{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:44:15Z","timestamp":1790703855062,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s43032-022-01078-8","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T16:03:07Z","timestamp":1664208187000},"page":"1198-1206","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Hyperemesis Gravidarum: Risk of Recurrence in Subsequent Pregnancies"],"prefix":"10.1007","volume":"30","author":[{"given":"Michael J.","family":"Fassett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan R.","family":"Peltier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian H.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki Y.","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3610-8841","authenticated-orcid":false,"given":"Darios","family":"Getahun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"1078_CR1","doi-asserted-by":"publisher","unstructured":"Matthews A, Haas DM, O\u2019Math\u00fana DP, Dowswell T. Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev\u00a02015;9:Cd007575. https:\/\/doi.org\/10.1002\/14651858.CD007575.","DOI":"10.1002\/14651858.CD007575"},{"key":"1078_CR2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ejogrb.2021.09.004","volume":"266","author":"LAW Jansen","year":"2021","unstructured":"Jansen LAW, Koot MH, Van\u2019tHooft J, Dean CR, Bossuyt PMM, Ganzevoort W, Gauw N, Van der Goes BY, Rodenburg J, Roseboom TJ, et al. The windsor definition for hyperemesis gravidarum: a multistakeholder international consensus definition. Eur J Obstet Gynecol Reprod Biol. 2021;266:15\u201322.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"1078_CR3","first-page":"94","volume":"100","author":"JA Gazmararian","year":"2002","unstructured":"Gazmararian JA, Petersen R, Jamieson DJ, Schild L, Adams MM, Deshpande AD, Franks AL. Hospitalizations during pregnancy among managed care enrollees. Obstet Gynecol. 2002;100:94\u2013100.","journal-title":"Obstet Gynecol"},{"key":"1078_CR4","first-page":"35","volume":"84","author":"MM Adams","year":"1994","unstructured":"Adams MM, Harlass FE, Sarno AP, Read JA, Rawlings JS. Antenatal hospitalization among enlisted servicewomen, 1987\u20131990. Obstet Gynecol. 1994;84:35\u20139.","journal-title":"Obstet Gynecol"},{"key":"1078_CR5","doi-asserted-by":"publisher","first-page":"e27678","DOI":"10.1371\/journal.pone.0027678","volume":"6","author":"FP McCarthy","year":"2011","unstructured":"McCarthy FP, Khashan AS, North RA, Moss-Morris R, Baker PN, Dekker G, Poston L, Kenny LC, Consortium S. A prospective cohort study investigating associations between hyperemesis gravidarum and cognitive, behavioural and emotional well-being in pregnancy. PLoS ONE. 2011;6:e27678.","journal-title":"PLoS ONE"},{"key":"1078_CR6","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1089\/jwh.2009.1431","volume":"18","author":"MS Fejzo","year":"2009","unstructured":"Fejzo MS, Poursharif B, Korst LM, Munch S, MacGibbon KW, Romero R, Goodwin TM. Symptoms and pregnancy outcomes associated with extreme weight loss among women with hyperemesis gravidarum. J Womens Health (Larchmt). 2009;18:1981\u20137.","journal-title":"J Womens Health (Larchmt)"},{"key":"1078_CR7","doi-asserted-by":"publisher","first-page":"100105","DOI":"10.1016\/j.eurox.2019.100105","volume":"5","author":"CR Dean","year":"2020","unstructured":"Dean CR, Bruin CM, O\u2019Hara ME, Roseboom TJ, Leeflang MM, Spijker R, Painter RC. The chance of recurrence of hyperemesis gravidarum: a systematic review. Eur J Obstet Gynecol Reprod Biol X. 2020;5:100105.","journal-title":"Eur J Obstet Gynecol Reprod Biol X"},{"key":"1078_CR8","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1111\/aogs.14197","volume":"100","author":"K Nijsten","year":"2021","unstructured":"Nijsten K, Dean C, van der Minnen LM, Bais JMJ, Ris-Stalpers C, van Eekelen R, Bremer HA, van der Ham DP, Heidema WM, Huisjes A, et al. Recurrence, postponing pregnancy, and termination rates after hyperemesis gravidarum: follow up of the MOTHER study. Acta Obstet Gynecol Scand. 