{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:24:42Z","timestamp":1792441482853,"version":"4.5.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32130098"],"award-info":[{"award-number":["32130098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1007\/s43032-024-01782-7","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T20:24:50Z","timestamp":1737491090000},"page":"792-803","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["MT1\/cAMP\/PKA Pathway in Melatonin-Regulated Sperm Capacitation"],"prefix":"10.1007","volume":"32","author":[{"given":"Tongjuan","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guobin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3826-3768","authenticated-orcid":false,"given":"Sheng","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"1782_CR1","doi-asserted-by":"publisher","first-page":"3480","DOI":"10.3390\/nu13103480","volume":"13","author":"C Vasey","year":"2021","unstructured":"Vasey C, McBride J, Penta K. Circadian rhythm dysregulation and restoration: the role of melatonin. Nutrients. 2021;13:3480. https:\/\/doi.org\/10.3390\/nu13103480.","journal-title":"Nutrients."},{"key":"1782_CR2","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1071\/RD18087","volume":"31","author":"S Gimeno-Martos","year":"2019","unstructured":"Gimeno-Martos S, Casao A, Yeste M, Cebrian-Perez JA, Muino-Blanco T, Perez-Pe R. Melatonin reduces cAMP-stimulated capacitation of ram spermatozoa. Reprod Fertil Dev. 2019;31:420\u201331. https:\/\/doi.org\/10.1071\/RD18087.","journal-title":"Reprod Fertil Dev"},{"key":"1782_CR3","doi-asserted-by":"publisher","first-page":"2701","DOI":"10.3390\/ijms21082701","volume":"21","author":"E Fern\u00e1ndez-Alegre","year":"2020","unstructured":"Fern\u00e1ndez-Alegre E, \u00c1lvarez-Fern\u00e1ndez I, Dom\u00ednguez JC, Casao A, Mart\u00ednez-Pastor F. Melatonin non-linearly modulates bull spermatozoa motility and physiology in capacitating and non-capacitating conditions. Int J Mol Sci. 2020;21:2701. https:\/\/doi.org\/10.3390\/ijms21082701.","journal-title":"Int J Mol Sci."},{"key":"1782_CR4","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1071\/RD14302","volume":"28","author":"M Gonzalez-Arto","year":"2016","unstructured":"Gonzalez-Arto M, Luna C, P\u00e9rez-P\u00e9 R, Mui\u00f1o-Blanco T, Cebri\u00e1n-P\u00e9rez JA, Casao A. New evidence of melatonin receptor contribution to ram sperm functionality. Reprod Fertil Dev. 2016;28:924\u201335. https:\/\/doi.org\/10.1071\/RD14302.","journal-title":"Reprod Fertil Dev"},{"key":"1782_CR5","doi-asserted-by":"publisher","first-page":"447","DOI":"10.3390\/molecules23020447","volume":"23","author":"K Yu","year":"2018","unstructured":"Yu K, Deng SL, Sun TC, Li YY, Liu YX. Melatonin regulates the synthesis of steroid hormones on male reproduction: a review. Molecules (Basel, Switzerland). 2018;23:447. https:\/\/doi.org\/10.3390\/molecules23020447.","journal-title":"Molecules (Basel, Switzerland)."},{"key":"1782_CR6","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.anireprosci.2018.11.007","volume":"200","author":"M Carvajal-Serna","year":"2019","unstructured":"Carvajal-Serna M, Torres-Ruda F, Cardozo JA, Grajales-Lombana H, Cebri\u00e1n-P\u00e9rez J, Mui\u00f1o-Blanco T, et al. Changes in melatonin concentrations in seminal plasma are not correlated with testosterone or antioxidant enzyme activity when rams are located in areas with an equatorial photoperiod. Anim Reprod Sci. 2019;200:22\u201330. https:\/\/doi.org\/10.1016\/j.anireprosci.2018.11.007.","journal-title":"Anim Reprod Sci"},{"key":"1782_CR7","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1007\/s00484-018-1571-x","volume":"62","author":"DM Golher","year":"2018","unstructured":"Golher DM, Kumaresan A, Saraf KK, Chhillar S, Nayak S, Tripathi UK, et al. Influence of season and climatic variables on testicular cytology, semen quality and melatonin concentrations in crossbred bucks reared under subtropical climate. Int J Biometeorol. 