{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T14:59:03Z","timestamp":1768834743066,"version":"3.49.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["1 R03 HD101893-o1"],"award-info":[{"award-number":["1 R03 HD101893-o1"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["U10HD077680"],"award-info":[{"award-number":["U10HD077680"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s43032-023-01197-w","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T17:02:38Z","timestamp":1677085358000},"page":"2495-2502","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Highly Atherogenic Lipid Particles are Associated with Preeclampsia After Successful Fertility Treatment for Obese Women who have Unexplained Infertility"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1298-265X","authenticated-orcid":false,"given":"R. A.","family":"Wild","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. K.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. R.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. S.","family":"Wrenn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"issue":"4","key":"1197_CR1","first-page":"e38","volume":"133","author":"D Mozaffarian","year":"2016","unstructured":"Mozaffarian D, et al. Heart disease and stroke statistics-2016 update: a report from the American Heart Association. Circulation. 2016;133(4):e38\u2013360.","journal-title":"Circulation."},{"issue":"23","key":"1197_CR2","doi-asserted-by":"publisher","first-page":"e884","DOI":"10.1161\/CIR.0000000000000772","volume":"141","author":"LS Mehta","year":"2020","unstructured":"Mehta LS, et al. Cardiovascular considerations in caring for pregnant patients: a scientific statement from the American Heart Association. Circulation. 2020;141(23):e884\u2013903.","journal-title":"Circulation."},{"key":"1197_CR3","doi-asserted-by":"publisher","first-page":"l2381","DOI":"10.1136\/bmj.l2381","volume":"366","author":"GJ Burton","year":"2019","unstructured":"Burton GJ, et al. Pre-eclampsia: pathophysiology and clinical implications. BMJ. 2019;366:l2381.","journal-title":"BMJ."},{"issue":"4","key":"1197_CR4","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1093\/aje\/kwu145","volume":"180","author":"CN Spracklen","year":"2014","unstructured":"Spracklen CN, et al. Maternal hyperlipidemia and the risk of preeclampsia: a meta-analysis. Am J Epidemiol. 2014;180(4):346\u201358.","journal-title":"Am J Epidemiol."},{"issue":"11","key":"1197_CR5","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1111\/1471-0528.12375","volume":"120","author":"ID Gallos","year":"2013","unstructured":"Gallos ID, et al. Pre-eclampsia is associated with, and preceded by, hypertriglyceridaemia: a meta-analysis. BJOG. 2013;120(11):1321\u201332.","journal-title":"BJOG."},{"issue":"1","key":"1197_CR6","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1055\/s-2007-1016255","volume":"16","author":"CA Hubel","year":"1998","unstructured":"Hubel CA. Dyslipidemia, iron, and oxidative stress in preeclampsia: assessment of maternal and feto-placental interactions. Semin Reprod Endocrinol. 1998;16(1):75\u201392.","journal-title":"Semin Reprod Endocrinol."},{"issue":"10","key":"1197_CR7","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1016\/S0026-0495(98)90337-7","volume":"47","author":"CA Hubel","year":"1998","unstructured":"Hubel CA, et al. Small low-density lipoproteins and vascular cell adhesion molecule-1 are increased in association with hyperlipidemia in preeclampsia. Metabolism. 1998;47(10):1281\u20138.","journal-title":"Metabolism."},{"issue":"1","key":"1197_CR8","doi-asserted-by":"publisher","first-page":"R5","DOI":"10.1152\/ajpregu.00440.2016","volume":"312","author":"FT Spradley","year":"2017","unstructured":"Spradley FT. Metabolic abnormalities and obesity's impact on the risk for developing preeclampsia. Am J Physiol Regul Integr Comp Physiol. 2017;312(1):R5\u2013r12.","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"issue":"4","key":"1197_CR9","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s13679-016-0233-8","volume":"5","author":"EH Zobel","year":"2016","unstructured":"Zobel EH, et al. Global changes in food supply and the obesity epidemic. Curr Obes Rep. 2016;5(4):449\u201355.","journal-title":"Curr Obes Rep."