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According to a recent study, uterine fibroid patients have altered gut microbiome. A variety of risk factors influence both fibroid development and gut homeostasis. Diet, lifestyle, physical activity, and environmental contaminants have an impact on estrogen and the gut flora. A better understanding of uterine fibroids\u2019 pathophysiology is required to develop effective preventative and treatment options. A few ways by which the gut microbiota contributes to UF include estrogen, impaired immune function, inflammation, and altered gut metabolites. Therefore, in the future, while treating fibroid patients, various strategies to deal with changes in the gut flora may be advantageous. For developing suggestions for clinical diagnosis and therapy, we reviewed the literature on the relationship between uterine fibroids and the gut microbiota.<\/jats:p>","DOI":"10.1007\/s43032-023-01289-7","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T10:02:00Z","timestamp":1688724120000},"page":"3443-3455","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Gut Microbiota: a Novel Player in the Pathogenesis of Uterine Fibroids"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-6339","authenticated-orcid":false,"given":"Vineetha K","family":"K","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6980-8134","authenticated-orcid":false,"given":"Rajeshwari G","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2708-0245","authenticated-orcid":false,"given":"Bhamini Krishna","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana P","family":"R","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,7]]},"reference":[{"issue":"2","key":"1289_CR1","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1097\/01.AOG.0000136079.62513.39","volume":"104","author":"EE Wallach","year":"2004","unstructured":"Wallach EE, Vlahos NF. 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No animal or human experiment was conducted in this study (This review was written as part of an ongoing prospective observational study on uterine fibroids and gut dysbiosis. Ethical Committee clearance was obtained from KMC &KH IEC, Ref No.474\/2020).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}