2018;62:1709\u201319. https:\/\/doi.org\/10.1007\/s00484-018-1571-x.","journal-title":"Int J Biometeorol"},{"key":"1782_CR8","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3892\/etm.2020.8678","volume":"20","author":"M HH","year":"2020","unstructured":"HH M, AE-T M, NF N, MF H, Toghan R, MI H. Men with idiopathic oligoasthenoteratozoospermia exhibit lower serum and seminal plasma melatonin levels: Comparative effect of night-light exposure with fertile males. Exp Ther Med. 2020;20:235\u201342. https:\/\/doi.org\/10.3892\/etm.2020.8678.","journal-title":"Exp Ther Med"},{"key":"1782_CR9","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1038\/168697b0","volume":"168","author":"MC Chang","year":"1951","unstructured":"Chang MC. Fertilizing capacity of spermatozoa deposited into the fallopian tubes. Nature. 1951;168:697\u20138. https:\/\/doi.org\/10.1038\/168697b0.","journal-title":"Nature"},{"key":"1782_CR10","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/170326a0","volume":"170","author":"CR Austin","year":"1952","unstructured":"Austin CR. The capacitation of the mammalian sperm. Nature. 1952;170:326. https:\/\/doi.org\/10.1038\/170326a0.","journal-title":"Nature"},{"key":"1782_CR11","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/s00441-012-1370-3","volume":"349","author":"J Signorelli","year":"2012","unstructured":"Signorelli J, Diaz ES, Morales P. Kinases, phosphatases and proteases during sperm capacitation. Cell Tissue Res. 2012;349:765\u201382. https:\/\/doi.org\/10.1007\/s00441-012-1370-3.","journal-title":"Cell Tissue Res"},{"key":"1782_CR12","doi-asserted-by":"publisher","first-page":"7977","DOI":"10.1074\/jbc.M109.085845","volume":"285","author":"D Krapf","year":"2010","unstructured":"Krapf D, Arcelay E, Wertheimer EV, Sanjay A, Pilder SH, Salicioni AM, et al. Inhibition of Ser\/Thr phosphatases induces capacitation-associated signaling in the presence of Src kinase inhibitors. J Biol Chem. 2010;285:7977\u201385. https:\/\/doi.org\/10.1074\/jbc.M109.085845.","journal-title":"J Biol Chem"},{"key":"1782_CR13","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/s0304-4157(00)00018-6","volume":"1469","author":"FM Flesch","year":"2000","unstructured":"Flesch FM, Gadella BM. Dynamics of the mammalian sperm plasma membrane in the process of fertilization. Biochem Biophys Acta. 2000;1469:197\u2013235. https:\/\/doi.org\/10.1016\/s0304-4157(00)00018-6.","journal-title":"Biochem Biophys Acta"},{"key":"1782_CR14","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.freeradbiomed.2021.01.014","volume":"164","author":"F Zhao","year":"2021","unstructured":"Zhao F, Whiting S, Lambourne S, Aitken RJ, Sun Y-p. Melatonin alleviates heat stress-induced oxidative stress and apoptosis in human spermatozoa. Free Radical Biol Med. 2021;164:410\u20136. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2021.01.014.","journal-title":"Free Radical Biol Med"},{"key":"1782_CR15","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1111\/j.1439-0531.2009.01466.x","volume":"45","author":"HY Jang","year":"2010","unstructured":"Jang HY, Kim YH, Kim BW, Park IC, Cheong HT, Kim JT, et al. Ameliorative effects of melatonin against hydrogen peroxide-induced oxidative stress on boar sperm characteristics and subsequent in vitro embryo development. Reprod Domest Anim = Zuchthygiene. 