{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:29:28Z","timestamp":1788888568524,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100000024","name":"CIHR","doi-asserted-by":"crossref","award":["This study was supported in part by Canadian Institute Heath Grant (CIHR): Reference Number\/ W11-179912."],"award-info":[{"award-number":["This study was supported in part by Canadian Institute Heath Grant (CIHR): Reference Number\/ W11-179912."]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s43032-023-01239-3","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T15:05:34Z","timestamp":1683039934000},"page":"3019-3026","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Clinical Significance of Embryonic Chromosomal Errors in Recurrent Pregnancy Loss: an Analysis of 1107 Miscarriages"],"prefix":"10.1007","volume":"30","author":[{"given":"Ann","family":"Korkidakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianne Y.","family":"Albert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jefferson","family":"Terry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faten F.","family":"AbdelHafez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3454-8555","authenticated-orcid":false,"given":"Mohamed A.","family":"Bedaiwy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"issue":"8716","key":"1239_CR1","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/0140-6736(90)92159-F","volume":"336","author":"GM Stirrat","year":"1990","unstructured":"Stirrat GM. Recurrent miscarriage. Lancet. 1990;336(8716):673\u20135.","journal-title":"Lancet"},{"issue":"4","key":"1239_CR2","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/tog.12832","volume":"24","author":"MR Chester","year":"2022","unstructured":"Chester MR, Tirlapur A, Jayaprakasan K. Current management of recurrent pregnancy loss. Obstet Gynaecol. 2022;24(4):260\u201371.","journal-title":"Obstet Gynaecol"},{"key":"1239_CR3","doi-asserted-by":"crossref","unstructured":"Practice Committee of the American Society for Reproductive Medicine. Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertil Steril. 2013;99(1):63.","DOI":"10.1016\/j.fertnstert.2012.09.023"},{"issue":"2","key":"1239_CR4","doi-asserted-by":"publisher","first-page":"hoy004","DOI":"10.1093\/hropen\/hoy004","volume":"2018","author":"R Bender Atik","year":"2018","unstructured":"Bender Atik R, et al. ESHRE guideline: recurrent pregnancy loss. Hum Reprod Open. 2018;2018(2):hoy004.","journal-title":"Hum Reprod Open"},{"key":"1239_CR5","volume-title":"Green-top Guideline No. 17","author":"Royal College of Obstetricians and Gynaecologists","year":"2011","unstructured":"Royal College of Obstetricians and Gynaecologists. The investigation and treatment of couples with recurrent first-trimester and second-trimester miscarriage. In: Green-top Guideline No. 17. London: RCOG; 2011."},{"issue":"1","key":"1239_CR6","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1097\/GRF.0b013e31802f1c28","volume":"50","author":"M Stephenson","year":"2007","unstructured":"Stephenson M, Kutteh W. Evaluation and management of recurrent early pregnancy loss. Clin Obstet Gynecol. 2007;50(1):132\u201345.","journal-title":"Clin Obstet Gynecol"},{"issue":"1","key":"1239_CR7","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/S0015-0282(16)58382-4","volume":"66","author":"MD Stephenson","year":"1996","unstructured":"Stephenson MD. Frequency of factors associated with habitual abortion in 197 couples. Fertil Steril. 1996;66(1):24\u20139.","journal-title":"Fertil Steril"},{"issue":"4","key":"1239_CR8","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1016\/j.fertnstert.2009.01.166","volume":"93","author":"CR Jaslow","year":"2010","unstructured":"Jaslow CR, Carney JL, Kutteh WH. Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses. Fertil Steril. 2010;93(4):1234\u201343.","journal-title":"Fertil Steril"},{"key":"1239_CR9","doi-asserted-by":"crossref","unstructured":"Practice Committee of the American Society for Reproductive Medicine. Evaluation and treatment of recurrent pregnancy loss: a committee opinion. Fertil Steril. 