{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:58:41Z","timestamp":1790891921579,"version":"4.1.0"},"reference-count":174,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100018628","name":"Scientific Research Foundation of Education Department of Anhui Province of China","doi-asserted-by":"publisher","award":["2022AH050494"],"award-info":[{"award-number":["2022AH050494"]}],"id":[{"id":"10.13039\/501100018628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ovarian dysfunctions, encompassing conditions such as polycystic ovary syndrome (PCOS), premature ovarian failure (POF), premature ovarian insufficiency (POI), and diminished ovarian reserve (DOR), are closely linked to disruptions in follicular development, often tied to granulosa cell (GC) abnormalities. Despite ongoing research, the precise mechanisms underlying these dysfunctions remain elusive. Increasing evidence highlights the pivotal role of non-coding RNAs (ncRNAs) in the pathogenesis of ovarian dysfunctions. As transcripts that do not encode proteins, ncRNAs are capable of regulating gene expression at various levels. They influence GCs by modulating key biological processes including proliferation, apoptosis, autophagy, cell cycle progression, steroidogenesis, mitochondrial function, inflammatory responses, and aging. Disruptions in GC development and function can lead to impaired follicular development, consequently contributing to ovarian dysfunctions. Thus, ncRNAs are likely integral to the regulatory mechanisms underlying these pathologies, exhibiting distinct expression patterns in affected individuals. This review delves into the regulatory roles of ncRNAs in GCs and their implications for ovarian dysfunctions (PCOS, POF, POI, DOR), offering insights into potential biomarkers for ovarian function assessment and novel therapeutic approaches for treating these conditions.<\/jats:p>","DOI":"10.1007\/s43032-025-01854-2","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T09:20:42Z","timestamp":1743758442000},"page":"2098-2120","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["The Role of Ovarian Granulosa Cells Related-ncRNAs in Ovarian Dysfunctions: Mechanism Research and Clinical Exploration"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2976-5068","authenticated-orcid":false,"given":"Liuqing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"issue":"1","key":"1854_CR1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1262\/jrd.2011-012","volume":"58","author":"F Matsuda","year":"2012","unstructured":"Matsuda F, Inoue N, Manabe N, Ohkura S. Follicular growth and Atresia in mammalian ovaries: regulation by survival and death of granulosa cells. J Reprod Dev. 2012;58(1):44\u201350.","journal-title":"J Reprod Dev"},{"issue":"4","key":"1854_CR2","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1152\/physrev.00032.2022","volume":"103","author":"EE Telfer","year":"2023","unstructured":"Telfer EE, Grosbois J, Odey YL, Rosario R, Anderson RA. Making a good egg: human oocyte health, aging, and in vitro development. Physiol Rev. 2023;103(4):2623\u201377.","journal-title":"Physiol Rev"},{"key":"1854_CR3","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/978-3-319-31973-5_8","volume":"58","author":"S El-Hayek","year":"2016","unstructured":"El-Hayek S, Clarke HJ. Control of oocyte growth and development by intercellular communication within the follicular niche. Results Probl Cell Differ. 2016;58:191\u2013224.","journal-title":"Results Probl Cell Differ"},{"key":"1854_CR4","doi-asserted-by":"crossref","unstructured":"Eppig JJ, Reproduction. Oocytes call, granulosa cells connect. Curr Biol. 2018;28(8):R354\u20136.","DOI":"10.1016\/j.cub.2018.03.005"},{"issue":"21","key":"1854_CR5","doi-asserted-by":"publisher","first-page":"2501","DOI":"10.1016\/j.cub.2014.09.023","volume":"24","author":"H Zhang","year":"2014","unstructured":"Zhang H, Risal S, Gorre N, et al. Somatic cells initiate primordial follicle activation and govern the development of dormant oocytes in mice. Curr Biol. 2014;24(21):2501\u20138.","journal-title":"Curr Biol"},{"issue":"12","key":"1854_CR6","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1016\/j.bbadis.2012.05.013","volume":"1822","author":"F S\u00e1nchez","year":"2012","unstructured":"S\u00e1nchez F, Smitz J. Molecular control of oogenesiss. Biochim Biophys Acta. 2012;1822(12):1896\u2013912.","journal-title":"Biochim Biophys Acta"},{"key":"1854_CR7","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1146\/annurev-physiol-022516-034102","volume":"79","author":"LA Jaffe","year":"2017","unstructured":"Jaffe LA, Egbert JR. Regulation of mammalian oocyte meiosis by intercellular communication within the ovarian follicle. Annu Rev Physiol. 2017;79:237\u201360.","journal-title":"Annu Rev Physiol"},{"issue":"5929","key":"1854_CR8","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1126\/science.1171396","volume":"324","author":"HY Fan","year":"2009","unstructured":"Fan HY, Liu Z, Shimada M, et al. MAPK3\/1 (ERK1\/2) in ovarian granulosa cells are essential for female fertility. Science. 2009;324(5929):938\u201341.","journal-title":"Science"},{"key":"1854_CR9","doi-asserted-by":"publisher","first-page":"e2403640","DOI":"10.1002\/advs.202403640","volume":"1","author":"X Wang","year":"2024","unstructured":"Wang X, Liao J, Shi H, et al. Granulosa Cell-Layer stiffening prevents escape of mural granulosa cells from the Post-Ovulatory follicle. Adv Sci (Weinh). Jul 2024;1:e2403640.","journal-title":"Adv Sci (Weinh)"},{"issue":"4","key":"1854_CR10","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1095\/biolreprod.111.097345","volume":"86","author":"LK Akison","year":"2012","unstructured":"Akison LK, Alvino ER, Dunning KR, Robker RL, Russell DL. Transient invasive migration in mouse cumulus oocyte complexes induced at ovulation by luteinizing hormone. Biol Reprod. 2012;86(4):125.","journal-title":"Biol Reprod"},{"issue":"1","key":"1854_CR11","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/rmb2.12292","volume":"19","author":"MH Alam","year":"2019","unstructured":"Alam MH, Miyano T. Interaction between growing oocytes and granulosa cells in vitro. Reprod Med Biol. 2019;19(1):13\u201323.","journal-title":"Reprod Med Biol"},{"issue":"3","key":"1854_CR12","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1093\/humrep\/deq390","volume":"26","author":"P Zhao","year":"2011","unstructured":"Zhao P, Qiao J, Huang S, et al. Gonadotrophin-induced paracrine regulation of human oocyte maturation by BDNF and GDNF secreted by granulosa cells. Hum Reprod. 2011;26(3):695\u2013702.","journal-title":"Hum Reprod"},{"issue":"10","key":"1854_CR13","doi-asserted-by":"publisher","first-page":"2706","DOI":"10.1080\/15548627.2021.1938914","volume":"17","author":"S Kumariya","year":"2021","unstructured":"Kumariya S, Ubba V, Jha RK, Gayen JR. Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective. Autophagy. 2021;17(10):2706\u201333.","journal-title":"Autophagy"},{"key":"1854_CR14","doi-asserted-by":"crossref","unstructured":"Xiao S, Du J, Yuan G, Luo X, Song L. Granulosa cells-related microRNAs in ovarian diseases: mechanism, facts and perspectives. Reprod Sci. 2024;31(12):3635\u20133650.","DOI":"10.1007\/s43032-024-01523-w"},{"issue":"11","key":"1854_CR15","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1080\/09513590.2022.2125951","volume":"38","author":"LY Cao","year":"2022","unstructured":"Cao LY, Zhang ZQ, Liu PP, et al. Aberrant BMP15\/HIF-1\u03b1\/SCF signaling pathway in human granulosa cells is involved in the PCOS related abnormal follicular development. Gynecol Endocrinol. 