{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:47:51Z","timestamp":1778795271245,"version":"3.51.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1007\/s43032-023-01233-9","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T17:02:17Z","timestamp":1685466137000},"page":"3253-3260","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Low Molecular Weight Heparin-Aspirin-Prednisolone Combination Does Not Increase the Live Birth Rate in Recurrent Implantation Failure: A Retrospective Cohort Study"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9277-7735","authenticated-orcid":false,"given":"Kiper","family":"Aslan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1953-2475","authenticated-orcid":false,"given":"Isil","family":"Kasapoglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5202-6235","authenticated-orcid":false,"given":"Ceren","family":"Cinar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8332-7353","authenticated-orcid":false,"given":"Cihan","family":"Cakir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8135-5468","authenticated-orcid":false,"given":"Berrin","family":"Avci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7660-8344","authenticated-orcid":false,"given":"Gurkan","family":"Uncu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"issue":"6","key":"1233_CR1","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/j.fertnstert.2018.06.039","volume":"110","author":"GD Adamson","year":"2018","unstructured":"Adamson GD, de Mouzon J, Chambers GM, et al. International Committee for Monitoring Assisted Reproductive Technology: world report on assisted reproductive technology, 2011. Fertil Steril. 2018;110(6):1067\u201380.","journal-title":"Fertil Steril"},{"key":"1233_CR2","doi-asserted-by":"crossref","unstructured":"Practice Committee of the American Society for Reproductive Medicine. Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertil Steril. 2013;99(1):63.","DOI":"10.1016\/j.fertnstert.2012.09.023"},{"issue":"1","key":"1233_CR3","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.fertnstert.2020.07.002","volume":"115","author":"P Pirtea","year":"2021","unstructured":"Pirtea P, De Ziegler D, Tao X, et al. Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers. Fertil Steril. 2021;115(1):45\u201353.","journal-title":"Fertil Steril"},{"issue":"4","key":"1233_CR4","first-page":"241","volume":"7","author":"AK Datta","year":"2015","unstructured":"Datta AK, Campbell S, Deval B, et al. Add-ons in IVF programme - hype or hope? Facts Views Vis Obgyn. 2015;7(4):241\u201350.","journal-title":"Facts Views Vis Obgyn"},{"issue":"7","key":"1233_CR5","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1093\/humrep\/deab098","volume":"36","author":"S Lensen","year":"2021","unstructured":"Lensen S, Hammarberg K, Polyakov A, et al. How common is add-on use and how do patients decide whether to use them? A national survey of IVF patients. Hum Reprod. 2021;36(7):1854\u201361. https:\/\/doi.org\/10.1093\/humrep\/deab098.","journal-title":"Hum Reprod"},{"issue":"1","key":"1233_CR6","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1172\/JCI0214996","volume":"110","author":"L Wang","year":"2002","unstructured":"Wang L, Brown JR, Varki A, et al. Heparin\u2019s anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins. J Clin Invest. 2002;110(1):127\u201336.","journal-title":"J Clin Invest"},{"issue":"2","key":"1233_CR7","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0925-4773(02)00342-8","volume":"119","author":"K Chobotova","year":"2002","unstructured":"Chobotova K, Spyropoulou I, Carver J, et al. Heparin-binding epidermal growth factor and its receptor ErbB4 mediate implantation of the human blastocyst. Mech Dev. 2002;119(2):137\u201344.","journal-title":"Mech Dev"},{"issue":"6","key":"1233_CR8","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1093\/humupd\/dmn031","volume":"14","author":"SM Nelson","year":"2008","unstructured":"Nelson SM, Greer IA. The potential role of heparin in assisted conception. Hum Reprod Update. 2008;14(6):623\u201345.","journal-title":"Hum Reprod Update"},{"key":"1233_CR9","doi-asserted-by":"publisher","first-page":"3014","DOI":"10.1093\/humrep\/del262","volume":"21","author":"O Erden","year":"2006","unstructured":"Erden O, Imir A, Guvenal T, Muslehiddinoglu A, Arici S, Cetin M, et al. Investigation of the effects of heparin and low molecular weight heparin on E-cadherin and laminin expression in rat pregnancy by immunohistochemistry. Hum Reprod. 2006;21:3014\u20138.","journal-title":"Hum Reprod"},{"issue":"6","key":"1233_CR10","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1093\/humrep\/13.6.1645","volume":"13","author":"KL Martin","year":"1998","unstructured":"Martin KL, Barlow DH, Sargent IL. Heparin-binding epidermal growth factor significantly improves human blastocyst development and hatching in serum-free medium. Hum Reprod. 