2012;98(5):1103\u201311.","DOI":"10.1016\/j.fertnstert.2012.06.048"},{"issue":"1","key":"1239_CR10","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.fertnstert.2012.03.038","volume":"98","author":"LA Bernardi","year":"2012","unstructured":"Bernardi LA, Plunkett BA, Stephenson MD. Is chromosome testing of the second miscarriage cost saving? A decision analysis of selective versus universal recurrent pregnancy loss evaluation. Fertil Steril. 2012;98(1):156\u201361.","journal-title":"Fertil Steril"},{"issue":"4","key":"1239_CR11","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1093\/humrep\/dey021","volume":"33","author":"F Popescu","year":"2018","unstructured":"Popescu F, Jaslow CR, Kutteh WH. Recurrent pregnancy loss evaluation combined with 24-chromosome microarray of miscarriage tissue provides a probable or definite cause of pregnancy loss in over 90% of patients. Hum Reprod. 2018;33(4):579\u201387.","journal-title":"Hum Reprod"},{"issue":"1","key":"1239_CR12","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.rbmo.2021.03.015","volume":"43","author":"EM Dahdouh","year":"2021","unstructured":"Dahdouh EM, Kutteh WH. Genetic testing of products of conception in recurrent pregnancy loss evaluation. Reprod Biomed Online. 2021;43(1):120\u20136.","journal-title":"Reprod Biomed Online"},{"issue":"4","key":"1239_CR13","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1093\/humrep\/dep452","volume":"25","author":"DS Johnson","year":"2010","unstructured":"Johnson DS, et al. Preclinical validation of a microarray method for full molecular karyotyping of blastomeres in a 24-h protocol. Hum Reprod. 2010;25(4):1066\u201375.","journal-title":"Hum Reprod"},{"key":"1239_CR14","volume-title":"Statistical models in S","author":"JM Chambers","year":"1992","unstructured":"Chambers JM, Hastie TJ. Statistical models in S. Pacific Grove: Wadsworth & Brooks\/Cole; 1992."},{"issue":"4","key":"1239_CR15","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1214\/aos\/1013699998","volume":"29","author":"Y Benjamini","year":"2001","unstructured":"Benjamini Y, Yekutieli D. The control of the false discovery rate in multiple testing under dependency. Ann Stat. 2001;29(4):1165\u201388.","journal-title":"Ann Stat"},{"issue":"3","key":"1239_CR16","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.fertnstert.2013.11.004","volume":"101","author":"JM Franasiak","year":"2014","unstructured":"Franasiak JM, et al. The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening. Fertil Steril. 2014;101(3):656-663.e1.","journal-title":"Fertil Steril"},{"issue":"5","key":"1239_CR17","doi-asserted-by":"publisher","first-page":"e96710","DOI":"10.1371\/journal.pone.0096710","volume":"9","author":"M Tsutsumi","year":"2014","unstructured":"Tsutsumi M, et al. Age-related decrease of meiotic cohesins in human oocytes. PLoS ONE. 2014;9(5):e96710.","journal-title":"PLoS ONE"},{"issue":"6","key":"1239_CR18","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1111\/j.1474-9726.2012.00866.x","volume":"11","author":"FE Duncan","year":"2012","unstructured":"Duncan FE, et al. Chromosome cohesion decreases in human eggs with advanced maternal age. Aging Cell. 2012;11(6):1121\u20134.","journal-title":"Aging Cell"},{"issue":"1","key":"1239_CR19","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1262\/jrd.2018-056","volume":"65","author":"G Shimoi","year":"2019","unstructured":"Shimoi G, et al. Destabilization of spindle assembly checkpoint causes aneuploidy during meiosis II in murine post-ovulatory aged oocytes. J Reprod Dev. 2019;65(1):57\u201366.","journal-title":"J Reprod Dev"},{"issue":"1","key":"1239_CR20","first-page":"711","volume":"18","author":"P Huo","year":"2019","unstructured":"Huo P, et al. High accuracy of quantitative fluorescence polymerase chain reaction combined with non-invasive pre-natal testing for mid-pregnancy diagnosis of common fetal aneuploidies: a single-center experience in China. Exp Ther Med. 2019;18(1):711\u201321.","journal-title":"Exp Ther Med"},{"issue":"6","key":"1239_CR21","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1111\/mmi.12527","volume":"91","author":"GD Mehta","year":"2014","unstructured":"Mehta GD, Agarwal M, Ghosh SK. Functional characterization of kinetochore protein, Ctf19 in meiosis I: an implication of differential impact of Ctf19 on the assembly of mitotic and meiotic kinetochores in Saccharomyces cerevisiae. Mol Microbiol. 