{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:30:12Z","timestamp":1788283812409,"version":"build-2803163510"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1007\/s43032-024-01731-4","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T16:27:21Z","timestamp":1730305641000},"page":"52-63","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tracing the Lipid Fingerprints of Preeclampsia"],"prefix":"10.1007","volume":"32","author":[{"given":"Suniti","family":"Vaishya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0551-7183","authenticated-orcid":false,"given":"Sadhana Ramchandra","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"issue":"5","key":"1731_CR1","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.jogc.2022.03.002","volume":"44","author":"LA Magee","year":"2022","unstructured":"Magee LA, Smith GN, Bloch C, C\u00f4t\u00e9 AM, Jain V, Nerenberg K, von Dadelszen P, Helewa M, Rey E. Guideline 426: hypertensive disorders of pregnancy: diagnosis, prediction, prevention, and management. J Obstet Gynecol Can. 2022;44(5):547\u201371.","journal-title":"J Obstet Gynecol Can"},{"issue":"14","key":"1731_CR2","doi-asserted-by":"publisher","first-page":"3154","DOI":"10.3390\/jcm10143154","volume":"10","author":"W Wojczakowski","year":"2021","unstructured":"Wojczakowski W, Kimber-Trojnar \u017b, Dziwisz F, S\u0142odzi\u0144ska M, S\u0142odzi\u0144ski H, Leszczy\u0144ska-Gorzelak B. Preeclampsia and cardiovascular risk for offspring. J Clin Med. 2021;10(14):3154.","journal-title":"J Clin Med"},{"issue":"1","key":"1731_CR3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12916-023-02740-x","volume":"21","author":"L Chen","year":"2023","unstructured":"Chen L, Mir SA, Bendt AK, Chua EW, Narasimhan K, Tan KM, Loy SL, Tan KH, Shek LP, Chan J, Yap F. Plasma lipidomic profiling reveals metabolic adaptations to pregnancy and signatures of cardiometabolic risk: a preconception and longitudinal cohort study. BMC Med. 2023;21(1):53.","journal-title":"BMC Med"},{"key":"1731_CR4","doi-asserted-by":"publisher","first-page":"e72779","DOI":"10.7554\/eLife.72779","volume":"11","author":"S Burugupalli","year":"2022","unstructured":"Burugupalli S, Smith AA, Oshlensky G, Huynh K, Giles C, Wang T, George A, Paul S, Nguyen A, Duong T, Mellett N. Ontogeny of circulating lipid metabolism in pregnancy and early childhood\u2013a longitudinal population study. Elife. 2022;11:e72779.","journal-title":"Elife"},{"issue":"1","key":"1731_CR5","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/oby.23915","volume":"32","author":"SW Waldrop","year":"2024","unstructured":"Waldrop SW, Niemiec S, Wood C, Gyllenhammer LE, Jansson T, Friedman JE, Tryggestad JB, Borengasser SJ, Davidson EJ, Yang IV, Kechris K. Cord blood DNA methylation of immune and lipid metabolism genes is associated with maternal triglycerides and child adiposity. Obesity. 2024;32(1):187\u201399.","journal-title":"Obesity"},{"issue":"5","key":"1731_CR6","doi-asserted-by":"publisher","first-page":"e0251227","DOI":"10.1371\/journal.pone.0251227","volume":"16","author":"S Nabweyambo","year":"2021","unstructured":"Nabweyambo S, Sande OJ, McGovern N, Bwanga F, Ssekagiri A, Keesiga A, Adroma M, Wasswa R, Atuheirwe M, Namugenyi J, Castelnuovo B. Circulating levels of angiogenic factors and their association with preeclampsia among pregnant women at Mulago National Referral Hospital in Uganda. PLoS ONE. 2021;16(5):e0251227.","journal-title":"PLoS ONE"},{"key":"1731_CR7","doi-asserted-by":"publisher","first-page":"807583","DOI":"10.3389\/fphys.2022.807583","volume":"13","author":"L Zhang","year":"2022","unstructured":"Zhang L, Bi S, Liang Y, Huang L, Li Y, Huang M, Huang B, Deng W, Liang J, Gu S, Chen J. Integrated metabolomic and lipidomic analysis in the placenta of preeclampsia. Front Physiol. 