{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:50:12Z","timestamp":1784893812753,"version":"3.55.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s43032-024-01771-w","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T16:22:48Z","timestamp":1736526168000},"page":"382-394","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nipecotic Acid Ameliorates Letrozole Induced Poly Cystic Ovarian Syndrome in Female Virgin Wistar Rats by Modulating Hypothalamic-Pituitary-Gonadal (HPG) Axis Regulated by GABA"],"prefix":"10.1007","volume":"32","author":[{"given":"Samreen","family":"Fatima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8174-0574","authenticated-orcid":false,"given":"Lucy","family":"Mohapatra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alok S.","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"issue":"9371","key":"1771_CR1","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1055\/s-2007-99292","volume":"361","author":"P Hardiman","year":"2003","unstructured":"Hardiman P, Pillay OS, Atiomo W. Polycystic ovary syndrome and endometrial carcinoma. Lancet. 2003;361(9371):1810\u20132. https:\/\/doi.org\/10.1055\/s-2007-99292.","journal-title":"Lancet"},{"issue":"4","key":"1771_CR2","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1093\/humrep\/deaa371","volume":"36","author":"J Liu","year":"2021","unstructured":"Liu J, Wu Q, Hao Y, Jiao M, Wang X, Jiang S, Han L. Measuring the global disease burden of polycystic ovary syndrome in 194 countries: Global Burden of Disease Study 2017. Hum Reprod. 2021;36(4):1108\u201319. https:\/\/doi.org\/10.1093\/humrep\/deaa371.","journal-title":"Hum Reprod"},{"issue":"4","key":"1771_CR3","doi-asserted-by":"publisher","first-page":"333","DOI":"10.4103\/ijmr.IJMR_1937_17","volume":"150","author":"MA Ganie","year":"2019","unstructured":"Ganie MA, Vasudevan V, Wani IA, Baba MS, Arif T, Rashid A. Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India. Indian J Med Res. 2019;150(4):333. https:\/\/doi.org\/10.4103\/ijmr.IJMR_1937_17.","journal-title":"Indian J Med Res"},{"key":"1771_CR4","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1385\/ENDO:30:1:19","volume":"30","author":"E Diamanti-Kandarakis","year":"2006","unstructured":"Diamanti-Kandarakis E, Kandarakis H, Legro RS. The role of genes and environment in the etiology of PCOS. Endocrine. 2006;30:19\u201326. https:\/\/doi.org\/10.1385\/ENDO:30:1:19.","journal-title":"Endocrine"},{"issue":"2","key":"1771_CR5","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1093\/HUMUPD\/DMH010","volume":"10","author":"S Jonard","year":"2004","unstructured":"Jonard S, Dewailly D. The follicular excess in polycystic ovaries, due to intra-ovarian hyperandrogenism, may be the main culprit for the follicular arrest. Hum Reprod Update. 2004;10(2):107\u201317. https:\/\/doi.org\/10.1093\/HUMUPD\/DMH010.","journal-title":"Hum Reprod Update"},{"issue":"2","key":"1771_CR6","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1097\/AOG.0000000000002698","volume":"132","author":"R Azziz","year":"2018","unstructured":"Azziz R. Polycystic ovary syndrome. Obstet Gynecol. 2018;132(2):321\u201336. https:\/\/doi.org\/10.1097\/AOG.0000000000002698.","journal-title":"Obstet Gynecol"},{"issue":"3","key":"1771_CR7","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.fertnstert.2018.04.024","volume":"110","author":"B Yilmaz","year":"2018","unstructured":"Yilmaz B, Vellanki P, Ata B, Yildiz BO. Diabetes mellitus and insulin resistance in mothers, fathers, sisters, and brothers of women with polycystic ovary syndrome: a systematic review and meta-analysis. Fertil Steril. 