{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T02:17:18Z","timestamp":1779934638323,"version":"3.53.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100015401","name":"Shaanxi Province Key R&D Program","doi-asserted-by":"crossref","award":["2020SF-046"],"award-info":[{"award-number":["2020SF-046"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s43032-023-01206-y","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T15:03:04Z","timestamp":1678892584000},"page":"2623-2633","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Protective Effect of Akkermansia muciniphila on the Preeclampsia-Like Mouse Model"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7953-0340","authenticated-orcid":false,"given":"Wei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanni","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuemin","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"1206_CR1","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/s0140-6736(20)32335-7","volume":"398","author":"LC Chappell","year":"2021","unstructured":"Chappell LC, Cluver CA, Kingdom J, Tong S. Pre-eclampsia. Lancet. 2021;398:341\u201354. https:\/\/doi.org\/10.1016\/s0140-6736(20)32335-7.","journal-title":"Lancet."},{"issue":"Suppl 1","key":"1206_CR2","doi-asserted-by":"publisher","first-page":"S18","DOI":"10.1111\/nure.12055","volume":"71","author":"A Jeyabalan","year":"2013","unstructured":"Jeyabalan A. Epidemiology of preeclampsia: impact of obesity. Nutr Rev. 2013;71(Suppl 1):S18\u201325. https:\/\/doi.org\/10.1111\/nure.12055.","journal-title":"Nutr. Rev."},{"key":"1206_CR3","doi-asserted-by":"publisher","first-page":"605","DOI":"10.2471\/blt.13.127464","volume":"92","author":"S Saleem","year":"2014","unstructured":"Saleem S, McClure EM, Goudar SS, et al. A prospective study of maternal, fetal and neonatal deaths in low- and middle-income countries. Bull World Health Organ. 2014;92:605\u201312. https:\/\/doi.org\/10.2471\/blt.13.127464.","journal-title":"Bull. World. Health. Organ."},{"key":"1206_CR4","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1053\/j.semperi.2009.02.010","volume":"33","author":"L Duley","year":"2009","unstructured":"Duley L. The global impact of pre-eclampsia and eclampsia. Semin Perinatol. 2009;33:130\u20137. https:\/\/doi.org\/10.1053\/j.semperi.2009.02.010.","journal-title":"Semin. Perinatol."},{"key":"1206_CR5","doi-asserted-by":"publisher","first-page":"94","DOI":"10.2174\/1874091x01408010094","volume":"8","author":"A Rafeeinia","year":"2014","unstructured":"Rafeeinia A, Tabandeh A, Khajeniazi S, Marjani A. Metabolic syndrome in preeclampsia women in gorgan. Open Biochem J. 2014;8:94\u20139. https:\/\/doi.org\/10.2174\/1874091x01408010094.","journal-title":"Open. Biochem. J."},{"key":"1206_CR6","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.earlhumdev.2017.09.010","volume":"114","author":"L Story","year":"2017","unstructured":"Story L, Chappell LC. Preterm pre-eclampsia: What every neonatologist should know. Early Hum Dev. 2017;114:26\u201330. https:\/\/doi.org\/10.1016\/j.earlhumdev.2017.09.010.","journal-title":"Early. Hum. Dev."},{"key":"1206_CR7","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1136\/gutjnl-2019-319101","volume":"69","author":"X Chen","year":"2020","unstructured":"Chen X, Li P, Liu M, et al. Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation. Gut. 2020;69:513\u201322. https:\/\/doi.org\/10.1136\/gutjnl-2019-319101.","journal-title":"Gut."},{"key":"1206_CR8","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nature18846","volume":"535","author":"JL Sonnenburg","year":"2016","unstructured":"Sonnenburg JL, B\u00e4ckhed F. Diet-microbiota interactions as moderators of human metabolism. Nature. 2016;535:56\u201364. https:\/\/doi.org\/10.1038\/nature18846.","journal-title":"Nature."},{"key":"1206_CR9","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jnutbio.2018.10.003","volume":"63","author":"S Sharma","year":"2019","unstructured":"Sharma S, Tripathi P. Gut microbiome and type 2 diabetes: where we are and where to go? J Nutr Biochem. 