2022;13:807583.","journal-title":"Front Physiol"},{"issue":"1","key":"1731_CR8","doi-asserted-by":"publisher","first-page":"16142","DOI":"10.1038\/s41598-020-72852-4","volume":"10","author":"SM Lee","year":"2020","unstructured":"Lee SM, Kang Y, Lee EM, Jung YM, Hong S, Park SJ, Park CW, Norwitz ER, Lee DY, Park JS. Metabolomic biomarkers in midtrimester maternal plasma can accurately predict the development of preeclampsia. Sci Rep. 2020;10(1):16142.","journal-title":"Sci Rep"},{"issue":"5","key":"1731_CR9","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1002\/wdev.238","volume":"5","author":"A Rani","year":"2016","unstructured":"Rani A, Wadhwani N, Chavan-Gautam P, Joshi S. Altered development and function of the placental regions in preeclampsia and its association with long\u2010chain polyunsaturated fatty acids. Wiley Interdisciplinary Reviews: Dev Biology. 2016;5(5):582\u201397.","journal-title":"Wiley Interdisciplinary Reviews: Dev Biology"},{"issue":"1\u20132","key":"1731_CR10","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.plefa.2010.09.005","volume":"84","author":"AV Kulkarni","year":"2011","unstructured":"Kulkarni AV, Mehendale SS, Yadav HR, Joshi SR. Reduced placental docosahexaenoic acid levels associated with increased levels of sFlt-1 in preeclampsia. Prostaglandins Leukot Essent Fatty Acids. 2011;84(1\u20132):51\u20135.","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"1731_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12884-021-04313-3","volume":"22","author":"H Herlambang","year":"2022","unstructured":"Herlambang H, Puspasari A, Maharani C, Enis RN, Tarawifa S, Fitri AD, Harahap H, Harahap AH, Kusdiyah E, Syamsunarno MR. Comprehensive fatty acid fractionation profilling in preeclampsia: a case control study with multivariable analysis. BMC Pregnancy Childbirth. 2022;22:1\u20137.","journal-title":"BMC Pregnancy Childbirth"},{"key":"1731_CR12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.prostaglandins.2018.09.006","volume":"139","author":"D Wojcik-Baszko","year":"2018","unstructured":"Wojcik-Baszko D, Charkiewicz K, Laudanski P. Role of dyslipidemia in preeclampsia\u2014A review of lipidomic analysis of blood, placenta, syncytiotrophoblast microvesicles and umbilical cord artery from women with preeclampsia. Prostaglandins Other Lipid Mediat. 2018;139:19\u201323.","journal-title":"Prostaglandins Other Lipid Mediat"},{"issue":"4","key":"1731_CR13","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1093\/aje\/kwu145","volume":"180","author":"CN Spracklen","year":"2014","unstructured":"Spracklen CN, Smith CJ, Saftlas AF, Robinson JG, Ryckman KK. Maternal hyperlipidemia and the risk of preeclampsia: a meta-analysis. Am J Epidemiol. 2014;180(4):346\u201358.","journal-title":"Am J Epidemiol"},{"issue":"2","key":"1731_CR14","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ajog.2019.03.025","volume":"221","author":"MC Adank","year":"2019","unstructured":"Adank MC, Benschop L, Peterbroers KR, Gregoor AM, Kors AW, Mulder MT, et al. Is maternal lipid profile in early pregnancy associated with pregnancy complications and blood pressure in pregnancy and long term postpartum? Am J Obstet Gynecol. 