2022;38(11):971\u20137.","journal-title":"Gynecol Endocrinol"},{"issue":"3","key":"1854_CR16","first-page":"492","volume":"41","author":"L Cai","year":"2021","unstructured":"Cai L, Zong DK, Tong GQ, Li L. Apoptotic mechanism of premature ovarian failure and rescue effect of traditional Chinese medicine: a review. J Tradit Chin Med. 2021;41(3):492\u20138.","journal-title":"J Tradit Chin Med"},{"issue":"6","key":"1854_CR17","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1093\/molehr\/gaw023","volume":"22","author":"C Conca Dioguardi","year":"2016","unstructured":"Conca Dioguardi C, Uslu B, Haynes M, et al. Granulosa cell and oocyte mitochondrial abnormalities in a mouse model of fragile X primary ovarian insufficiency. Mol Hum Reprod. 2016;22(6):384\u201396.","journal-title":"Mol Hum Reprod"},{"issue":"6","key":"1854_CR18","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1007\/s10815-019-01446-5","volume":"36","author":"Y Fan","year":"2019","unstructured":"Fan Y, Chang Y, Wei L, et al. Apoptosis of mural granulosa cells is increased in women with diminished ovarian reserve. J Assist Reprod Genet. 2019;36(6):1225\u201335.","journal-title":"J Assist Reprod Genet"},{"issue":"3","key":"1854_CR19","doi-asserted-by":"publisher","first-page":"e1847","DOI":"10.1002\/wrna.1847","volume":"15","author":"S Dayal","year":"2024","unstructured":"Dayal S, Chaubey D, Joshi DC, Ranmale S, Pillai B. Noncoding RNAs: emerging regulators of behavioral complexity. Wiley Interdiscip Rev RNA. 2024;15(3):e1847.","journal-title":"Wiley Interdiscip Rev RNA"},{"issue":"17","key":"1854_CR20","doi-asserted-by":"publisher","first-page":"9336","DOI":"10.3390\/ijms22179336","volume":"22","author":"K Pankiewicz","year":"2021","unstructured":"Pankiewicz K, Lauda\u0144ski P, Issat T. The role of noncoding RNA in the pathophysiology and treatment of premature ovarian insufficiency. Int J Mol Sci. 2021;22(17):9336.","journal-title":"Int J Mol Sci"},{"key":"1854_CR21","doi-asserted-by":"publisher","first-page":"174","DOI":"10.3389\/fendo.2019.00174","volume":"10","author":"J Tu","year":"2019","unstructured":"Tu J, Cheung AH, Chan CL, Chan WY. The role of microRNAs in ovarian granulosa cells in health and disease. Front Endocrinol (Lausanne). 2019;10:174.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"5","key":"1854_CR22","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1007\/s00404-023-06922-z","volume":"308","author":"J Luo","year":"2023","unstructured":"Luo J, Sun Z. MicroRNAs in POI, DOR and POR. Arch Gynecol Obstet. 2023;308(5):1419\u201330.","journal-title":"Arch Gynecol Obstet"},{"key":"1854_CR23","doi-asserted-by":"publisher","first-page":"1056061","DOI":"10.3389\/fgene.2023.1056061","volume":"14","author":"Z Lv","year":"2023","unstructured":"Lv Z, Lv Z, Song L, Zhang Q, Zhu S. Role of lncRNAs in the pathogenic mechanism of human decreased ovarian reserve. Front Genet. 2023;14:1056061.","journal-title":"Front Genet"},{"issue":"1","key":"1854_CR24","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nrc.2017.99","volume":"18","author":"E Anastasiadou","year":"2018","unstructured":"Anastasiadou E, Jacob LS, Slack FJ. Non-coding RNA networks in cancer. Nat Rev Cancer. 2018;18(1):5\u201318.","journal-title":"Nat Rev Cancer"},{"key":"1854_CR25","doi-asserted-by":"publisher","first-page":"43673","DOI":"10.1038\/srep43673","volume":"7","author":"A Martirosyan","year":"2017","unstructured":"Martirosyan A, De Martino A, Pagnani A, Marinari E. CeRNA crosstalk stabilizes protein expression and affects the correlation pattern of interacting proteins. Sci Rep. 2017;7:43673.","journal-title":"Sci Rep"},{"issue":"9","key":"1854_CR26","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1101\/gr.247239.118","volume":"29","author":"M Fabbri","year":"2019","unstructured":"Fabbri M, Girnita L, Varani G, Calin GA. Decrypting noncoding RNA interactions, structures, and functional networks. Genome Res. 2019;29(9):1377\u201388.","journal-title":"Genome Res"},{"issue":"3","key":"1854_CR27","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41576-023-00662-1","volume":"25","author":"K Nemeth","year":"2024","unstructured":"Nemeth K, Bayraktar R, Ferracin M, Calin GA. Non-coding RNAs in disease: from mechanisms to therapeutics. Nat Rev Genet. 2024;25(3):211\u201332.","journal-title":"Nat Rev Genet"},{"issue":"1","key":"1854_CR28","doi-asserted-by":"publisher","first-page":"R17","DOI":"10.1093\/hmg\/ddl046","volume":"15","author":"JS Mattick","year":"2006","unstructured":"Mattick JS, Makunin IV. Non-coding RNA. Hum Mol Genet. 2006;15(1):R17\u201329.","journal-title":"Hum Mol Genet"},{"issue":"1","key":"1854_CR29","doi-asserted-by":"publisher","first-page":"5611","DOI":"10.1038\/s41467-020-19381-w","volume":"11","author":"L Stoll","year":"2020","unstructured":"Stoll L, Rodr\u00edguez-Trejo A, Guay C, et al. A circular RNA generated from an intron of the insulin gene controls insulin secretion. Nat Commun. 2020;11(1):5611.","journal-title":"Nat Commun"},{"issue":"3","key":"1854_CR30","doi-asserted-by":"publisher","first-page":"20190027","DOI":"10.1515\/jib-2019-0027","volume":"16","author":"P Zhang","year":"2019","unstructured":"Zhang P, Wu W, Chen Q, Chen M. Non-Coding RNAs and their integrated networks. J Integr Bioinform. 2019;16(3):20190027.","journal-title":"J Integr Bioinform"},{"issue":"1","key":"1854_CR31","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.cell.2014.03.008","volume":"157","author":"TR Cech","year":"2014","unstructured":"Cech TR, Steitz JA. The noncoding RNA revolution-trashing old rules to Forge new ones. Cell. 2014;157(1):77\u201394.","journal-title":"Cell"},{"issue":"11","key":"1854_CR32","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/j.bbamcr.2010.06.013","volume":"1803","author":"F Wahid","year":"2010","unstructured":"Wahid F, Shehzad A, Khan T, Kim YY. MicroRNAs: synthesis, mechanism, function, and recent clinical trials. Biochim Biophys Acta. 2010;1803(11):1231\u201343.","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"1854_CR33","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/nrm2632","volume":"10","author":"VN Kim","year":"2009","unstructured":"Kim VN, Han J, Siomi MC. Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol. 2009;10(2):126\u201339.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"10","key":"1854_CR34","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1261\/rna.7131604","volume":"10","author":"RS Pillai","year":"2004","unstructured":"Pillai RS, Artus CG, Filipowicz W. Tethering of human ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis. RNA. 2004;10(10):1518\u201325.","journal-title":"RNA"},{"issue":"5","key":"1854_CR35","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/0092-8674(93)90530-4","volume":"75","author":"B Wightman","year":"1993","unstructured":"Wightman B, Ha I, Ruvkun G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates Temporal pattern formation in C. elegans. Cell. 1993;75(5):855\u201362.","journal-title":"Cell"},{"issue":"7","key":"1854_CR36","doi-asserted-by":"publisher","first-page":"R42","DOI":"10.1186\/gb-2003-4-7-r42","volume":"4","author":"EC Lai","year":"2003","unstructured":"Lai EC, Tomancak P, Williams RW, Rubin GM. Computational identification of drosophila microRNA genes. Genome Biol. 2003;4(7):R42.","journal-title":"Genome Biol"},{"issue":"2","key":"1854_CR37","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1006\/dbio.1999.9523","volume":"216","author":"PH Olsen","year":"1999","unstructured":"Olsen PH, Ambros V. The lin-4 regulatory RNA controls developmental timing in caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev Biol. 1999;216(2):671\u201380.","journal-title":"Dev Biol"},{"issue":"1","key":"1854_CR38","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1242\/dev.006486","volume":"135","author":"C Klattenhoff","year":"2008","unstructured":"Klattenhoff C, Theurkauf W. Biogenesis and germline functions of PiRNAs. Development. 