{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:42:19Z","timestamp":1784097739486,"version":"3.55.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2021JDZH0040"],"award-info":[{"award-number":["2021JDZH0040"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019014","name":"Chengdu Science and Technology Program","doi-asserted-by":"publisher","award":["2019-YF05-00218-SN"],"award-info":[{"award-number":["2019-YF05-00218-SN"]}],"id":[{"id":"10.13039\/501100019014","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research project of Sichuan Provincial Health Commission","award":["19PJ033"],"award-info":[{"award-number":["19PJ033"]}]},{"name":"The pre-research project of the Natural Science Foundation of Chengdu University of Traditional Chinese Medicine","award":["ZKYY2021"],"award-info":[{"award-number":["ZKYY2021"]}]},{"name":"Chengdu University of Traditional Chinese Medicine Xinglin Scholars Discipline Talent Research Promotion Plan Hospital Special","award":["2020yky02"],"award-info":[{"award-number":["2020yky02"]}]},{"name":"The subject of Sichuan Provincial Administration of Traditional Chinese Medicine","award":["2021MS451"],"award-info":[{"award-number":["2021MS451"]}]},{"name":"Research project of Sichuan Maternity and Child Health Association","award":["21FX02"],"award-info":[{"award-number":["21FX02"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recurrent spontaneous abortion (RSA) is the most common pregnancy-related complication, affecting 1\u20135% of pregnancies. Currently, immune imbalance at the maternal\u2013fetal interface is one of the main causes of recurrent abortion. Icariin (ICA) can exert immunomodulatory effects in a variety of autoimmune diseases. Nevertheless, it has not been reported for use in recurrent abortion. In this study, to clarify the effects and mechanisms of ICA for recurrent abortion, female mice CBA\/J were randomly divided into Normal group, RSA group and RSA\u2009+\u2009ICA group. From 0.5\u00a0days of pregnancy to 12.5\u00a0days, the RSA\u2009+\u2009ICA group was subjected to orally ICA (50\u00a0mg\/Kg) daily, and the Normal group and the RSA group were given with an equal volume of distilled water. The results showed the amount of reabsorbed embryo in the RSA group was significantly higher than that in the normal-pregnancy group. However, ICA treatment showed a rescue effect on spontaneous abortion in RSA mice. ICA was able to increase the ratio of the labyrinth to total placental area in abortion-prone model. Further investigation showed that ICA treatment can expand the regulatory T cell (Treg) population in mice prone to abortion, significantly decrease the populations of Th1 cells, and reduce the expression of pro-inflammatory factors. Additionally, ICA treatment was able to decrease the expression of mechanical target of rapamycin (mTOR) in the placenta. ICA may increase Treg cell expansion and reducing pro-inflammatory factors expression via the mTOR pathway, then reducing placental inflammation and improving pregnancy outcomes in abortion-prone mice.<\/jats:p>","DOI":"10.1007\/s43032-023-01185-0","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T17:02:47Z","timestamp":1678294967000},"page":"2794-2804","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Effects of Treatment with Icariin on Immune Tolerance in the Recurrent Spontaneous Abortion Mice"],"prefix":"10.1007","volume":"30","author":[{"given":"Fang","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinxiu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2167-5368","authenticated-orcid":false,"given":"Xin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"issue":"9535","key":"1185_CR1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0140-6736(06)69204-0","volume":"368","author":"R Rai","year":"2006","unstructured":"Rai R, Regan L. Recurrent miscarriage. Lancet. 2006;368(9535):601\u201311.","journal-title":"Lancet"},{"issue":"4","key":"1185_CR2","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.fertnstert.2009.01.166","volume":"93","author":"CR Jaslow","year":"2010","unstructured":"Jaslow CR, Carney JL, Kutteh WH. Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses. Fertil Steril. 2010;93(4):1234\u201343.","journal-title":"Fertil Steril"},{"issue":"4","key":"1185_CR3","first-page":"250","volume":"38","author":"DR Mishell Jr","year":"1993","unstructured":"Mishell DR Jr. Recurrent abortion. J Reprod Med. 1993;38(4):250\u20139.","journal-title":"J Reprod Med"},{"issue":"4","key":"1185_CR4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.placenta.2014.02.004","volume":"35","author":"J Alijotas-Reig","year":"2014","unstructured":"Alijotas-Reig J, Llurba E, Gris JM. Potentiating maternal immune tolerance in pregnancy: a new challenging role for regulatory T cells. Placenta. 2014;35(4):241\u20138.","journal-title":"Placenta"},{"issue":"1","key":"1185_CR5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00281-006-0023-6","volume":"28","author":"AC Zenclussen","year":"2006","unstructured":"Zenclussen AC. Regulatory T cells in pregnancy. Springer Semin Immunopathol. 2006;28(1):31\u20139.","journal-title":"Springer Semin Immunopathol"},{"issue":"10","key":"1185_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399407000294","volume":"9","author":"AC Zenclussen","year":"2007","unstructured":"Zenclussen AC, Schumacher A, Zenclussen ML, Wafula P, Volk HD. Immunology of pregnancy: cellular mechanisms allowing fetal survival within the maternal uterus. Expert Rev Mol Med. 2007;9(10):1\u201314.","journal-title":"Expert Rev Mol Med"},{"issue":"1 Pt A","key":"1185_CR7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.imlet.2014.06.013","volume":"162","author":"C La Rocca","year":"2014","unstructured":"La Rocca C, Carbone F, Longobardi S, Matarese G. The immunology of pregnancy: regulatory T cells control maternal immune tolerance toward the fetus. Immunol Lett. 2014;162(1 Pt A):41\u20138.","journal-title":"Immunol Lett"},{"issue":"1","key":"1185_CR8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.cyto.2014.09.011","volume":"74","author":"I Raphael","year":"2015","unstructured":"Raphael I, Nalawade S, Eagar TN, Forsthuber TG. T cell subsets and their signature cytokines in autoimmune and inflammatory diseases. Cytokine. 2015;74(1):5\u201317.","journal-title":"Cytokine"},{"issue":"6","key":"1185_CR9","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/cmi.2014.54","volume":"11","author":"B Fu","year":"2014","unstructured":"Fu B, Tian Z, Wei H. TH17 cells in human recurrent pregnancy loss and pre-eclampsia. Cell Mol Immunol. 2014;11(6):564\u201370.","journal-title":"Cell Mol Immunol"},{"key":"1185_CR10","first-page":"51","volume":"3","author":"A Schmidt","year":"2012","unstructured":"Schmidt A, Oberle N, Krammer PH. Molecular mechanisms of treg-mediated T cell suppression. Front Immunol. 2012;3:51.","journal-title":"Front Immunol"},{"issue":"5","key":"1185_CR11","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1600-0897.2010.00864.x","volume":"64","author":"AS Bansal","year":"2010","unstructured":"Bansal AS. Joining the immunological dots in recurrent miscarriage. Am J Reprod Immunol. 2010;64(5):307\u201315.","journal-title":"Am J Reprod Immunol"},{"issue":"12","key":"1185_CR12","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1007\/s43032-021-00599-y","volume":"28","author":"D Li","year":"2021","unstructured":"Li D, Zheng L, Zhao D, Xu Y, Wang Y. The role of immune cells in recurrent spontaneous abortion. Reprod Sci. 2021;28(12):3303\u201315.","journal-title":"Reprod Sci"},{"issue":"5","key":"1185_CR13","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1189\/jlb.0712347","volume":"93","author":"S Durr","year":"2013","unstructured":"Durr S, Kindler V. Implication of indolamine 2,3 dioxygenase in the tolerance toward fetuses, tumors, and allografts. J Leukoc Biol. 2013;93(5):681\u20137.","journal-title":"J Leukoc Biol"},{"issue":"2","key":"1185_CR14","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jri.2010.02.006","volume":"85","author":"T Shima","year":"2010","unstructured":"Shima T, Sasaki Y, Itoh M, Nakashima A, Ishii N, Sugamura K, et al. Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice. J Reprod Immunol. 2010;85(2):121\u20139.","journal-title":"J Reprod Immunol"},{"issue":"9","key":"1185_CR15","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/2006","volume":"4","author":"MP Piccinni","year":"1998","unstructured":"Piccinni MP, Beloni L, Livi C, Maggi E, Scarselli G, Romagnani S. Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. Nat Med. 1998;4(9):1020\u20134.","journal-title":"Nat Med"},{"issue":"5380","key":"1185_CR16","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1126\/science.281.5380.1191","volume":"281","author":"DH Munn","year":"1998","unstructured":"Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science. 1998;281(5380):1191\u20133.","journal-title":"Science"},{"issue":"1","key":"1185_CR17","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2174\/138920311795659407","volume":"12","author":"H Zhou","year":"2011","unstructured":"Zhou H, Huang S. Role of mTOR signaling in tumor cell motility, invasion and metastasis. Curr Protein Pept Sci. 2011;12(1):30\u201342.","journal-title":"Curr Protein Pept Sci"},{"issue":"1","key":"1185_CR18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1172\/JCI73939","volume":"125","author":"YC Kim","year":"2015","unstructured":"Kim YC, Guan KL. mTOR: a pharmacologic target for autophagy regulation. J Clin Invest. 2015;125(1):25\u201332.","journal-title":"J Clin Invest"},{"issue":"4","key":"1185_CR19","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1365-2567.2009.03125.x","volume":"127","author":"GM Delgoffe","year":"2009","unstructured":"Delgoffe GM, Powell JD. mTOR: taking cues from the immune microenvironment. Immunology. 2009;127(4):459\u201365.","journal-title":"Immunology"},{"issue":"5","key":"1185_CR20","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.it.2009.02.002","volume":"30","author":"T Weichhart","year":"2009","unstructured":"Weichhart T, Saemann MD. The multiple facets of mTOR in immunity. Trends Immunol. 2009;30(5):218\u201326.","journal-title":"Trends Immunol"},{"issue":"10","key":"1185_CR21","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nri3901","volume":"15","author":"T Weichhart","year":"2015","unstructured":"Weichhart T, Hengstschlager M, Linke M. Regulation of innate immune cell function by mTOR. Nat Rev Immunol. 2015;15(10):599\u2013614.","journal-title":"Nat Rev Immunol"},{"key":"1185_CR22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102373","volume":"110","author":"T Suto","year":"2020","unstructured":"Suto T, Karonitsch T. The immunobiology of mTOR in autoimmunity. J Autoimmun. 2020;110: 102373.","journal-title":"J Autoimmun"},{"issue":"12","key":"1185_CR23","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.2217\/imt.14.84","volume":"6","author":"NM Chapman","year":"2014","unstructured":"Chapman NM, Chi H. mTOR signaling, Tregs and immune modulation. Immunotherapy. 2014;6(12):1295\u2013311.","journal-title":"Immunotherapy"},{"issue":"14","key":"1185_CR24","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1182\/blood-2014-11-610857","volume":"125","author":"E Pasquier","year":"2015","unstructured":"Pasquier E, de Saint ML, Bohec C, Chauleur C, Bretelle F, Marhic G, et al. Enoxaparin for prevention of unexplained recurrent miscarriage: a multicenter randomized double-blind placebo-controlled trial. Blood. 2015;125(14):2200\u20135.","journal-title":"Blood"},{"issue":"3","key":"1185_CR25","first-page":"50","volume":"7","author":"R Shen","year":"2018","unstructured":"Shen R, Wang JH. The effect of icariin on immunity and its potential application. Am J Clin Exp Immunol. 