2019;221(2):150\u2013e1.","journal-title":"Am J Obstet Gynecol"},{"key":"1731_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11306-020-1639-6","volume":"16","author":"AC Morillon","year":"2020","unstructured":"Morillon AC, Yakkundi S, Thomas G, Gethings LA, Langridge JI, Baker PN, Kenny LC, English JA, McCarthy FP. Association between phospholipid metabolism in plasma and spontaneous preterm birth: a discovery lipidomic analysis in the cork pregnancy cohort. Metabolomics. 2020;16:1\u20130.","journal-title":"Metabolomics"},{"key":"1731_CR16","doi-asserted-by":"crossref","unstructured":"He B, Liu Y, Maurya MR, Benny P, Lassiter C, Li H, Subramaniam S, Garmire LX. The maternal blood lipidome is indicative of the pathogenesis of severe preeclampsia. J Lipid Res. 2021;62.","DOI":"10.1016\/j.jlr.2021.100118"},{"issue":"4","key":"1731_CR17","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1080\/15548627.2015.1034414","volume":"11","author":"M Melland-Smith","year":"2015","unstructured":"Melland-Smith M, Ermini L, Chauvin S, Craig-Barnes H, Tagliaferro A, Todros T, Post M, Caniggia I. Disruption of sphingolipid metabolism augments ceramide-induced autophagy in preeclampsia. Autophagy. 2015;11(4):653\u201369.","journal-title":"Autophagy"},{"issue":"7","key":"1731_CR18","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.amjhyper.2004.03.666","volume":"17","author":"DA Enquobahrie","year":"2004","unstructured":"Enquobahrie DA, Williams MA, Butler CL, Frederick IO, Miller RS, Luthy DA. Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia. Am J Hypertens. 2004;17(7):574\u201381.","journal-title":"Am J Hypertens"},{"key":"1731_CR19","doi-asserted-by":"publisher","first-page":"102583","DOI":"10.1016\/j.plefa.2023.102583","volume":"196","author":"AA Godhamgaonkar","year":"2023","unstructured":"Godhamgaonkar AA, Wadhwani NS, Randhir KN, Selukar SS, Dalvi S, Dangat K, Wagh GN, Lalwani S, Chandhiok N, Kulkarni B, Fall C. Erythrocyte fatty acids and desaturase indices in early pregnancy are associated with risk of preeclampsia. Prostaglandins Leukot Essent Fatty Acids. 2023;196:102583.","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"1","key":"1731_CR20","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1097\/HJH.0000000000002596","volume":"39","author":"AA Khaire","year":"2021","unstructured":"Khaire AA, Thakar SR, Wagh GN, Joshi SR. Placental lipid metabolism in preeclampsia. J Hypertens. 2021;39(1):127\u201334.","journal-title":"J Hypertens"},{"issue":"5","key":"1731_CR21","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1194\/jlr.E400004-JLR200","volume":"46","author":"E Fahy","year":"2005","unstructured":"Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Seyama Y, Shaw W, Shimizu T. A comprehensive classification system for lipids1. J Lipid Res. 2005;46(5):839\u201361.","journal-title":"J Lipid Res"},{"key":"1731_CR22","first-page":"10","volume":"22","author":"JW Mulder","year":"2024","unstructured":"Mulder JW, Kusters DM, van Lennep JE, Hutten BA. Lipid metabolism during pregnancy: consequences for mother and child. Curr Opin Lipidol. 2024;22:10\u201397.","journal-title":"Curr Opin Lipidol"},{"issue":"3","key":"1731_CR23","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1111\/aogs.14505","volume":"102","author":"HN Skytte","year":"2023","unstructured":"Skytte HN, Christensen JJ, Gunnes N, Holven KB, Lekva T, Henriksen T, Michelsen TM, Roland MC. Metabolic profiling of pregnancies complicated by preeclampsia: a longitudinal study. Acta Obstet Gynecol Scand. 