2018;110(3):523\u201333. https:\/\/doi.org\/10.1016\/j.fertnstert.2018.04.024.","journal-title":"Fertil Steril"},{"issue":"2","key":"1771_CR8","doi-asserted-by":"publisher","first-page":"583","DOI":"10.3390\/ijms23020583","volume":"23","author":"H Sadeghi","year":"2022","unstructured":"Sadeghi H, Adeli I, Calina D, Docea A, Mousavi T, Daniali M, et al. Polycystic ovary syndrome: a comprehensive review of pathogenesis, management, and drug repurposing. Int J Mol Sci. 2022;23(2):583. https:\/\/doi.org\/10.3390\/ijms23020583.","journal-title":"Int J Mol Sci"},{"key":"1771_CR9","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/ijir.2013.49","volume":"27","author":"A Agarwal","year":"2005","unstructured":"Agarwal A, Nandipati KC, Sharma RK, Zippe CD, Raina R. Role of oxidative stress in pathophysiology of erectile dysfunction. J Androl. 2005;27:335\u201347. https:\/\/doi.org\/10.1038\/ijir.2013.49.","journal-title":"J Androl"},{"issue":"8","key":"1771_CR10","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3390\/medsci7080084","volume":"7","author":"EA Coutinho","year":"2019","unstructured":"Coutinho EA, Kauffman AS. The role of the brain in the pathogenesis and physiology of polycystic ovary syndrome (PCOS). Med Sci. 2019;7(8):84. https:\/\/doi.org\/10.3390\/medsci7080084.","journal-title":"Med Sci"},{"key":"1771_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13048-017-0359-7","volume":"10","author":"A Ullah","year":"2017","unstructured":"Ullah A, Jahan S, Razak S, Pirzada M, Ullah H, Almajwal A, Rauf N, Afsar T. Protective effects of GABA against metabolic and reproductive disturbances in letrozole induced polycystic ovarian syndrome in rats. J Ovarian Res. 2017;10:1\u20138. https:\/\/doi.org\/10.1186\/s13048-017-0359-7.","journal-title":"J Ovarian Res"},{"issue":"4","key":"1771_CR12","doi-asserted-by":"publisher","first-page":"512","DOI":"10.2478\/jomb-2018-0051","volume":"38","author":"RA Radwan","year":"2019","unstructured":"Radwan RA, Abuelezz NZ, Abdelraouf SM, Bakeer EM, Abd El Rahman AA. Decreased serum level of gamma-amino butyric acid in Egyptian infertile females with polycystic ovary syndrome is correlated with dyslipidemia, total testosterone and 25 (OH) vitamin D levels. J Med Biochem. 2019;38(4):512. https:\/\/doi.org\/10.2478\/jomb-2018-0051.","journal-title":"J Med Biochem"},{"issue":"1","key":"1771_CR13","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3949\/ccjm.70.1.31","volume":"70","author":"TL Marx","year":"2003","unstructured":"Marx TL, Mehta AE. Polycystic ovary syndrome: pathogenesis and treatment over the short and long term. Cleve Clin J Med. 2003;70(1):31\u201345. https:\/\/doi.org\/10.3949\/ccjm.70.1.31.","journal-title":"Cleve Clin J Med"},{"issue":"1","key":"1771_CR14","doi-asserted-by":"publisher","first-page":"85","DOI":"10.5935\/1518-0557.20220024","volume":"27","author":"A Manouchehri","year":"2023","unstructured":"Manouchehri A, Abbaszadeh S, Ahmadi M, Nejad FK, Bahmani M, Dastyar N. Polycystic ovaries and herbal remedies: A systematic review. JBRA Assist Reprod. 2023;27(1):85\u201391. https:\/\/doi.org\/10.5935\/1518-0557.20220024.","journal-title":"JBRA Assist Reprod"},{"key":"1771_CR15","unstructured":"PubChem [Internet]. Bethesda (MD): National Library of Medicine (US), National Center for Biotechnology Information., 2004-. PubChem Compound Summary for CID 4498, Nipecotic acid [cited 2024 Oct 18]. https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Nipecotic-acid"},{"key":"1771_CR16","doi-asserted-by":"publisher","first-page":"114269","DOI":"10.1016\/j.ejmech.2022.114269","volume":"234","author":"K Singh","year":"2022","unstructured":"Singh K, Kumar P, Bhatia R, Mehta V, Kumar B, Akhtar MJ. Nipecotic acid