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Participants with a gestational age of\u2009&lt;\u200937\u00a0weeks, BMI of\u2009\u2265\u200935\u00a0kg\/m<jats:sup>2<\/jats:sup>, cerebrovascular or cardiovascular complications, multiple pregnancies, gestational hypertension, gestational diabetes, chronic hypertension, thyroid disease, birth weight of\u2009&lt;\u20092,500\u00a0g, emergency cesarean section, or cases in which epidural anesthesia was re-administered during delivery were excluded from the study. Maternal blood was collected on admission, and immediately after delivery, and umbilical artery blood was collected from the fetus. The oxidative stress status was assessed by measuring diacron-reactive oxygen metabolite (an index of the degree of lipid peroxide oxidation), biological antioxidant potential (an index of antioxidant capacity) and calculating the ratio of BAP\/d-ROMs (an index of the oxidative stress). The results showed that maternal oxidative stress immediately after delivery was lower in the LEA group than in the No LEA group. Moreover, the fetuses experienced less oxidative stress in the LEA group than in the No LEA group. Taken together, these results suggest that LEA may reduce maternal and fetal oxidative stress associated with childbirth.<\/jats:p>","DOI":"10.1007\/s43032-024-01580-1","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T14:01:23Z","timestamp":1715349683000},"page":"2753-2762","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of Maternal and Fetal Oxidative Stress During Delivery with Epidural Analgesia"],"prefix":"10.1007","volume":"31","author":[{"given":"Tomoo","family":"Yuba","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3965-0716","authenticated-orcid":false,"given":"Yoshihisa","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kinishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Uokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiyo","family":"Ootaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichi","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Fujino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"issue":"2","key":"1580_CR1","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1161\/01.ATV.0000149143.04821.eb","volume":"25","author":"CF Mueller","year":"2005","unstructured":"Mueller CF, Laude K, McNally JS, Harrison DG. 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