2023;102(3):334\u201343.","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"10","key":"1731_CR24","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.3390\/jcm13102795","volume":"13","author":"N Saadat","year":"2024","unstructured":"Saadat N, Aguate F, Nowak AL, Hyer S, Lin AB, Decot H, Koch H, Walker DS, Lydic T, Padmanabhan V, Campos GD. Changes in lipid profiles with the Progression of Pregnancy in Black women. J Clin Med. 2024;13(10):2795.","journal-title":"J Clin Med"},{"key":"1731_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12884-021-04251-0","volume":"21","author":"E Aparicio","year":"2021","unstructured":"Aparicio E, Mart\u00edn-Grau C, Hern\u00e1ndez-Martinez C, Voltas N, Canals J, Arija V. Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy. BMC Pregnancy Childbirth. 2021;21:1\u20130.","journal-title":"BMC Pregnancy Childbirth"},{"issue":"1","key":"1731_CR26","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.1038\/sj.ejcn.1600984","volume":"54","author":"E Herrera","year":"2000","unstructured":"Herrera E. Metabolic adaptations in pregnancy and their implications for the availability of substrates to the fetus. Eur J Clin Nutr. 2000;54(1):S47\u201351.","journal-title":"Eur J Clin Nutr"},{"key":"1731_CR27","doi-asserted-by":"publisher","first-page":"102080","DOI":"10.1016\/j.plefa.2020.102080","volume":"155","author":"AK Duttaroy","year":"2020","unstructured":"Duttaroy AK, Basak S. Maternal dietary fatty acids and their roles in human placental development. Prostaglandins Leukot Essent Fatty Acids. 2020;155:102080.","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"issue":"10\u201311","key":"1731_CR28","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.clinbiochem.2012.04.012","volume":"45","author":"L De Oliveira","year":"2012","unstructured":"De Oliveira L, C\u00e2mara NO, Bonetti T, Turco EG, Bertolla RP, Moron AF, Sass N, Da Silva ID. Lipid fingerprinting in women with early-onset preeclampsia: a first look. Clin Biochem. 2012;45(10\u201311):852\u20135.","journal-title":"Clin Biochem"},{"issue":"10","key":"1731_CR29","doi-asserted-by":"publisher","first-page":"e110747","DOI":"10.1371\/journal.pone.0110747","volume":"9","author":"HA Korkes","year":"2014","unstructured":"Korkes HA, Sass N, Moron AF, C\u00e2mara NO, Bonetti T, Cerdeira AS, Da Silva ID, De Oliveira L. Lipidomic assessment of plasma and placenta of women with early-onset preeclampsia. PLoS ONE. 2014;9(10):e110747.","journal-title":"PLoS ONE"},{"issue":"1","key":"1731_CR30","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1038\/s41598-018-37757-3","volume":"9","author":"SM Lee","year":"2019","unstructured":"Lee SM, Moon JY, Lim BY, Kim SM, Park CW, Kim BJ, Jun JK, Norwitz ER, Choi MH, Park JS. Increased biosynthesis and accumulation of cholesterol in maternal plasma, but not amniotic fluid in pre-eclampsia. Sci Rep. 2019;9(1):1550.","journal-title":"Sci Rep"},{"issue":"8","key":"1731_CR31","doi-asserted-by":"publisher","first-page":"2970","DOI":"10.3390\/jcm12082970","volume":"12","author":"IM Williams","year":"2023","unstructured":"Williams IM, Albertolle ME, Layden AJ, Tao SY, Fisher SJ, Gandley RE, Roberts JM. Lipidomics Reveals Elevated Plasmalogens in women with obesity who develop Preeclampsia. J Clin Med. 2023;12(8):2970.","journal-title":"J Clin Med"},{"issue":"2","key":"1731_CR32","doi-asserted-by":"publisher","first-page":"71","DOI":"10.5830\/CVJA-2016-009","volume":"27","author":"P Gathiram","year":"2016","unstructured":"Gathiram P, Moodley JJ. Pre-eclampsia: its pathogenesis and pathophysiolgy: review articles. Cardiovasc J Afr. 2016;27(2):71\u20138.","journal-title":"Cardiovasc J Afr"},{"key":"1731_CR33","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.biochi.2022.12.002","volume":"208","author":"Y Yang","year":"2023","unstructured":"Yang Y, Wu L, Lv Y, Miao Z, Wang Y, Yan J, Li J, Li C, Ding H. LC-MS\/MS based untargeted lipidomics uncovers lipid signatures of late-onset preeclampsia. Biochimie. 