as potential lead molecule for the development of GABA uptake inhibitors; structural insights and design strategies. Eur J Med Chem. 2022;234:114269. https:\/\/doi.org\/10.1016\/j.ejmech.2022.114269.","journal-title":"Eur J Med Chem"},{"issue":"D1","key":"1771_CR17","doi-asserted-by":"publisher","first-page":"D1032","DOI":"10.1093\/nar\/gkv1146","volume":"44","author":"S Joseph","year":"2016","unstructured":"Joseph S, Barai RS, Bhujbalrao R, Idicula-Thomas S, PCOSKB. A KnowledgeBase on genes, diseases, ontology terms and biochemical pathways associated with PolyCystic Ovary Syndrome. Nucleic Acids Res. 2016;44(D1):D1032\u20135. https:\/\/doi.org\/10.1093\/nar\/gkv1146.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"1771_CR18","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/s0165-5728(98)00264-1","volume":"1","author":"J Tian","year":"1999","unstructured":"Tian J, Chau C, Hales TG, Kaufman DL. GABAA receptors mediate inhibition of T cell responses. J Neuroimmunol. 1999;96(1):21\u20138. https:\/\/doi.org\/10.1016\/s0165-5728(98)00264-1","journal-title":"J Neuroimmunol"},{"issue":"6","key":"1771_CR19","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.jtcme.2022.08.003","volume":"12","author":"DP Prajapati","year":"2022","unstructured":"Prajapati DP, Patel M, Dharamsi A. Beneficial effect of polyherbal formulation in letrozole induced polycystic ovarian syndrome (PCOS). J Traditional Complement Med. 2022;12(6):575\u201383. https:\/\/doi.org\/10.1016\/j.jtcme.2022.08.003.","journal-title":"J Traditional Complement Med"},{"issue":"1","key":"1771_CR20","doi-asserted-by":"publisher","first-page":"1397060","DOI":"10.1155\/2022\/1397060","volume":"2022","author":"A Younas","year":"2022","unstructured":"Younas A, Hussain L, Shabbir A, Asif M, Hussain M, Manzoor F. Effects of Fagonia indica on letrozole-induced polycystic ovarian syndrome (PCOS) in young adult female rats. Evidence\u2010Based Complement Altern Med. 2022;2022(1):1397060. https:\/\/doi.org\/10.1155\/2022\/1397060.","journal-title":"Evidence\u2010Based Complement Altern Med"},{"issue":"2","key":"1771_CR21","doi-asserted-by":"publisher","first-page":"101953","DOI":"10.1016\/j.jsps.2024.101953","volume":"32","author":"PV Gadhave","year":"2024","unstructured":"Gadhave PV, Sutar GV, Sajane SJ, Redasani VK, Das K, Alobid S, Almoteer AI, Rabbani SI, Yasmin F, Gilkaramenthi R, AlAnazi MA. Protective effects of vanillic acid on letrozole-induced polycystic ovarian syndrome: A comprehensive study in female wistar rats. Saudi Pharm J. 2024;32(2):101953. https:\/\/doi.org\/10.1016\/j.jsps.2024.101953.","journal-title":"Saudi Pharm J"},{"key":"1771_CR22","doi-asserted-by":"publisher","first-page":"112870","DOI":"10.1016\/j.biopha.2022.112870","volume":"149","author":"YF Ibrahim","year":"2022","unstructured":"Ibrahim YF, Alorabi M, Abdelzaher WY, Toni ND, Thabet K, Hegazy A, Bahaa HA, Batiha GE, Welson NN, Morsy MA, Venugopala KN. Diacerein ameliorates letrozole-induced polycystic ovarian syndrome in rats. Biomed Pharmacother. 2022;149:112870. https:\/\/doi.org\/10.1016\/j.biopha.2022.112870.","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"1771_CR23","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0361-9230(95)02103-5","volume":"39","author":"SP Jaw","year":"1996","unstructured":"Jaw SP, Nguyen B, Vuong QT, Trinh TA, Nguyen M, Truong DD. Effects of GABA uptake inhibitors on posthypoxic myoclonus in rats. Brain Res Bull. 1996;39(3):189\u201392. https:\/\/doi.org\/10.1016\/0361-9230(95)02103-5.","journal-title":"Brain Res Bull"},{"key":"1771_CR24","doi-asserted-by":"publisher","unstructured":"Bhattamisra SK, Mohapatra L, Panda BP, Parida S. Effect of