{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T20:06:33Z","timestamp":1785009993747,"version":"3.55.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2022YFC2700073"],"award-info":[{"award-number":["2022YFC2700073"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201880"],"award-info":[{"award-number":["82201880"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020771","name":"Natural Science Foundation for Young Scientists of Shanxi Province","doi-asserted-by":"publisher","award":["82471731"],"award-info":[{"award-number":["82471731"]}],"id":[{"id":"10.13039\/501100020771","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["226-2024-00040"],"award-info":[{"award-number":["226-2024-00040"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract <\/jats:title>\n          <jats:p>Here, we report on a rare case of a successful live birth in a patient with empty follicle syndrome. A 35-year-old woman with ovulatory disorder and a 4-year history of primary infertility conducted in vitro fertilization-embryo transfer (IVF-ET) treatment in our hospital. The patient experienced six controlled ovarian stimulation cycles. In the first two cycles, despite adequate ovarian response, normal development of multiple follicles, and normal serum estradiol (E2) levels, no oocytes were retrieved from these mature follicles during the aspiration procedure. The patient was diagnosed with \u201cempty follicle syndrome\u201d. Whole exome sequencing (WES) identified a missense mutation in the luteinizing hormone\/chorionic gonadotropin receptor (LHCGR). In subsequent cycles, we try to increase the trigger dosage, combine gonadotropin-releasing hormone agonists (GnRH agonist) with human chorionic gonadotropin (HCG) for a dual trigger, supplement with luteinizing hormone (LH)-like active substances during the stimulation process, and extend the time between triggering and oocyte retrieval. In the end, successful oocyte retrieval and pregnancy were achieved.<\/jats:p>","DOI":"10.1007\/s43032-024-01738-x","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T17:53:12Z","timestamp":1732125192000},"page":"660-667","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Successful Live Birth Outcome in A Patient with Empty Follicle Syndrome: A Case Report and Literature Review"],"prefix":"10.1007","volume":"32","author":[{"given":"Fang","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6982-445X","authenticated-orcid":false,"given":"Xiaomei","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"issue":"3","key":"1738_CR1","doi-asserted-by":"publisher","first-page":"147","DOI":"10.4103\/0974-1208.92290","volume":"4","author":"M Smisha","year":"2011","unstructured":"Smisha M, Sankar K, Thomas B, et al. Recurrent genuine empty follicle syndrome. J Hum Reprod Sci. 2011;4(3):147\u20139.","journal-title":"J Hum Reprod Sci"},{"key":"1738_CR2","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1016\/j.fertnstert.2011.09.047","volume":"96","author":"TB Mesen","year":"2011","unstructured":"Mesen TB, Yu B, Richter KS, Widra E, DeCherney AH, Segars JH. The prevalence of genuine empty follicle syndrome. Fertil Steril. 2011;96:1375\u20137.","journal-title":"Fertil Steril"},{"key":"1738_CR3","doi-asserted-by":"publisher","first-page":"132","DOI":"10.5653\/cerm.2012.39.4.132","volume":"39","author":"JH Kim","year":"2012","unstructured":"Kim JH, Jee BC. Empty follicle syndrome. Clin Exp Reprod Med. 2012;39:132\u20137.","journal-title":"Clin Exp Reprod Med"},{"issue":"3","key":"1738_CR4","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.fertnstert.2007.07.1312","volume":"90","author":"T Stevenson","year":"2008","unstructured":"Stevenson T, Lashen H. Empty follicle syndrome: The reality of a controversial syndrome, a systematic review. Fertil Steril. 2008;90(3):691\u20138.","journal-title":"Fertil Steril"},{"key":"1738_CR5","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1055\/s-0032-1324721","volume":"30","author":"AC Latronico","year":"2012","unstructured":"Latronico AC, Arnhold IJ. Inactivating mutations of the human luteinizing hormone receptor in both sexes. Semin Reprod Med. 2012;30:382\u20136.","journal-title":"Semin Reprod Med"},{"issue":"2","key":"1738_CR6","doi-asserted-by":"publisher","first-page":"e125","DOI":"10.1016\/j.fertnstert.2011.05.057","volume":"96","author":"KO Yariz","year":"2011","unstructured":"Yariz KO, Walsh T, Uzak A, et al. Inherited mutation of the luteinizing hormone\/choriogonado-tropin receptor (LHCGR) in empty follicle syndrome. Fertil Steril. 2011;96(2):e125\u201330.","journal-title":"Fertil Steril"},{"key":"1738_CR7","doi-asserted-by":"crossref","unstructured":"Snaifer E, Hugues JN, Poncelet C, et al. \"Empty follicle syndrome\" after human error: pregnancy obtained after repeated oocyte retrieval in a gonadotropin-releasing hormone antagonist cycle. Fertil Steril. 2008;90(850):e13\u20135.","DOI":"10.1016\/j.fertnstert.2007.08.008"},{"key":"1738_CR8","doi-asserted-by":"crossref","unstructured":"Reichman DE, Hornstein MD, Jackson KV, et al. Empty follicle syndrome--does repeat administration of hCG really work? Fertil Steril. 2010;94(1):375\u20137.","DOI":"10.1016\/j.fertnstert.2009.09.040"},{"key":"1738_CR9","doi-asserted-by":"crossref","unstructured":"Vutyavanich T, Piromlertamorn W, Ellis J, et al. Immature oocytes in \"apparent empty follicle syndrome\": a case report. 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Cureus. 2024;16(1):e52783.","DOI":"10.7759\/cureus.52783"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-024-01738-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-024-01738-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-024-01738-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T08:06:19Z","timestamp":1740816379000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-024-01738-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,20]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["1738"],"URL":"https:\/\/doi.org\/10.1007\/s43032-024-01738-x","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,20]]},"assertion":[{"value":"5 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The datasets generated during and\/or analyzed during the current study are available from the corresponding author on reasonable request.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the institutional ethics committee of Sir Run Run Shaw Hospital. We have obtained informed consent from the patient with regard to the publication of this case series.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}