2023;208:46\u201355.","journal-title":"Biochimie"},{"key":"1731_CR34","doi-asserted-by":"publisher","first-page":"104704","DOI":"10.1016\/j.ebiom.2023.104704","volume":"94","author":"LA Bartho","year":"2023","unstructured":"Bartho LA, Keenan E, Walker SP, MacDonald TM, Nijagal B, Tong S, Tu\u2019uhevaha J. Plasma lipids are dysregulated preceding diagnosis of preeclampsia or delivery of a growth restricted infant. Ebiomedicine. 2023;94:104704. https:\/\/doi.org\/10.1016\/j.ebiom.2023.104704.","journal-title":"Ebiomedicine"},{"issue":"3","key":"1731_CR35","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/S0092-8674(00)81661-X","volume":"99","author":"MJ Lee","year":"1999","unstructured":"Lee MJ, Thangada S, Claffey KP, Ancellin N, Liu CH, Kluk M, Volpi M, Ramadan I, Hla T. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell. 1999;99(3):301\u201312.","journal-title":"Cell"},{"issue":"13","key":"1731_CR36","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.3390\/molecules24132404","volume":"24","author":"X Wang","year":"2019","unstructured":"Wang X, Zhan E, Lu G, Mu Q, Zhang T, Yang N. Sphingosine-1-phosphate improves the biological features of mouse bone marrow-derived EPCs partially through PI3K\/AKT\/eNOS\/NO pathway. Molecules. 2019;24(13):2404.","journal-title":"Molecules"},{"key":"1731_CR37","doi-asserted-by":"crossref","unstructured":"Del Gaudio I, Sreckovic I, Zardoya-Laguardia P, Bernhart E, Christoffersen C, Frank S, Marsche G, Illanes SE, Wadsack C. Circulating cord blood HDL-S1P complex preserves the integrity of the feto-placental vasculature. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of lipids. 2020;1865(4):158632.","DOI":"10.1016\/j.bbalip.2020.158632"},{"issue":"3","key":"1731_CR38","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.3390\/ijms21031019","volume":"21","author":"I Del Gaudio","year":"2020","unstructured":"Del Gaudio I, Sasset L, Di Lorenzo A, Wadsack C. Sphingolipid signature of human feto-placental vasculature in preeclampsia. Int J Mol Sci. 2020;21(3):1019.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"1731_CR39","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.preghy.2016.08.083","volume":"6","author":"RM Ferreira","year":"2016","unstructured":"Ferreira RM, Borges V, Hueb JC, Bazan R, da Silva Ferreira S, Roscani MG, Pera\u00e7oli JC, Martin LC, Bazan SG. 1 Cardiovascular risk factors in women with preeclampsia history and their association with myocardial hypertrophy and intima-media thickening of the carotids: Cardiovascular risks and metabolic diseases. Pregnancy Hypertension: Int J Women\u2019s Cardiovasc Health. 2016;6(3):178.","journal-title":"Pregnancy Hypertension: Int J Women\u2019s Cardiovasc Health"},{"issue":"8","key":"1731_CR40","first-page":"158955","volume":"1866","author":"P Patanapirunhakit","year":"2021","unstructured":"Patanapirunhakit P, Karlsson H, Mulder M, Ljunggren S, Graham D, Freeman D. Sphingolipids in HDL\u2013potential markers for adaptation to pregnancy? Biochim et Biophys Acta (BBA)-Molecular Cell Biology Lipids. 