol Cell"},{"key":"1057_CR5","doi-asserted-by":"publisher","first-page":"5077","DOI":"10.1242\/jcs.03285","volume":"119","author":"L Tu","year":"2006","unstructured":"Tu L, Kong XP, Sun TT, Kreibich G. Integrity of all four transmembrane domains of the tetraspanin uroplakin Ib is required for its exit from the ER. J Cell Sci. 2006;119:5077\u201386.","journal-title":"J Cell Sci"},{"key":"1057_CR6","doi-asserted-by":"publisher","first-page":"4221","DOI":"10.1091\/mbc.e02-04-0211","volume":"13","author":"L Tu","year":"2002","unstructured":"Tu L, Sun TT, Kreibich G. Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum. Mol Biol Cell. 2002;13:4221\u201330.","journal-title":"Mol Biol Cell"},{"key":"1057_CR7","doi-asserted-by":"crossref","unstructured":"Szyma\u0144ska B, Matuszewski M, Dembowski J, Piwowar A. Initial evaluation of uroplakins UPIIIa and UPII in selected benign urological diseases. Biomolecules. 2021;11:1816.","DOI":"10.3390\/biom11121816"},{"key":"1057_CR8","doi-asserted-by":"publisher","first-page":"520","DOI":"10.3892\/ol.2021.12781","volume":"22","author":"J Zhu","year":"2021","unstructured":"Zhu J, Lu Q, Li B, Li H, Wu C, Li C, et al. Potential of the cell-free blood-based biomarker uroplakin 2 RNA to detect recurrence after surgical resection of lung adenocarcinoma. Oncol Lett. 2021;22:520.","journal-title":"Oncol Lett"},{"key":"1057_CR9","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.humpath.2021.04.005","volume":"113","author":"MZ Leivo","year":"2021","unstructured":"Leivo MZ, Tacha DE, Hansel DE. Expression of uroplakin II and GATA-3 in bladder cancer mimickers: caveats in the use of a limited panel to determine cell of origin in bladder lesions. Hum Pathol. 2021;113:28\u201333.","journal-title":"Hum Pathol"},{"key":"1057_CR10","doi-asserted-by":"publisher","first-page":"975","DOI":"10.14348\/molcells.2020.0126","volume":"43","author":"Y Byun","year":"2020","unstructured":"Byun Y, Choi YC, Jeong Y, Yoon J, Baek K. Long noncoding RNA expression profiling reveals upregulation of uroplakin 1A and uroplakin 1A antisense RNA 1 under hypoxic conditions in lung cancer cells. Mol Cells. 2020;43:975\u201388.","journal-title":"Mol Cells"},{"key":"1057_CR11","doi-asserted-by":"publisher","first-page":"6737","DOI":"10.7150\/jca.48132","volume":"11","author":"Y Song","year":"2020","unstructured":"Song Y, Wang H, Zou XJ, Zhang YX, Guo ZQ, Liu L, et al. Reciprocal regulation of HIF-1\u03b1 and uroplakin 1A promotes glycolysis and proliferation in hepatocellular carcinoma. J Cancer. 2020;11:6737\u201347.","journal-title":"J Cancer"},{"key":"1057_CR12","doi-asserted-by":"publisher","first-page":"4093","DOI":"10.21037\/tcr-20-211","volume":"9","author":"Z Zhu","year":"2020","unstructured":"Zhu Z, Xu J, Li L, Ye W, Chen B, Zeng J, et al. Comprehensive analysis reveals CTHRC1, SERPINE1, VCAN and UPK1B as the novel prognostic markers in gastric cancer. Translational cancer research. 2020;9:4093\u2013110.","journal-title":"Translational cancer research"},{"key":"1057_CR13","doi-asserted-by":"publisher","first-page":"15029","DOI":"10.1074\/jbc.M410538200","volume":"280","author":"K Sakakibara","year":"2005","unstructured":"Sakakibara K, Sato K, Yoshino K, Oshiro N, Hirahara S, Mahbub Hasan AK, et al. Molecular identification and characterization of Xenopus egg uroplakin III, an egg raft-associated transmembrane protein that is tyrosine-phosphorylated upon fertilization. J Biol Chem. 2005;280:15029\u201337.","journal-title":"J Biol Chem"},{"key":"1057_CR14","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1002\/mrd.21336","volume":"78","author":"AK Hasan","year":"2011","unstructured":"Hasan AK, Fukami Y, Sato K. Gamete membrane microdomains and their associated molecules in fertilization signaling. Mol Reprod Dev. 2011;78:814\u201330.","journal-title":"Mol Reprod Dev"},{"key":"1057_CR15","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.ydbio.2005.08.020","volume":"286","author":"AK Mahbub Hasan","year":"2005","unstructured":"Mahbub Hasan AK, Sato K, Sakakibara K, Ou Z, Iwasaki T, Ueda Y, et al. Uroplakin III, a novel Src substrate in Xenopus egg rafts, is a target for sperm protease