2019;63:101\u20138. https:\/\/doi.org\/10.1016\/j.jnutbio.2018.10.003.","journal-title":"J. Nutr. Biochem."},{"key":"1206_CR10","doi-asserted-by":"publisher","first-page":"639","DOI":"10.3389\/fmicb.2018.00639","volume":"9","author":"C He","year":"2018","unstructured":"He C, Cheng D, Peng C, Li Y, Zhu Y, Lu N. High-Fat Diet Induces Dysbiosis of Gastric Microbiota Prior to Gut Microbiota in Association With Metabolic Disorders in Mice. Front Microbiol. 2018;9:639. https:\/\/doi.org\/10.3389\/fmicb.2018.00639.","journal-title":"Front. Microbiol."},{"key":"1206_CR11","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1161\/hypertensionaha.115.05315","volume":"65","author":"T Yang","year":"2015","unstructured":"Yang T, Santisteban MM, Rodriguez V, et al. Gut dysbiosis is linked to hypertension. Hypertension. 2015;65:1331\u201340. https:\/\/doi.org\/10.1161\/hypertensionaha.115.05315.","journal-title":"Hypertension."},{"key":"1206_CR12","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13568-018-0558-7","volume":"8","author":"Q Jiang","year":"2018","unstructured":"Jiang Q, He X, Zou Y, Ding Y, Li H, Chen H. Altered gut microbiome promotes proteinuria in mice induced by Adriamycin. AMB Express. 2018;8:31. https:\/\/doi.org\/10.1186\/s13568-018-0558-7.","journal-title":"AMB Express."},{"key":"1206_CR13","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1186\/s12866-021-02327-7","volume":"21","author":"L Huang","year":"2021","unstructured":"Huang L, Cai M, Li L, et al. Gut microbiota changes in preeclampsia, abnormal placental growth and healthy pregnant women. BMC Microbiol. 2021;21:265. https:\/\/doi.org\/10.1186\/s12866-021-02327-7.","journal-title":"BMC Microbiol."},{"key":"1206_CR14","doi-asserted-by":"publisher","first-page":"e14875","DOI":"10.14814\/phy2.14875","volume":"9","author":"JA Ishimwe","year":"2021","unstructured":"Ishimwe JA. Maternal microbiome in preeclampsia pathophysiology and implications on offspring health. Physiol Rep. 2021;9:e14875. https:\/\/doi.org\/10.14814\/phy2.14875.","journal-title":"Physiol. Rep."},{"key":"1206_CR15","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1099\/mic.0.000444","volume":"163","author":"WM de Vos","year":"2017","unstructured":"de Vos WM. Microbe Profile: Akkermansia muciniphila: a conserved intestinal symbiont that acts as the gatekeeper of our mucosa. Microbiology (Reading). 2017;163:646\u20138. https:\/\/doi.org\/10.1099\/mic.0.000444.","journal-title":"Microbiology (Reading)"},{"key":"1206_CR16","doi-asserted-by":"publisher","first-page":"e16876","DOI":"10.1371\/journal.pone.0016876","volume":"6","author":"MW van Passel","year":"2011","unstructured":"van Passel MW, Kant R, Zoetendal EG, et al. The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes. PLoS One. 2011;6:e16876. https:\/\/doi.org\/10.1371\/journal.pone.0016876.","journal-title":"PLoS One."},{"key":"1206_CR17","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3389\/fmicb.2020.00219","volume":"11","author":"Y Xu","year":"2020","unstructured":"Xu Y, Wang N, Tan HY, Li S, Zhang C, Feng Y. Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems. Front Microbiol. 2020;11:219. https:\/\/doi.org\/10.3389\/fmicb.2020.00219.","journal-title":"Front. Microbiol."},{"key":"1206_CR18","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1099\/ijs.0.02873-0","volume":"54","author":"M Derrien","year":"2004","unstructured":"Derrien M, Vaughan EE, Plugge CM, de Vos WM. Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. Int J Syst Evol Microbiol. 2004;54:1469\u201376. https:\/\/doi.org\/10.1099\/ijs.0.02873-0.","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"1206_CR19","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1007\/s00284-020-01992-7","volume":"77","author":"AV Ropot","year":"2020","unstructured":"Ropot AV, Karamzin AM, Sergeyev OV. Cultivation of the Next-Generation Probiotic Akkermansia muciniphila, Methods of Its Safe Delivery to the Intestine, and Factors Contributing to Its Growth In Vivo. Curr Microbiol. 