},{"issue":"5","key":"1197_CR10","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1001\/jama.2020.21096","volume":"325","author":"SM Ogunwole","year":"2021","unstructured":"Ogunwole SM, Zera CA, Stanford FC. Obesity management in women of reproductive age. JAMA. 2021;325(5):433\u20134.","journal-title":"JAMA."},{"issue":"1","key":"1197_CR11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/MOL.0000000000000375","volume":"28","author":"E Bj\u00f6rnson","year":"2017","unstructured":"Bj\u00f6rnson E, et al. Kinetics of plasma triglycerides in abdominal obesity. Curr Opin Lipidol. 2017;28(1):11\u20138.","journal-title":"Curr Opin Lipidol."},{"issue":"1","key":"1197_CR12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1515\/hmbci-2015-0023","volume":"24","author":"D Best","year":"2015","unstructured":"Best D, Bhattacharya S. Obesity and fertility. Horm Mol Biol Clin Investig. 2015;24(1):5\u201310.","journal-title":"Horm Mol Biol Clin Investig."},{"issue":"1","key":"1197_CR13","doi-asserted-by":"publisher","first-page":"e1003883","DOI":"10.1371\/journal.pmed.1003883","volume":"19","author":"RS Legro","year":"2022","unstructured":"Legro RS, et al. Effects of preconception lifestyle intervention in infertile women with obesity: the FIT-PLESE randomized controlled trial. PLoS Med. 2022;19(1):e1003883.","journal-title":"PLoS Med."},{"issue":"11","key":"1197_CR14","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1016\/j.metabol.2005.05.017","volume":"54","author":"E Llurba","year":"2005","unstructured":"Llurba E, et al. Atherogenic lipoprotein subfraction profile in preeclamptic women with and without high triglycerides: different pathophysiologic subsets in preeclampsia. Metabolism. 2005;54(11):1504\u20139.","journal-title":"Metabolism."},{"issue":"2","key":"1197_CR15","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.metabol.2009.07.027","volume":"59","author":"SJ Kim-Dorner","year":"2010","unstructured":"Kim-Dorner SJ, et al. Should triglycerides and the triglycerides to high-density lipoprotein cholesterol ratio be used as surrogates for insulin resistance? Metabolism. 2010;59(2):299\u2013304.","journal-title":"Metabolism."},{"issue":"2","key":"1197_CR16","doi-asserted-by":"publisher","first-page":"475","DOI":"10.4314\/ahs.v22i2.55","volume":"22","author":"U Salma","year":"2022","unstructured":"Salma U. Relationship of serum lipid profiles in preeclampsia and normal pregnancy. Bangladesh. Afr Health Sci. 2022;22(2):475\u20139.","journal-title":"Bangladesh. Afr Health Sci."},{"issue":"12","key":"1197_CR17","doi-asserted-by":"publisher","first-page":"e0243538","DOI":"10.1371\/journal.pone.0243538","volume":"15","author":"E Tesfa","year":"2020","unstructured":"Tesfa E, Nibret E, Munshea A. Maternal lipid profile and risk of pre-eclampsia in African pregnant women: a systematic review and meta-analysis. PLoS One. 2020;15(12):e0243538.","journal-title":"PLoS One."},{"issue":"8858","key":"1197_CR18","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1016\/0140-6736(93)90889-O","volume":"341","author":"JM Roberts","year":"1993","unstructured":"Roberts JM, Redman CW. Pre-eclampsia: more than pregnancy-induced hypertension. Lancet. 1993;341(8858):1447\u201351.","journal-title":"Lancet."},{"issue":"5","key":"1197_CR19","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1016\/0002-9378(89)90665-0","volume":"161","author":"JM Roberts","year":"1989","unstructured":"Roberts JM, et al. Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol. 1989;161(5):1200\u20134.","journal-title":"Am J Obstet Gynecol."},{"issue":"1","key":"1197_CR20","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1046\/j.1365-2796.2000.00698.x","volume":"248","author":"J Hulthe","year":"2000","unstructured":"Hulthe J, et al. LDL particle size in relation to intima-media thickness and plaque occurrence in the carotid and femoral arteries in patients with hypercholesterolaemia. J Intern Med. 2000;248(1):42\u201352.","journal-title":"J Intern Med."