2008;135(1):3\u20139.","journal-title":"Development"},{"issue":"1","key":"1854_CR39","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.cell.2007.03.026","volume":"129","author":"S Houwing","year":"2007","unstructured":"Houwing S, Kamminga LM, Berezikov E, et al. A role for Piwi and PiRNAs in germ cell maintenance and transposon Silencing in zebrafish. Cell. 2007;129(1):69\u201382.","journal-title":"Cell"},{"issue":"16","key":"1854_CR40","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1101\/gad.1454806","volume":"20","author":"K Saito","year":"2006","unstructured":"Saito K, Nishida KM, Mori T, et al. Specific association of Piwi with RasiRNAs derived from retrotransposon and heterochromatic regions in the drosophila genome. Genes Dev. 2006;20(16):2214\u201322.","journal-title":"Genes Dev"},{"issue":"1","key":"1854_CR41","doi-asserted-by":"publisher","first-page":"32","DOI":"10.2183\/pjab.96.003","volume":"96","author":"K Sato","year":"2020","unstructured":"Sato K, Siomi MC. The PiRNA pathway in drosophila ovarian germ and somatic cells. Proc Jpn Acad Ser B Phys Biol Sci. 2020;96(1):32\u201342.","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"issue":"1","key":"1854_CR42","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s13059-024-03214-w","volume":"25","author":"L Hou","year":"2024","unstructured":"Hou L, Liu W, Zhang H, et al. Divergent composition and transposon-silencing activity of small RNAs in mammalian oocytes. Genome Biol. 2024;25(1):80.","journal-title":"Genome Biol"},{"issue":"12","key":"1854_CR43","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1016\/j.celrep.2015.02.062","volume":"10","author":"EF Roovers","year":"2015","unstructured":"Roovers EF, Rosenkranz D, Mahdipour M, et al. Piwi proteins and PiRNAs in mammalian oocytes and early embryos. Cell Rep. 2015;10(12):2069\u201382.","journal-title":"Cell Rep"},{"issue":"5","key":"1854_CR44","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1095\/biolreprod.111.096669","volume":"87","author":"CX Yang","year":"2012","unstructured":"Yang CX, Du ZQ, Wright EC, Rothschild MF, Prather RS, Ross JW. Small RNA profile of the cumulus-oocyte complex and early embryos in the pig. Biol Reprod. 2012;87(5):117.","journal-title":"Biol Reprod"},{"issue":"1","key":"1854_CR45","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1093\/biolre\/iox062","volume":"97","author":"D Chen","year":"2017","unstructured":"Chen D, Zhang Z, Chen B, et al. Altered microRNA and Piwi-interacting RNA profiles in cumulus cells from patients with diminished ovarian reserve. Biol Reprod. 2017;97(1):91\u2013103.","journal-title":"Biol Reprod"},{"issue":"8","key":"1854_CR46","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1038\/s41594-024-01287-6","volume":"31","author":"Z Li","year":"2024","unstructured":"Li Z, Li Z, Zhang Y, et al. Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target Silencing. Nat Struct Mol Biol. 2024;31(8):1222\u201331.","journal-title":"Nat Struct Mol Biol"},{"issue":"5785","key":"1854_CR47","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1126\/science.1129333","volume":"313","author":"VV Vagin","year":"2006","unstructured":"Vagin VV, Sigova A, Li C, Seitz H, Gvozdev V, Zamore PD. A distinct small RNA pathway silences selfish genetic elements in the germline. Science. 2006;313(5785):320\u20134.","journal-title":"Science"},{"issue":"2","key":"1854_CR48","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","volume":"22","author":"L Statello","year":"2021","unstructured":"Statello L, Guo CJ, Chen LL, Huarte M. Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol. 2021;22(2):96\u2013118.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"15","key":"1854_CR49","doi-asserted-by":"publisher","first-page":"8309","DOI":"10.3390\/ijms23158309","volume":"23","author":"C Garcia-Padilla","year":"2022","unstructured":"Garcia-Padilla C, Lozano-Velasco E, Mu\u00f1oz-Gallardo MDM, et al. LncRNA H19 impairs chemo and radiotherapy in tumorigenesis. Int J Mol Sci. 2022;23(15):8309.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"1854_CR50","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1007\/s00335-021-09939-4","volume":"33","author":"C Camilleri-Robles","year":"2022","unstructured":"Camilleri-Robles C, Amador R, Klein CC, Guig\u00f3 R, Corominas M, Ruiz-Romero M. Genomic and functional conservation of lncRNAs: lessons from flies. Mamm Genome. 2022;33(2):328\u201342.","journal-title":"Mamm Genome"},{"issue":"1","key":"1854_CR51","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s00239-023-10151-y","volume":"92","author":"F Weghorst","year":"2024","unstructured":"Weghorst F, Torres Marc\u00e9n M, Faridi G, Lee YCG, Cramer KS. Deep conservation and unexpected evolutionary history of neighboring lncRNAs MALAT1 and NEAT1. J Mol Evol. 2024;92(1):30\u201341.","journal-title":"J Mol Evol"},{"issue":"4","key":"1854_CR52","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.tig.2014.01.004","volume":"30","author":"S Diederichs","year":"2014","unstructured":"Diederichs S. The four dimensions of noncoding RNA conservation. Trends Genet. 2014;30(4):121\u20133.","journal-title":"Trends Genet"},{"issue":"3","key":"1854_CR53","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.bbagen.2013.10.035","volume":"1840","author":"P Johnsson","year":"2014","unstructured":"Johnsson P, Lipovich L, Grand\u00e9r D, Morris KV. Evolutionary conservation of long non-coding RNAs; sequence, structure, function. Biochim Biophys Acta. 2014;1840(3):1063\u201371.","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"1854_CR54","doi-asserted-by":"publisher","first-page":"6053","DOI":"10.1038\/s41467-020-19879-3","volume":"11","author":"H Fang","year":"2020","unstructured":"Fang H, Bonora G, Lewandowski JP, et al. Trans- and cis-acting effects of Firre on epigenetic features of the inactive X chromosome. Nat Commun. 2020;11(1):6053.","journal-title":"Nat Commun"},{"issue":"Pt 4","key":"1854_CR55","doi-asserted-by":"publisher","first-page":"125170","DOI":"10.1016\/j.ijbiomac.2023.125170","volume":"242","author":"N Li","year":"2023","unstructured":"Li N, Zhou Y, Cai J, et al. A novel trans-acting lncRNA of ACTG1 that induces the remodeling of ovarian follicles. Int J Biol Macromol. 2023;242(Pt 4):125170.","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"1854_CR56","first-page":"151","volume":"1856","author":"A Bhan","year":"2015","unstructured":"Bhan A, Mandal SS. LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer. Biochim Biophys Acta. 2015;1856(1):151\u201364.","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"1854_CR57","doi-asserted-by":"publisher","first-page":"e202009045","DOI":"10.1083\/jcb.202009045","volume":"220","author":"MC Bridges","year":"2021","unstructured":"Bridges MC, Daulagala AC, Kourtidis A. LNCcation: LncRNA localization and function. J Cell Biol. 2021;220(2):e202009045.","journal-title":"J Cell Biol"},{"issue":"5","key":"1854_CR58","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s42255-020-0205-x","volume":"2","author":"KV Tran","year":"2020","unstructured":"Tran KV, Brown EL, DeSouza T, et al. Human thermogenic adipocyte regulation by the long noncoding RNA LINC00473. Nat Metab. 2020;2(5):397\u2013412.","journal-title":"Nat Metab"},{"issue":"7341","key":"1854_CR59","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/nature09819","volume":"472","author":"KC Wang","year":"2011","unstructured":"Wang KC, Yang YW, Liu B, et al. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature. 