2020;77:1363\u201372. https:\/\/doi.org\/10.1007\/s00284-020-01992-7.","journal-title":"Curr. Microbiol."},{"key":"1206_CR20","doi-asserted-by":"publisher","first-page":"681632","DOI":"10.3389\/fphys.2021.681632","volume":"12","author":"CA Waker","year":"2021","unstructured":"Waker CA, Kaufman MR, Brown TL. Current State of Preeclampsia Mouse Models: Approaches, Relevance, and Standardization. Front Physiol. 2021;12:681632. https:\/\/doi.org\/10.3389\/fphys.2021.681632.","journal-title":"Front. Physiol."},{"key":"1206_CR21","doi-asserted-by":"publisher","first-page":"149","DOI":"10.2144\/btn-2020-0153","volume":"70","author":"JP Shaffer","year":"2021","unstructured":"Shaffer JP, Marotz C, Belda-Ferre P, et al. A comparison of DNA\/RNA extraction protocols for high-throughput sequencing of microbial communities. Biotechniques. 2021;70:149\u201359. https:\/\/doi.org\/10.2144\/btn-2020-0153.","journal-title":"Biotechniques."},{"key":"1206_CR22","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1080\/1061186x.2022.2068558","volume":"30","author":"Y Liu","year":"2022","unstructured":"Liu Y, Zhang Q, Gao X, Wang T. Study on lipid nanomicelles targeting placenta for the treatment of preeclampsia. J Drug Target. 2022;30:894\u2013909. https:\/\/doi.org\/10.1080\/1061186x.2022.2068558.","journal-title":"J Drug. Target."},{"key":"1206_CR23","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.bbi.2010.12.017","volume":"25","author":"EY Hsiao","year":"2011","unstructured":"Hsiao EY, Patterson PH. Activation of the maternal immune system induces endocrine changes in the placenta via IL-6. Brain Behav Immun. 2011;25:604\u201315. https:\/\/doi.org\/10.1016\/j.bbi.2010.12.017.","journal-title":"Brain. Behav. Immun."},{"key":"1206_CR24","doi-asserted-by":"publisher","unstructured":"Couter CJ, Surana NK. Isolation and flow cytometric characterization of murine small intestinal lymphocytes. J Vis Exp.\u00a02016;(111):e54114. https:\/\/doi.org\/10.3791\/54114.","DOI":"10.3791\/54114"},{"key":"1206_CR25","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/978-1-4939-7030-8_6","volume":"2017","author":"Y Wang","year":"1614","unstructured":"Wang Y, Thatcher SE, Cassis LA. Measuring Blood Pressure Using a Noninvasive Tail Cuff Method in Mice. Methods Mol Biol. 1614;2017:69\u201373. https:\/\/doi.org\/10.1007\/978-1-4939-7030-8_6.","journal-title":"Methods. Mol. Biol."},{"key":"1206_CR26","doi-asserted-by":"publisher","first-page":"296.e1","DOI":"10.1016\/j.ajog.2020.08.103","volume":"224","author":"I Sterpu","year":"2021","unstructured":"Sterpu I, Fransson E, Hugerth LW, et al. No evidence for a placental microbiome in human pregnancies at term. Am J Obstet Gynecol. 2021;224:296.e1-296.e23. https:\/\/doi.org\/10.1016\/j.ajog.2020.08.103.","journal-title":"Am. J. Obstet. Gynecol."},{"key":"1206_CR27","doi-asserted-by":"publisher","first-page":"267.e1","DOI":"10.1016\/j.ajog.2018.10.018","volume":"220","author":"KR Theis","year":"2019","unstructured":"Theis KR, Romero R, Winters AD, et al. Does the human placenta delivered at term have a microbiota? Results of cultivation, quantitative real-time PCR, 16S rRNA gene sequencing, and metagenomics. Am J Obstet Gynecol. 2019;220:267.e1-267.e39. https:\/\/doi.org\/10.1016\/j.ajog.2018.10.018.","journal-title":"Am. J. Obstet. Gynecol."},{"key":"1206_CR28","doi-asserted-by":"publisher","unstructured":"Wang J, Zhang C, Guo C, Li X. Chitosan ameliorates DSS-induced ulcerative colitis mice by enhancing intestinal barrier function and improving microflora. Int J Mol Sci.\u00a02019;20:5751. https:\/\/doi.org\/10.3390\/ijms20225751.","DOI":"10.3390\/ijms20225751"},{"key":"1206_CR29","doi-asserted-by":"publisher","first-page":"110479","DOI":"10.1016\/j.ygeno.2022.110479","volume":"114","author":"J Yan","year":"2022","unstructured":"Yan J, Yu W, Lu C, et al. Orai2 deficiency attenutates experimental colitis by facilitating the colonization of Akkermansia muciniphila. Genomics. 2022;114:110479. https:\/\/doi.org\/10.1016\/j.ygeno.2022.110479.","journal-title":"Genomics."