2010;45:943\u201350. https:\/\/doi.org\/10.1111\/j.1439-0531.2009.01466.x.","journal-title":"Reprod Domest Anim = Zuchthygiene"},{"key":"1782_CR16","doi-asserted-by":"publisher","first-page":"655794","DOI":"10.3389\/fcell.2021.655794","volume":"9","author":"S Miguel-Jimenez","year":"2021","unstructured":"Miguel-Jimenez S, Pina-Beltran B, Gimeno-Martos S, Carvajal-Serna M, Casao A, Perez-Pe R. NADPH Oxidase 5 and melatonin: Involvement in ram sperm capacitation. Front Cell Dev Biol. 2021;9:655794. https:\/\/doi.org\/10.3389\/fcell.2021.655794.","journal-title":"Front Cell Dev Biol"},{"key":"1782_CR17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/rda.12378","volume":"49","author":"J Cebri\u00e1n-P\u00e9rez","year":"2014","unstructured":"Cebri\u00e1n-P\u00e9rez J, Casao A, Gonz\u00e1lez-Arto M, dos Santos HT, P\u00e9rez-P\u00e9 R, Mui\u00f1o-Blanco T. Melatonin in sperm biology: Breaking paradigms. Reprod Domest Anim. 2014;49:11\u201321. https:\/\/doi.org\/10.1111\/rda.12378.","journal-title":"Reprod Domest Anim"},{"key":"1782_CR18","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/0009-9120(92)80056-m","volume":"25","author":"RJ van Vuuren","year":"1992","unstructured":"van Vuuren RJ, Pitout MJ, van Aswegen CH, Theron JJ. Putative melatonin receptor in human spermatozoa. Clin Biochem. 1992;25:125\u20137. https:\/\/doi.org\/10.1016\/0009-9120(92)80056-m.","journal-title":"Clin Biochem"},{"key":"1782_CR19","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1071\/RD11242","volume":"24","author":"A Casao","year":"2012","unstructured":"Casao A, Gallego M, Abecia JA, Forcada F, P\u00e9rez-P\u00e9 R, Mui\u00f1o-Blanco T, et al. Identification and immunolocalisation of melatonin MT(1) and MT(2) receptors in Rasa Aragonesa ram spermatozoa. Reprod Fertil Dev. 2012;24:953\u201361. https:\/\/doi.org\/10.1071\/RD11242.","journal-title":"Reprod Fertil Dev"},{"key":"1782_CR20","doi-asserted-by":"publisher","first-page":"662","DOI":"10.3390\/ijms18030662","volume":"18","author":"M Gonz\u00e1lez-Arto","year":"2017","unstructured":"Gonz\u00e1lez-Arto M, Aguilar D, Gaspar-Torrubia E, Gallego M, Carvajal-Serna M, Herrera-Marcos LV, et al. Melatonin MT\u2081 and MT\u2082 receptors in the ram reproductive tract. Int J Mol Sci. 2017;18:662. https:\/\/doi.org\/10.3390\/ijms18030662.","journal-title":"Int J Mol Sci."},{"key":"1782_CR21","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1111\/andr.12504","volume":"6","author":"M Rocco","year":"2018","unstructured":"Rocco M, Betarelli R, Placci A, Fern\u00e1ndez-Novell JM, Spinaci M, Casao A, et al. Melatonin affects the motility and adhesiveness of in vitro capacitated boar spermatozoa via a mechanism that does not depend on intracellular ROS levels. Andrology. 2018;6:720\u201336. https:\/\/doi.org\/10.1111\/andr.12504.","journal-title":"Andrology"},{"key":"1782_CR22","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1530\/REP-08-0202","volume":"136","author":"M Fujinoki","year":"2008","unstructured":"Fujinoki M. Melatonin-enhanced hyperactivation of hamster sperm. Reproduction. 2008;136:533\u201341. https:\/\/doi.org\/10.1530\/REP-08-0202.","journal-title":"Reproduction"},{"key":"1782_CR23","doi-asserted-by":"publisher","unstructured":"Alonso CAI, Lottero-Leconte R, Luque GM, Vernaz ZJ, Di Siervi N, Gervasi MG, et al. MRP4-mediated cAMP efflux is essential for mouse spermatozoa capacitation. J Cell Sci. 2019;132:jcs230565. https:\/\/doi.org\/10.1242\/jcs.230565.","DOI":"10.1242\/jcs.230565"},{"issue":"6","key":"1782_CR24","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1093\/abbs\/gmw039","volume":"48","author":"X Wan","year":"2016","unstructured":"Wan X, Ru Y, Chu C, Ni Z, Zhou Y, Wang S, et al. Bisphenol A accelerates capacitation-associated protein tyrosine phosphorylation of rat sperm by activating protein kinase A. Acta Biochim Biophys Sin. 2016;48(6):573\u201380. https:\/\/doi.org\/10.1093\/abbs\/gmw039.","journal-title":"Acta Biochim Biophys Sin"},{"key":"1782_CR25","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3389\/fcell.2018.00060","volume":"6","author":"DA Tourzani","year":"2018","unstructured":"Tourzani DA, Paudel B, Miranda