{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:47:39Z","timestamp":1772138859069,"version":"3.50.1"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s43032-024-01768-5","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T17:04:20Z","timestamp":1736960660000},"page":"428-434","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Methotrexate fixed dosing protocol for ambulatory treatment of ectopic pregnancy"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1461-6634","authenticated-orcid":false,"given":"Christine","family":"Doran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1390-0094","authenticated-orcid":false,"given":"Christy","family":"Pratt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6530-8415","authenticated-orcid":false,"given":"Thomas","family":"Delate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Nazareth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"issue":"10","key":"1768_CR1","first-page":"599","volume":"101","author":"E Hendriks","year":"2020","unstructured":"Hendriks E, Rosenberg R, Prine L. Ectopic pregnancy: diagnosis and management. Am Fam Physician. 2020;101(10):599\u2013606.","journal-title":"Am Fam Physician"},{"key":"1768_CR2","doi-asserted-by":"publisher","unstructured":"ACOG Practice Bulletin No. 193: Tubal ectopic pregnancy. Obstetrics and Gynecology. 2018;131(3):e91\u2013e103. https:\/\/doi.org\/10.1097\/AOG.0000000000002560.","DOI":"10.1097\/AOG.0000000000002560"},{"issue":"13","key":"1768_CR3","doi-asserted-by":"publisher","first-page":"e15","DOI":"10.1111\/1471-0528.14189","volume":"123","author":"C Elson","year":"2016","unstructured":"Elson C, Salim R, Potdar N, Ross CM. Diagnosis and management of ectopic pregnancy: green-top guideline no. 21. BJOG. 2016;123(13):e15\u201355. https:\/\/doi.org\/10.1111\/1471-0528.14189.","journal-title":"BJOG"},{"issue":"5","key":"1768_CR4","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.jogc.2021.01.002","volume":"43","author":"L Po","year":"2021","unstructured":"Po L, et al. Guideline no. 414: management of pregnancy of unknown location and tubal and nontubal ectopic pregnancies. J Obstet Gynaecol Can. 2021;43(5):614-630.e1. https:\/\/doi.org\/10.1016\/j.jogc.2021.01.002.","journal-title":"J Obstet Gynaecol Can"},{"key":"1768_CR5","unstructured":"Institute of Obstetricians and Gynaecologists, Royal College of Physicians of Ireland and Directorate of Clinical Strategy and Programmes, Health Service Executive - Clinical practice guideline: The diagnosis and management of ectopic pregnancy, vol. 1, no. Guideline No. 33, pp. 1\u201324, 2014"},{"issue":"3","key":"1768_CR6","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.fertnstert.2013.06.013","volume":"100","author":"S Pfeifer","year":"2013","unstructured":"Pfeifer S, Goldberg J, Lobo R, Thomas M. Medical treatment of ectopic pregnancy: a committee opinion. Fertil Steril. 2013;100(3):638\u201344. https:\/\/doi.org\/10.1016\/j.fertnstert.2013.06.013.","journal-title":"Fertil Steril"},{"key":"1768_CR7","unstructured":"Ectopic pregnancy and miscarriage: diagnosis and initial management. NICE guideline. 2019. https:\/\/www.nice.org.uk\/guidance\/ng126. Accessed 17 Mar 2024."},{"key":"1768_CR8","doi-asserted-by":"publisher","unstructured":"Xiao C, Shi Q, Cheng Q, Xu J. Non-surgical management of tubal ectopic pregnancy a systematic review and meta-analysis. Lippincott Williams and Wilkins. 2021. https:\/\/doi.org\/10.1097\/MD.0000000000027851.","DOI":"10.1097\/MD.0000000000027851"},{"key":"1768_CR9","doi-asserted-by":"publisher","unstructured":"Alur-Gupta S, Cooney LG, Senapati S, Sammel MD, Barnhart KT. Two-dose versus single-dose methotrexate for treatment of ectopic pregnancy: a meta-analysis. Mosby Inc. 2019. https:\/\/doi.org\/10.1016\/j.ajog.2019.01.002","DOI":"10.1016\/j.ajog.2019.01.002"},{"key":"1768_CR10","doi-asserted-by":"publisher","unstructured":"Yuk JS, Lee JH, Park WI, Ahn HS, Kim HJ. Systematic review and meta-analysis of single-dose and non-single-dose methotrexate protocols