},{"issue":"5","key":"1197_CR21","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1161\/01.ATV.0000063385.12476.A7","volume":"23","author":"S Wolfrum","year":"2003","unstructured":"Wolfrum S, Jensen KS, Liao JK. Endothelium-dependent effects of statins. Arterioscler Thromb Vasc Biol. 2003;23(5):729\u201336.","journal-title":"Arterioscler Thromb Vasc Biol."},{"issue":"9","key":"1197_CR22","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1096\/fasebj.3.9.2545495","volume":"3","author":"RF Furchgott","year":"1989","unstructured":"Furchgott RF, Vanhoutte PM. Endothelium-derived relaxing and contracting factors. Faseb J. 1989;3(9):2007\u201318.","journal-title":"Faseb J."},{"issue":"11","key":"1197_CR23","first-page":"41","volume":"23","author":"SR Salafia Carolyn","year":"2022","unstructured":"Salafia Carolyn SR, Thomas T, Paneth N, Abela G, Wild RA. Pregnancy-induced hypertension: the potential role of cholesterol crystals in the maternal decidua. J Clin Lipidol. 2022;23(11):41.","journal-title":"J Clin Lipidol."},{"issue":"1","key":"1197_CR24","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3109\/10641955.2015.1115060","volume":"35","author":"NI El Khouly","year":"2016","unstructured":"El Khouly NI, et al. Value of first-trimester serum lipid profile in early prediction of preeclampsia and its severity: a prospective cohort study. Hypertens Pregnancy. 2016;35(1):73\u201381.","journal-title":"Hypertens Pregnancy."},{"issue":"2","key":"1197_CR25","doi-asserted-by":"publisher","first-page":"150.e1","DOI":"10.1016\/j.ajog.2019.03.025","volume":"221","author":"MC Adank","year":"2019","unstructured":"Adank MC, et al. Is maternal lipid profile in early pregnancy associated with pregnancy complications and blood pressure in pregnancy and long term postpartum? Am J Obstet Gynecol. 2019;221(2):150.e1\u2013150.e13.","journal-title":"Am J Obstet Gynecol."},{"key":"1197_CR26","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.clinbiochem.2020.05.003","volume":"81","author":"D Ardali\u0107","year":"2020","unstructured":"Ardali\u0107 D, et al. Lipid profile and lipid oxidative modification parameters in the first trimester of high- risk pregnancies - possibilities for preeclampsia prediction. Clin Biochem. 2020;81:34\u201340.","journal-title":"Clin Biochem."},{"issue":"7893","key":"1197_CR27","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/s41586-021-04249-w","volume":"601","author":"M Rasmussen","year":"2022","unstructured":"Rasmussen M, et al. RNA profiles reveal signatures of future health and disease in pregnancy. Nature. 2022;601(7893):422\u20137.","journal-title":"Nature."},{"issue":"3","key":"1197_CR28","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1001\/jamacardio.2021.5617","volume":"7","author":"A Hauspurg","year":"2022","unstructured":"Hauspurg A, et al. Association of N-terminal pro-brain natriuretic peptide concentration in early pregnancy with development of hypertensive disorders of pregnancy and future hypertension. JAMA Cardiol. 2022;7(3):268\u201376.","journal-title":"JAMA Cardiol."}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-023-01197-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-023-01197-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-023-01197-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T12:48:33Z","timestamp":1701953313000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-023-01197-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,22]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["1197"],"URL":"https:\/\/doi.org\/10.1007\/s43032-023-01197-w","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,22]]},"assertion":[{"value":"19 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"IRB approval obtained from the University of Oklahoma","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"For all authors, yes.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"For all authors, yes.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"None related to this manuscript. Dr. Wren was the Clinical Director of Quest laboratories at the time of the lipoprotein analysis.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}