PV, Visconti PE, Gervasi MG. Changes in protein O-GlcNAcylation during mouse epididymal sperm maturation. Front Cell Dev Biol. 2018;6:60. https:\/\/doi.org\/10.3389\/fcell.2018.00060.","journal-title":"Front Cell Dev Biol"},{"key":"1782_CR26","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/j.1600-079X.2009.00722.x","volume":"48","author":"A Casao","year":"2010","unstructured":"Casao A, Mendoza N, Perez-Pe R, Grasa P, Abecia JA, Forcada F, et al. Melatonin prevents capacitation and apoptotic-like changes of ram spermatozoa and increases fertility rate. J Pineal Res. 2010;48:39\u201346. https:\/\/doi.org\/10.1111\/j.1600-079X.2009.00722.x.","journal-title":"J Pineal Res"},{"key":"1782_CR27","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1083\/jcb.83.3.544","volume":"83","author":"PM Saling","year":"1979","unstructured":"Saling PM, Storey BT. Mouse gamete interactions during fertilization in vitro. Chlortetracycline as a fluorescent probe for the mouse sperm acrosome reaction. J Cell Biol. 1979;83:544\u201355. https:\/\/doi.org\/10.1083\/jcb.83.3.544.","journal-title":"J Cell Biol"},{"key":"1782_CR28","doi-asserted-by":"publisher","first-page":"10241","DOI":"10.3390\/ijms221910241","volume":"22","author":"DA Tourzani","year":"2021","unstructured":"Tourzani DA, Battistone MA, Salicioni AM, Breton S, Visconti PE, Gervasi MG. Caput ligation renders immature mouse sperm motile and capable to undergo cAMP-dependent phosphorylation. Int J Mol Sci. 2021;22:10241. https:\/\/doi.org\/10.3390\/ijms221910241.","journal-title":"Int J Mol Sci."},{"key":"1782_CR29","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1111\/rda.13745","volume":"55","author":"F Ren","year":"2020","unstructured":"Ren F, Feng T, Niu T, Yuan Y, Liu Q, Xiao J, et al. Notoginsenoside R1 protects boar sperm during liquid storage at 17\u00b0C. Reprod Domest Anim = Zuchthygiene. 2020;55:1072\u20139. https:\/\/doi.org\/10.1111\/rda.13745.","journal-title":"Reprod Domest Anim = Zuchthygiene"},{"key":"1782_CR30","doi-asserted-by":"publisher","first-page":"16187","DOI":"10.3390\/ijms232416187","volume":"23","author":"K Repova","year":"2022","unstructured":"Repova K, Baka T, Krajcirovicova K, Stanko P, Aziriova S, Reiter RJ, et al. Melatonin as a potential approach to anxiety treatment. Int J Mol Sci. 2022;23:16187. https:\/\/doi.org\/10.3390\/ijms232416187.","journal-title":"Int J Mol Sci."},{"key":"1782_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.theriogenology.2022.05.008","volume":"188","author":"N Lu","year":"2022","unstructured":"Lu N, Jiang X, Zhang C, Li B, Tu W, Lei H, et al. Melatonin mediates via melatonin receptor 1 in a temperature-dependent manner regulating ATP metabolism and antioxidative enzyme activity of boar spermatozoa in vitro. Theriogenology. 2022;188:1\u201312. https:\/\/doi.org\/10.1016\/j.theriogenology.2022.05.008.","journal-title":"Theriogenology"},{"key":"1782_CR32","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1093\/biolre\/ioab046","volume":"104","author":"M Yang","year":"2021","unstructured":"Yang M, Guan S, Tao J, Zhu K, Lv D, Wang J, et al. Melatonin promotes male reproductive performance and increases testosterone synthesis in mammalian Leydig cells\u2020. Biol Reprod. 2021;104:1322\u201336. https:\/\/doi.org\/10.1093\/biolre\/ioab046.","journal-title":"Biol Reprod"},{"key":"1782_CR33","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1186\/s13287-017-0687-y","volume":"8","author":"S Navid","year":"2017","unstructured":"Navid S, Abbasi M, Hoshino Y. The effects of melatonin on colonization of neonate spermatogonial mouse stem cells in a three-dimensional soft agar culture system. Stem Cell Res Ther. 2017;8:233. https:\/\/doi.org\/10.1186\/s13287-017-0687-y.","journal-title":"Stem Cell Res