2021;1866(8):158955.","journal-title":"Biochim et Biophys Acta (BBA)-Molecular Cell Biology Lipids"},{"issue":"5","key":"1731_CR41","doi-asserted-by":"publisher","first-page":"e0177601","DOI":"10.1371\/journal.pone.0177601","volume":"12","author":"K Charkiewicz","year":"2017","unstructured":"Charkiewicz K, Goscik J, Blachnio-Zabielska A, Raba G, Sakowicz A, Kalinka J, Chabowski A, Laudanski P. Sphingolipids as a new factor in the pathomechanism of preeclampsia\u2013Mass spectrometry analysis. PLoS ONE. 2017;12(5):e0177601.","journal-title":"PLoS ONE"},{"key":"1731_CR42","doi-asserted-by":"crossref","unstructured":"Stephenson DJ, MacKnight HP, Hoeferlin LA, Washington SL, Sawyers C, Archer KJ, Strauss JF, Walsh SW, Chalfant CE. Bioactive lipid mediators in plasma are predictors of preeclampsia irrespective of aspirin therapy. J Lipid Res. 2023;64(6).","DOI":"10.1016\/j.jlr.2023.100377"},{"issue":"2","key":"1731_CR43","doi-asserted-by":"publisher","first-page":"e2590","DOI":"10.1038\/cddis.2016.483","volume":"8","author":"LJ Bailey","year":"2017","unstructured":"Bailey LJ, Alahari S, Tagliaferro A, Post M, Caniggia I. Augmented trophoblast cell death in preeclampsia can proceed via ceramide-mediated necroptosis. Cell Death Dis. 2017;8(2):e2590.","journal-title":"Cell Death Dis"},{"issue":"1","key":"1731_CR44","first-page":"605101","volume":"2012","author":"SJ Thomson","year":"2012","unstructured":"Thomson SJ, Askari A, Bishop-Bailey D. Anti-inflammatory effects of epoxyeicosatrienoic acids. Int J Vascular Med. 2012;2012(1):605101.","journal-title":"Int J Vascular Med"},{"issue":"24","key":"1731_CR45","doi-asserted-by":"publisher","first-page":"9628","DOI":"10.3390\/ijms21249628","volume":"21","author":"M Szczuko","year":"2020","unstructured":"Szczuko M, Kikut J, Komorniak N, Bilicki J, Celewicz Z, Zi\u0119tek M. The role of arachidonic and linoleic acid derivatives in pathological pregnancies and the human reproduction process. Int J Mol Sci. 2020;21(24):9628.","journal-title":"Int J Mol Sci"},{"issue":"9","key":"1731_CR46","doi-asserted-by":"publisher","first-page":"21520","DOI":"10.3390\/ijms160921520","volume":"16","author":"M Austdal","year":"2015","unstructured":"Austdal M, Tanger\u00e5s LH, Skr\u00e5stad RB, Salvesen K\u00c5, Austgulen R, Iversen AC, Bathen TF. First trimester urine and serum metabolomics for prediction of preeclampsia and gestational hypertension: a prospective screening study. Int J Mol Sci. 2015;16(9):21520\u201338.","journal-title":"Int J Mol Sci"},{"issue":"12","key":"1731_CR47","doi-asserted-by":"publisher","first-page":"3863","DOI":"10.3390\/ijms19123863","volume":"19","author":"CG Reyes-Hern\u00e1ndez","year":"2018","unstructured":"Reyes-Hern\u00e1ndez CG, Ramiro-Cortijo D, Rodr\u00edguez-Rodr\u00edguez P, Giambelluca S, Simonato M, Gonz\u00e1lez MD, L\u00f3pez de Pablo AL, L\u00f3pez-Gim\u00e9nez MD, Cogo P, de S\u00e1enz M, Carnielli VP. Effects of arachidonic and docosohexahenoic acid supplementation during gestation in rats. Implication of placental oxidative stress. Int J Mol Sci. 2018;19(12):3863.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"1731_CR48","doi-asserted-by":"publisher","first-page":"e96510","DOI":"10.1371\/journal.pone.0096510","volume":"9","author":"D Yuan","year":"2014","unstructured":"Yuan D, Ran Y, Liu Q, Zhang Y, Li H, Li P, Zhu D. Enhancement of the HIF-1\u03b1\/15-LO\/15-HETE axis promotes hypoxia-induced endothelial proliferation in preeclamptic pregnancy. PLoS ONE. 2014;9(5):e96510.","journal-title":"PLoS ONE"},{"issue":"1\u20132","key":"1731_CR49","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.plefa.2011.10.006","volume":"86","author":"Y Wang","year":"2012","unstructured":"Wang Y, Zhu D, An Y, Sun J, Cai L, Zheng J. Preeclampsia activates 15-lipoxygenase and its metabolite 15-hydroxyeicosatetraenoic acid enhances constriction in umbilical arteries. Prostaglandins Leukot Essent Fatty Acids. 