{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T19:27:16Z","timestamp":1771010836386,"version":"3.50.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1007\/s43032-023-01299-5","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T17:01:37Z","timestamp":1690477297000},"page":"1-16","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Systematic Review of Autoimmune Oophoritis Therapies"],"prefix":"10.1007","volume":"31","author":[{"given":"Elizabeth","family":"Levit","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhuchitra","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Nylander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5969-376X","authenticated-orcid":false,"given":"James H.","family":"Segars","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,7,27]]},"reference":[{"issue":"5","key":"1299_CR1","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/humrep\/dew027","volume":"31","author":"L Webber","year":"2016","unstructured":"European Society for Human Reproduction and Embryology (ESHRE) Guideline Group on POI, Webber L, Davies M, et al. ESHRE guideline: management of women with premature ovarian insufficiency. Hum Reprod. 2016;31(5):926\u201337.","journal-title":"Hum Reprod."},{"issue":"2","key":"1299_CR2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0015-0282(16)58095-9","volume":"65","author":"GS Conway","year":"1996","unstructured":"Conway GS, Kaltsas G, Patel A, Davies MC, Jacobs HS. Characterization of idiopathic premature ovarian failure. Fertil Steril. 1996;65(2):337\u201341.","journal-title":"Fertil Steril."},{"issue":"1","key":"1299_CR3","first-page":"9","volume":"74","author":"C Betterle","year":"2003","unstructured":"Betterle C, Zanchetta R. Update on autoimmune polyendocrine syndromes (APS). Acta Biomed. 2003;74(1):9\u201333.","journal-title":"Acta Biomed."},{"issue":"8","key":"1299_CR4","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1210\/jc.2011-0414","volume":"96","author":"G Reato","year":"2011","unstructured":"Reato G, Morlin L, Chen S, Furmaniak J, Rees Smith B, Masiero S, Albergoni P, Cervato S, Zanchetta R, Betterle C. Premature ovarian failure in patients with autoimmune Addison\u2019s disease: clinical, genetic, and immunological evaluation. J Clin Endocrinol Metab. 2011;96(8):1255\u201361.","journal-title":"J Clin Endocrinol Metab."},{"issue":"1","key":"1299_CR5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1080\/13625187.2019.1702638","volume":"25","author":"B Grossmann","year":"2020","unstructured":"Grossmann B, Saur S, Rall K, et al. Prevalence of autoimmune disease in women with premature ovarian failure. Eur J Contracept Reprod Health Care. 2020;25(1):72\u20135.","journal-title":"Eur J Contracept Reprod Health Care."},{"issue":"8","key":"1299_CR6","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1177\/0300060519863525","volume":"47","author":"L Cao","year":"2019","unstructured":"Cao L, Liu W, Zhu Z. Clinical characteristics and relationship between myasthenia gravis and premature ovarian failure: report of two cases. J Int Med Res. 2019;47(8):3992\u20137.","journal-title":"J Int Med Res."},{"issue":"4","key":"1299_CR7","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3109\/13697137.2015.1020484","volume":"18","author":"SS Faubion","year":"2015","unstructured":"Faubion SS, Kuhle CL, Shuster LT, Rocca WA. Long-term health consequences of premature or early menopause and considerations for management. Climacteric. 2015;18(4):483\u201391.","journal-title":"Climacteric."},{"issue":"4","key":"1299_CR8","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3109\/13697137.2011.571320","volume":"14","author":"D Singer","year":"2011","unstructured":"Singer D, Mann E, Hunter MS, Pitkin J, Panay N. The silent grief: psychosocial aspects of premature ovarian failure. Climacteric. 2011;14(4):428\u201337.","journal-title":"Climacteric."},{"issue":"10","key":"1299_CR9","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1210\/jc.2009-0817","volume":"94","author":"A La Marca","year":"2009","unstructured":"La Marca A, Marzotti S, Brozzetti A, et al. Primary ovarian insufficiency due to steroidogenic cell autoimmunity is associated with a preserved pool of functioning follicles. J Clin Endocrinol Metab. 