essential for fertilization. Dev Biol. 2005;286:483\u201392.","journal-title":"Dev Biol"},{"key":"1057_CR16","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00418-016-1486-8","volume":"147","author":"S Kuriyama","year":"2017","unstructured":"Kuriyama S, Tamiya Y, Tanaka M. Spatiotemporal expression of UPK3B and its promoter activity during embryogenesis and spermatogenesis. Histochem Cell Biol. 2017;147:17\u201326.","journal-title":"Histochem Cell Biol"},{"key":"1057_CR17","doi-asserted-by":"crossref","unstructured":"Liao Y, Chang HC, Liang FX, Chung PJ, Wei Y, Nguyen TP, et al Uroplakins play conserved roles in egg fertilization and acquired additional urothelial functions during mammalian divergence. Mol Biol Cell. 2018:mbcE18080496.","DOI":"10.1091\/mbc.E18-08-0496"},{"key":"1057_CR18","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/978-1-4939-9009-2_5","volume":"1920","author":"KI Sato","year":"2019","unstructured":"Sato KI, Tokmakov AA. Membrane microdomains as platform to study membrane-associated events during oogenesis, meiotic maturation, and fertilization in Xenopus laevis. Methods Mol Biol. 2019;1920:59\u201373.","journal-title":"Methods Mol Biol"},{"key":"1057_CR19","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.ygcen.2019.06.003","volume":"281","author":"S Babu Munipalli","year":"2019","unstructured":"Babu Munipalli S, Yenugu S. Uroplakin expression in the male reproductive tract of rat. Gen Comp Endocrinol. 2019;281:153\u201363.","journal-title":"Gen Comp Endocrinol"},{"key":"1057_CR20","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1038\/ki.2009.73","volume":"75","author":"XR Wu","year":"2009","unstructured":"Wu XR, Kong XP, Pellicer A, Kreibich G, Sun TT. Uroplakins in urothelial biology, function, and disease. Kidney Int. 2009;75:1153\u201365.","journal-title":"Kidney Int"},{"key":"1057_CR21","doi-asserted-by":"publisher","first-page":"9630","DOI":"10.1073\/pnas.93.18.9630","volume":"93","author":"XR Wu","year":"1996","unstructured":"Wu XR, Sun TT, Medina JJ. In vitro binding of type 1-fimbriated Escherichia coli to uroplakins Ia and Ib: relation to urinary tract infections. Proc Natl Acad Sci USA. 1996;93:9630\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1057_CR22","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1126\/science.282.5393.1494","volume":"282","author":"MA Mulvey","year":"1998","unstructured":"Mulvey MA, Lopez-Boado YS, Wilson CL, Roth R, Parks WC, Heuser J, et al. Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli. Science. 1998;282:1494\u20137.","journal-title":"Science"},{"key":"1057_CR23","doi-asserted-by":"publisher","first-page":"2803","DOI":"10.1093\/emboj\/19.12.2803","volume":"19","author":"JJ Martinez","year":"2000","unstructured":"Martinez JJ, Mulvey MA, Schilling JD, Pinkner JS, Hultgren SJ. Type 1 pilus-mediated bacterial invasion of bladder epithelial cells. EMBO J. 2000;19:2803\u201312.","journal-title":"EMBO J"},{"key":"1057_CR24","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.jri.2015.02.009","volume":"110","author":"A Rajesh","year":"2015","unstructured":"Rajesh A, Yenugu S. Effect of immunization against prostate- and testis-expressed (PATE) proteins on sperm function and fecundity in the rat. J Reprod Immunol. 2015;110:117\u201329.","journal-title":"J Reprod Immunol"},{"key":"1057_CR25","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1111\/andr.12321","volume":"5","author":"A Rajesh","year":"2017","unstructured":"Rajesh A, Yenugu S. shRNA mediated ablation of prostate and testis expressed (Pate) messenger RNA results in impaired sperm function and fertility. Andrology. 2017;5:541\u20137.","journal-title":"Andrology"},{"key":"1057_CR26","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.ydbio.2005.11.030","volume":"290","author":"M Bou Khalil","year":"2006","unstructured":"Bou Khalil M, Chakrabandhu K, Xu H, Weerachatyanukul W, Buhr M, Berger T, et al. Sperm capacitation induces an increase in lipid rafts having zona pellucida binding ability and containing sulfogalactosylglycerolipid. Dev Biol. 2006;290:220\u201335.","journal-title":"Dev Biol"},{"key":"1057_CR27","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1177\/0300985813485099","volume":"50","author":"G-C KN","year":"2013","unstructured":"KN G-C, Ak O, DK M. Principles for valid histopathologic scoring in research. Vet Pathol. 