},{"key":"1206_CR30","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.3389\/fmicb.2017.01804","volume":"8","author":"W Wu","year":"2017","unstructured":"Wu W, Lv L, Shi D, et al. Protective Effect of Akkermansia muciniphila against Immune-Mediated Liver Injury in a Mouse Model. Front Microbiol. 2017;8:1804. https:\/\/doi.org\/10.3389\/fmicb.2017.01804.","journal-title":"Front. Microbiol."},{"key":"1206_CR31","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1203\/01.pdr.0000196332.37565.7d","volume":"59","author":"S Amu","year":"2006","unstructured":"Amu S, Hahn-Zoric M, Malik A, et al. Cytokines in the placenta of Pakistani newborns with and without intrauterine growth retardation. Pediatr Res. 2006;59:254\u20138. https:\/\/doi.org\/10.1203\/01.pdr.0000196332.37565.7d.","journal-title":"Pediatr. Res."},{"key":"1206_CR32","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.ijcard.2015.11.061","volume":"209","author":"U Kucuk","year":"2016","unstructured":"Kucuk U, Eyuboglu M, Kucuk HO, Degirmencioglu G. Importance of using proper post hoc test with ANOVA. Int J Cardiol. 2016;209:346. https:\/\/doi.org\/10.1016\/j.ijcard.2015.11.061.","journal-title":"Int. J. Cardiol."},{"key":"1206_CR33","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1037\/a0028087","volume":"17","author":"AJ Bishara","year":"2012","unstructured":"Bishara AJ, Hittner JB. Testing the significance of a correlation with nonnormal data: comparison of Pearson, Spearman, transformation, and resampling approaches. Psychol Methods. 2012;17:399\u2013417. https:\/\/doi.org\/10.1037\/a0028087.","journal-title":"Psychol. Methods."},{"key":"1206_CR34","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1097\/hjh.0000000000002596","volume":"39","author":"AA Khaire","year":"2021","unstructured":"Khaire AA, Thakar SR, Wagh GN, Joshi SR. Placental lipid metabolism in preeclampsia. J Hypertens. 2021;39:127\u201334. https:\/\/doi.org\/10.1097\/hjh.0000000000002596.","journal-title":"J. Hypertens."},{"key":"1206_CR35","doi-asserted-by":"publisher","first-page":"R805","DOI":"10.1152\/ajpregu.00239.2015","volume":"309","author":"NV DiPatrizio","year":"2015","unstructured":"DiPatrizio NV, Igarashi M, Narayanaswami V, et al. Fasting stimulates 2-AG biosynthesis in the small intestine: role of cholinergic pathways. Am J Physiol Regul Integr Comp Physiol. 2015;309:R805\u201313. https:\/\/doi.org\/10.1152\/ajpregu.00239.2015.","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"1206_CR36","doi-asserted-by":"publisher","first-page":"5106","DOI":"10.1002\/jcp.27315","volume":"234","author":"S Eghbal-Fard","year":"2019","unstructured":"Eghbal-Fard S, Yousefi M, Heydarlou H, et al. The imbalance of Th17\/Treg axis involved in the pathogenesis of preeclampsia. J Cell Physiol. 2019;234:5106\u201316. https:\/\/doi.org\/10.1002\/jcp.27315.","journal-title":"J. Cell. Physiol."},{"key":"1206_CR37","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/s41575-022-00631-9","volume":"19","author":"PD Cani","year":"2022","unstructured":"Cani PD, Depommier C, Derrien M, Everard A, de Vos WM. Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms. Nat Rev Gastroenterol Hepatol. 2022;19:625\u201337. https:\/\/doi.org\/10.1038\/s41575-022-00631-9.","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"1206_CR38","doi-asserted-by":"crossref","unstructured":"de Alwis N, Binder NK, Beard S, et al. The L-NAME mouse model of preeclampsia and impact to long-term maternal cardiovascular health. Life Sci Alliance. 2022;5(12):e202201517.","DOI":"10.26508\/lsa.202201517"},{"key":"1206_CR39","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1093\/ajh\/hpx130","volume":"31","author":"K Yoshikawa","year":"2017","unstructured":"Yoshikawa K, Umekawa T, Maki S, et al. Tadalafil Improves L-NG-Nitroarginine Methyl Ester-Induced Preeclampsia With Fetal Growth Restriction-Like Symptoms in Pregnant Mice. Am J Hypertens. 2017;31:89\u201396. https:\/\/doi.org\/10.1093\/ajh\/hpx130.","journal-title":"Am. J. Hypertens."