2011;472(7341):120\u20134.","journal-title":"Nature"},{"issue":"1","key":"1854_CR60","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.cell.2010.09.001","volume":"143","author":"UA \u00d8rom","year":"2010","unstructured":"\u00d8rom UA, Derrien T, Beringer M, et al. Long noncoding RNAs with enhancer-like function in human cells. Cell. 2010;143(1):46\u201358.","journal-title":"Cell"},{"issue":"7","key":"1854_CR61","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.cell.2007.05.022","volume":"129","author":"JL Rinn","year":"2007","unstructured":"Rinn JL, Kertesz M, Wang JK, et al. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell. 2007;129(7):1311\u201323.","journal-title":"Cell"},{"key":"1854_CR62","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13046-020-01798-2","volume":"40","author":"Y Liu","year":"2021","unstructured":"Liu Y, Liu X, Lin C, et al. Noncoding RNAs regulate alternative splicing in cancer. J Exp Clin Cancer Res. 2021;40:11.","journal-title":"J Exp Clin Cancer Res"},{"issue":"6","key":"1854_CR63","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1261\/rna.053561.115","volume":"2","author":"J Carlevaro-Fita","year":"2016","unstructured":"Carlevaro-Fita J, Rahim A, Guig\u00f3 R, Vardy LA, Johnson R. Cytoplasmic long noncoding RNAs are frequently bound to and degraded at ribosomes in human cells. RNA. 2016;2(6):867\u201382.","journal-title":"RNA"},{"issue":"16","key":"1854_CR64","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1101\/gad.1811209","volume":"23","author":"JT Lee","year":"2009","unstructured":"Lee JT. Lessons from X-chromosome inactivation: long NcRNA as guides and tethers to the epigenome. Genes Dev. 2009;23(16):1831\u201342.","journal-title":"Genes Dev"},{"issue":"6","key":"1854_CR65","first-page":"603","volume":"2","author":"Z Pasman","year":"1996","unstructured":"Pasman Z, Been MD, Garcia-Blanco MA. Exon circularization in mammalian nuclear extracts. RNA. 1996;2(6):603\u201310.","journal-title":"RNA"},{"issue":"13","key":"1854_CR66","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1007\/s00018-016-2174-5","volume":"73","author":"SU Schmitz","year":"2016","unstructured":"Schmitz SU, Grote P, Herrmann BG. Mechanisms of long noncoding RNA function in development and disease. Cell Mol Life Sci. 2016;73(13):2491\u2013509.","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"1854_CR67","doi-asserted-by":"publisher","first-page":"e30733","DOI":"10.1371\/journal.pone.0030733","volume":"7","author":"J Salzman","year":"2012","unstructured":"Salzman J, Gawad C, Wang PL, Lacayo N, Brown PO. Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLoS ONE. 2012;7(2):e30733.","journal-title":"PLoS ONE"},{"issue":"11","key":"1854_CR68","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","volume":"20","author":"LS Kristensen","year":"2019","unstructured":"Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB, Kjems J. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 2019;20(11):675\u201391.","journal-title":"Nat Rev Genet"},{"key":"1854_CR69","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.bbrc.2023.08.037","volume":"678","author":"G Lindner","year":"2023","unstructured":"Lindner G, Takenaka K, Santucci K, Gao Y, Janitz M. Protein-coding circular RNAs - mechanism, detection, and their role in cancer and neurodegenerative diseases. Biochem Biophys Res Commun. 2023;678:68\u201377.","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"1854_CR70","doi-asserted-by":"publisher","first-page":"975","DOI":"10.7150\/ijms.71840","volume":"19","author":"X Zhao","year":"2022","unstructured":"Zhao X, Zhong Y, Wang X, Shen J, An W. Advances in circular RNA and its applications. Int J Med Sci. 2022;19(6):975\u201385.","journal-title":"Int J Med Sci"},{"issue":"2","key":"1854_CR71","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1261\/rna.035667.112","volume":"19","author":"WR Jeck","year":"2013","unstructured":"Jeck WR, Sorrentino JA, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA. 2013;19(2):141\u201357.","journal-title":"RNA"},{"issue":"1","key":"1854_CR72","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2174\/1574893618666230505101059","volume":"19","author":"JY Hwang","year":"2024","unstructured":"Hwang JY, Kook TL, Paulus SM, Park JW. Translation of circular RNAs: functions of translated products and related bioinformatics approaches. Curr Bioinform. 2024;19(1):3\u201313.","journal-title":"Curr Bioinform"},{"issue":"7441","key":"1854_CR73","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature11993","volume":"495","author":"TB Hansen","year":"2013","unstructured":"Hansen TB, Jensen TI, Clausen BH, et al. Natural RNA circles function as efficient microRNA sponges. Nature. 2013;495(7441):384\u20138.","journal-title":"Nature"},{"key":"1854_CR74","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/978-981-13-1426-1_6","volume":"1087","author":"AC Panda","year":"2018","unstructured":"Panda AC. Circular RNAs act as miRNA sponges. Adv Exp Med Biol. 2018;1087:67\u201379.","journal-title":"Adv Exp Med Biol"},{"issue":"5209","key":"1854_CR75","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1126\/science.7536344","volume":"268","author":"CY Chen","year":"1995","unstructured":"Chen CY, Sarnow P. Initiation of protein synthesis by the eukaryotic translational apparatus on circular RNAs. Science. 1995;268(5209):415\u20137.","journal-title":"Science"},{"issue":"2","key":"1854_CR76","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1261\/rna.048272.114","volume":"21","author":"Y Wang","year":"2015","unstructured":"Wang Y, Wang Z. Efficient backsplicing produces translatable circular mRNAs. RNA. 2015;21(2):172\u20139.","journal-title":"RNA"},{"issue":"5","key":"1854_CR77","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/cr.2017.31","volume":"27","author":"Y Yang","year":"2017","unstructured":"Yang Y, Fan X, Mao M, et al. Extensive translation of circular RNAs driven by N6-methyladenosine. Cell Res. 2017;27(5):626\u201341.","journal-title":"Cell Res"},{"issue":"6","key":"1854_CR78","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1002\/cbin.11137","volume":"43","author":"MS D\u2019Arcy","year":"2019","unstructured":"D\u2019Arcy MS. Cell death: a review of the major forms of apoptosis, necrosis and autophagy. Cell Biol Int. 2019;43(6):582\u201392.","journal-title":"Cell Biol Int"},{"key":"1854_CR79","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3389\/fendo.2018.00061","volume":"9","author":"SLP Regan","year":"2018","unstructured":"Regan SLP, Knight PG, Yovich JL, Leung Y, Arfuso F, Dharmarajan A. Granulosa cell apoptosis in the ovarian Follicle-A changing view. Front Endocrinol (Lausanne). 2018;9:61.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"1854_CR80","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1159\/000014628","volume":"9","author":"AL Johnson","year":"2000","unstructured":"Johnson AL. Granulosa cell apoptosis: conservation of cell signaling in an avian ovarian model system. Biol Signals Recept. 2000;9(2):96\u2013101.","journal-title":"Biol Signals Recept"},{"issue":"5","key":"1854_CR81","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1262\/jrd.50.493","volume":"50","author":"N Manabe","year":"2004","unstructured":"Manabe N, Goto Y, Matsuda-Minehata F, et al. Regulation mechanism of selective Atresia in Porcine follicles: regulation of granulosa cell apoptosis during Atresia. J Reprod Dev. 2004;50(5):493\u2013514.","journal-title":"J Reprod Dev"},{"issue":"1","key":"1854_CR82","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13048-023-01121-5","volume":"16","author":"D Bao","year":"2023","unstructured":"Bao D, Gao L, Xin H, Wang L. lncRNA-FMR6 directly binds SAV1 to increase apoptosis of granulosa cells in premature ovarian failure. J Ovarian Res. 2023;16(1):65.","journal-title":"J Ovarian Res"},{"issue":"6","key":"1854_CR83","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1007\/s10815-023-02815-x","volume":"40","author":"L Zhu","year":"2023","unstructured":"Zhu L, Yao X, Mo Y, et al. miR-4433a-3p promotes granulosa cell apoptosis by targeting peroxisome proliferator-activated receptor alpha and inducing immune cell infiltration in polycystic ovarian syndrome. J Assist Reprod Genet. 