Ther"},{"key":"1782_CR34","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1002\/aja.1001620402","volume":"162","author":"RJ Reiter","year":"1981","unstructured":"Reiter RJ. The mammalian pineal gland: structure and function. Am J Anat. 1981;162:287\u2013313. https:\/\/doi.org\/10.1002\/aja.1001620402.","journal-title":"Am J Anat"},{"key":"1782_CR35","doi-asserted-by":"publisher","first-page":"112001","DOI":"10.1016\/j.biopha.2021.112001","volume":"144","author":"W Yong","year":"2021","unstructured":"Yong W, Ma H, Na M, Gao T, Zhang Y, Hao L, et al. Roles of melatonin in the field of reproductive medicine. Biomed Pharmacother. 2021;144:112001. https:\/\/doi.org\/10.1016\/j.biopha.2021.112001.","journal-title":"Biomed Pharmacother"},{"key":"1782_CR36","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1242\/dev.121.4.1139","volume":"121","author":"PE Visconti","year":"1995","unstructured":"Visconti PE, Moore GD, Bailey JL, Leclerc P, Connors SA, Pan D, et al. Capacitation of mouse spermatozoa. II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway. Development (Cambridge, England). 1995;121:1139\u201350. https:\/\/doi.org\/10.1242\/dev.121.4.1139.","journal-title":"Development (Cambridge, England)"},{"key":"1782_CR37","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1095\/biolreprod56.3.707","volume":"56","author":"HL Galantino-Homer","year":"1997","unstructured":"Galantino-Homer HL, Visconti PE, Kopf GS. Regulation of protein tyrosine phosphorylation during bovine sperm capacitation by a cyclic adenosine 3\u20195\u2019-monophosphate-dependent pathway. Biol Reprod. 1997;56:707\u201319. https:\/\/doi.org\/10.1095\/biolreprod56.3.707.","journal-title":"Biol Reprod"},{"key":"1782_CR38","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/0303-7207(95)03733-0","volume":"117","author":"RJ Aitken","year":"1996","unstructured":"Aitken RJ, Buckingham DW, Harkiss D, Paterson M, Fisher H, Irvine DS. The extragenomic action of progesterone on human spermatozoa is influenced by redox regulated changes in tyrosine phosphorylation during capacitation. Mol Cell Endocrinol. 1996;117:83\u201393. https:\/\/doi.org\/10.1016\/0303-7207(95)03733-0.","journal-title":"Mol Cell Endocrinol"},{"key":"1782_CR39","doi-asserted-by":"publisher","first-page":"110953","DOI":"10.1016\/j.mce.2020.110953","volume":"516","author":"M Finkelstein","year":"2020","unstructured":"Finkelstein M, Etkovitz N, Breitbart H. Ca(2+) signaling in mammalian spermatozoa. Mol Cell Endocrinol. 2020;516:110953. https:\/\/doi.org\/10.1016\/j.mce.2020.110953.","journal-title":"Mol Cell Endocrinol"},{"key":"1782_CR40","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12958-017-0297-7","volume":"15","author":"L Zhang","year":"2017","unstructured":"Zhang L, Zhang Z, Wang F, Tian X, Ji P, Liu G. Effects of melatonin administration on embryo implantation and offspring growth in mice under different schedules of photoperiodic exposure. Reprod Biol Endocrinol. 2017;15:78. https:\/\/doi.org\/10.1186\/s12958-017-0297-7.","journal-title":"Reprod Biol Endocrinol"},{"key":"1782_CR41","doi-asserted-by":"publisher","first-page":"1294726","DOI":"10.3389\/fcell.2024.1294726","volume":"12","author":"P Pei","year":"2024","unstructured":"Pei P, Shen J, He X, Zeng Y, Zeng Y, Zhang T, Wang S. Multiplexing of TMT labeling reveals folate-deficient diet-specific proteome changes in NTDs. Front Cell Dev Biol. 2024;12:1294726. https:\/\/doi.org\/10.3389\/fcell.2024.1294726.","journal-title":"Front Cell Dev Biol"},{"issue":"5","key":"1782_CR42","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3109\/09513590.2013.879856","volume":"30","author":"T Nishihara","year":"2014","unstructured":"Nishihara T, Hashimoto S, Ito K, Nakaoka Y, Matsumoto K, Hosoi Y, et al. Oral melatonin supplementation improves oocyte and embryo quality in women undergoing in vitro fertilization-embryo transfer. Gynecol Endocrinol. 