2014;91(6):1179\u201399.","journal-title":"Mol Microbiol"},{"issue":"4","key":"1239_CR22","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/35066065","volume":"2","author":"T Hassold","year":"2001","unstructured":"Hassold T, Hunt P. To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet. 2001;2(4):280\u201391.","journal-title":"Nat Rev Genet"},{"key":"1239_CR23","doi-asserted-by":"publisher","unstructured":"Simpson J, Carson S. Genetic and nongenetic causes of pregnancy loss.\u00a0The Global Library of Women\u2019s Medicine. 2013. https:\/\/doi.org\/10.3843\/GLOWM.10319","DOI":"10.3843\/GLOWM.10319"},{"issue":"2","key":"1239_CR24","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1159\/000477707","volume":"152","author":"A Soler","year":"2017","unstructured":"Soler A, et al. Overview of chromosome abnormalities in first trimester miscarriages: a series of 1,011 consecutive chorionic villi sample karyotypes. Cytogenet Genome Res. 2017;152(2):81\u20139.","journal-title":"Cytogenet Genome Res"},{"issue":"4","key":"1239_CR25","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1097\/01.GIM.0000160075.96707.04","volume":"7","author":"J Menasha","year":"2005","unstructured":"Menasha J, et al. Incidence and spectrum of chromosome abnormalities in spontaneous abortions: new insights from a 12-year study. Genet Med. 2005;7(4):251\u201363.","journal-title":"Genet Med"},{"issue":"1","key":"1239_CR26","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/BF00389450","volume":"70","author":"T Hassold","year":"1985","unstructured":"Hassold T, Chiu D. Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy. Hum Genet. 1985;70(1):11\u20137.","journal-title":"Hum Genet"},{"issue":"8161","key":"1239_CR27","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0140-6736(80)90658-3","volume":"1","author":"D Warburton","year":"1980","unstructured":"Warburton D, et al. Monosomy X: a chromosomal anomaly associated with young maternal age. Lancet. 1980;1(8161):167\u20139.","journal-title":"Lancet"},{"issue":"9","key":"1239_CR28","first-page":"383","volume":"63","author":"J Terry","year":"2021","unstructured":"Terry J. The value of ancillary testing in amniotic fluid infection\/inflammation-related early pregnancy loss and perinatal death in British Columbia. BC Med J. 2021;63(9):383\u20137.","journal-title":"BC Med J"},{"key":"1239_CR29","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/1757-2215-7-65","volume":"7","author":"ST Qi","year":"2014","unstructured":"Qi ST, et al. Arrested human embryos are more likely to have abnormal chromosomes than developing embryos from women of advanced maternal age. J Ovarian Res. 2014;7:65.","journal-title":"J Ovarian Res"},{"issue":"1","key":"1239_CR30","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1053\/sper.2002.29853","volume":"26","author":"RJ Wapner","year":"2002","unstructured":"Wapner RJ, Lewis D. Genetics and metabolic causes of stillbirth. Semin Perinatol. 2002;26(1):70\u20134.","journal-title":"Semin Perinatol"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-023-01239-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-023-01239-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-023-01239-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T17:16:46Z","timestamp":1696526206000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-023-01239-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,2]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["1239"],"URL":"https:\/\/doi.org\/10.1007\/s43032-023-01239-3","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,2]]},"assertion":[{"value":"29 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}