2023;40(6):1447\u201359.","journal-title":"J Assist Reprod Genet"},{"issue":"1","key":"1854_CR84","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1210\/en.2017-00219","volume":"159","author":"M Wang","year":"2018","unstructured":"Wang M, Sun J, Xu B, et al. Functional characterization of microRNA-27a-3p expression in human polycystic ovary syndrome. Endocrinology. 2018;159(1):297\u2013309.","journal-title":"Endocrinology"},{"issue":"1","key":"1854_CR85","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12958-024-01189-8","volume":"22","author":"W Ju","year":"2024","unstructured":"Ju W, Zhao S, Wu H, et al. miR-6881-3p contributes to diminished ovarian reserve by regulating granulosa cell apoptosis by targeting SMAD4. Reprod Biol Endocrinol. 2024;22(1):17.","journal-title":"Reprod Biol Endocrinol"},{"issue":"6","key":"1854_CR86","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1210\/jc.2017-02344","volume":"103","author":"L Hong","year":"2018","unstructured":"Hong L, Peng S, Li Y, et al. miR-106a increases granulosa cell viability and is downregulated in women with diminished ovarian reserve. J Clin Endocrinol Metab. 2018;103(6):2157\u201366.","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"1854_CR87","doi-asserted-by":"publisher","first-page":"5162","DOI":"10.1002\/jcp.30222","volume":"236","author":"F Wang","year":"2021","unstructured":"Wang F, Chen X, Sun B, et al. Hypermethylation-mediated downregulation of lncRNA PVT1 promotes granulosa cell apoptosis in premature ovarian insufficiency via interacting with Foxo3a. J Cell Physiol. 2021;236(7):5162\u201375.","journal-title":"J Cell Physiol"},{"issue":"1","key":"1854_CR88","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s13048-021-00905-x","volume":"14","author":"C Zheng","year":"2021","unstructured":"Zheng C, Liu S, Qin Z, Zhang X, Song Y. LncRNA DLEU1 is overexpressed in premature ovarian failure and sponges miR-146b-5p to increase granulosa cell apoptosis. J Ovarian Res. 2021;14(1):151.","journal-title":"J Ovarian Res"},{"issue":"6","key":"1854_CR89","doi-asserted-by":"publisher","first-page":"14107","DOI":"10.1080\/21655979.2022.2080366","volume":"13","author":"Y Guo","year":"2022","unstructured":"Guo Y, Peng X, Cheng R, Chen H, Luo X. Long non-coding RNA-X-inactive specific transcript inhibits cell viability, and induces apoptosis through the microRNA-30c-5p\/Bcl2-like protein 11 signaling axis in human granulosa-like tumor cells. Bioengineered. 2022;13(6):14107\u201317.","journal-title":"Bioengineered"},{"issue":"12","key":"1854_CR90","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1002\/cam4.4615","volume":"11","author":"X Zhang","year":"2022","unstructured":"Zhang X, Zhang R, Hao J, et al. miRNA-122-5p in POI ovarian-derived exosomes promotes granulosa cell apoptosis by regulating BCL9. Cancer Med. 2022;11(12):2414\u201326.","journal-title":"Cancer Med"},{"key":"1854_CR91","doi-asserted-by":"publisher","first-page":"789939","DOI":"10.3389\/fendo.2021.789939","volume":"12","author":"G Zhou","year":"2022","unstructured":"Zhou G, Gu Y, Zhou F, et al. Adipocytes-Derived extracellular vesicle-miR-26b promotes apoptosis of cumulus cells and induces polycystic ovary syndrome. Front Endocrinol (Lausanne). 2022;12:789939.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"10","key":"1854_CR92","doi-asserted-by":"publisher","first-page":"3092","DOI":"10.1007\/s43032-023-01251-7","volume":"30","author":"Z Zhou","year":"2023","unstructured":"Zhou Z, Zhang Y, Zhang X, et al. Follicular fluid-derived small extracellular vesicles alleviate DHEA-Induced granulosa cell apoptosis by delivering LINC00092. Reprod Sci. 2023;30(10):3092\u2013102.","journal-title":"Reprod Sci"},{"issue":"8","key":"1854_CR93","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.3724\/abbs.2023089","volume":"55","author":"R Chen","year":"2023","unstructured":"Chen R, Wu X, Qiu H, et al. Obesity-induced inflammatory miR-133a mediates apoptosis of granulosa cells and causes abnormal folliculogenesis. Acta Biochim Biophys Sin (Shanghai). 2023;55(8):1234\u201346.","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"6","key":"1854_CR94","doi-asserted-by":"publisher","first-page":"410","DOI":"10.3109\/09513599909167588","volume":"13","author":"T Maruo","year":"1999","unstructured":"Maruo T, Laoag-Fernandez JB, Takekida S, et al. Regulation of granulosa cell proliferation and apoptosis during follicular development. Gynecol Endocrinol. 1999;13(6):410\u20139.","journal-title":"Gynecol Endocrinol"},{"issue":"1","key":"1854_CR95","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1186\/s12958-021-00850-w","volume":"19","author":"YX Wu","year":"2021","unstructured":"Wu YX, Lin YS, Li SC, et al. microRNA-194 is increased in polycystic ovary syndrome granulosa cell and induce KGN cells apoptosis by direct targeting heparin-binding EGF-like growth factor. Reprod Biol Endocrinol. 2021;19(1):170.","journal-title":"Reprod Biol Endocrinol"},{"issue":"5","key":"1854_CR96","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.3390\/ijms25052720","volume":"25","author":"S Dong","year":"2024","unstructured":"Dong S, Jiang S, Hou B, et al. miR-128-3p regulates follicular granulosa cell proliferation and apoptosis by targeting the growth hormone secretagogue receptor. Int J Mol Sci. 2024;25(5):2720.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"1854_CR97","doi-asserted-by":"publisher","first-page":"100782","DOI":"10.1016\/j.repbio.2023.100782","volume":"23","author":"Z Gong","year":"2023","unstructured":"Gong Z, Shi X, Xu W, et al. LncRNA PWRN2 promotes polycystic ovary syndrome progression via epigenetically reducing ATRX by recruiting LSD1. Reprod Biol. 2023;23(3):100782.","journal-title":"Reprod Biol"},{"key":"1854_CR98","doi-asserted-by":"publisher","first-page":"105844","DOI":"10.1016\/j.jsbmb.2021.105844","volume":"209","author":"D Bao","year":"2021","unstructured":"Bao D, Li M, Zhou D, et al. miR-130b-3p is high-expressed in polycystic ovarian syndrome and promotes granulosa cell proliferation by targeting SMAD4. J Steroid Biochem Mol Biol. 2021;209:105844.","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"4","key":"1854_CR99","doi-asserted-by":"publisher","first-page":"10373","DOI":"10.1080\/21655979.2022.2053797","volume":"13","author":"L Chen","year":"2022","unstructured":"Chen L, Kong C. LINC00173 regulates polycystic ovarian syndrome progression by promoting apoptosis and repressing proliferation in ovarian granulosa cells via the microRNA-124-3p (miR-124-3p)\/jagged canonical Notch ligand 1 (JAG1) pathway. Bioengineered. 2022;13(4):10373\u201385.","journal-title":"Bioengineered"},{"issue":"1","key":"1854_CR100","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12958-021-00839-5","volume":"19","author":"L Xu","year":"2021","unstructured":"Xu L, Xiong F, Bai Y, et al. Circ_0043532 regulates miR-182\/SGK3 axis to promote granulosa cell progression in polycystic ovary syndrome. Reprod Biol Endocrinol. 