2014;30(5):359\u201362. https:\/\/doi.org\/10.3109\/09513590.2013.879856.","journal-title":"Gynecol Endocrinol"},{"issue":"1","key":"1782_CR43","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1186\/s12967-024-05707-5","volume":"22","author":"Y Tan","year":"2024","unstructured":"Tan Y, Wang J, Liu C, Wu S, Zhou M, Zhang Y, et al. KLF4 regulates trophoblast function and associates with unexplained recurrent spontaneous abortion. J Transl Med. 2024;22(1):922. https:\/\/doi.org\/10.1186\/s12967-024-05707-5.","journal-title":"J Transl Med"},{"issue":"30","key":"1782_CR44","doi-asserted-by":"publisher","first-page":"17864","DOI":"10.1073\/pnas.2002449117","volume":"117","author":"B Saha","year":"2020","unstructured":"Saha B, Ganguly A, Home P, Bhattacharya B, Ray S, Ghosh A, et al. TEAD4 ensures postimplantation development by promoting trophoblast self-renewal: An implication in early human pregnancy loss. Proc Natl Acad Sci U S A. 2020;117(30):17864\u201375. https:\/\/doi.org\/10.1073\/pnas.2002449117.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1782_CR45","doi-asserted-by":"publisher","first-page":"e14304","DOI":"10.1111\/and.14304","volume":"54","author":"SK Bhalothia","year":"2022","unstructured":"Bhalothia SK, Mehta JS, Kumar T, Prakash C, Talluri TR, Pal RS, et al. Melatonin and canthaxanthin enhances sperm viability and protect ram spermatozoa from oxidative stress during liquid storage at 4\u00b0C. Andrologia. 2022;54:e14304. https:\/\/doi.org\/10.1111\/and.14304.","journal-title":"Andrologia"},{"key":"1782_CR46","doi-asserted-by":"publisher","first-page":"3921","DOI":"10.3390\/ijms20163921","volume":"20","author":"CY Li","year":"2019","unstructured":"Li CY, Hao HS, Zhao YH, Zhang PP, Wang HY, Pang YW, et al. Melatonin improves the fertilization capacity of sex-sorted bull sperm by inhibiting apoptosis and increasing fertilization capacitation via MT1. Int J Mol Sci. 2019;20:3921. https:\/\/doi.org\/10.3390\/ijms20163921.","journal-title":"Int J Mol Sci."},{"key":"1782_CR47","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1111\/j.1600-079X.2011.00873.x","volume":"51","author":"CM Da Silva","year":"2011","unstructured":"Da Silva CM, Mac\u00edas-Garc\u00eda B, Mir\u00f3-Mor\u00e1n A, Gonz\u00e1lez-Fern\u00e1ndez L, Morillo-Rodriguez A, Ortega-Ferrusola C, et al. Melatonin reduces lipid peroxidation and apoptotic-like changes in stallion spermatozoa. J Pineal Res. 2011;51:172\u20139. https:\/\/doi.org\/10.1111\/j.1600-079X.2011.00873.x.","journal-title":"J Pineal Res"},{"key":"1782_CR48","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1007\/s11250-020-02289-4","volume":"52","author":"M Carvajal Serna","year":"2020","unstructured":"Carvajal Serna M, Neira Rivera E, Cardozo JA, Grajales Lombana H, Cebri\u00e1n P\u00e9rez JA, Mui\u00f1o Blanco T, et al. Melatonin membrane receptors MT1 and MT2 are expressed in ram spermatozoa from non-seasonal breeds. Trop Anim Health Prod. 2020;52:2549\u201357. https:\/\/doi.org\/10.1007\/s11250-020-02289-4.","journal-title":"Trop Anim Health Prod"},{"issue":"8","key":"1782_CR49","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1016\/j.theriogenology.2016.06.016","volume":"86","author":"M Gonz\u00e1lez-Arto","year":"2016","unstructured":"Gonz\u00e1lez-Arto M, Vicente-Carrillo A, Mart\u00ednez-Pastor F, Fern\u00e1ndez-Alegre E, Roca J, Mir\u00f3 J, et al. Melatonin receptors MT1 and MT2 are expressed in spermatozoa from several seasonal and nonseasonal breeder species. Theriogenology. 