2009;94(10):3816\u201323.","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"1299_CR10","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1365-2265.2012.04387.x","volume":"77","author":"A Falorni","year":"2012","unstructured":"Falorni A, Brozzetti A, Aglietti MC, et al. Progressive decline of residual follicle pool after clinical diagnosis of autoimmune ovarian insufficiency. Clin Endocrinol (Oxf). 2012;77(3):453\u20138.","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"3","key":"1299_CR11","first-page":"287","volume":"23","author":"AK Bartmann","year":"2019","unstructured":"Bartmann AK, Silveira LDF, Silva LFI, et al. Autoimmune hypothyroidism and intermittent ovarian failure\u2014case report. JBRA Assist Reprod. 2019;23(3):287\u20139.","journal-title":"JBRA Assist Reprod."},{"issue":"5","key":"1299_CR12","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4158\/EP.9.5.380","volume":"9","author":"B Patel","year":"2003","unstructured":"Patel B, Haddad R, Saxena I, Gossain VV. Spontaneous long-term remission in a patient with premature ovarian failure. Endocr Pract. 2003;9(5):380\u20133.","journal-title":"Endocr Pract."},{"issue":"Pt 2","key":"1299_CR13","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1177\/000456329703400216","volume":"34","author":"R Gama","year":"1997","unstructured":"Gama R, Wright J. Transient primary ovarian and thyroid failure. Ann Clin Biochem. 1997;34(Pt 2):208\u20139.","journal-title":"Ann Clin Biochem."},{"issue":"3","key":"1299_CR14","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1365-2265.1989.tb01254.x","volume":"31","author":"R Taylor","year":"1989","unstructured":"Taylor R, Smith NM, Angus B, Horne CH, Dunlop W. Return of fertility after twelve years of autoimmune ovarian failure. Clin Endocrinol (Oxf). 1989;31(3):305\u20138.","journal-title":"Clin Endocrinol (Oxf)."},{"issue":"4","key":"1299_CR15","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.fertnstert.2005.04.060","volume":"84","author":"VK Bakalov","year":"2005","unstructured":"Bakalov VK, Anasti JN, Calis KA, et al. Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46,XX spontaneous premature ovarian failure. Fertil Steril. 2005;84(4):958\u201365.","journal-title":"Fertil Steril."},{"issue":"1","key":"1299_CR16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1472-6874-3-2","volume":"3","author":"JA Novosad","year":"2003","unstructured":"Novosad JA, Kalantaridou SN, Tong ZB, Nelson LM. Ovarian antibodies as detected by indirect immunofluorescence are unreliable in the diagnosis of autoimmune premature ovarian failure: a controlled evaluation. BMC Womens Health. 2003;3(1):2.","journal-title":"BMC Womens Health."},{"key":"1299_CR17","doi-asserted-by":"crossref","first-page":"626924","DOI":"10.3389\/fendo.2021.626924","volume":"12","author":"B Ishizuka","year":"2021","unstructured":"Ishizuka B. Current understanding of the etiology, symptomatology, and treatment options in premature ovarian insufficiency (POI). Front Endocrinol (Lausanne). 2021;12:626924.","journal-title":"Front Endocrinol (Lausanne)."},{"key":"1299_CR18","unstructured":"National Heart, Lung, and Blood Institute. Study Quality Assessment Tools.\u00a0https:\/\/www.nhlbi.nih.gov\/health-topics\/study-quality-assessment-tools. Accessed May 18, 2023.\u00a0"},{"issue":"6","key":"1299_CR19","first-page":"316","volume":"39","author":"S Smith","year":"1994","unstructured":"Smith S, Hosid S. Premature ovarian failure associated with autoantibodies to the zona pellucida. Int J Fertil Menopausal Stud. 1994;39(6):316\u20139.","journal-title":"Int J Fertil Menopausal Stud."},{"issue":"2","key":"1299_CR20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0002-9343(86)90277-9","volume":"81","author":"SL Rabinowe","year":"1986","unstructured":"Rabinowe SL, Berger MJ, Welch WR, Dluhy RG. Lymphocyte dysfunction in autoimmune oophoritis. Resumption of menses with corticosteroids. Am J Med. 1986;81(2):347\u201350.","journal-title":"Am J Med."},{"issue":"4","key":"1299_CR21","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S0015-0282(16)55854-3","volume":"59","author":"Z Blumenfeld","year":"1993","unstructured":"Blumenfeld Z, Halachmi S, Peretz BA, et al. Premature ovarian failure\u2014the prognostic application of autoimmunity on conception after ovulation induction. Fertil Steril. 1993;59(4):750\u20135.","journal-title":"Fertil Steril."