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Patients with UFs showed higher PSS than controls (18.5\u2009\u00b1\u20095.0 vs. 13.8\u2009\u00b1\u20095.0, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and PSS values were very high in those with HMB, severe dysmenorrhea, and impaired social and working life. Patients with UFs also showed significantly higher score for MEDI-Q Total Score (16.51\u2009\u00b1\u200912.99 vs. 10.86\u2009\u00b1\u200912.36) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) as well as for the subscales MSD (2.54\u2009\u00b1\u20091.07 vs. 1.57\u2009\u00b1\u20090.98) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and MESI (0.76\u2009\u00b1\u20090.30 vs 0.60\u2009\u00b1\u20090.39) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The menstrual distress was associated to being uncomfortable about uterine bleeding; in fact, MEDI-Q Total Score was significantly higher in women with HMB compared to those with moderate\/normal bleeding. UF characteristics (number, type, and size) did not correlate with perceived stress or menstrual distress. In conclusion, women with UFs have significantly higher levels of perceived stress and menstrual distress than controls and HMB plays a major role in determining such conditions.<\/jats:p>","DOI":"10.1007\/s43032-022-01126-3","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T18:02:50Z","timestamp":1670263370000},"page":"1608-1615","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Uterine Fibroids, Perceived Stress, and Menstrual Distress: a Key Role of Heavy Menstrual Bleeding"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5790-587X","authenticated-orcid":false,"given":"Silvia","family":"Vannuccini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Clemenza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Cassioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Castellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdo","family":"Ricca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8851-625X","authenticated-orcid":false,"given":"Felice","family":"Petraglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"1126_CR1","doi-asserted-by":"crossref","unstructured":"Stewart EA, Laughlin-Tommaso SK, Catherino WH, Lalitkumar S, Gupta D, Vollenhoven B. 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