2018;7(3):50\u20136.","journal-title":"Am J Clin Exp Immunol"},{"issue":"1","key":"1185_CR26","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cell.2019.11.026","volume":"180","author":"JY Lee","year":"2020","unstructured":"Lee JY, Hall JA, Kroehling L, Wu L, Najar T, Nguyen HH, et al. Serum amyloid a proteins induce pathogenic Th17 cells and promote inflammatory disease. Cell. 2020;180(1):79-91 e16.","journal-title":"Cell"},{"key":"1185_CR27","doi-asserted-by":"crossref","unstructured":"Liang P, Peng S, Zhang M, Ma Y, Zhen X, Li H. Huai Qi Huang corrects the balance of Th1\/Th2 and Treg\/Th17 in an ovalbumin-induced asthma mouse model. Biosci Rep. 2017;37(6):BSR20171071.","DOI":"10.1042\/BSR20171071"},{"key":"1185_CR28","volume":"151","author":"Z Bi","year":"2022","unstructured":"Bi Z, Zhang W, Yan X. Anti-inflammatory and immunoregulatory effects of icariin and icaritin. Biomed Pharmacother. 2022;151: 113180.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"1185_CR29","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1080\/21655979.2021.1943602","volume":"12","author":"Y Tang","year":"2021","unstructured":"Tang Y, Li Y, Xin D, Chen L, Xiong Z, Yu X. Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K\/AKT\/mTOR signaling. Bioengineered. 2021;12(1):2984\u201399.","journal-title":"Bioengineered"},{"issue":"2","key":"1185_CR30","volume":"22","author":"H Chen","year":"2022","unstructured":"Chen H, Song L, Xu X, Han Z, Peng F, Zhang Q, et al. The effect of icariin on autoimmune premature ovarian insufficiency via modulation of Nrf2\/HO-1\/Sirt1 pathway in mice. Reprod Biol. 2022;22(2): 100638.","journal-title":"Reprod Biol"},{"key":"1185_CR31","volume":"876","author":"X Sun","year":"2020","unstructured":"Sun X, Cheng H, Liu B, Du Y, Dong J, Huang J. Icariin reduces LPS-induced acute lung injury in mice undergoing bilateral adrenalectomy by regulating GRalpha. Eur J Pharmacol. 2020;876: 173032.","journal-title":"Eur J Pharmacol"},{"key":"1185_CR32","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.theriogenology.2018.10.028","volume":"125","author":"JL Wang","year":"2019","unstructured":"Wang JL, Liu B, Zhang C, Wang XM, Zhen D, Huang XM, et al. Effects of icariin on ovarian function in d-galactose-induced aging mice. Theriogenology. 2019;125:157\u201367.","journal-title":"Theriogenology"},{"issue":"2","key":"1185_CR33","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.pbb.2011.01.008","volume":"98","author":"J Wu","year":"2011","unstructured":"Wu J, Du J, Xu C, Le J, Xu Y, Liu B, et al. Icariin attenuates social defeat-induced down-regulation of glucocorticoid receptor in mice. Pharmacol Biochem Behav. 2011;98(2):273\u20138.","journal-title":"Pharmacol Biochem Behav"},{"issue":"5","key":"1185_CR34","doi-asserted-by":"crossref","first-page":"7398","DOI":"10.3892\/mmr.2017.7513","volume":"16","author":"W Zhang","year":"2017","unstructured":"Zhang W, Yuan W, Xu N, Li J, Chang W. Icariin improves acute kidney injury and proteinuria in a rat model of pregnancyinduced hypertension. Mol Med Rep. 2017;16(5):7398\u2013404.","journal-title":"Mol Med Rep"},{"key":"1185_CR35","doi-asserted-by":"crossref","first-page":"103075","DOI":"10.1016\/j.jri.2019.103075","volume":"137","author":"J Wang","year":"2020","unstructured":"Wang J, Liu C, Que W, Fujino M, Tong G, Yan H, et al. Immunomodulatory effects of Salvianolic acid B in a spontaneous abortion mouse model. J Reprod Immunol. 2020;137:103075.","journal-title":"J Reprod Immunol"},{"key":"1185_CR36","doi-asserted-by":"crossref","DOI":"10.1016\/j.aanat.2020.151508","volume":"230","author":"MS Hosseini","year":"2020","unstructured":"Hosseini MS, Ali-Hassanzadeh M, Nadimi E, Karbalay-Doust S, Noorafshan A, Gharesi-Fard B. Stereological study of the placental structure in abortion-prone mice model (CBA\/JxDBA\/2J). Ann Anat. 2020;230: 151508.","journal-title":"Ann Anat"},{"key":"1185_CR37","doi-asserted-by":"crossref","unstructured":"Ander SE, Diamond MS, Coyne CB. Immune responses at the maternal-fetal interface. Sci Immunol. 2019;4(31):eaat6114.","DOI":"10.1126\/sciimmunol.aat6114"},{"key":"1185_CR38","volume":"131","author":"M Wang","year":"2020","unstructured":"Wang M, Gao H, Li W, Wu B. Icariin and its metabolites regulate lipid metabolism: from effects to molecular mechanisms. Biomed Pharmacother. 