2021;100:1636\u201343.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"1078_CR9","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1055\/s-0039-1696670","volume":"38","author":"D Getahun","year":"2021","unstructured":"Getahun D, Fassett MJ, Jacobsen SJ, Xiang AH, Takhar HS, Wing DA, Peltier MR. Autism spectrum disorders in children exposed in utero to hyperemesis gravidarum. Am J Perinatol. 2021;38:265\u201372.","journal-title":"Am J Perinatol"},{"key":"1078_CR10","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1517\/14656566.2010.537655","volume":"12","author":"O Sanu","year":"2011","unstructured":"Sanu O, Lamont RF. Hyperemesis gravidarum: pathogenesis and the use of antiemetic agents. Expert Opin Pharmacother. 2011;12:737\u201348.","journal-title":"Expert Opin Pharmacother"},{"key":"1078_CR11","first-page":"c2050","volume":"340","author":"A Vikanes","year":"2010","unstructured":"Vikanes A, Skjaerven R, Grjibovski AM, Gunnes N, Vangen S, Magnus P. Recurrence of hyperemesis gravidarum across generations: population based cohort study. BMJ. 2010;340:c2050.","journal-title":"BMJ"},{"key":"1078_CR12","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1038\/s41467-018-03258-0","volume":"9","author":"MS Fejzo","year":"2018","unstructured":"Fejzo MS, Sazonova OV, Sathirapongsasuti JF, Hallgrimsdottir IB, Vacic V, MacGibbon KW, Schoenberg FP, Mancuso N, Slamon DJ, Mullin PM. andMe Research T: Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum. Nat Commun. 2018;9:1178.","journal-title":"Nat Commun"},{"key":"1078_CR13","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1055\/a-0661-0287","volume":"78","author":"MS Fejzo","year":"2018","unstructured":"Fejzo MS, Arzy D, Tian R, MacGibbon KW, Mullin PM. Evidence GDF15 plays a role in familial and recurrent hyperemesis gravidarum. Geburtshilfe Frauenheilkd. 2018;78:866\u201370.","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"1078_CR14","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1055\/a-0830-1346","volume":"79","author":"MS Fejzo","year":"2019","unstructured":"Fejzo MS, Fasching PA, Schneider MO, Schwitulla J, Beckmann MW, Schwenke E, MacGibbon KW, Mullin PM. Analysis of GDF15 and IGFBP7 in hyperemesis gravidarum support causality. Geburtshilfe Frauenheilkd. 2019;79:382\u20138.","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"1078_CR15","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ejogrb.2011.01.010","volume":"156","author":"TJ Roseboom","year":"2011","unstructured":"Roseboom TJ, Ravelli AC, van der Post JA, Painter RC. Maternal characteristics largely explain poor pregnancy outcome after hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol. 2011;156:56\u20139.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"1078_CR16","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1097\/01.AOG.0000195059.82029.74","volume":"107","author":"DB Fell","year":"2006","unstructured":"Fell DB, Dodds L, Joseph KS, Allen VM, Butler B. Risk factors for hyperemesis gravidarum requiring hospital admission during pregnancy. Obstet Gynecol. 2006;107:277\u201384.","journal-title":"Obstet Gynecol"},{"key":"1078_CR17","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.annepidem.2010.05.009","volume":"20","author":"A Vikanes","year":"2010","unstructured":"Vikanes A, Grjibovski AM, Vangen S, Gunnes N, Samuelsen SO, Magnus P. Maternal body composition, smoking, and hyperemesis gravidarum. Ann Epidemiol. 2010;20:592\u20138.","journal-title":"Ann Epidemiol"},{"key":"1078_CR18","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1093\/humrep\/dew128","volume":"31","author":"L Fiaschi","year":"2016","unstructured":"Fiaschi L, Nelson-Piercy C, Tata LJ. Hospital admission for hyperemesis gravidarum: a nationwide study of occurrence, reoccurrence and risk factors among 8.2 million pregnancies. Hum Reprod. 