2021;19(1):167.","journal-title":"Reprod Biol Endocrinol"},{"issue":"1","key":"1854_CR101","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13048-024-01392-6","volume":"17","author":"F Xuan","year":"2024","unstructured":"Xuan F, Jin R, Zhou W, et al. LncRNA SNHG12 promotes cell proliferation and inhibits apoptosis of granulosa cells in polycystic ovarian syndrome by sponging miR-129 and miR-125b. J Ovarian Res. 2024;17(1):72.","journal-title":"J Ovarian Res"},{"key":"1854_CR102","doi-asserted-by":"crossref","unstructured":"Lu X, Gao H, Zhu B, Lin G, Circular. RNA circ_RANBP9 exacerbates polycystic ovary syndrome via microRNA-136-5p\/XIAP axis. Bioengineered. 2021;12(1):6748\u201358.","DOI":"10.1080\/21655979.2021.1964157"},{"issue":"9","key":"1854_CR103","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1507\/endocrj.EJ21-0653","volume":"69","author":"YT Sun","year":"2022","unstructured":"Sun YT, Cai JH, Bao S. Overexpression of lncRNA HCP5 in human umbilical cord mesenchymal stem cell-derived exosomes promoted the proliferation and inhibited the apoptosis of ovarian granulosa cells via the Musashi RNA-binding protein 2\/oestrogen receptor alpha 1 axis. Endocr J. 2022;69(9):1117\u201329.","journal-title":"Endocr J"},{"issue":"1","key":"1854_CR104","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1186\/s13287-022-03056-y","volume":"13","author":"Q Qu","year":"2022","unstructured":"Qu Q, Liu L, Cui Y, et al. miR-126-3p containing exosomes derived from human umbilical cord mesenchymal stem cells promote angiogenesis and attenuate ovarian granulosa cell apoptosis in a preclinical rat model of premature ovarian failure. Stem Cell Res Ther. 2022;13(1):352.","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"1854_CR105","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s13048-021-00891-0","volume":"14","author":"Y Chen","year":"2021","unstructured":"Chen Y, Miao J, Lou G. Knockdown of circ-FURIN suppresses the proliferation and induces apoptosis of granular cells in polycystic ovary syndrome via miR-195-5p\/BCL2 axis. J Ovarian Res. 2021;14(1):156.","journal-title":"J Ovarian Res"},{"issue":"1","key":"1854_CR106","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12958-022-00891-9","volume":"20","author":"X Xu","year":"2022","unstructured":"Xu X, Guan R, Gong K, Xie H, Shi L. Circ_FURIN knockdown assuages Testosterone-induced human ovarian granulosa-like tumor cell disorders by sponging miR-423-5p to reduce MTM1 expression in polycystic ovary syndrome. Reprod Biol Endocrinol. 2022;20(1):32.","journal-title":"Reprod Biol Endocrinol"},{"key":"1854_CR107","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.reprotox.2021.10.003","volume":"106","author":"W Wu","year":"2021","unstructured":"Wu W, Duan C, Lv H, et al. MiR-let-7d-3p inhibits granulosa cell proliferation by targeting TLR4 in polycystic ovary syndrome. Reprod Toxicol. 2021;106:61\u20138.","journal-title":"Reprod Toxicol"},{"issue":"1","key":"1854_CR108","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/s41580-021-00404-3","volume":"23","author":"HK Matthews","year":"2022","unstructured":"Matthews HK, Bertoli C, de Bruin RAM. Cell cycle control in cancer. Nat Rev Mol Cell Biol. 2022;23(1):74\u201388.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"1854_CR109","doi-asserted-by":"publisher","first-page":"108522","DOI":"10.1016\/j.isci.2023.108522","volume":"27","author":"Z Yang","year":"2023","unstructured":"Yang Z, Pan J, Zhou C, et al. LncRNA SNHG5 adversely governs follicular growth in PCOS via miR-92a-3p\/CDKN1C axis. iScience. 2023;27(2):108522.","journal-title":"iScience"},{"issue":"6","key":"1854_CR110","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1007\/s13770-024-00652-2","volume":"21","author":"G Yang","year":"2024","unstructured":"Yang G, Zhang B, Xu M, et al. Improving granulosa cell function in premature ovarian failure with umbilical cord mesenchymal stromal cell exosome-derived Hsa_circ_0002021. Tissue Eng Regen Med. 2024;21(6):897\u2013914.","journal-title":"Tissue Eng Regen Med"},{"key":"1854_CR111","doi-asserted-by":"publisher","first-page":"110697","DOI":"10.1016\/j.mce.2019.110697","volume":"503","author":"Y Chen","year":"2020","unstructured":"Chen Y, Zhang X, An Y, Liu B, Lu M. LncRNA HCP5 promotes cell proliferation and inhibits apoptosis via miR-27a-3p\/IGF-1 axis in human granulosa-like tumor cell line KGN. Mol Cell Endocrinol. 2020;503:110697.","journal-title":"Mol Cell Endocrinol"},{"issue":"5","key":"1854_CR112","doi-asserted-by":"publisher","first-page":"103697","DOI":"10.1016\/j.rbmo.2023.103697","volume":"48","author":"T Zhang","year":"2024","unstructured":"Zhang T, Zhang J, Yang G, et al. Long non-coding RNA PWRN1 affects ovarian follicular development by regulating the function of granulosa cells. Reprod Biomed Online. 2024;48(5):103697.","journal-title":"Reprod Biomed Online"},{"issue":"11","key":"1854_CR113","doi-asserted-by":"publisher","first-page":"gaad036","DOI":"10.1093\/molehr\/gaad036","volume":"29","author":"H Fan","year":"2023","unstructured":"Fan H, Zhou D, Zhang X, et al. hsa_circRNA_BECN1 acts as a CeRNA to promote polycystic ovary syndrome progression by sponging the miR-619-5p\/Rab5b axis. Mol Hum Reprod. 2023;29(11):gaad036.","journal-title":"Mol Hum Reprod"},{"key":"1854_CR114","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.omtn.2020.10.041","volume":"23","author":"D Li","year":"2020","unstructured":"Li D, Wang X, Dang Y, et al. LncRNA GCAT1 is involved in premature ovarian insufficiency by regulating p27 translation in GCs via competitive binding to PTBP1. Mol Ther Nucleic Acids. 2020;23:132\u201341.","journal-title":"Mol Ther Nucleic Acids"},{"issue":"1","key":"1854_CR115","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13048-021-00769-1","volume":"14","author":"G Yao","year":"2021","unstructured":"Yao G, Kong Y, Yang G, et al. Lnc-GULP1-2:1 affects granulosa cell proliferation by regulating COL3A1 expression and localization. J Ovarian Res. 2021;14(1):16.","journal-title":"J Ovarian Res"},{"issue":"3","key":"1854_CR116","doi-asserted-by":"publisher","first-page":"305","DOI":"10.5603\/EP.a2023.0020","volume":"74","author":"J Lu","year":"2023","unstructured":"Lu J, Xuan F, Chen A, et al. MicroRNA-646 inhibits the proliferation of ovarian granulosa cells via insulin-like growth factor 1 (IGF-1) in polycystic ovarian syndrome (PCOS). Endokrynol Pol. 2023;74(3):305\u201314.","journal-title":"Endokrynol Pol"},{"key":"1854_CR117","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1042\/bse0550105","volume":"55","author":"T Yonekawa","year":"2013","unstructured":"Yonekawa T, Thorburn A. Autophagy and cell death. Essays Biochem. 2013;55:105\u201317.","journal-title":"Essays Biochem"},{"key":"1854_CR118","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/bs.ctdb.2015.07.012","volume":"114","author":"AL Anding","year":"2015","unstructured":"Anding AL, Baehrecke EH. Autophagy in cell life and cell death. Curr Top Dev Biol. 2015;114:67\u201391.","journal-title":"Curr Top Dev Biol"},{"issue":"1","key":"1854_CR119","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/s41420-024-01811-z","volume":"10","author":"C Luo","year":"2024","unstructured":"Luo C, Wei L, Qian F, et al. LncRNA HOTAIR regulates autophagy and proliferation mechanisms in premature ovarian insufficiency through the miR-148b-3p\/ATG14 axis. Cell Death Discov. 2024;10(1):44.","journal-title":"Cell Death Discov"},{"issue":"1","key":"1854_CR120","doi-asserted-by":"publisher","first-page":"2227280","DOI":"10.1080\/09513590.2023.2227280","volume":"39","author":"C Chen","year":"2023","unstructured":"Chen C, Jiang X, Ding C, Sun X, Wan L, Wang C. Downregulated lncRNA HOTAIR ameliorates polycystic ovaries syndrome via IGF-1 mediated PI3K\/Akt pathway. Gynecol Endocrinol. 