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To that aim, we use mouse uterus with normal gland development (control group) and gland development inhibited by progesterone\u00a0(experimental group). Animals were sacrificed on the PN Days 5, 10 and 15. YAP and p-YAP by immunohistochemistry and immunoblotting techniques to identify the main components of Hippo Signaling Pathway. <jats:italic>YAP<\/jats:italic>, <jats:italic>LATS1<\/jats:italic>, <jats:italic>LATS 2<\/jats:italic>, <jats:italic>MST1<\/jats:italic>, <jats:italic>NF2<\/jats:italic> and <jats:italic>TAZ<\/jats:italic> used for the RT-qPCR methods. In conclusion, Hippo signaling pathway components were reduced during the adenogenesis process in mouse with impaired gland development.\u00a0<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>\n          <jats:p>A summary of our study. When the control and experimental\u00a0groups were compared, significant differences were observed in terms of the Hippo\u00a0signaling pathway.<\/jats:p>","DOI":"10.1007\/s43032-025-01793-y","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T13:17:45Z","timestamp":1742390265000},"page":"1685-1698","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Alterations in the Hippo Signaling Pathway During Adenogenesis Impairment in Postnatal Mouse Uterus"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-004X","authenticated-orcid":false,"given":"\u0130rem","family":"\u0130nan\u00e7","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0691-3508","authenticated-orcid":false,"given":"Onur","family":"Bender","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1309-5291","authenticated-orcid":false,"given":"Arzu","family":"Atalay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6734-3847","authenticated-orcid":false,"given":"Serdal Kenan","family":"K\u00f6se","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-269X","authenticated-orcid":false,"given":"Esra","family":"Erdemli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"issue":"9","key":"1793_CR1","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1093\/molehr\/gat031","volume":"19","author":"PS Cooke","year":"2013","unstructured":"Cooke PS, Spencer TE, Bartol FF, Hayashi K. 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