2016;31:1675\u201384.","journal-title":"Hum Reprod"},{"key":"1078_CR19","doi-asserted-by":"publisher","first-page":"475","DOI":"10.3109\/01443615.2012.666580","volume":"32","author":"M Rashid","year":"2012","unstructured":"Rashid M, Rashid MH, Malik F, Herath RP. Hyperemesis gravidarum and fetal gender: a retrospective study. J Obstet Gynaecol. 2012;32:475\u20138.","journal-title":"J Obstet Gynaecol"},{"key":"1078_CR20","doi-asserted-by":"publisher","first-page":"632","DOI":"10.3109\/14767058.2011.598588","volume":"25","author":"PM Mullin","year":"2012","unstructured":"Mullin PM, Ching C, Schoenberg F, MacGibbon K, Romero R, Goodwin TM, Fejzo MS. Risk factors, treatments, and outcomes associated with prolonged hyperemesis gravidarum. J Matern Fetal Neonatal Med. 2012;25:632\u20136.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"1078_CR21","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/j.1542-2011.2010.00019.x","volume":"56","author":"MS Fejzo","year":"2011","unstructured":"Fejzo MS, Macgibbon KW, Romero R, Goodwin TM, Mullin PM. Recurrence risk of hyperemesis gravidarum. J Midwifery Womens Health. 2011;56:132\u20136.","journal-title":"J Midwifery Womens Health"},{"key":"1078_CR22","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1007\/s10654-015-0039-0","volume":"30","author":"TI Korevaar","year":"2015","unstructured":"Korevaar TI, Steegers EA, de Rijke YB, Schalekamp-Timmermans S, Visser WE, Hofman A, Jaddoe VW, Tiemeier H, Visser TJ, Medici M, Peeters RP. Reference ranges and determinants of total hCG levels during pregnancy: the Generation R Study. Eur J Epidemiol. 2015;30:1057\u201366.","journal-title":"Eur J Epidemiol"},{"key":"1078_CR23","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1002\/pd.2715","volume":"31","author":"AU Derbent","year":"2011","unstructured":"Derbent AU, Yanik FF, Simavli S, Atasoy L, Urun E, Kuscu UE, Turhan NO. First trimester maternal serum PAPP-A and free beta-HCG levels in hyperemesis gravidarum. Prenat Diagn. 2011;31:450\u20133.","journal-title":"Prenat Diagn"},{"key":"1078_CR24","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.3109\/00016340903284927","volume":"88","author":"I Sandven","year":"2009","unstructured":"Sandven I, Abdelnoor M, Nesheim BI, Melby KK. Helicobacter pylori infection and hyperemesis gravidarum: a systematic review and meta-analysis of case-control studies. Acta Obstet Gynecol Scand. 2009;88:1190\u2013200.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"1078_CR25","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1111\/j.1471-0528.2005.00765.x","volume":"112","author":"LI Trogstad","year":"2005","unstructured":"Trogstad LI, Stoltenberg C, Magnus P, Skjaerven R, Irgens LM. Recurrence risk in hyperemesis gravidarum. Bjog. 2005;112:1641\u20135.","journal-title":"Bjog"},{"issue":"3","key":"1078_CR26","first-page":"309","volume":"27","author":"ME O'Hara","year":"2017","unstructured":"O\u2019Hara ME. Experiences of hyperemesis gravidarum in a subsequent pregnancy. Midirs. 2017;27(3):309\u201318.","journal-title":"Midirs"},{"key":"1078_CR27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.7812\/TPP\/12-031","volume":"16","author":"C Koebnick","year":"2012","unstructured":"Koebnick C, Langer-Gould AM, Gould MK, Chao CR, Iyer RL, Smith N, Chen W, Jacobsen SJ. Sociodemographic characteristics of members of a large, integrated health care system: comparison with US Census Bureau data. Perm J. 2012;16:37\u201341.","journal-title":"Perm J"},{"key":"1078_CR28","doi-asserted-by":"publisher","first-page":"e15","DOI":"10.1097\/AOG.0000000000002456","volume":"131","author":"ACOG Practice Bulletin No","year":"2018","unstructured":"ACOG Practice Bulletin No. 189: Nausea and vomiting of pregnancy. Obstet Gynecol. 2018;131:e15\u201330.","journal-title":"Obstet Gynecol"},{"key":"1078_CR29","first-page":"1333","volume":"75","author":"TM Goodwin","year":"1992","unstructured":"Goodwin TM, Montoro M, Mestman JH, Pekary AE, Hershman JM. The role of chorionic gonadotropin in transient hyperthyroidism of hyperemesis gravidarum. J Clin Endocrinol Metab. 