2023;39(1):2227280.","journal-title":"Gynecol Endocrinol"},{"issue":"1","key":"1854_CR121","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/jcmm.14753","volume":"24","author":"B Jiang","year":"2020","unstructured":"Jiang B, Xue M, Xu D, Song J, Zhu S. Down-regulated lncRNA HOTAIR alleviates polycystic ovaries syndrome in rats by reducing expression of insulin-like growth factor 1 via microRNA-130a. J Cell Mol Med. 2020;24(1):451\u201364.","journal-title":"J Cell Mol Med"},{"key":"1854_CR122","doi-asserted-by":"publisher","first-page":"112288","DOI":"10.1016\/j.biopha.2021.112288","volume":"144","author":"X Chen","year":"2021","unstructured":"Chen X, Tang H, Liang Y, et al. Acupuncture regulates the autophagy of ovarian granulosa cells in polycystic ovarian syndrome ovulation disorder by inhibiting the PI3K\/AKT\/mTOR pathway through LncMEG3. Biomed Pharmacother. 2021;144:112288.","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"1854_CR123","doi-asserted-by":"publisher","first-page":"113473","DOI":"10.1016\/j.yexcr.2023.113473","volume":"424","author":"YX Liu","year":"2023","unstructured":"Liu YX, Ke Y, Qiu P, Gao J, Deng GP. LncRNA NEAT1 inhibits apoptosis and autophagy of ovarian granulosa cells through miR-654\/STC2-mediated MAPK signaling pathway. Exp Cell Res. 2023;424(1):113473.","journal-title":"Exp Cell Res"},{"issue":"5","key":"1854_CR124","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1007\/s10815-024-03092-y","volume":"41","author":"L Yu","year":"2024","unstructured":"Yu L, Wang C, Liu M, et al. Follicular fluid-derived exosomal lncRNA LIPE-AS1 modulates steroid metabolism and survival of granulosa cells leading to oocyte maturation arrest in polycystic ovary syndrome. J Assist Reprod Genet. 2024;41(5):1387\u2013401.","journal-title":"J Assist Reprod Genet"},{"issue":"1","key":"1854_CR125","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s12958-020-00585-0","volume":"18","author":"S Xie","year":"2020","unstructured":"Xie S, Zhang Q, Zhao J, Hao J, Fu J, Li Y. MiR-423-5p May regulate ovarian response to ovulation induction via CSF1. Reprod Biol Endocrinol. 2020;18(1):26.","journal-title":"Reprod Biol Endocrinol"},{"key":"1854_CR126","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.trsl.2022.12.007","volume":"256","author":"Y Liu","year":"2023","unstructured":"Liu Y, Zhang S, Chen L, et al. The molecular mechanism of miR-96-5p in the pathogenesis and treatment of polycystic ovary syndrome. Transl Res. 2023;256:1\u201313.","journal-title":"Transl Res"},{"key":"1854_CR127","doi-asserted-by":"publisher","first-page":"114015","DOI":"10.1016\/j.ygcen.2022.114015","volume":"321\u2013322","author":"JH Cai","year":"2022","unstructured":"Cai JH, Sun YT, Bao S. HucMSCs-exosomes containing miR-21 promoted Estrogen production in ovarian granulosa cells via LATS1-mediated phosphorylation of LOXL2 and YAP. Gen Comp Endocrinol. 2022;321\u2013322:114015.","journal-title":"Gen Comp Endocrinol"},{"issue":"7","key":"1854_CR128","doi-asserted-by":"publisher","first-page":"e22960","DOI":"10.1096\/fj.202201940RR","volume":"37","author":"X Jiang","year":"2023","unstructured":"Jiang X, Zhang Z, Hou M, Yang X, Cui L. Plasma exosomes and contained miRNAs affect the reproductive phenotype in polycystic ovary syndrome. FASEB J. 2023;37(7):e22960.","journal-title":"FASEB J"},{"key":"1854_CR129","doi-asserted-by":"publisher","first-page":"800739","DOI":"10.3389\/fphys.2021.800739","volume":"12","author":"HC Alberico","year":"2022","unstructured":"Alberico HC, Woods DC. Role of granulosa cells in the aging ovarian landscape: A focus on mitochondrial and metabolic function. Front Physiol. 2022;12:800739.","journal-title":"Front Physiol"},{"issue":"7","key":"1854_CR130","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.1007\/s43032-024-01459-1","volume":"31","author":"Z An","year":"2024","unstructured":"An Z, Xie C, Lu H, et al. Mitochondrial morphology and function abnormality in ovarian granulosa cells of patients with diminished ovarian reserve. Reprod Sci. 2024;31(7):2009\u201320.","journal-title":"Reprod Sci"},{"key":"1854_CR131","doi-asserted-by":"publisher","first-page":"1193749","DOI":"10.3389\/fmed.2023.1193749","volume":"10","author":"Y Gao","year":"2023","unstructured":"Gao Y, Zou Y, Wu G, Zheng L. Oxidative stress and mitochondrial dysfunction of granulosa cells in polycystic ovarian syndrome. Front Med (Lausanne). 2023;10:1193749.","journal-title":"Front Med (Lausanne)"},{"key":"1854_CR132","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1038\/ncomms1770","volume":"3","author":"K Wang","year":"2012","unstructured":"Wang K, Long B, Jiao JQ, et al. miR-484 regulates mitochondrial network through targeting Fis1. Nat Commun. 2012;3:781.","journal-title":"Nat Commun"},{"key":"1854_CR133","doi-asserted-by":"publisher","first-page":"102684","DOI":"10.1016\/j.redox.2023.102684","volume":"62","author":"X Wang","year":"2023","unstructured":"Wang X, Yang J, Li H, et al. miR-484 mediates oxidative stress-induced ovarian dysfunction and promotes granulosa cell apoptosis via SESN2 downregulation. Redox Biol. 2023;62:102684.","journal-title":"Redox Biol"},{"issue":"3","key":"1854_CR134","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.7150\/ijbs.68028","volume":"18","author":"H Li","year":"2022","unstructured":"Li H, Wang X, Mu H, et al. Mir-484 contributes to diminished ovarian reserve by regulating granulosa cell function via YAP1-mediated mitochondrial function and apoptosis. Int J Biol Sci. 2022;18(3):1008\u201321.","journal-title":"Int J Biol Sci"},{"key":"1854_CR135","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.omtn.2020.12.008","volume":"23","author":"J Huang","year":"2020","unstructured":"Huang J, Zhao J, Geng X, et al. Long non-coding RNA lnc-CCNL1-3:1 promotes granulosa cell apoptosis and suppresses glucose uptake in women with polycystic ovary syndrome. Mol Ther Nucleic Acids. 2020;23:614\u201328.","journal-title":"Mol Ther Nucleic Acids"},{"issue":"1","key":"1854_CR136","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s40659-023-00441-6","volume":"56","author":"X Chen","year":"2023","unstructured":"Chen X, He H, Long B, et al. Acupuncture regulates the apoptosis of ovarian granulosa cells in polycystic ovarian syndrome-related abnormal follicular development through LncMEG3-mediated Inhibition of miR-21-3p. Biol Res. 2023;56(1):31.","journal-title":"Biol Res"},{"issue":"5","key":"1854_CR137","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.3390\/antiox11051019","volume":"11","author":"R Battaglia","year":"2022","unstructured":"Battaglia R, Caponnetto A, Caringella AM, et al. Resveratrol treatment induces Mito-miRNome modification in follicular fluid from aged women with a poor prognosis for in vitro fertilization cycles. Antioxid (Basel). 2022;11(5):1019.","journal-title":"Antioxid (Basel)"},{"issue":"1","key":"1854_CR138","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1186\/s12905-022-01994-6","volume":"22","author":"X Yang","year":"2022","unstructured":"Yang X, Wang K, Lang J, et al. Up-regulation of miR-133a-3p promotes ovary insulin resistance on granulosa cells of obese PCOS patients via inhibiting PI3K\/AKT signaling. BMC Womens Health. 2022;22(1):412.","journal-title":"BMC Womens Health"},{"issue":"1","key":"1854_CR139","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/s41420-021-00493-1","volume":"7","author":"D Li","year":"2021","unstructured":"Li D, Wang X, Li G, Dang Y, Zhao S, Qin Y. LncRNA ZNF674-AS1 regulates granulosa cell glycolysis and proliferation by interacting with ALDOA. Cell Death Discov. 2021;7(1):107.","journal-title":"Cell Death Discov"},{"issue":"5","key":"1854_CR140","doi-asserted-by":"publisher","first-page":"11611","DOI":"10.1080\/21655979.2022.2070584","volume":"13","author":"F He","year":"2022","unstructured":"He F, Liu Y, Li T, et al. MicroRNA-146 attenuates lipopolysaccharide induced ovarian dysfunction by inhibiting the TLR4\/NF- \u039aB signaling pathway. Bioengineered. 