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The results indicated that HFCS increases oxidative stress by increasing the level of MDA and decreasing GSH, SOD, and CAT activity in the blood of maternal. However, BA administration significantly decreased MDA levels and increased GSH levels, SOD, and CAT activity (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In addition, HFCS consumption significantly increased plasma TNF-\u03b1, IL-6, and leptin levels compared to control, BA, and HFCS\u2009+\u2009BA groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). However, BA administration significantly decreased plasma TNF-\u03b1, IL-6, and leptin levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Furthermore, BA (20\u00a0mg\/kg) significantly decreased HFCS-induced histopathological and immunohistochemical alterations in the placenta, uterus, and fetal tissue. In conclusion, BA may prevent HFCS toxicity in maternal and fetal tissues, as it regulates oxidative imbalance in pregnant rat and alleviates histopathological and immunohistochemical changes. The findings indicate a need for further studies to assess the potential of boron in preventing or mitigating the effects of HFCS during pregnancy.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1007\/s43032-025-01792-z","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T17:43:26Z","timestamp":1737049406000},"page":"514-525","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Effect of Boric Acid on Oxidative Stress, Inflammation, and Apoptosis in Embryonic and Fetal Tissues Damage Caused by Consumption of High-Fructose Corn Syrup in Pregnant Rats"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9994-1251","authenticated-orcid":false,"given":"Mehmet","family":"Ba\u015fe\u011fmez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Y\u00fcksel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"issue":"5","key":"1792_CR1","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1080\/09637486.2020.1862068","volume":"72","author":"N Khorshidian","year":"2021","unstructured":"Khorshidian N, Shadnoush M, Zabihzadeh Khajavi M, Sohrabvandi S, Yousefi M, Mortazavian AM. 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