{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:26:58Z","timestamp":1788668818947,"version":"build-2803163510"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Atypical placental site nodule (APSN) is a rare benign gestational trophoblastic disease (GTD). It is a tumor-like transformation that has a certain probability of developing into a placental site trophoblastic tumor (PSTT) or epithelioid trophoblastic tumor (ETT). Because of its atypical clinical presentation, it is difficult to diagnose and susceptible to misdiagnosis highly, thus delaying the patient\u2019s condition. We report a scarce case of atypical nodules at the placental site of the uterine incision diverticulum in a 35-year-old female, who was irregular vaginal bleeding after a cesarean Sect.\u00a02\u00a0years. She was diagnosed by several local hospitals with intrauterine residue and was given a variety of Traditional Chinese Medicine (TCM) orally, but the symptoms of irregular vaginal bleeding have not been alleviated. After being transferred to several hospitals, she went to Hubei Maternal and Child Health Hospital for treatment. Under the condition of excluding the second pregnancy, she underwent hysteroscopic resection of lesions and laparoscopic repair of uterine incision diverticulum. The pathological diagnosis after the operation suggested that the focus at the uterine incision was an atypical placental nodule that invaded the myometrium of the uterus. The operation completely removed the focus, and then the patient was followed up every 3\u00a0months in the first postoperative year, then every 6\u00a0months up to 3\u00a0years, and then annually thereafter up to 5\u00a0years, and then maybe every 2\u00a0years thereafter. The patient\u2019s condition was quickly controlled, and the prognosis was good.<\/jats:p>","DOI":"10.1007\/s43032-023-01361-2","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T17:01:46Z","timestamp":1696266106000},"page":"555-559","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Atypical Placental Site Nodules within the Diverticulum of the Uterine Incision, a Rare Gestational Trophoblastic Disease Misdiagnosed as Intrauterine Residue: A Case Report"],"prefix":"10.1007","volume":"31","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuting","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingzhu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7870-0579","authenticated-orcid":false,"given":"Jie","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"key":"1361_CR1","doi-asserted-by":"publisher","unstructured":"McCluggage WG, Singh N, Gilks CB. Key changes to the World Health Organization (WHO) classification of female genital tumours introduced in the 5th edition (2020). Histopathology. 2022;80(5):762\u2013778. https:\/\/doi.org\/10.1111\/his.14609","DOI":"10.1111\/his.14609"},{"issue":"3","key":"1361_CR2","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1097\/PGP.0000000000000598","volume":"39","author":"J Dholakia","year":"2020","unstructured":"Dholakia J, Chen W, O\u2019Malley DM, Ronnett BM. A rare case of atypical placental site nodule with an emerging intermediate trophoblastic tumor. Int J Gynecol Pathol. 2020;39(3):238\u201346. https:\/\/doi.org\/10.1097\/PGP.0000000000000598.","journal-title":"Int J Gynecol Pathol"},{"key":"1361_CR3","doi-asserted-by":"publisher","first-page":"100994","DOI":"10.1016\/j.gore.2022.100994","volume":"41","author":"AL Brodsky","year":"2022","unstructured":"Brodsky AL, Hom-Tedla M, Fadare O, Mchale MT. Persistent trophoblastic atypia on endocervical curettage found to be an epithelioid trophoblastic tumor: a case report and review of the literature. Gynecol Oncol Rep. 2022;41:100994. https:\/\/doi.org\/10.1016\/j.gore.2022.100994.","journal-title":"Gynecol Oncol Rep."},{"key":"1361_CR4","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000934","author":"CE Perez","year":"2023","unstructured":"Perez CE, Chapel DB, Skala SL. Application of current pathologic criteria for atypical placental site nodule suggests that refined criteria are needed. Int J Gynecol Pathol. 2023. https:\/\/doi.org\/10.1097\/PGP.0000000000000934.","journal-title":"Int J Gynecol Pathol"},{"key":"1361_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.bpobgyn.2021.02.005","volume":"74","author":"B Kaur","year":"2021","unstructured":"Kaur B. Pathology of gestational trophoblastic disease (GTD). Best Pract Res Clin Obstet Gynaecol. 2021;74:3\u201328. https:\/\/doi.org\/10.1016\/j.bpobgyn.2021.02.005.","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"1","key":"1361_CR6","doi-asserted-by":"publisher","first-page":"65","DOI":"10.5858\/arpa.2018-0234-RA","volume":"143","author":"P Hui","year":"2019","unstructured":"Hui P. Gestational trophoblastic tumors: a timely review of diagnostic pathology. Arch Pathol Lab Med. 2019;143(1):65\u201374. https:\/\/doi.org\/10.5858\/arpa.2018-0234-RA.","journal-title":"Arch Pathol Lab Med"},{"issue":"1","key":"1361_CR7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/GCO.0000000000000674","volume":"33","author":"JJ Clark","year":"2021","unstructured":"Clark JJ, Slater S, Seckl MJ. Treatment of gestational trophoblastic disease in the 2020s. Curr Opin Obstet Gynecol. 2021;33(1):7\u201312. https:\/\/doi.org\/10.1097\/GCO.0000000000000674.","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"1","key":"1361_CR8","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1097\/PGP.0000000000000468","volume":"38","author":"WA Mccarthy","year":"2019","unstructured":"Mccarthy WA, Paquette C, Colavita M, Lawrence WD. Atypical placental site nodule arising in a postcesarean section scar. Int J Gynecol Pathol. 2019;38(1):71\u20135. https:\/\/doi.org\/10.1097\/PGP.0000000000000468.","journal-title":"Int J Gynecol Pathol"},{"issue":"3","key":"1361_CR9","doi-asserted-by":"publisher","first-page":"369","DOI":"10.11152\/mu-3149","volume":"24","author":"MM Cirstoiu","year":"2022","unstructured":"Cirstoiu MM, Sajin M, Baros A, Vasilescu S, Turcan N. The role of the ultrasound examination in atypical placental site trophoblastic tumour differential diagnosis and management. A case report. Med Ultrason. 2022;24(3):369\u201371. https:\/\/doi.org\/10.11152\/mu-3149.","journal-title":"Med Ultrason"},{"issue":"1","key":"1361_CR10","doi-asserted-by":"publisher","first-page":"100046","DOI":"10.1016\/j.modpat.2022.100046","volume":"36","author":"G Jeremie","year":"2023","unstructured":"Jeremie G, Allias F, Trecourt A, et al. Molecular analyses of chorionic-type intermediate trophoblastic lesions: atypical placental site nodules are closer to placental site nodules than epithelioid trophoblastic tumors. Mod Pathol. 2023;36(1):100046. https:\/\/doi.org\/10.1016\/j.modpat.2022.100046.","journal-title":"Mod Pathol"},{"key":"1361_CR11","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000958","author":"U Jo","year":"2023","unstructured":"Jo U, Kim GH, Kim KR. Reconsideration of the diagnostic criteria for an atypical placental site nodule comparing typical placental site nodule of the uterus: a report of two cases. Int J Gynecol Pathol. 2023. https:\/\/doi.org\/10.1097\/PGP.0000000000000958.","journal-title":"Int J Gynecol Pathol"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-023-01361-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-023-01361-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-023-01361-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T18:15:30Z","timestamp":1706638530000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-023-01361-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,2]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["1361"],"URL":"https:\/\/doi.org\/10.1007\/s43032-023-01361-2","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,2]]},"assertion":[{"value":"9 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the institutional review board of Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan. The informed consent requirement was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Written informed consent was obtained from the patient for the publication of any potentially identifiable images or data included in this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}