2012;86(1\u20132):79\u201384.","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"1731_CR50","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.prostaglandins.2017.09.004","volume":"134","author":"JL Faulkner","year":"2018","unstructured":"Faulkner JL, Plenty NL, Wallace K, Amaral LM, Cunningham MW, Murphy S, LaMarca B. Selective inhibition of 20-hydroxyeicosatetraenoic acid lowers blood pressure in a rat model of preeclampsia. Prostaglandins Other Lipid Mediat. 2018;134:108\u201313.","journal-title":"Prostaglandins Other Lipid Mediat"},{"issue":"5","key":"1731_CR51","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.3892\/mmr.2014.2017","volume":"9","author":"S Lu","year":"2014","unstructured":"Lu S, Zhu C, Long A, Tan L, Li Q, Zhu Y. Effect of 20-hydroxyeicosatetraenoic acid on biological behavior of human villous trophoblasts and uterine vascular smooth muscle cells. Mol Med Rep. 2014;9(5):1889\u201394.","journal-title":"Mol Med Rep"},{"key":"1731_CR52","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.phrs.2018.04.002","volume":"132","author":"SA Mathew","year":"2018","unstructured":"Mathew SA, Bhonde RR. Omega-3 polyunsaturated fatty acids promote angiogenesis in placenta derived mesenchymal stromal cells. Pharmacol Res. 2018;132:90\u20138.","journal-title":"Pharmacol Res"},{"issue":"11","key":"1731_CR53","first-page":"755","volume":"23","author":"C Yang","year":"2017","unstructured":"Yang C, Lim W, Bazer FW, Song G. Oleic acid stimulation of motility of human extravillous trophoblast cells is mediated by stearoyl-CoA desaturase-1 activity. MHR: Basic Sci Reproductive Med. 2017;23(11):755\u201370.","journal-title":"MHR: Basic Sci Reproductive Med"},{"issue":"8","key":"1731_CR54","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.3390\/ijms18081651","volume":"18","author":"Y Ye","year":"2017","unstructured":"Ye Y, Vattai A, Zhang X, Zhu J, Thaler CJ, Mahner S, Jeschke U. Von Sch\u00f6nfeldt V. Role of plasminogen activator inhibitor type 1 in pathologies of female reproductive diseases. Int J Mol Sci. 2017;18(8):1651.","journal-title":"Int J Mol Sci"},{"issue":"11","key":"1731_CR55","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1093\/molehr\/gaaa061","volume":"26","author":"AM Rampersaud","year":"2020","unstructured":"Rampersaud AM, Dunk CE, Lye SJ, Renaud SJ. Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1. Mol Hum Reprod. 2020;26(11):850\u201365.","journal-title":"Mol Hum Reprod"},{"issue":"4","key":"1731_CR56","doi-asserted-by":"publisher","first-page":"e0249907","DOI":"10.1371\/journal.pone.0249907","volume":"16","author":"SK Natarajan","year":"2021","unstructured":"Natarajan SK, Bruett T, Muthuraj PG, Sahoo PK, Power J, Mott JL, Hanson C, Anderson-Berry A. Saturated free fatty acids induce placental trophoblast lipoapoptosis. PLoS ONE. 2021;16(4):e0249907.","journal-title":"PLoS ONE"},{"issue":"3","key":"1731_CR57","doi-asserted-by":"publisher","first-page":"500","DOI":"10.3390\/antiox11030500","volume":"11","author":"MJ Ya\u00f1ez","year":"2022","unstructured":"Ya\u00f1ez MJ, Leiva A. Human placental intracellular cholesterol transport: a focus on lysosomal and mitochondrial dysfunction and oxidative stress. Antioxidants. 