2013;50:1007\u201315.","journal-title":"Vet Pathol"},{"key":"1057_CR28","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/1746-6148-9-123","volume":"9","author":"R K","year":"2013","unstructured":"R K. Multiparametric and semi-quantitative scoring systems for the evaluation of mouse modelhistopathology\u2014A systematic review. BMC Vet Res. 2013;9:123.","journal-title":"BMC Vet Res"},{"key":"1057_CR29","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.12688\/f1000research.21142.1","volume":"8","author":"G de BrandineSena","year":"2019","unstructured":"de BrandineSena G, Smith AD. Falco: high-speed FastQC emulation for quality control of sequencing data. F1000Research. 2019;8:1874.","journal-title":"F1000Research"},{"key":"1057_CR30","doi-asserted-by":"publisher","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","volume":"34","author":"S Chen","year":"2018","unstructured":"Chen S, Zhou Y, Chen Y, Gu J. fastp: an ultra-fast all-in-one FASTQ preprocessor. Bioinformatics. 2018;34:i884\u201390.","journal-title":"Bioinformatics"},{"key":"1057_CR31","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics. 2013;29:15\u201321.","journal-title":"Bioinformatics"},{"key":"1057_CR32","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao Y, Smyth GK, Shi W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 2014;30:923\u201330.","journal-title":"Bioinformatics"},{"key":"1057_CR33","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15:550.","journal-title":"Genome Biol"},{"key":"1057_CR34","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1002\/nau.20688","volume":"28","author":"T Aboushwareb","year":"2009","unstructured":"Aboushwareb T, Zhou G, Deng FM, Turner C, Andersson KE, Tar M, et al. Alterations in bladder function associated with urothelial defects in uroplakin II and IIIa knockout mice. Neurourol Urodyn. 2009;28:1028\u201333.","journal-title":"Neurourol Urodyn"},{"key":"1057_CR35","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1083\/jcb.151.5.961","volume":"151","author":"P Hu","year":"2000","unstructured":"Hu P, Deng FM, Liang FX, Hu CM, Auerbach AB, Shapiro E, et al. Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux. J Cell Biol. 2000;151:961\u201372.","journal-title":"J Cell Biol"},{"key":"1057_CR36","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.kint.2015.11.017","volume":"89","author":"AR Carpenter","year":"2016","unstructured":"Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, et al. Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Kidney Int. 2016;89:612\u201324.","journal-title":"Kidney Int"},{"key":"1057_CR37","doi-asserted-by":"publisher","first-page":"3128","DOI":"10.1091\/mbc.E18-08-0496","volume":"29","author":"Y Liao","year":"2018","unstructured":"Liao Y, Chang HC, Liang FX, Chung PJ, Wei Y, Nguyen TP, et al. Uroplakins play conserved roles in egg fertilization and acquired additional urothelial functions during mammalian divergence. Mol Biol Cell. 2018;29:3128\u201343.","journal-title":"Mol Biol Cell"},{"key":"1057_CR38","first-page":"252","volume":"69","author":"MA Matuszewski","year":"2016","unstructured":"Matuszewski MA, Tupikowski K, Do\u0142owy \u0141, Szyma\u0144ska B, Dembowski J, Zdrojowy R. Uroplakins and their potential applications in urology. Cent European J Urol. 2016;69:252\u20137.","journal-title":"Cent European J Urol"},{"key":"1057_CR39","doi-asserted-by":"publisher","first-page":"19277","DOI":"10.1038\/s41598-021-98303-2","volume":"11","author":"BMM Zwaans","year":"2021","unstructured":"Zwaans BMM, Carabulea AL, Bartolone SN, Ward EP, Chancellor MB, Lamb LE. Voiding defects in acute radiation cystitis driven by urothelial barrier defect through loss of E-cadherin, ZO-1 and Uroplakin III. Sci Rep. 2021;11:19277.","journal-title":"Sci Rep"},{"key":"1057_CR40","doi-asserted-by":"publisher","first-page":"F1019","DOI":"10.1152\/ajprenal.00173.2018","volume":"315","author":"AR Jackson","year":"2018","unstructured":"Jackson AR, Li B, Cohen SH, Ching CB, McHugh KM, Becknell B. The uroplakin plaque promotes renal structural integrity during congenital and acquired urinary tract obstruction. Am J Physiol Renal Physiol. 