isoflavone rich soya seed extract on glucose utilization and endurance capacity in diabetic rat. 2013:42\u201352. https:\/\/doi.org\/10.13005\/BPJ\/948","DOI":"10.13005\/BPJ\/948"},{"key":"1771_CR25","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/fsn3.2301","volume":"7","author":"L Mohapatra","year":"2016","unstructured":"Mohapatra L, Bhattamishra SK, Panigrahy R, Parida S, Pati P. Antidiabetic effect of Sargassum wightii and Ulva fasciata in high fat diet and multi low dose streptozotocin induced type 2 diabetic mice. Pharm Biosci J. 2016;7:13\u201323. https:\/\/doi.org\/10.1002\/fsn3.2301","journal-title":"Pharm Biosci J"},{"issue":"6","key":"1771_CR26","doi-asserted-by":"publisher","first-page":"645","DOI":"10.22038\/IJBMS.2018.25778.6349","volume":"21","author":"G Jelodar","year":"2018","unstructured":"Jelodar G, Masoomi S, Rahmanifar F. Hydroalcoholic extract of flaxseed improves polycystic ovary syndrome in a rat model. Iran J Basic Med Sci. 2018;21(6):645. https:\/\/doi.org\/10.22038\/IJBMS.2018.25778.6349.","journal-title":"Iran J Basic Med Sci"},{"issue":"4","key":"1771_CR27","doi-asserted-by":"publisher","first-page":"651","DOI":"10.15171\/apb.2017.078","volume":"7","author":"MS Ataabadi","year":"2017","unstructured":"Ataabadi MS, Alaee S, Bagheri MJ, Bahmanpoor S. Role of essential oil of Mentha spicata (Spearmint) in addressing reverse hormonal and folliculogenesis disturbances in a polycystic ovarian syndrome in a rat model. Adv Pharm Bull. 2017;7(4):651. https:\/\/doi.org\/10.15171\/apb.2017.078.","journal-title":"Adv Pharm Bull"},{"issue":"2","key":"1771_CR28","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.arcmed.2003.10.005","volume":"35","author":"H Kafali","year":"2004","unstructured":"Kafali H, Iriadam M, Ozardali I, Demir N. Letrozole-induced polycystic ovaries in the rat: a new model for cystic ovarian disease. Arch Med Res. 2004;35(2):103\u20138. https:\/\/doi.org\/10.1016\/j.arcmed.2003.10.005.","journal-title":"Arch Med Res"},{"issue":"4","key":"1771_CR29","doi-asserted-by":"publisher","first-page":"R193","DOI":"10.1530\/REP-14-0517","volume":"149","author":"KA Walters","year":"2015","unstructured":"Walters KA. Role of androgens in normal and pathological ovarian function. Reproduction. 2015;149(4):R193\u2013218. https:\/\/doi.org\/10.1530\/REP-14-0517.","journal-title":"Reproduction"},{"issue":"1\u20132","key":"1771_CR30","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jneuroim.2007.05.013","volume":"1","author":"MG Reyes-Garc\u00eda","year":"2007","unstructured":"Reyes-Garc\u00eda MG, Hern\u00e1ndez-Hern\u00e1ndez F, Hern\u00e1ndez-T\u00e9llez B, Garc\u00eda-Tamayo F. GABA (A) receptor subunits RNA expression in mice peritoneal macrophages modulate their IL-6\/IL-12 production. J Neuroimmunol. 2007;188(1\u20132):64\u20138. https:\/\/doi.org\/10.1016\/j.jneuroim.2007.05.013","journal-title":"J Neuroimmunol"},{"issue":"1","key":"1771_CR31","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/0304-3940(92)90764-x","volume":"147","author":"J Sol\u00eds","year":"1992","unstructured":"Sol\u00eds J, Nicoll RA. Postsynaptic action of endogenous GABA released by nipecotic acid in the hippocampus. Neurosci Lett. 1992;147(1):16\u201320. https:\/\/doi.org\/10.1016\/0304-3940(92)90764-x.","journal-title":"Neurosci Lett"},{"issue":"02","key":"1771_CR32","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1055\/a-1290-0119","volume":"71","author":"M Dhanawat","year":"2021","unstructured":"Dhanawat M, Gupta S, Mehta DK, Das R. Design, synthesis and enhanced BBB penetration studies of L-serine-tethered nipecotic acid-prodrug. Drug Res. 2021;71(02):94\u2013103. https:\/\/doi.org\/10.1055\/a-1290-0119.","journal-title":"Drug