2020;131: 110675.","journal-title":"Biomed Pharmacother"},{"key":"1185_CR39","doi-asserted-by":"crossref","first-page":"2704532","DOI":"10.1155\/2017\/2704532","volume":"2017","author":"R Ye","year":"2017","unstructured":"Ye R, Xu S, Liu Y, Pang L, Lian X, Zhong Y, et al. Protective effect of icariin on the development of preimplantation mouse embryos against hydrogen peroxide-induced oxidative injury. Oxid Med Cell Longev. 2017;2017:2704532.","journal-title":"Oxid Med Cell Longev"},{"issue":"12","key":"1185_CR40","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1080\/09513590802288275","volume":"24","author":"J Calleja-Agius","year":"2008","unstructured":"Calleja-Agius J, Brincat MP. Recurrent miscarriages: what is the role of cytokines? Gynecol Endocrinol. 2008;24(12):663\u20138.","journal-title":"Gynecol Endocrinol"},{"issue":"5","key":"1185_CR41","doi-asserted-by":"crossref","first-page":"R153","DOI":"10.1530\/REP-13-0583","volume":"147","author":"EA Bonney","year":"2014","unstructured":"Bonney EA, Brown SA. To drive or be driven: the path of a mouse model of recurrent pregnancy loss. Reproduction. 2014;147(5):R153\u201367.","journal-title":"Reproduction"},{"key":"1185_CR42","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1477-7827-12-74","volume":"12","author":"L Wu","year":"2014","unstructured":"Wu L, Luo LH, Zhang YX, Li Q, Xu B, Zhou GX, et al. Alteration of Th17 and Treg cells in patients with unexplained recurrent spontaneous abortion before and after lymphocyte immunization therapy. Reprod Biol Endocrinol. 2014;12:74.","journal-title":"Reprod Biol Endocrinol"},{"issue":"9\u201310","key":"1185_CR43","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.cca.2011.01.002","volume":"412","author":"V Saini","year":"2011","unstructured":"Saini V, Arora S, Yadav A, Bhattacharjee J. Cytokines in recurrent pregnancy loss. Clin Chim Acta. 2011;412(9\u201310):702\u20138.","journal-title":"Clin Chim Acta"},{"issue":"3","key":"1185_CR44","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.clim.2009.08.009","volume":"133","author":"LP Jin","year":"2009","unstructured":"Jin LP, Chen QY, Zhang T, Guo PF, Li DJ. The CD4+CD25 bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage. Clin Immunol. 2009;133(3):402\u201310.","journal-title":"Clin Immunol"},{"issue":"2","key":"1185_CR45","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1159\/000491905","volume":"48","author":"J Jin","year":"2018","unstructured":"Jin J, Hu K, Ye M, Wu D, He Q. Rapamycin reduces podocyte apoptosis and is involved in autophagy and mTOR\/ P70S6K\/4EBP1 signaling. Cell Physiol Biochem. 2018;48(2):765\u201372.","journal-title":"Cell Physiol Biochem"},{"issue":"1","key":"1185_CR46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20110892","volume":"441","author":"B Magnuson","year":"2012","unstructured":"Magnuson B, Ekim B, Fingar DC. Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem J. 2012;441(1):1\u201321.","journal-title":"Biochem J"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-023-01185-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-023-01185-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-023-01185-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:31:45Z","timestamp":1729038705000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-023-01185-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,8]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["1185"],"URL":"https:\/\/doi.org\/10.1007\/s43032-023-01185-0","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,8]]},"assertion":[{"value":"3 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants performed by any of the authors. All the animal experiments in this study were performed in accordance with the guidelines of the Chinese Animal Care Committee and were approved by the Institutional Animal Care and Treatment Committee of Chengdu University of Traditional Chinese Medicine.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}