2022;11(3):500.","journal-title":"Antioxidants"},{"issue":"9","key":"1731_CR58","doi-asserted-by":"publisher","first-page":"e0163972","DOI":"10.1371\/journal.pone.0163972","volume":"11","author":"SH Brown","year":"2016","unstructured":"Brown SH, Eather SR, Freeman DJ, Meyer BJ, Mitchell TW. A lipidomic analysis of placenta in preeclampsia: evidence for lipid storage. PLoS ONE. 2016;11(9):e0163972.","journal-title":"PLoS ONE"},{"issue":"4","key":"1731_CR59","doi-asserted-by":"publisher","first-page":"e0175118","DOI":"10.1371\/journal.pone.0175118","volume":"12","author":"A Dobierzewska","year":"2017","unstructured":"Dobierzewska A, Soman S, Illanes SE, Morris AJ. Plasma cross-gestational sphingolipidomic analyses reveal potential first trimester biomarkers of preeclampsia. PLoS ONE. 2017;12(4):e0175118.","journal-title":"PLoS ONE"},{"issue":"6","key":"1731_CR60","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1039\/D0MO00074D","volume":"16","author":"MT Odenkirk","year":"2020","unstructured":"Odenkirk MT, Stratton KG, Gritsenko MA, Bramer LM, Webb-Robertson BJM, Bloodsworth KJ, Weitz KK, Lipton AK, Monroe ME, Ash JR, Fourches D. Unveiling molecular signatures of preeclampsia and gestational diabetes mellitus with multi-omics and innovative cheminformatics visualization tools. Mol Omics. 2020;16(6):521\u201332.","journal-title":"Mol Omics"},{"issue":"4","key":"1731_CR61","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1194\/jlr.P064451","volume":"57","author":"S Anand","year":"2016","unstructured":"Anand S, Young S, Esplin MS, Peaden B, Tolley HD, Porter TF, et al. Detection and confirmation of serum lipid biomarkers for preeclampsia using direct infusion mass spectrometry [S]. J Lipid Res. 2016;57(4):687\u201396.","journal-title":"J Lipid Res"},{"issue":"1","key":"1731_CR62","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3390\/nu15010140","volume":"15","author":"KM Maner-Smith","year":"2022","unstructured":"Maner-Smith KM, Ferranti E, Dunlop A, Corwin E, Ortlund EA. African American women with cardiometabolic complications of pregnancy have decreased serum abundance of Specialized pro-resolving lipid mediators and endocannabinoids. Nutrients. 2022;15(1):140.","journal-title":"Nutrients"},{"issue":"2","key":"1731_CR63","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.biochi.2008.10.004","volume":"91","author":"L Romanowicz","year":"2009","unstructured":"Romanowicz L, Ba\u0144kowski E. Lipid compounds of the umbilical cord vein and their alterations in preeclampsia. Biochimie. 2009;91(2):288\u201394.","journal-title":"Biochimie"},{"issue":"1","key":"1731_CR64","doi-asserted-by":"publisher","first-page":"14616","DOI":"10.1038\/s41598-018-32804-5","volume":"8","author":"T J\u00e4\u00e4skel\u00e4inen","year":"2018","unstructured":"J\u00e4\u00e4skel\u00e4inen T, K\u00e4rkk\u00e4inen O, Jokkala J, Litonius K, Heinonen S, Auriola S, Lehtonen M, Hanhineva K, Laivuori H, FINNPEC. A non-targeted LC-MS profiling reveals elevated levels of carnitine precursors and trimethylated compounds in the cord plasma of pre-eclamptic infants. Sci Rep. 2018;8(1):14616.","journal-title":"Sci Rep"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-024-01731-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-024-01731-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-024-01731-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T17:56:31Z","timestamp":1736790991000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-024-01731-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,30]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["1731"],"URL":"https:\/\/doi.org\/10.1007\/s43032-024-01731-4","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,30]]},"assertion":[{"value":"23 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors report no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}