{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:01:59Z","timestamp":1769824919005,"version":"3.49.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171629"],"award-info":[{"award-number":["82171629"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017964","name":"Tianjin Municipal Health Commission","doi-asserted-by":"publisher","award":["ZC20005"],"award-info":[{"award-number":["ZC20005"]}],"id":[{"id":"10.13039\/100017964","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s43032-023-01214-y","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T17:11:26Z","timestamp":1679418686000},"page":"2758-2766","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Excessively Increased Skeletal Muscle Mass of the Bilateral Lower Limbs is Associated with Hyperuricemia in Females with Polycystic Ovarian Syndrome"],"prefix":"10.1007","volume":"30","author":[{"given":"Xiaoyan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5013-7142","authenticated-orcid":false,"given":"Huiying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"issue":"6","key":"1214_CR1","doi-asserted-by":"publisher","first-page":"e157","DOI":"10.1097\/AOG.0000000000002656","volume":"131","author":"ACOG Practice bulletin no","year":"2018","unstructured":"ACOG Practice bulletin no. 194: polycystic ovary syndrome. Obstet Gynecol. 2018;131(6):e157\u201371.","journal-title":"Obstet Gynecol"},{"issue":"1","key":"1214_CR2","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.fertnstert.2016.05.003","volume":"106","author":"D Lizneva","year":"2016","unstructured":"Lizneva D, et al. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil Steril. 2016;106(1):6\u201315.","journal-title":"Fertil Steril"},{"key":"1214_CR3","doi-asserted-by":"publisher","unstructured":"Wawrzkiewicz-Ja\u0142owiecka A,\u00a0Kowalczyk K, Trybek P, Jarosz T, Radosz P, Setlak M,\u00a0et al. In search of new therapeutics\u2014molecular aspects of the PCOS pathophysiology: genetics, hormones, metabolism and beyond. Int J Mol Sci. 2020;21(19):7054. https:\/\/doi.org\/10.3390\/ijms21197054.","DOI":"10.3390\/ijms21197054"},{"issue":"9711","key":"1214_CR4","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/S0140-6736(09)60883-7","volume":"375","author":"P Richette","year":"2010","unstructured":"Richette P, Bardin T. Gout. Lancet. 2010;375(9711):318\u201328.","journal-title":"Lancet"},{"issue":"8","key":"1214_CR5","first-page":"1260","volume":"56","author":"S Kuriyama","year":"2014","unstructured":"Kuriyama S, et al. Relationship between serum uric acid levels and muscle strength\/volume: a new insight from a large-scale survey. Nihon Jinzo Gakkai Shi. 2014;56(8):1260\u20139.","journal-title":"Nihon Jinzo Gakkai Shi"},{"issue":"8","key":"1214_CR6","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.1016\/j.bbadis.2018.05.003","volume":"1864","author":"MG Battelli","year":"2018","unstructured":"Battelli MG, et al. The role of xanthine oxidoreductase and uric acid in metabolic syndrome. Biochim Biophys Acta Mol Basis Dis. 2018;1864(8):2557\u201365.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"1","key":"1214_CR7","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s12958-018-0419-x","volume":"16","author":"L Mu","year":"2018","unstructured":"Mu L, et al. Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome. Reprod Biol Endocrinol. 2018;16(1):104.","journal-title":"Reprod Biol Endocrinol"},{"issue":"1","key":"1214_CR8","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12958-021-00748-7","volume":"19","author":"J Hu","year":"2021","unstructured":"Hu J, et al. Uric acid participating in female reproductive disorders: a review. Reprod Biol Endocrinol. 2021;19(1):65.","journal-title":"Reprod Biol Endocrinol"},{"issue":"5","key":"1214_CR9","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1111\/jch.13865","volume":"22","author":"I Bellos","year":"2020","unstructured":"Bellos I, et al. The prognostic role of serum uric acid levels in preeclampsia: a meta-analysis. J Clin Hypertens (Greenwich). 2020;22(5):826\u201334.","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"1214_CR10","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.ejogrb.2022.02.014","volume":"271","author":"X Li","year":"2022","unstructured":"Li X, et al. Comparison of health-related quality of life in different polycystic ovary syndrome phenotypes: a cross-sectional study. Eur J Obstet Gynecol Reprod Biol. 2022;271:189\u201394.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"1214_CR11","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.ijcard.2018.03.045","volume":"261","author":"M Kuwabara","year":"2018","unstructured":"Kuwabara M, et al. Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: a five-year cohort study in Japan. Int J Cardiol. 2018;261:183\u20138.","journal-title":"Int J Cardiol"},{"issue":"5","key":"1214_CR12","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s40618-016-0582-x","volume":"40","author":"U Durmus","year":"2017","unstructured":"Durmus U, Duran C, Ecirli S. Visceral adiposity index levels in overweight and\/or obese, and non-obese patients with polycystic ovary syndrome and its relationship with metabolic and inflammatory parameters. J Endocrinol Invest. 2017;40(5):487\u201397.","journal-title":"J Endocrinol Invest"},{"issue":"11","key":"1214_CR13","doi-asserted-by":"publisher","first-page":"e0206850","DOI":"10.1371\/journal.pone.0206850","volume":"13","author":"N Ali","year":"2018","unstructured":"Ali N, et al. Prevalence of hyperuricemia and the relationship between serum uric acid and obesity: a study on Bangladeshi adults. PLoS One. 2018;13(11):e0206850.","journal-title":"PLoS ONE"},{"key":"1214_CR14","doi-asserted-by":"publisher","unstructured":"Kuwabara M,\u00a0Kuwabara R, Niwa K, Hisatome I, Smits G, Roncal-Jimenez CA, et al. Different risk for hypertension, diabetes, dyslipidemia, and hyperuricemia according to level of body mass index in Japanese and American subjects. Nutrients. 2018;10(8):1011. https:\/\/doi.org\/10.3390\/nu10081011.","DOI":"10.3390\/nu10081011"},{"key":"1214_CR15","doi-asserted-by":"publisher","first-page":"712855","DOI":"10.3389\/fendo.2021.712855","volume":"12","author":"H Yang","year":"2021","unstructured":"Yang H, et al. Neck circumference is associated with hyperuricemia in women with polycystic ovary syndrome. Front Endocrinol (Lausanne). 2021;12:712855.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1214_CR16","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13098-017-0212-6","volume":"9","author":"T Miyagami","year":"2017","unstructured":"Miyagami T, et al. The waist circumference-adjusted associations between hyperuricemia and other lifestyle-related diseases. Diabetol Metab Syndr. 2017;9:11.","journal-title":"Diabetol Metab Syndr"},{"key":"1214_CR17","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.2147\/CIA.S223048","volume":"14","author":"QX Han","year":"2019","unstructured":"Han QX, et al. Risk factors for hyperuricemia in Chinese centenarians and near-centenarians. Clin Interv Aging. 2019;14:2239\u201347.","journal-title":"Clin Interv Aging"},{"issue":"3","key":"1214_CR18","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","volume":"21","author":"LK Chen","year":"2020","unstructured":"Chen LK, et al. Asian working group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc. 2020;21(3):300-307.e2.","journal-title":"J Am Med Dir Assoc"},{"key":"1214_CR19","doi-asserted-by":"publisher","unstructured":"Rotterdam ESHRE\/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41\u20137. https:\/\/doi.org\/10.1093\/humrep\/deh098.","DOI":"10.1093\/humrep\/deh098"},{"issue":"10","key":"1214_CR20","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1136\/annrheumdis-2015-208237","volume":"74","author":"T Neogi","year":"2015","unstructured":"Neogi T, et al. 2015 Gout classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2015;74(10):1789\u201398.","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"1214_CR21","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1055\/s-0031-1279740","volume":"119","author":"D Macut","year":"2011","unstructured":"Macut D, et al. Insulin resistance in non-obese women with polycystic ovary syndrome: relation to byproducts of oxidative stress. Exp Clin Endocrinol Diabetes. 2011;119(7):451\u20135.","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"36","key":"1214_CR22","doi-asserted-by":"publisher","first-page":"5554","DOI":"10.2174\/1381612822666160720160634","volume":"22","author":"G Muscogiuri","year":"2016","unstructured":"Muscogiuri G, et al. Current insights into inositol isoforms, Mediterranean and ketogenic diets for polycystic ovary syndrome: from bench to bedside. Curr Pharm Des. 2016;22(36):5554\u20137.","journal-title":"Curr Pharm Des"},{"key":"1214_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mehy.2017.06.013","volume":"105","author":"B Chiofalo","year":"2017","unstructured":"Chiofalo B, et al. Fasting as possible complementary approach for polycystic ovary syndrome: hope or hype? Med Hypotheses. 