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A. Pai Management Institute"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The review aims to summarize the available research focusing on the importance of monocarboxylate transporter (<jats:italic>MCT8<\/jats:italic>) in thyroid hormone trafficking across the placenta and fetal development. A systematic search was carried out in PubMed; studies available in English related to \u201cmonocarboxylate transporter\u201d, \u201cadverse pregnancy\u201d, \u201cfetal development,\u201d and \u201cthyroid hormone\u201d were identified and assessed. The references within the resulting articles were manually searched. <jats:italic>MCT8<\/jats:italic> is a highly active and selective thyroid hormone transporter that facilitates the cellular uptake of triiodothyronine (T3), thyroxine (T4), reverse triiodothyronine (rT3), and diiodothyronine (T2) in different tissues. <jats:italic>MCT8<\/jats:italic> is expressed in the placenta from the first trimester onwards, allowing the transport of thyroid hormone from mother to fetus. Mutations in <jats:italic>MCT8<\/jats:italic> cause an X-linked disorder known as Allan-Herndon-Dudley syndrome (AHDS), characterized by severe psychomotor impairment and peripheral thyrotoxicosis. Hence, any maternal thyroid dysfunction may cause severe consequences for the fetus and newborn. Further research regarding <jats:italic>MCT8<\/jats:italic> gene expression, polymorphic variation, and adverse pregnancy outcomes must be done to establish that <jats:italic>MCT8<\/jats:italic> is a novel prognostic marker for the early detection of pregnancy-related complications.<\/jats:p>","DOI":"10.1007\/s43032-022-01162-z","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T16:03:00Z","timestamp":1672761780000},"page":"1758-1769","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Role and Clinical Significance of Monocarboxylate Transporter 8 (MCT8) During Pregnancy"],"prefix":"10.1007","volume":"30","author":[{"given":"Jinsu","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Sairoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anmi","family":"Jose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidyashree G.","family":"Poojari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahana","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shama Prasada","family":"K","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnananda","family":"Prabhu R V","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3322-5399","authenticated-orcid":false,"given":"Mahadev","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"1162_CR1","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1038\/ncpendmet0262","volume":"2","author":"ECH Friesema","year":"2006","unstructured":"Friesema ECH, Jansen J, Heuer H, Trajkovic M, Bauer K, Visser TJ. 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