2018;315:F1019\u201331.","journal-title":"Am J Physiol Renal Physiol"},{"key":"1057_CR41","first-page":"694","volume":"54","author":"JB Finlay","year":"2015","unstructured":"Finlay JB, Liu X, Ermel RW, Adamson TW. Maternal weight gain as a predictor of litter size in Swiss Webster, C57BL\/6J, and BALB\/cJ mice. J Am Assoc Lab Anim Sci. 2015;54:694\u20139.","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"1057_CR42","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.micinf.2008.10.008","volume":"11","author":"P Thumbikat","year":"2009","unstructured":"Thumbikat P, Berry RE, Schaeffer AJ, Klumpp DJ. Differentiation-induced uroplakin III expression promotes urothelial cell death in response to uropathogenic E. coli. Microbes Infect. 2009;11:57\u201365.","journal-title":"Microbes Infect"},{"key":"1057_CR43","doi-asserted-by":"publisher","first-page":"e1000415","DOI":"10.1371\/journal.ppat.1000415","volume":"5","author":"P Thumbikat","year":"2009","unstructured":"Thumbikat P, Berry RE, Zhou G, Billips BK, Yaggie RE, Zaichuk T, et al. Bacteria-induced uroplakin signaling mediates bladder response to infection. PLoS Pathog. 2009;5:e1000415.","journal-title":"PLoS Pathog"},{"key":"1057_CR44","doi-asserted-by":"publisher","unstructured":"Mu\u00f1oz-Carrillo JL, et al.\u00a0Cytokine profiling plays a crucial role in activating immune system to clear infectious pathogens.\u00a0In: Tyagi RK, Bisen PS, editors. Immune response activation and immunomodulation. London: IntechOpen; 2018. https:\/\/doi.org\/10.5772\/intechopen.80843.","DOI":"10.5772\/intechopen.80843"},{"key":"1057_CR45","doi-asserted-by":"crossref","unstructured":"Ali MA, Wang Y, Qin Z, Yuan X, Zhang Y, Zeng C. Odorant and taste receptors in sperm chemotaxis and cryopreservation: roles and implications in sperm capacitation, motility and fertility. Genes (Basel). 2021;12:488.","DOI":"10.3390\/genes12040488"},{"key":"1057_CR46","doi-asserted-by":"crossref","unstructured":"Wu SY, Jiang YH, Jhang JF, Hsu YH, Ho HC, Kuo HC. Inflammation and barrier function deficits in the bladder urothelium of patients with chronic spinal cord injury and recurrent urinary tract infections. Biomedicines. 2022;10:220.","DOI":"10.3390\/biomedicines10020220"},{"key":"1057_CR47","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1002\/iub.2574","volume":"73","author":"X Chen","year":"2021","unstructured":"Chen X, Li Y, Dai H, Zhang H, Wan D, Zhou X, et al. Cyclin-dependent kinase 7 is essential for spermatogenesis by regulating retinoic acid signaling pathways and the STAT3 molecular pathway. IUBMB Life. 2021;73:1446\u201359.","journal-title":"IUBMB Life"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-022-01057-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-022-01057-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-022-01057-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T23:29:09Z","timestamp":1679873349000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-022-01057-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,30]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["1057"],"URL":"https:\/\/doi.org\/10.1007\/s43032-022-01057-z","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"type":"print","value":"1933-7191"},{"type":"electronic","value":"1933-7205"}],"subject":[],"published":{"date-parts":[[2022,8,30]]},"assertion":[{"value":"25 April 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures involving animals were conducted using the guidelines for the care and use of laboratory animals and this study was specifically approved by the Institutional Animal Ethics Committee of University of Hyderabad (UH\/IAEC\/SY\/2021\u20131\/20).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All the authors have read the manuscript and consent to publish.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors have no conflicts or competing interests to declare.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}