2017;105:1\u20133.","journal-title":"Med Hypotheses"},{"key":"1214_CR24","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.ejim.2017.03.014","volume":"41","author":"R Molino-Lova","year":"2017","unstructured":"Molino-Lova R, et al. Higher uric acid serum levels are associated with better muscle function in the oldest old: results from the Mugello Study. Eur J Intern Med. 2017;41:39\u201343.","journal-title":"Eur J Intern Med"},{"issue":"5","key":"1214_CR25","doi-asserted-by":"publisher","first-page":"e0154692","DOI":"10.1371\/journal.pone.0154692","volume":"11","author":"XW Dong","year":"2016","unstructured":"Dong XW, et al. Elevated serum uric acid is associated with greater bone mineral density and skeletal muscle mass in middle-aged and older adults. PLoS One. 2016;11(5):e0154692.","journal-title":"PLoS ONE"},{"issue":"2","key":"1214_CR26","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.numecd.2019.08.019","volume":"30","author":"RO Alvim","year":"2020","unstructured":"Alvim RO, et al. Influence of muscle mass on the serum uric acid levels in children and adolescents. Nutr Metab Cardiovasc Dis. 2020;30(2):300\u20135.","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"3","key":"1214_CR27","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s12603-009-0054-5","volume":"13","author":"KM Beavers","year":"2009","unstructured":"Beavers KM, et al. Low relative skeletal muscle mass indicative of sarcopenia is associated with elevations in serum uric acid levels: findings from NHANES III. J Nutr Health Aging. 2009;13(3):177\u201382.","journal-title":"J Nutr Health Aging"},{"issue":"1","key":"1214_CR28","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1055\/a-0805-2197","volume":"129","author":"KI Tanaka","year":"2021","unstructured":"Tanaka KI, et al. Higher serum uric acid is a risk factor of reduced muscle mass in men with type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes. 2021;129(1):50\u20135.","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"1214_CR29","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1159\/000341683","volume":"40","author":"D Macut","year":"2013","unstructured":"Macut D, Bjeki\u0107-Macut J, Savi\u0107-Radojevi\u0107 A. Dyslipidemia and oxidative stress in PCOS. Front Horm Res. 2013;40:51\u201363.","journal-title":"Front Horm Res"},{"issue":"5","key":"1214_CR30","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1152\/japplphysiol.00893.2019","volume":"128","author":"O Horwath","year":"2020","unstructured":"Horwath O, et al. Fiber type-specific hypertrophy and increased capillarization in skeletal muscle following testosterone administration in young women. J Appl Physiol (1985). 2020;128(5):1240\u201350.","journal-title":"J Appl Physiol (1985)"},{"issue":"9","key":"1214_CR31","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1055\/s-2004-825923","volume":"36","author":"E Marinello","year":"2004","unstructured":"Marinello E, et al. Effect of testosterone on purine nucleotide metabolism in rat liver. Horm Metab Res. 2004;36(9):614\u20139.","journal-title":"Horm Metab Res"},{"issue":"6","key":"1214_CR32","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1055\/s-2007-1004914","volume":"22","author":"M Pizzichini","year":"1990","unstructured":"Pizzichini M, et al. Influence of testosterone on purine nucleotide turnover in rat kidney. Horm Metab Res. 1990;22(6):334\u20138.","journal-title":"Horm Metab Res"},{"key":"1214_CR33","doi-asserted-by":"publisher","unstructured":"Nishikawa H, Asai A, Fukunishi S, Nishiguchi S, Higuchi K. Metabolic syndrome and sarcopenia. Nutrients. 2021;13(10):3519. https:\/\/doi.org\/10.3390\/nu13103519.","DOI":"10.3390\/nu13103519"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-023-01214-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-023-01214-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-023-01214-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T15:14:12Z","timestamp":1694618052000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-023-01214-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,21]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["1214"],"URL":"https:\/\/doi.org\/10.1007\/s43032-023-01214-y","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,21]]},"assertion":[{"value":"6 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethical Ethics Committee of Tianjin Medical University General Hospital (IRB number: IRB2022-WZ-054).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Written informed consent was obtained from individual or guardian participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}