1998;13(6):1645\u201352.","journal-title":"Hum Reprod"},{"issue":"1","key":"1233_CR11","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1002\/ijgo.13160","volume":"150","author":"T Wang","year":"2020","unstructured":"Wang T, Kang X, Zhao A, et al. Low-dose aspirin improves endometrial receptivity in the midluteal phase in unexplained recurrent pregnancy loss. Int J Gynaecol Obstet. 2020;150(1):77\u201382.","journal-title":"Int J Gynaecol Obstet"},{"key":"1233_CR12","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.7863\/ultra.16.01020","volume":"35","author":"X Kang","year":"2016","unstructured":"Kang X, Wang T, He L, et al. Effect of low-dose aspirin on midluteal phase uterine artery blood flow in patients with recurrent pregnancy loss. J Ultrasound Med. 2016;35:2583\u20137.","journal-title":"J Ultrasound Med"},{"issue":"4","key":"1233_CR13","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1016\/j.fertnstert.2005.05.012","volume":"84","author":"S Quenby","year":"2005","unstructured":"Quenby S, Kalumbi C, Bates M, et al. Prednisolone reduces preconceptual endometrial natural killer cells in women with recurrent miscarriage. Fertil Steril. 2005;84(4):980\u20134.","journal-title":"Fertil Steril"},{"issue":"1-2","key":"1233_CR14","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jri.2010.07.001","volume":"87","author":"E Tuckerman","year":"2010","unstructured":"Tuckerman E, Mariee N, Prakash A, et al. Uterine natural killer cells in peri-implantation endometrium from women with repeated implantation failure after IVF. J Reprod Immunol. 2010;87(1-2):60\u20136.","journal-title":"J Reprod Immunol"},{"issue":"7","key":"1233_CR15","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1093\/humrep\/der092","volume":"26","author":"AP Ferraretti","year":"2011","unstructured":"Ferraretti AP, La Marca A, Fauser BC, et al. ESHRE working group on Poor Ovarian Response Definition. ESHRE consensus on the definition of \u2018poor response\u2019 to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod. 2011;26(7):1616\u201324.","journal-title":"Hum Reprod"},{"issue":"2","key":"1233_CR16","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1093\/humrep\/deaa317","volume":"36","author":"D Cimadomo","year":"2021","unstructured":"Cimadomo D, Craciunas L, Vermeulen N, et al. Definition, diagnostic and therapeutic options in recurrent implantation failure: an international survey of clinicians and embryologists. Hum Reprod. 2021;36(2):305\u201317.","journal-title":"Hum Reprod"},{"issue":"2","key":"1233_CR17","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1210\/jc.2004-0476","volume":"90","author":"K Chobotova","year":"2005","unstructured":"Chobotova K, Karpovich N, Carver J, et al. Heparin-binding epidermal growth factor and its receptors mediate decidualization and potentiate survival of human endometrial stromal cells. J Clin Endocrinol Metab. 2005;90(2):913\u20139.","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"1233_CR18","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1242\/dev.02237","volume":"133","author":"DR Armant","year":"2006","unstructured":"Armant DR, Kilburn BA, Petkova A, et al. Human trophoblast survival at low oxygen concentrations requires metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor. Development. 2006;133(4):751\u20139.","journal-title":"Development."},{"issue":"9","key":"1233_CR19","doi-asserted-by":"publisher","first-page":"2523","DOI":"10.1093\/humrep\/dem201","volume":"22","author":"R Ganapathy","year":"2007","unstructured":"Ganapathy R, Whitley GS, Cartwright JE, et al. Effect of heparin and fractionated heparin on trophoblast invasion. Hum Reprod. 2007;22(9):2523\u20137.","journal-title":"Hum Reprod"},{"issue":"4","key":"1233_CR20","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.placenta.2006.04.001","volume":"28","author":"N Di Simone","year":"2007","unstructured":"Di Simone N, Di Nicuolo F, Sanguinetti M, et al. Low-molecular weight heparin induces in vitro trophoblast invasiveness: role of matrix metalloproteinases and tissue inhibitors. Placenta. 2007;28(4):298\u2013304.","journal-title":"Placenta."},{"issue":"2","key":"1233_CR21","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1097\/01.AOG.0000128902.84876.d4","volume":"104","author":"S Quenby","year":"2004","unstructured":"Quenby S, Mountfield S, Cartwright JE, et al. Effects of low-molecular-weight and unfractionated heparin on trophoblast function. Obstet Gynecol. 2004;104(2):354\u201361.","journal-title":"Obstet Gynecol"},{"issue":"7","key":"1233_CR22","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1093\/humrep\/dep086","volume":"24","author":"B Urman","year":"2009","unstructured":"Urman B, Ata B, Yakin K, et al. Luteal phase empirical low molecular weight heparin administration in patients with failed ICSI embryo transfer cycles: a randomized open-labeled pilot trial. Hum Reprod. 