},{"key":"1206_CR40","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.4103\/0366-6999.158322","volume":"128","author":"YW Han","year":"2015","unstructured":"Han YW, Yang Z, Ding XY, Yu H. Differences in Liver Injury and Trophoblastic Mitochondrial Damage in Different Preeclampsia-like Mouse Models. Chin Med J (Engl). 2015;128:1627\u201335. https:\/\/doi.org\/10.4103\/0366-6999.158322.","journal-title":"Chin. Med. J. (Engl)"},{"key":"1206_CR41","doi-asserted-by":"publisher","unstructured":"Markovic S, Roussel T, Neeman M, Frydman L. Deuterium magnetic resonance imaging and the discrimination of fetoplacental metabolism in normal and L-NAME-induced preeclamptic mice. Metabolites. 2021;11:376. https:\/\/doi.org\/10.3390\/metabo11060376.","DOI":"10.3390\/metabo11060376"},{"key":"1206_CR42","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1038\/s41598-020-80643-0","volume":"11","author":"T Kawamura","year":"2021","unstructured":"Kawamura T, Tanaka H, Tachibana R, et al. Maternal tadalafil therapy for fetal growth restriction prevents non-alcoholic fatty liver disease and adipocyte hypertrophy in the offspring. Sci Rep. 2021;11:1186. https:\/\/doi.org\/10.1038\/s41598-020-80643-0.","journal-title":"Sci. Rep."},{"key":"1206_CR43","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s11095-019-2745-x","volume":"37","author":"A Al Shoyaib","year":"2019","unstructured":"Al Shoyaib A, Archie SR, Karamyan VT. Intraperitoneal Route of Drug Administration: Should it Be Used in Experimental Animal Studies? Pharm Res. 2019;37:12. https:\/\/doi.org\/10.1007\/s11095-019-2745-x.","journal-title":"Pharm. Res."},{"key":"1206_CR44","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3389\/fcimb.2019.00224","volume":"9","author":"LJ Lv","year":"2019","unstructured":"Lv LJ, Li SH, Li SC, et al. Early-Onset Preeclampsia Is Associated With Gut Microbial Alterations in Antepartum and Postpartum Women. Front Cell Infect Microbiol. 2019;9:224. https:\/\/doi.org\/10.3389\/fcimb.2019.00224.","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"1206_CR45","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1161\/circresaha.122.320771","volume":"131","author":"J Jin","year":"2022","unstructured":"Jin J, Gao L, Zou X, et al. Gut Dysbiosis Promotes Preeclampsia by Regulating Macrophages and Trophoblasts. Circ Res. 2022;131:492\u2013506. https:\/\/doi.org\/10.1161\/circresaha.122.320771.","journal-title":"Circ. Res."},{"key":"1206_CR46","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.jcmgh.2022.05.015","volume":"14","author":"H Cuddihey","year":"2022","unstructured":"Cuddihey H, MacNaughton WK, Sharkey KA. Role of the Endocannabinoid System in the Regulation of Intestinal Homeostasis. Cell Mol Gastroenterol Hepatol. 2022;14:947\u201363. https:\/\/doi.org\/10.1016\/j.jcmgh.2022.05.015.","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"1206_CR47","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1124\/jpet.110.168237","volume":"335","author":"A Alhamoruni","year":"2010","unstructured":"Alhamoruni A, Lee AC, Wright KL, Larvin M, O\u2019Sullivan SE. Pharmacological effects of cannabinoids on the Caco-2 cell culture model of intestinal permeability. J Pharmacol Exp Ther. 2010;335:92\u2013102. https:\/\/doi.org\/10.1124\/jpet.110.168237.","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"1206_CR48","doi-asserted-by":"publisher","first-page":"5005","DOI":"10.1073\/pnas.1612177114","volume":"114","author":"N Acharya","year":"2017","unstructured":"Acharya N, Penukonda S, Shcheglova T, Hagymasi AT, Basu S, Srivastava PK. Endocannabinoid system acts as a regulator of immune homeostasis in the gut. Proc Natl Acad Sci\u00a0USA. 2017;114:5005\u201310. https:\/\/doi.org\/10.1073\/pnas.1612177114.","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"1206_CR49","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1007\/s00251-006-0138-x","volume":"58","author":"D Ziring","year":"2006","unstructured":"Ziring D, Wei B, Velazquez P, Schrage M, Buckley NE, Braun J. Formation of B and T cell subsets require the cannabinoid receptor CB2. Immunogenetics. 