1992;75:1333\u20137.","journal-title":"J Clin Endocrinol Metab"},{"key":"1078_CR30","doi-asserted-by":"crossref","unstructured":"Getahun D, Rhoads GG, Fassett MJ, Chen W, Strauss JA, Demissie K, Jacobsen SJ: Accuracy of reporting maternal and infant perinatal service system coding and clinical utilization coding. J Med Stat Inform 2013;1:1\u20133.\u00a0http:\/\/www.hoajonline.com\/medicalstat\/2053-7662\/2051\/2053.\u00a0Accessed 15 Aug 2022","DOI":"10.7243\/2053-7662-1-3"},{"key":"1078_CR31","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/pds.3319","volume":"22","author":"SE Andrade","year":"2013","unstructured":"Andrade SE, Scott PE, Davis RL, Li DK, Getahun D, Cheetham TC, Raebel MA, Toh S, Dublin S, Pawloski PA, et al. Validity of health plan and birth certificate data for pregnancy research. Pharmacoepidemiol Drug Saf. 2013;22:7\u201315.","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"1078_CR32","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1177\/1403494807085189","volume":"36","author":"A Vikanes","year":"2008","unstructured":"Vikanes A, Grjibovski AM, Vangen S, Magnus P. Variations in prevalence of hyperemesis gravidarum by country of birth: a study of 900,074 pregnancies in Norway, 1967\u20132005. Scand J Public Health. 2008;36:135\u201342.","journal-title":"Scand J Public Health"},{"key":"1078_CR33","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/0002-9378(87)90126-8","volume":"156","author":"RH Depue","year":"1987","unstructured":"Depue RH, Bernstein L, Ross RK, Judd HL, Henderson BE. Hyperemesis gravidarum in relation to estradiol levels, pregnancy outcome, and other maternal factors: a seroepidemiologic study. Am J Obstet Gynecol. 1987;156:1137\u201341.","journal-title":"Am J Obstet Gynecol"},{"key":"1078_CR34","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ygyno.2005.12.047","volume":"102","author":"LA Cole","year":"2006","unstructured":"Cole LA, Dai D, Butler SA, Leslie KK, Kohorn EI. Gestational trophoblastic diseases: 1 Pathophysiology of hyperglycosylated hCG. Gynecol Oncol. 2006;102:145\u201350.","journal-title":"Gynecol Oncol"},{"key":"1078_CR35","doi-asserted-by":"publisher","first-page":"e27678","DOI":"10.1371\/journal.pone.0027678","volume":"6","author":"FP McCarthy","year":"2011","unstructured":"McCarthy FP, Khashan AS, North RA, Moss-Morris R, Baker PN, Dekker G, Poston L, Kenny LC. A prospective cohort study investigating associations between hyperemesis gravidarum and cognitive, behavioural and emotional well-being in pregnancy. PLoS ONE. 2011;6:e27678.","journal-title":"PLoS ONE"},{"key":"1078_CR36","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1089\/dna.2014.2687","volume":"34","author":"I Hromadnikova","year":"2015","unstructured":"Hromadnikova I, Kotlabova K, Ondrackova M, Pirkova P, Kestlerova A, Novotna V, Hympanova L, Krofta L. Expression profile of C19MC microRNAs in placental tissue in pregnancy-related complications. DNA Cell Biol. 2015;34:437\u201357.","journal-title":"DNA Cell Biol"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-022-01078-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-022-01078-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-022-01078-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T17:23:26Z","timestamp":1683221006000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-022-01078-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,26]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["1078"],"URL":"https:\/\/doi.org\/10.1007\/s43032-022-01078-8","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,26]]},"assertion":[{"value":"31 January 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The opinions expressed are solely the authors\u2019 responsibility and do not necessarily reflect the official views of the Kaiser Permanente Community Benefit Funds. The funding agency has no role in the design, conduct, and report of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}