2009;24(7):1640\u20137.","journal-title":"Hum Reprod"},{"issue":"8","key":"1233_CR23","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1016\/j.fertnstert.2010.12.033","volume":"95","author":"B Berker","year":"2011","unstructured":"Berker B, Ta\u015fkin S, Kahraman K, et al. The role of low-molecular-weight heparin in recurrent implantation failure: a prospective, quasi-randomized, controlled study. Fertil Steril. 2011;95(8):2499\u2013502.","journal-title":"Fertil Steril"},{"issue":"2","key":"1233_CR24","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1080\/03009734.2020.1751751","volume":"125","author":"L Nardo","year":"2020","unstructured":"Nardo L, Chouliaras S. Adjuvants in IVF-evidence for what works and what does not work. Ups J Med Sci. 2020;125(2):144\u201351.","journal-title":"Ups J Med Sci"},{"issue":"5","key":"1233_CR25","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/S0015-0282(99)00088-6","volume":"71","author":"M Rubinstein","year":"1999","unstructured":"Rubinstein M, Marazzi A, Polak de Fried E. Low-dose aspirin treatment improves ovarian responsiveness, uterine and ovarian blood flow velocity, implantation, and pregnancy rates in patients undergoing in vitro fertilization: a prospective, randomized, double-blind placebo-controlled assay. Fertil Steril. 1999;71(5):825\u20139.","journal-title":"Fertil Steril"},{"issue":"12","key":"1233_CR26","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1001\/jama.2021.14781","volume":"326","author":"KW Davidson","year":"2021","unstructured":"US Preventive Services Task Force, Davidson KW, Barry MJ, Mangione CM, Cabana M, Caughey AB, Davis EM, et al. Aspirin use to prevent preeclampsia and related morbidity and mortality: US Preventive Services Task Force recommendation statement. JAMA. 2021;326(12):1186\u201391.","journal-title":"JAMA"},{"key":"1233_CR27","doi-asserted-by":"crossref","first-page":"100547","DOI":"10.1016\/j.ajogmf.2021.100382","volume":"3","author":"CA Combs","year":"2021","unstructured":"Combs CA, Zhou MK, Pandipati S, et al. Prevalence of preeclampsia risk factors: implications for low-dose aspirin prophylaxis. Am J Obstet Gynecol MFM. 2021;3:100547.","journal-title":"Am J Obstet Gynecol MFM"},{"issue":"1","key":"1233_CR28","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1097\/AOG.0000000000002709","volume":"132","author":"ACOG Committee Opinion No. 743","year":"2018","unstructured":"ACOG Committee Opinion No. 743. Summary: Low-dose aspirin use during pregnancy. Obstet Gynecol. 2018;132(1):254\u20136.","journal-title":"Obstet Gynecol"},{"issue":"2","key":"1233_CR29","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.ajog.2016.09.076","volume":"216","author":"S Roberge","year":"2017","unstructured":"Roberge S, Nicolaides K, Demers S, et al. The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis. Am J Obstet Gynecol. 2017;216(2):110\u2013120.e6.","journal-title":"Am J Obstet Gynecol"},{"key":"1233_CR30","doi-asserted-by":"crossref","unstructured":"Siristatidis CS, Basios G, Pergialiotis V, et al. Aspirin for in vitro fertilisation. Cochrane Database Syst Rev. 2016;11(11):CD004832.","DOI":"10.1002\/14651858.CD004832.pub4"},{"issue":"7","key":"1233_CR31","first-page":"CD004734","volume":"2014","author":"PG de Jong","year":"2014","unstructured":"de Jong PG, Kaandorp S, Di Nisio M, et al. Aspirin and\/or heparin for women with unexplained recurrent miscarriage with or without inherited thrombophilia. Cochrane Database Syst Rev. 2014;2014(7):CD004734.","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"1233_CR32","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1097\/GCO.0b013e3282f8aff5","volume":"20","author":"CM Boomsma","year":"2008","unstructured":"Boomsma CM, Macklon NS. Does glucocorticoid therapy in the peri-implantation period have an impact on IVF outcomes? Curr Opin Obstet Gynecol. 2008;20(3):249\u201356.","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"12","key":"1233_CR33","doi-asserted-by":"publisher","first-page":"2562","DOI":"10.1093\/humrep\/deg502","volume":"18","author":"S Quenby","year":"2003","unstructured":"Quenby S, Farquharson R, Young M, et al. Successful pregnancy outcome following 19 consecutive miscarriages: case report. Hum Reprod. 2003;18(12):2562\u20134.","journal-title":"Hum Reprod"},{"key":"1233_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jri.2018.10.001","volume":"131","author":"S Cooper","year":"2019","unstructured":"Cooper S, Laird SM, Mariee N, et al. The effect of prednisolone on endometrial uterine NK cell concentrations and pregnancy outcome in women with reproductive failure. A retrospective cohort study. J Reprod Immunol. 2019;131:1\u20136.","journal-title":"J Reprod Immunol"},{"issue":"5","key":"1233_CR35","first-page":"CD012852","volume":"5","author":"EN Hamuly\u00e1k","year":"2020","unstructured":"Hamuly\u00e1k EN, Scheres LJ, Marijnen MC, et al. Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and recurrent pregnancy loss. Cochrane Database Syst Rev. 2020;5(5):CD012852.","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"1233_CR36","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1002\/uog.15789","volume":"47","author":"S Roberge","year":"2016","unstructured":"Roberge S, Demers S, Nicolaides KH, et al. Prevention of pre-eclampsia by low-molecular-weight heparin in addition to aspirin: a meta-analysis. Ultrasound Obstet Gynecol. 2016;47(5):548\u201353.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"1233_CR37","first-page":"1","volume":"5","author":"M Mascarenhas","year":"2021","unstructured":"Mascarenhas M, Jeve Y, Polanski L, et al. Management of recurrent implantation failure: British Fertility Society policy and practice guideline. Hum Fertil (Camb). 2021;5:1\u201325.","journal-title":"Hum Fertil (Camb)"},{"issue":"5","key":"1233_CR38","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.rbmo.2020.08.007","volume":"41","author":"T Shaulov","year":"2020","unstructured":"Shaulov T, Sierra S, Sylvestre C. Recurrent implantation failure in IVF: a Canadian Fertility and Andrology Society clinical practice guideline. Reprod Biomed Online. 2020;41(5):819\u201333.","journal-title":"Reprod Biomed Online"},{"issue":"4","key":"1233_CR39","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1007\/s00404-014-3262-0","volume":"290","author":"MF Gomaa","year":"2014","unstructured":"Gomaa MF, Elkholy AG, El-Said MM, et al. Combined oral prednisolone and heparin versus heparin: the effect on peripheral NK cells and clinical outcome in patients with unexplained recurrent miscarriage. A double-blind placebo randomized controlled trial. Arch Gynecol Obstet. 2014;290(4):757\u201362.","journal-title":"Arch Gynecol Obstet"},{"issue":"6","key":"1233_CR40","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1111\/j.1471-0528.2005.00523.x","volume":"112","author":"BK Tan","year":"2005","unstructured":"Tan BK, Vandekerckhove P, Kennedy R, et al. Investigation and current management of recurrent IVF treatment failure in the UK. BJOG. 2005;112(6):773\u201380.","journal-title":"BJOG."},{"issue":"4","key":"1233_CR41","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.rbmo.2013.12.006","volume":"28","author":"LT Polanski","year":"2014","unstructured":"Polanski LT, Baumgarten MN, Quenby S, et al. What exactly do we mean by \u2018recurrent implantation failure\u2019? A systematic review and opinion. Reprod Biomed Online. 2014;28(4):409\u201323.","journal-title":"Reprod Biomed Online"},{"issue":"3","key":"1233_CR42","doi-asserted-by":"publisher","first-page":"hoaa021","DOI":"10.1093\/hropen\/hoaa021","volume":"2020","author":"F Carvalho","year":"2020","unstructured":"ESHRE PGT Consortium Steering Committee, Carvalho F, Coonen E, Goossens V, et al. ESHRE PGT Consortium good practice recommendations for the organisation of PGT. Hum Reprod Open. 2020;2020(3):hoaa021.","journal-title":"Hum Reprod Open"},{"issue":"2","key":"1233_CR43","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1002\/jemt.1070250207","volume":"25","author":"J Mulholland","year":"1993","unstructured":"Mulholland J, Jones CJ. Characteristics of uterine aging. Microsc Res Tech. 1993;25(2):148\u201368.","journal-title":"Microsc Res Tech"},{"issue":"5","key":"1233_CR44","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1016\/j.fertnstert.2021.06.045","volume":"116","author":"B Ata","year":"2021","unstructured":"Ata B, Kalafat E, Somigliana E. A new definition of recurrent implantation failure on the basis of anticipated blastocyst aneuploidy rates across female age. Fertil Steril. 2021;116(5):1320\u20137.","journal-title":"Fertil Steril"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-023-01233-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-023-01233-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-023-01233-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T21:37:06Z","timestamp":1699911426000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-023-01233-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,30]]},"references-count":44,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["1233"],"URL":"https:\/\/doi.org\/10.1007\/s43032-023-01233-9","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,30]]},"assertion":[{"value":"2 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethics approval for the study was obtained from the Bursa Uludag University Clinical Trials Ethical Committee (2021-17\/42).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Patient consent was not required as this study was based on publicly available data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The authors consent for publication of this article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}