2006;58:714\u201325. https:\/\/doi.org\/10.1007\/s00251-006-0138-x.","journal-title":"Immunogenetics."},{"key":"1206_CR50","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/nri2660","volume":"9","author":"CT Weaver","year":"2009","unstructured":"Weaver CT, Hatton RD. Interplay between the TH17 and TReg cell lineages: a (co-)evolutionary perspective. Nat Rev Immunol. 2009;9:883\u20139. https:\/\/doi.org\/10.1038\/nri2660.","journal-title":"Nat. Rev. Immunol."},{"key":"1206_CR51","doi-asserted-by":"publisher","first-page":"3317","DOI":"10.2147\/copd.S337181","volume":"16","author":"Y Wang","year":"2021","unstructured":"Wang Y, Li N, Li Q, et al. Xuanbai Chengqi Decoction Ameliorates Pulmonary Inflammation via Reshaping Gut Microbiota and Rectifying Th17\/Treg Imbalance in a Murine Model of Chronic Obstructive Pulmonary Disease. Int J Chron Obstruct Pulmon Dis. 2021;16:3317\u201335. https:\/\/doi.org\/10.2147\/copd.S337181.","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"1206_CR52","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.2337\/db14-1916","volume":"64","author":"DE Roopchand","year":"2015","unstructured":"Roopchand DE, Carmody RN, Kuhn P, et al. Dietary Polyphenols Promote Growth of the Gut Bacterium Akkermansia muciniphila and Attenuate High-Fat Diet-Induced Metabolic Syndrome. Diabetes. 2015;64:2847\u201358. https:\/\/doi.org\/10.2337\/db14-1916.","journal-title":"Diabetes."},{"key":"1206_CR53","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1038\/s41386-019-0437-1","volume":"44","author":"Y Yang","year":"2019","unstructured":"Yang Y, Zhong Z, Wang B, et al. Early-life high-fat diet-induced obesity programs hippocampal development and cognitive functions via regulation of gut commensal Akkermansia muciniphila. Neuropsychopharmacology. 2019;44:2054\u201364. https:\/\/doi.org\/10.1038\/s41386-019-0437-1.","journal-title":"Neuropsychopharmacology."},{"key":"1206_CR54","doi-asserted-by":"publisher","first-page":"2216","DOI":"10.1039\/d1fo04094d","volume":"13","author":"K Qian","year":"2022","unstructured":"Qian K, Chen S, Wang J, Sheng K, Wang Y, Zhang M. A \u03b2-N-acetylhexosaminidase Amuc_2109 from Akkermansia muciniphila protects against dextran sulfate sodium-induced colitis in mice by enhancing intestinal barrier and modulating gut microbiota. Food Funct. 2022;13:2216\u201327. https:\/\/doi.org\/10.1039\/d1fo04094d.","journal-title":"Food. Funct."},{"key":"1206_CR55","doi-asserted-by":"publisher","first-page":"e22834","DOI":"10.1002\/jcla.22834","volume":"33","author":"R Aggarwal","year":"2019","unstructured":"Aggarwal R, Jain AK, Mittal P, Kohli M, Jawanjal P, Rath G. Association of pro- and anti-inflammatory cytokines in preeclampsia. J Clin Lab Anal. 2019;33:e22834. https:\/\/doi.org\/10.1002\/jcla.22834.","journal-title":"J. Clin. Lab. Anal."},{"key":"1206_CR56","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.placenta.2011.03.010","volume":"32","author":"FP McCarthy","year":"2011","unstructured":"McCarthy FP, Kingdom JC, Kenny LC, Walsh SK. Animal models of preeclampsia; uses and limitations. Placenta. 2011;32:413\u20139. https:\/\/doi.org\/10.1016\/j.placenta.2011.03.010.","journal-title":"Placenta."}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-023-01206-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-023-01206-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-023-01206-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T15:14:05Z","timestamp":1694618045000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-023-01206-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,15]]},"references-count":56,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["1206"],"URL":"https:\/\/doi.org\/10.1007\/s43032-023-01206-y","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,15]]},"assertion":[{"value":"7 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Procedures of animal experiments in this study were approved by the Second Affiliated Hospital of Xi\u2019an Jiaotong University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}