{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:41:20Z","timestamp":1771051280047,"version":"3.50.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T00:00:00Z","timestamp":1689206400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002352","name":"Ain Shams University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002352","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                <jats:title>Abstract<\/jats:title>\n                <jats:p>This study compares the effectiveness and safety of oxytocin infusion against oral misoprostol for inducing labour in pregnant women with term prelabor membrane rupture. We randomized 173 pregnant women presenting with term prelabor rupture of membranes (PROM) at Ain Shams University Maternity Hospital into Group A (underwent induction of labor (IOL) by 25\u03bcg misoprostol oral tablet every 4 h, for maximum 5 doses) and an identical Group B: (underwent IOL by oxytocin infusion according to the hospital protocol). Our primary outcome was rate of vaginal delivery within 24 h, while the secondary outcomes included the time till active phase, induction to delivery interval, maternal pyrexia, nausea and vomiting, fetal distress, Apgar score, birth weight, and neonatal intensive care unit admission. Both groups showed high rates of vaginal delivery (82.4% &amp; 87.1% for misoprostol group and oxytocin group respectively) with no significant difference between the two groups (<jats:italic>p<\/jats:italic>=0.394). However, patients induced by misoprostol took significantly less time to reach active phase with a shorter induction to delivery interval as compared to patients induced with oxytocin. This difference was clear in multiparous women, but not observed in primiparous women when subgroup analysis was done. No significant difference was found as regards other outcomes. Our study showed that both oral misoprostol and oxytocin are effective and safe for IOL in patients with PROM, with shorter induction-delivery interval in patients induced by oral misoprostol, an effect that is clear in multiparous but not primiparous women.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>NCT05215873, on 31\/01\/2022, \u201cretrospectively registered\u201d.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s43032-023-01290-0","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T19:01:38Z","timestamp":1689274898000},"page":"3507-3514","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Oxytocin Versus Oral Misoprostol for Induction of Labor in Pregnant Women with Term Prelabor Rupture of Membranes: a Randomized Clinical Trial"],"prefix":"10.1007","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9918-2363","authenticated-orcid":false,"given":"Rania Hassan Mostafa","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1221-9600","authenticated-orcid":false,"given":"Mohamed Samir Eid","family":"Sweed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6634-5763","authenticated-orcid":false,"given":"Gasser Adly","family":"El-Bishry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3860-1197","authenticated-orcid":false,"given":"Raghda Khaled","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,13]]},"reference":[{"issue":"7","key":"1290_CR1","doi-asserted-by":"publisher","first-page":"CD004945","DOI":"10.1002\/14651858.CD004945.pub5","volume":"2020","author":"P Middleton","year":"2020","unstructured":"Middleton P, Shepherd E, Morris J, Crowther CA, Gomersall JC. Induction of labour at or beyond 37 weeks' gestation. Cochrane Database Syst Rev. 2020;(7):CD004945. https:\/\/doi.org\/10.1002\/14651858.CD004945.pub5. Accessed 23 December 2022.","journal-title":"Cochrane Database Syst Rev"},{"key":"1290_CR2","doi-asserted-by":"publisher","unstructured":"Practice Bulletin No. 172: Premature Rupture of Membranes. Obstet Gynecol. 2016;128(4):e165\u201377. https:\/\/doi.org\/10.1097\/AOG.0000000000001712.","DOI":"10.1097\/AOG.0000000000001712"},{"issue":"1","key":"1290_CR3","doi-asserted-by":"publisher","first-page":"CD005302","DOI":"10.1002\/14651858.CD005302.pub3","volume":"2017","author":"P Middleton","year":"2017","unstructured":"Middleton P, Shepherd E, Flenady V, McBain RD, Crowther CA. Planned early birth versus expectant management (waiting) for prelabour rupture of membranes at term (37 weeks or more). Cochrane Database Syst Rev. 2017;(1):CD005302. https:\/\/doi.org\/10.1002\/14651858.CD005302.pub3. Accessed 23 December 2022.","journal-title":"Cochrane Database Syst Rev"},{"key":"1290_CR4","doi-asserted-by":"publisher","unstructured":"Hofmeyr GJ, G\u00fclmezoglu AM, Pileggi C. Vaginal misoprostol for cervical ripening and induction of labour. Cochrane Database Syst Rev. 2010;(10):CD000941. https:\/\/doi.org\/10.1002\/14651858.CD000941.pub2. Accessed 23 December 2022.","DOI":"10.1002\/14651858.CD000941.pub2"},{"issue":"6","key":"1290_CR5","doi-asserted-by":"publisher","first-page":"592","DOI":"10.3109\/14767058.2013.831066","volume":"27","author":"FK Aghideh","year":"2014","unstructured":"Aghideh FK, Mullin PM, Ingles S, et al. A comparison of obstetrical outcomes with labor induction agents used at term. J Matern Fetal Neonatal Med. 2014;27(6):592\u20136. https:\/\/doi.org\/10.3109\/14767058.2013.831066.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"1290_CR6","doi-asserted-by":"publisher","unstructured":"Alfirevic Z, Aflaifel N, Weeks A. Oral misoprostol for induction of labour. Cochrane Database Syst Rev. 2014;(6):CD001338. https:\/\/doi.org\/10.1002\/14651858.CD001338.pub3. Accessed 23 December 2022.","DOI":"10.1002\/14651858.CD001338.pub3"},{"issue":"2","key":"1290_CR7","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1080\/01443615.2017.1329284","volume":"38","author":"L Pourali","year":"2018","unstructured":"Pourali L, Saghafi N, Eslami Hasan Abadi S, Tara F, Vatanchi AM, Motamedi E. Induction of labour in term premature rupture of membranes; oxytocin versus sublingual misoprostol; a randomised clinical trial [published correction appears in J Obstet Gynaecol. 