},{"issue":"7","key":"1299_CR22","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1093\/humrep\/14.7.1777","volume":"14","author":"SN Kalantaridou","year":"1999","unstructured":"Kalantaridou SN, Braddock DT, Patronas NJ, Nelson LM. Treatment of autoimmune premature ovarian failure. Hum Reprod. 1999;14(7):1777\u201382.","journal-title":"Hum Reprod."},{"issue":"2","key":"1299_CR23","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0015-0282(16)45687-6","volume":"36","author":"CB Coulam","year":"1981","unstructured":"Coulam CB, Kempers RD. Randall RV Premature ovarian failure: evidence for the autoimmune mechanism. Fertil Steril. 1981;36(2):238\u201340.","journal-title":"Fertil Steril."},{"key":"1299_CR24","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1136\/pgmj.61.722.1079","volume":"61","author":"N Finer","year":"1985","unstructured":"Finer N, Fogelman I, Bottazzo G. Pregnancy in a woman with premature ovarian failure. Postgrad Med J. 1985;61:1079\u201380.","journal-title":"Postgrad Med J."},{"key":"1299_CR25","doi-asserted-by":"crossref","unstructured":"Jung C, Paspaliaris W, Grill V, Lee D, Ward G. Reversible autoimmune thyroidiitis and oophoritis in a patient with Addison\u2019s disease. Intern Med J. 2007;37(6):422\u2013423.","DOI":"10.1111\/j.1445-5994.2007.01378.x"},{"issue":"6","key":"1299_CR26","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/0002-9343(73)90066-1","volume":"54","author":"M Edmonds","year":"1973","unstructured":"Edmonds M, Lamki L, Killinger DW, Volp\u00e9 R. Autoimmune thyroiditis, adrenalitis and oophoritis. Am J Med. 1973;54(6):782\u20137.","journal-title":"Am J Med."},{"issue":"4","key":"1299_CR27","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4274\/jcrpe.378","volume":"3","author":"EDP Cakir","year":"2011","unstructured":"Cakir EDP, Ozdemir O, Eren E, Saglam H, Okan M, Tanm OF. Resolution of autoimmune oophoritis after thymectomy in a myasthenia gravis patient. J Clin Res Pediatr Endocrinol. 2011;3(4):212\u20135.","journal-title":"J Clin Res Pediatr Endocrinol."},{"issue":"1","key":"1299_CR28","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0015-0282(16)46768-3","volume":"39","author":"BG Bateman","year":"1983","unstructured":"Bateman BG, Nunley WC Jr, Kitchin JD 3rd. Reversal of apparent premature ovarian failure in a patient with myasthenia gravis. Fertil Steril. 1983;39(1):108\u201310.","journal-title":"Fertil Steril."},{"issue":"2","key":"1299_CR29","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/mus.20067","volume":"30","author":"MM Ryan","year":"2004","unstructured":"Ryan MM, Jones HR Jr. Myasthenia gravis and premature ovarian failure. Muscle Nerve. 2004;30(2):231\u20133.","journal-title":"Muscle Nerve."},{"issue":"11","key":"1299_CR30","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1177\/0961203312449492","volume":"21","author":"YS Chang","year":"2012","unstructured":"Chang YS, Lai CC, Chen WS, Wang SH, Chou CT, Tsai CY. Protein-losing enteropathy and premature ovarian failure in a young woman with systemic lupus erythematosus. Lupus. 2012;21(11):1237\u20139.","journal-title":"Lupus."},{"issue":"7","key":"1299_CR31","doi-asserted-by":"crossref","first-page":"2430.e17","DOI":"10.1016\/j.fertnstert.2011.01.170","volume":"95","author":"F Ferrau","year":"2011","unstructured":"Ferrau F, Gangemi S, Vita G, Trimarchi F, Cannavo S. Pregnancy after azathioprine therapy for ulcerative colitis in a woman with autoimmune premature ovarian failure and Addison\u2019s disease: HLA haplotype characterization. Fertil Steril. 2011;95(7):2430.e17.","journal-title":"Fertil Steril."},{"issue":"2","key":"1299_CR32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/aji.12306","volume":"73","author":"N Rogenhofer","year":"2015","unstructured":"Rogenhofer N, Pavlik R, Jeschke U, Wypior G, Ochsenk\u00fchn R, Thaler CJ. Effective ovarian stimulation in a patient with resistant ovary syndrome and antigonadotrophin antibodies. Am J Reprod Immunol. 2015;73(2):185\u201391.","journal-title":"Am J Reprod Immunol."},{"issue":"1","key":"1299_CR33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12958-018-0350-1","volume":"16","author":"I Virant-Klun","year":"2018","unstructured":"Virant-Klun I, Vogler A. In vitro maturation of oocytes from excised ovarian tissue in a patient with autoimmune ovarian insufficiency possibly associated with Epstein-Barr virus infection. Reprod Biol Endocrinol. 2018;16(1):33.","journal-title":"Reprod Biol Endocrinol."