Res"},{"issue":"2","key":"1771_CR33","doi-asserted-by":"publisher","first-page":"109","DOI":"10.4103\/0974-8490.94736","volume":"4","author":"BN Desai","year":"2012","unstructured":"Desai BN, Maharjan RH, Nampoothiri LP. Aloe barbadensis Mill. Formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model. Pharmacognosy Res. 2012;4(2):109. https:\/\/doi.org\/10.4103\/0974-8490.94736.","journal-title":"Pharmacognosy Res"},{"issue":"2","key":"1771_CR34","doi-asserted-by":"publisher","first-page":"107","DOI":"10.5468\/ogs.22129","volume":"66","author":"Z Khosrowpour","year":"2022","unstructured":"Khosrowpour Z, Fahimi S, Jafari F, Tansaz M, Sahranavard S, Faizi M. Beneficial effects of Teucrium polium hydroalcoholic extract on letrozole-induced polycystic ovary syndrome in rat model. Obstet Gynecol Sci. 2022;66(2):107\u201317. https:\/\/doi.org\/10.5468\/ogs.22129.","journal-title":"Obstet Gynecol Sci"},{"issue":"3","key":"1771_CR35","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1093\/humupd\/dms059","volume":"19","author":"M Murri","year":"2013","unstructured":"Murri M, Luque-Ram\u00edrez M, Insenser M, Ojeda-Ojeda M, Escobar-Morreale HF. Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis. Hum Reprod Update. 2013;19(3):268\u201388. https:\/\/doi.org\/10.1093\/humupd\/dms059.","journal-title":"Hum Reprod Update"},{"issue":"20","key":"1771_CR36","doi-asserted-by":"publisher","first-page":"6984","DOI":"10.3390\/molecules27206984","volume":"27","author":"G Papagiouvannis","year":"2022","unstructured":"Papagiouvannis G, Theodosis-Nobelos P, Rekka EA. Nipecotic Acid Derivatives as Potent Agents against Neurodegeneration: A Preliminary Study. Molecules. 2022;27(20):6984. https:\/\/doi.org\/10.3390\/molecules27206984.","journal-title":"Molecules"},{"key":"1771_CR37","doi-asserted-by":"publisher","first-page":"155632","DOI":"10.1016\/j.cyto.2021.155632","volume":"146","author":"Z He","year":"2021","unstructured":"He Z, Wang Y, Zhuan L, Li Y, Tang ZO, Wu Z, Ma Y. MIF-mediated NF-\u03baB signaling pathway regulates the pathogenesis of polycystic ovary syndrome in rats. Cytokine. 2021;146:155632. https:\/\/doi.org\/10.1016\/j.cyto.2021.155632.","journal-title":"Cytokine"},{"issue":"7","key":"1771_CR38","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.3390\/ijms22073789","volume":"22","author":"E Rudnicka","year":"2021","unstructured":"Rudnicka E, Suchta K, Grymowicz M, Calik-Ksepka A, Smolarczyk K, Duszewska AM, Smolarczyk R, Meczekalski B. Chronic low-grade inflammation in pathogenesis of PCOS. Int J Mol Sci. 2021;22(7):3789. https:\/\/doi.org\/10.3390\/ijms22073789.","journal-title":"Int J Mol Sci"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-024-01771-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-024-01771-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-024-01771-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T18:39:39Z","timestamp":1739471979000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-024-01771-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,10]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["1771"],"URL":"https:\/\/doi.org\/10.1007\/s43032-024-01771-w","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,10]]},"assertion":[{"value":"30 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Institutional Animal Ethical Committee (IAEC) of Amity Institute of Pharmacy, Amity University Uttar Pradesh-Lucknow, approved the procedure for experimentation with the IAEC Approval number: AUUP\/AIP\/16\/2023.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationship that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}