2016;86(8):1958\u201368. https:\/\/doi.org\/10.1016\/j.theriogenology.2016.06.016.","journal-title":"Theriogenology"},{"issue":"3","key":"1782_CR50","doi-asserted-by":"publisher","first-page":"662","DOI":"10.3390\/ijms18030662","volume":"18","author":"M Gonz\u00e1lez-Arto","year":"2017","unstructured":"Gonz\u00e1lez-Arto M, Aguilar D, Gaspar-Torrubia E, Gallego M, Carvajal-Serna M, Herrera-Marcos LV, et al. Melatonin MT\u2081 and MT\u2082 receptors in the ram reproductive tract. Int J Mol Sci. 2017;18(3):662. https:\/\/doi.org\/10.3390\/ijms18030662.","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1782_CR51","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/j.1600-079X.2012.01026.x","volume":"54","author":"SY Shiu","year":"2013","unstructured":"Shiu SY, Leung WY, Tam CW, Liu VW, Yao KM. Melatonin MT1 receptor-induced transcriptional up-regulation of p27(Kip1) in prostate cancer antiproliferation is mediated via inhibition of constitutively active nuclear factor kappa B (NF-\u03baB): potential implications on prostate cancer chemoprevention and therapy. J Pineal Res. 2013;54(1):69\u201379. https:\/\/doi.org\/10.1111\/j.1600-079X.2012.01026.x.","journal-title":"J Pineal Res"},{"key":"1782_CR52","doi-asserted-by":"publisher","first-page":"110992","DOI":"10.1016\/j.mce.2020.110992","volume":"518","author":"C Baro Graf","year":"2020","unstructured":"Baro Graf C, Ritagliati C, Stival C, Luque GM, Gentile I, Buffone MG, et al. Everything you ever wanted to know about PKA regulation and its involvement in mammalian sperm capacitation. Mol Cell Endocrinol. 2020;518:110992. https:\/\/doi.org\/10.1016\/j.mce.2020.110992.","journal-title":"Mol Cell Endocrinol"},{"key":"1782_CR53","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1002\/mrd.20034","volume":"67","author":"HL Galantino-Homer","year":"2004","unstructured":"Galantino-Homer HL, Florman HM, Storey BT, Dobrinski I, Kopf GS. Bovine sperm capacitation: assessment of phosphodiesterase activity and intracellular alkalinization on capacitation-associated protein tyrosine phosphorylation. Mol Reprod Dev. 2004;67:487\u2013500. https:\/\/doi.org\/10.1002\/mrd.20034.","journal-title":"Mol Reprod Dev"},{"key":"1782_CR54","doi-asserted-by":"publisher","first-page":"560","DOI":"10.5603\/EP.a2018.0051","volume":"69","author":"M Juszczak","year":"2018","unstructured":"Juszczak M, Krzyminska A, Bojanowska E, Roszczyk M. The role of the cAMP\/PKA signalling pathway in the inhibitory influence of melatonin on oxytocin and vasopressin secretion from the rat hypothalamo-neurohypophysial system. Endokrynol Pol. 2018;69:560\u20136. https:\/\/doi.org\/10.5603\/EP.a2018.0051.","journal-title":"Endokrynol Pol"},{"key":"1782_CR55","doi-asserted-by":"publisher","first-page":"13483","DOI":"10.1073\/pnas.0405580101","volume":"101","author":"MA Nolan","year":"2004","unstructured":"Nolan MA, Babcock DF, Wennemuth G, Brown W, Burton KA, McKnight GS. Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility. Proc Natl Acad Sci USA. 2004;101:13483\u20138. https:\/\/doi.org\/10.1073\/pnas.0405580101.","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-024-01782-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-024-01782-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-024-01782-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T08:06:38Z","timestamp":1740816398000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-024-01782-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,21]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["1782"],"URL":"https:\/\/doi.org\/10.1007\/s43032-024-01782-7","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,21]]},"assertion":[{"value":"10 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the animal experiments were allowed by the Institutional Animal Care and Use Committee of Yangzhou University (SYXK2022-0044).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Every participant in this project agreed to the publication of the results.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no conflicts of interest with regard to the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}