},{"issue":"12","key":"1299_CR34","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1080\/09513590.2021.1928065","volume":"37","author":"L Chansel-Debordeaux","year":"2021","unstructured":"Chansel-Debordeaux L, Rault E, Depuydt C, et al. Successful live birth after in vitro maturation treatment in a patient with autoimmune premature ovarian failure: a case report and review of the literature. Gynecol Endocrinol. 2021;37(12):1138\u201342.","journal-title":"Gynecol Endocrinol."},{"issue":"4","key":"1299_CR35","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.fertnstert.2020.04.049","volume":"114","author":"M Grynberg","year":"2020","unstructured":"Grynberg M, Jacquesson L, Sifer C. In vitro maturation of oocytes for preserving fertility in autoimmune premature ovarian insufficiency. Fertil Steril. 2020;114(4):848\u201353.","journal-title":"Fertil Steril."},{"issue":"14","key":"1299_CR36","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1471-2288-14-43","volume":"26","author":"CR Hooijmans","year":"2014","unstructured":"Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE\u2019s risk of bias tool for animal studies. BMC Med Res Methodol. 2014;26(14):43. https:\/\/doi.org\/10.1186\/1471-2288-14-43.","journal-title":"BMC Med Res Methodol."},{"key":"1299_CR37","doi-asserted-by":"crossref","first-page":"113996","DOI":"10.1016\/j.jep.2021.113996","volume":"273","author":"S Chen","year":"2021","unstructured":"Chen S, Lu Y, Chen Y, et al. The effect of Bu Shen Huo Xue Tang on autoimmune premature ovarian insufficiency via modulation of the Nrf2\/Keap1 signaling pathway in mice. J Ethnopharmacol. 2021;273:113996.","journal-title":"J Ethnopharmacol."},{"issue":"4","key":"1299_CR38","first-page":"3302","volume":"15","author":"P Wang","year":"2018","unstructured":"Wang P, Lu Y, Chen S, Chen Y, Hu C, Zuo Y. Protective function of Bu Shen Huo Xue formula on the immunity of B6AF1 mice with experimental autoimmune premature ovarian failure. Exp Ther Med. 2018;15(4):3302\u201310.","journal-title":"Exp Ther Med."},{"key":"1299_CR39","doi-asserted-by":"crossref","first-page":"100638","DOI":"10.1016\/j.repbio.2022.100638","volume":"22","author":"H Chen","year":"2022","unstructured":"Chen H, Song L, Xu X, Han Z, Peng F, Zhang Q, Liu C, Liang X. The effect of icariin on autoimmune premature ovarian insufficiency via modulation of Nrf2\/HO-1\/Sirt-1 pathay in mice. Reprod Biol. 2022;22:100638.","journal-title":"Reprod Biol."},{"issue":"11","key":"1299_CR40","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.3390\/ijms17111855","volume":"17","author":"Q Ding","year":"2016","unstructured":"Ding Q, Wang Y, Li N, et al. Bidirectional estrogen-like effects of genistein on murine experimental autoimmune ovarian disease. Int J Mol Sci. 2016;17(11):1855.","journal-title":"Int J Mol Sci."},{"issue":"19","key":"1299_CR41","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.4103\/0366-6999.190668","volume":"129","author":"X He","year":"2016","unstructured":"He X, Wang SY, Yin CH, Wang T, Jia CW, Ma YM. Hydrogen-rich water exerting a protective effect on ovarian reserve function in a mouse model of immune premature ovarian failure induced by zona pellucida 3. Chin Med J (Engl). 2016;129(19):2331\u20137.","journal-title":"Chin Med J (Engl)."},{"issue":"9","key":"1299_CR42","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1016\/j.peptides.2006.03.001","volume":"27","author":"V Berberian","year":"2006","unstructured":"Berberian V, S\u00e1nchez S, S\u00e1nchez-Borzone M, Attademo AM, Lasaga M, Celis ME. Effect of alpha-melanotropin hormone on serum levels of luteinizing hormone and progesterone in experimental rat autoimmune oophoritis. Peptides. 2006;27(9):2295\u20139.","journal-title":"Peptides."},{"issue":"8","key":"1299_CR43","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/cbin.11165","volume":"43","author":"H Li","year":"2019","unstructured":"Li H, Zhao W, Wang L, et al. Human placenta-derived mesenchymal stem cells inhibit apoptosis of granulosa cells induced by IRE1\u03b1 pathway in autoimmune POF mice. Cell Biol Int. 2019;43(8):899\u2013909.","journal-title":"Cell Biol Int."},{"issue":"1","key":"1299_CR44","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s13287-019-1313-y","volume":"10","author":"X Lu","year":"2019","unstructured":"Lu X, Cui J, Cui L, et al. The effects of human umbilical cord-derived mesenchymal stem cell transplantation on endometrial receptivity are associated with Th1\/Th2 balance change and uNK cell expression of uterine in autoimmune premature ovarian failure mice. Stem Cell Res Ther. 2019;10(1):214.","journal-title":"Stem Cell Res Ther."