in the treatment of ectopic pregnancy. John Wiley and Sons Ltd. 2018. https:\/\/doi.org\/10.1002\/ijgo.12473.","DOI":"10.1002\/ijgo.12473"},{"key":"1768_CR11","doi-asserted-by":"publisher","unstructured":"Yang C, Cai J, Geng Y, Gao Y. Multiple-dose and double-dose versus single-dose administration of methotrexate for the treatment of ectopic pregnancy: a systematic review and meta-analysis. Elsevier Ltd. 2017. https:\/\/doi.org\/10.1016\/j.rbmo.2017.01.004.","DOI":"10.1016\/j.rbmo.2017.01.004"},{"key":"1768_CR12","doi-asserted-by":"publisher","unstructured":"Zhang J, Zhang Y, Gan L, Ying Liu X, Ping Du S. Predictors and clinical features of methotrexate (MTX) therapy for ectopic pregnancy. BMC Pregnancy Childbirth, vol. 20, no. 1, Dec. 2020, https:\/\/doi.org\/10.1186\/s12884-020-03350-8.","DOI":"10.1186\/s12884-020-03350-8"},{"key":"1768_CR13","unstructured":"Data brief: health care workforce challenges threaten hospitals\u2019 ability to care for patients. https:\/\/www.aha.org. Accessed 24 Mar 2024."},{"key":"1768_CR14","doi-asserted-by":"publisher","unstructured":"Hajenius PJ, Mol F, Mol BWJ, Bossuyt PMM, Ankum WM, Van Der Veen F. Interventions for tubal ectopic pregnancy. John Wiley and Sons Ltd. 2007. https:\/\/doi.org\/10.1002\/14651858.CD000324.pub2.","DOI":"10.1002\/14651858.CD000324.pub2"},{"key":"1768_CR15","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s00404-016-4229-0","volume":"295","author":"LR Hoyos","year":"2017","unstructured":"Hoyos LR, Malik M, Najjar M, Abdallah M, Vilchez G, Awonuga A. Morbid obesity and outcome of ectopic pregnancy following capped single-dose regimen methotrexate. Arch Gynecol Obstet. 2017;295:375\u201381. https:\/\/doi.org\/10.1007\/s00404-016-4229-0.","journal-title":"Arch Gynecol Obstet"},{"issue":"2","key":"1768_CR16","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1097\/GRF.0b013e3182510a48","volume":"55","author":"GH Lipscomb","year":"2012","unstructured":"Lipscomb GH. Medical management of ectopic pregnancy. Clin Obstet Gynecol. 2012;55(2):424\u201332. https:\/\/doi.org\/10.1097\/GRF.0b013e3182510a48.","journal-title":"Clin Obstet Gynecol"},{"key":"1768_CR17","doi-asserted-by":"publisher","unstructured":"Almutairy S, Aldakhil LO. clinical presentation as a predictor of the response to methotrexate therapy in patients with ectopic pregnancy. J Pregnancy. 2022;2022. https:\/\/doi.org\/10.1155\/2022\/5778321.","DOI":"10.1155\/2022\/5778321"},{"key":"1768_CR18","doi-asserted-by":"publisher","unstructured":"Khalil A, Saber A, Aljohani K, Khan M. The efficacy and success rate of methotrexate in the management of ectopic pregnancy. Cureus. 2022. https:\/\/doi.org\/10.7759\/cureus.26737.","DOI":"10.7759\/cureus.26737"},{"issue":"3","key":"1768_CR19","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.fertnstert.2006.10.007","volume":"87","author":"S Menon","year":"2007","unstructured":"Menon S, Colins J, Barnhart KT. Establishing a human chorionic gonadotropin cutoff to guide methotrexate treatment of ectopic pregnancy: a systematic review. Fertil Steril. 2007;87(3):481\u20134. https:\/\/doi.org\/10.1016\/j.fertnstert.2006.10.007.","journal-title":"Fertil Steril"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-024-01768-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-024-01768-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-024-01768-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T18:39:04Z","timestamp":1739471944000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-024-01768-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,15]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["1768"],"URL":"https:\/\/doi.org\/10.1007\/s43032-024-01768-5","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,15]]},"assertion":[{"value":"30 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"IRB approved","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors and corresponding organizations give consent for publication","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}