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Expression levels of the receptivity markers <jats:italic>PROK1, PROKR1, PROK2, PROKR2<\/jats:italic> and <jats:italic>HOXA10<\/jats:italic> genes were determined by RT- PCR. When the patients diagnosed with endometrial polyp and the healthy controls were compared, it was observed statistically significantly that the expression of <jats:italic>PROKR1<\/jats:italic> increased in endometrium tissue of patients with endometrial polyp (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In patients diagnosed with myoma uteri, gene expression levels of endometrial PROKR1 was statistically significant increased and gene expression levels of <jats:italic>PROK1, PROKR2, HOXA10<\/jats:italic> were found to be statistically significantly decreased compared to the controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Changes in the endometrial expression of the <jats:italic>HOXA10<\/jats:italic> and prokineticin gene family in patients with myoma uteri and endometrial polyps may explain certain aspects of infertility in these patients.<\/jats:p>","DOI":"10.1007\/s43032-025-01802-0","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T17:35:48Z","timestamp":1738863348000},"page":"728-737","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Effect of Endometrial Polyp and Myoma Uteri on Fertility-Related Genes in the Endometrium"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7961-0087","authenticated-orcid":false,"given":"G\u00fcrkan","family":"\u00d6zbey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-4263","authenticated-orcid":false,"given":"G\u00f6rkem","family":"Tuncay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9325-7993","authenticated-orcid":false,"given":"Senem Arda","family":"D\u00fcz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8600-0946","authenticated-orcid":false,"given":"Y\u0131lmaz","family":"\u00c7i\u011fremi\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2010-6211","authenticated-orcid":false,"given":"Abdullah","family":"Karaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"1802_CR1","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/s0029-7844(02)02511-5","volume":"101","author":"SH Eisinger","year":"2003","unstructured":"Eisinger SH, Meldrum S, Fiscella K, le Roux HD, Guzick DS. 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