},{"issue":"1","key":"1299_CR45","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13287-018-0772-x","volume":"9","author":"N Yin","year":"2018","unstructured":"Yin N, Wang Y, Lu X, et al. hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17\/Tc17 and Th17\/Treg cell ratios through the PI3K\/Akt signal pathway. Stem Cell Res Ther. 2018;9(1):37.","journal-title":"Stem Cell Res Ther."},{"issue":"7","key":"1299_CR46","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1177\/1933719117732156","volume":"25","author":"N Yin","year":"2018","unstructured":"Yin N, Zhao W, Luo Q, Yuan W, Luan X, Zhang H. Restoring ovarian function with human placenta-derived mesenchymal stem cells in autoimmune-induced premature ovarian failure mice mediated by Treg cells and associated cytokines. Reprod Sci. 2018;25(7):1073\u201382.","journal-title":"Reprod Sci."},{"key":"1299_CR47","first-page":"3249495","volume":"2020","author":"Z Wang","year":"2020","unstructured":"Wang Z, Wei Q, Wang H, et al. Mesenchymal stem cell therapy using human umbilical cord in a rat model of autoimmune-induced premature ovarian failure. Stem Cells Int. 2020;2020:3249495.","journal-title":"Stem Cells Int."},{"key":"1299_CR48","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.reprotox.2015.07.080","volume":"58","author":"J Lim","year":"2015","unstructured":"Lim J, Ortiz L, Nakamura BN, et al. Effects of deletion of the transcription factor Nrf2 and benzo [a]pyrene treatment on ovarian follicles and ovarian surface epithelial cells in mice. Reprod Toxicol. 2015;58:24\u201332.","journal-title":"Reprod Toxicol."},{"issue":"3","key":"1299_CR49","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1128\/MCB.26.3.940-954.2006","volume":"26","author":"X Hu","year":"2006","unstructured":"Hu X, Roberts JR, Apopa PL, Kan YW, Ma Q. Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice. Mol Cell Biol. 2006;26(3):940\u201354.","journal-title":"Mol Cell Biol."},{"issue":"2","key":"1299_CR50","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1530\/EJE-10-0257","volume":"163","author":"A Brozzetti","year":"2010","unstructured":"Brozzetti A, Marzotti S, La Torre D, et al. Autoantibody responses in autoimmune ovarian insufficiency and in Addison's disease are IgG1 dominated and suggest a predominant, but not exclusive, Th1 type of response. Eur J Endocrinol. 2010;163(2):309\u201317.","journal-title":"Eur J Endocrinol."},{"issue":"6","key":"1299_CR51","doi-asserted-by":"crossref","first-page":"e13125.51","DOI":"10.1111\/aji.13125","volume":"81","author":"M Kobayashi","year":"2019","unstructured":"Kobayashi M, Nakashima A, Yoshino O, et al. Decreased effector regulatory T cells and increased activated CD4+ T cells in premature ovarian insufficiency. Am J Reprod Immunol. 2019;81(6):e13125.51.","journal-title":"Am J Reprod Immunol."},{"issue":"43","key":"1299_CR52","doi-asserted-by":"crossref","first-page":"17474","DOI":"10.1073\/pnas.1312830110","volume":"110","author":"K Kawamura","year":"2013","unstructured":"Kawamura K, Cheng Y, Suzuki N, Deguchi M, Sato Y, Takae S, Ho CH, Kawamura N, Tamura M, Hashimoto S, Sugishita Y, Morimoto Y, Hosoi Y, Yoshioka N, Ishizuka B, Hsueh AJ. Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment. Proc Natl Acad Sci U S A. 2013;110(43):17474\u20139.","journal-title":"Proc Natl Acad Sci U S A."}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-023-01299-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-023-01299-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-023-01299-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T17:02:51Z","timestamp":1704992571000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-023-01299-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,27]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["1299"],"URL":"https:\/\/doi.org\/10.1007\/s43032-023-01299-5","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,27]]},"assertion":[{"value":"9 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"N\/A","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"N\/A","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"N\/A","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}