2019 Jul;39(5):735. J Obstet Gynaecol. 2018;38(2):167\u201371. https:\/\/doi.org\/10.1080\/01443615.2017.1329284.","journal-title":"J Obstet Gynaecol"},{"issue":"4","key":"1290_CR8","doi-asserted-by":"publisher","first-page":"896","DOI":"10.5114\/aoms.2018.76115","volume":"15","author":"NG Kulhan","year":"2019","unstructured":"Kulhan NG, Kulhan M. Labor induction in term nulliparous women with premature rupture of membranes: oxytocin versus dinoprostone. Arch Med Sci. 2019;15(4):896\u2013901. https:\/\/doi.org\/10.5114\/aoms.2018.76115.","journal-title":"Arch Med Sci"},{"issue":"5","key":"1290_CR9","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1080\/14767050600589807","volume":"19","author":"\u015e Zetero\u011flu","year":"2006","unstructured":"Zetero\u011flu \u015e, Engin-\u00dcst\u00fcn Y, \u00dcst\u00fcn Y, G\u00fcvercin\u00e7i M, \u015eahin G, Kamaci M. A prospective randomized study comparing misoprostol and oxytocin for premature rupture of membranes at term. J Matern Fetal Neonatal Med. 2006;19(5):283\u20137. https:\/\/doi.org\/10.1080\/14767050600589807.","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"65","key":"1290_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta20650","volume":"20","author":"Z Alfirevic","year":"2016","unstructured":"Alfirevic Z, Keeney E, Caldwell D, Welton N, Medley N, Dias S, et al. Which method is best for the induction of labour? A systematic review, network meta-analysis and cost-effectiveness analysis. Health Technol Assess. 2016;20(65):1\u2013584.","journal-title":"Health Technol Assess"},{"key":"1290_CR11","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1111\/1471-0528.12935","volume":"122","author":"K McMaster","year":"2015","unstructured":"McMaster K, Sanchez-Ramos L, Kaunitz AM. Balancing the efficacy and safety of misoprostol: a meta-analysis comparing 25 versus 50 micrograms of intravaginal misoprostol for the induction of labour. BJOG. 2015;122:468\u201376.","journal-title":"BJOG."},{"issue":"3","key":"1290_CR12","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1097\/01.AOG.0000172425.56840.57","volume":"106","author":"MG Lin","year":"2005","unstructured":"Lin MG, Nuthalapaty FS, Carver AR, Case AS, Ramsey PS. Misoprostol for labor induction in women with term premature rupture of membranes: a meta-analysis. Obstet Gynecol. 2005;106(3):593\u2013601. https:\/\/doi.org\/10.1097\/01.AOG.0000172425.56840.57.","journal-title":"Obstet Gynecol"},{"key":"1290_CR13","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/1471-2393-11-84","volume":"11","author":"EL Mozurkewich","year":"2011","unstructured":"Mozurkewich EL, Chilimigras JL, Berman DR, et al. Methods of induction of labour: a systematic review. BMC Pregnancy Childbirth. 2011;11:84. https:\/\/doi.org\/10.1186\/1471-2393-11-84.","journal-title":"BMC Pregnancy Childbirth"},{"key":"1290_CR14","doi-asserted-by":"publisher","unstructured":"Unthanan S, Petcharat K, Prommas S, Smanchat B, Bhamarapravatana K, Suwannarurk K. Sublingual Misoprostol versus Oxytocin to Induce Labor in Term Premature Rupture of Membranes in Pregnant Women: A Randomized Single-Blind Controlled Trial. Biomed Res Int. 2022:9449036. https:\/\/doi.org\/10.1155\/2022\/9449036.","DOI":"10.1155\/2022\/9449036"},{"issue":"3","key":"1290_CR15","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1055\/s-0039-1696642","volume":"38","author":"TS Freret","year":"2021","unstructured":"Freret TS, Chac\u00f3n KM, Bryant AS, Kaimal AJ, Clapp MA. Oxytocin Compared to Buccal Misoprostol for Induction of Labor after Term Prelabor Rupture of Membranes. Am J Perinatol. 2021;38(3):224\u201330. https:\/\/doi.org\/10.1055\/s-0039-1696642.","journal-title":"Am J Perinatol"},{"issue":"3","key":"1290_CR16","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1590\/s1516-31802003000300003","volume":"121","author":"MM de Aquino","year":"2003","unstructured":"de Aquino MM, Cecatti JG. Misoprostol versus oxytocin for labor induction in term and post-term pregnancy: randomized controlled trial. Sao Paulo Med J. 2003;121(3):102\u20136. https:\/\/doi.org\/10.1590\/s1516-31802003000300003.","journal-title":"Sao Paulo Med J"},{"key":"1290_CR17","unstructured":"Wilson-Liverman A. Randomized Comparison of Vaginal Misoprostol and Intravenous Oxytocin for Labor Induction in Multiparous Women. In: Clinical Trials.gov. last viewed on 17th May 2023. https:\/\/clinicaltrials.gov\/ct2\/show\/results\/NCT01634854?view=results."}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-023-01290-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-023-01290-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-023-01290-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T22:06:18Z","timestamp":1701468378000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-023-01290-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,13]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["1290"],"URL":"https:\/\/doi.org\/10.1007\/s43032-023-01290-0","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,13]]},"assertion":[{"value":"9 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the ethical committee, faculty of Medicine, Ain Shams University (FMASU REC) on 16-01-2021; (MS 733\/2020\/2021).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was taken from all participants before recruitment in the study, and after explaining the purpose and procedures of the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}