2022;13(5):11611\u201323.","journal-title":"Bioengineered"},{"issue":"4","key":"1854_CR141","doi-asserted-by":"publisher","first-page":"e13776","DOI":"10.1111\/aji.13776","volume":"90","author":"Z Yang","year":"2023","unstructured":"Yang Z, Wu S, He S, et al. LncRNA AOC4P impacts the differentiation of macrophages and T-lymphocyte by regulating the NF-\u03baB pathways of KGN cells: potential pathogenesis of polycystic ovary syndrome. Am J Reprod Immunol. 2023;90(4):e13776.","journal-title":"Am J Reprod Immunol"},{"issue":"1","key":"1854_CR142","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13048-023-01115-3","volume":"16","author":"D Sun","year":"2023","unstructured":"Sun D, Wang Y, Sun N, et al. LncRNA DANCR counteracts premature ovarian insufficiency by regulating the senescence process of granulosa cells through stabilizing the interaction between p53 and hNRNPC. J Ovarian Res. 2023;16(1):41.","journal-title":"J Ovarian Res"},{"key":"1854_CR143","doi-asserted-by":"publisher","first-page":"110030","DOI":"10.1016\/j.cellsig.2021.110030","volume":"85","author":"D Yuan","year":"2021","unstructured":"Yuan D, Luo J, Sun Y, Hao L, Zheng J, Yang Z. PCOS follicular fluid derived Exosomal miR-424-5p induces granulosa cells senescence by targeting CDCA4 expression. Cell Signal. 2021;85:110030.","journal-title":"Cell Signal"},{"issue":"16","key":"1854_CR144","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.21037\/atm-21-4174","volume":"9","author":"D Zhang","year":"2021","unstructured":"Zhang D, Yi S, Cai B, et al. Involvement of ferroptosis in the granulosa cells proliferation of PCOS through the circRHBG\/miR-515\/SLC7A11 axis. Ann Transl Med. 2021;9(16):1348.","journal-title":"Ann Transl Med"},{"key":"1854_CR145","doi-asserted-by":"publisher","first-page":"777510","DOI":"10.3389\/fgene.2021.777510","volume":"12","author":"C He","year":"2021","unstructured":"He C, Wang K, Gao Y, et al. Roles of noncoding RNA in reproduction. Front Genet. 2021;12:777510.","journal-title":"Front Genet"},{"issue":"5","key":"1854_CR146","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1093\/nar\/gkab059","volume":"49","author":"K Ishino","year":"2021","unstructured":"Ishino K, Hasuwa H, Yoshimura J, et al. Hamster PIWI proteins bind to PiRNAs with stage-specific size variations during oocyte maturation. Nucleic Acids Res. 2021;49(5):2700\u201320.","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"1854_CR147","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.cell.2009.04.027","volume":"137","author":"C Li","year":"2009","unstructured":"Li C, Vagin VV, Lee S, et al. Collapse of germline PiRNAs in the absence of Argonaute3 reveals somatic PiRNAs in flies. Cell. 2009;137(3):509\u201321.","journal-title":"Cell"},{"issue":"3","key":"1854_CR148","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.cell.2009.03.040","volume":"137","author":"CD Malone","year":"2009","unstructured":"Malone CD, Brennecke J, Dus M, et al. Specialized PiRNA pathways act in germline and somatic tissues of the drosophila ovary. Cell. 2009;137(3):522\u201335.","journal-title":"Cell"},{"issue":"3","key":"1854_CR149","doi-asserted-by":"publisher","first-page":"e90267","DOI":"10.1371\/journal.pone.0090267","volume":"9","author":"X Ma","year":"2014","unstructured":"Ma X, Wang S, Do T, et al. Piwi is required in multiple cell types to control germline stem cell lineage development in the drosophila ovary. PLoS ONE. 2014;9(3):e90267.","journal-title":"PLoS ONE"},{"issue":"1","key":"1854_CR150","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1038\/s41598-020-57901-2","volume":"10","author":"OA Sokolova","year":"2020","unstructured":"Sokolova OA, Mikhaleva EA, Kharitonov SL, Abramov YA, Gvozdev VA, Klenov MS. Special vulnerability of somatic niche cells to transposable element activation in Drosophila larval ovaries. Sci Rep. 2020;10(1):1076.","journal-title":"Sci Rep"},{"issue":"4","key":"1854_CR151","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.celrep.2015.09.030","volume":"13","author":"Z Williams","year":"2015","unstructured":"Williams Z, Morozov P, Mihailovic A, et al. Discovery and characterization of PiRNAs in the human fetal ovary. Cell Rep. 2015;13(4):854\u201363.","journal-title":"Cell Rep"},{"issue":"9","key":"1854_CR152","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/S2213-8587(22)00163-2","volume":"10","author":"AE Joham","year":"2022","unstructured":"Joham AE, Norman RJ, Stener-Victorin E, et al. Polycystic ovary syndrome. Lancet Diabetes Endocrinol. 2022;10(9):668\u201380.","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"1854_CR153","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.fertnstert.2016.05.003","volume":"106","author":"D Lizneva","year":"2016","unstructured":"Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil Steril. 2016;106(1):6\u201315.","journal-title":"Fertil Steril"},{"issue":"5","key":"1854_CR154","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1093\/humupd\/dmv029","volume":"21","author":"S Palomba","year":"2015","unstructured":"Palomba S, de Wilde MA, Falbo A, Koster MP, La Sala GB, Fauser BC. Pregnancy complications in women with polycystic ovary syndrome. Hum Reprod Update. 2015;21(5):575\u201392.","journal-title":"Hum Reprod Update"},{"issue":"4","key":"1854_CR155","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/nrendo.2010.217","volume":"7","author":"MO Goodarzi","year":"2011","unstructured":"Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz R. Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nat Rev Endocrinol. 2011;7(4):219\u201331.","journal-title":"Nat Rev Endocrinol"},{"issue":"3","key":"1854_CR156","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1210\/jc.2007-1650","volume":"93","author":"M Das","year":"2008","unstructured":"Das M, Djahanbakhch O, Hacihanefioglu B, et al. Granulosa cell survival and proliferation are altered in polycystic ovary syndrome. J Clin Endocrinol Metab. 2008;93(3):881\u20137.","journal-title":"J Clin Endocrinol Metab"},{"key":"1854_CR157","doi-asserted-by":"publisher","first-page":"825431","DOI":"10.3389\/fendo.2022.825431","volume":"13","author":"M Tu","year":"2022","unstructured":"Tu M, Wu Y, Wang F, et al. Effect of lncRNA MALAT1 on the granulosa cell proliferation and pregnancy outcome in patients with PCOS. Front Endocrinol (Lausanne). 2022;13:825431.","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"1854_CR158","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s00404-019-05129-5","volume":"300","author":"C Zhang","year":"2019","unstructured":"Zhang C, Liu J, Lai M, et al. Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome. Arch Gynecol Obstet. 2019;300(2):431\u201340.","journal-title":"Arch Gynecol Obstet"},{"issue":"3","key":"1854_CR159","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.fertnstert.2020.08.019","volume":"115","author":"X Jiang","year":"2021","unstructured":"Jiang X, Li J, Zhang B, et al. Differential expression profile of plasma exosomal microRNAs in women with polycystic ovary syndrome. Fertil Steril. 2021;115(3):782\u201392.","journal-title":"Fertil Steril"},{"key":"1854_CR160","doi-asserted-by":"publisher","first-page":"689916","DOI":"10.3389\/fgene.2021.689916","volume":"12","author":"J Duan","year":"2021","unstructured":"Duan J, Cai H, Huang Y, Shi L. SNAI2-Induced CircMTO1 promotes cell proliferation and inhibits apoptosis through the miR-320b\/MCL1 axis in human Granulosa-Like tumor cells. Front Genet. 2021;12:689916.","journal-title":"Front Genet"},{"key":"1854_CR161","doi-asserted-by":"publisher","first-page":"e8640","DOI":"10.7717\/peerj.8640","volume":"8","author":"J Hu","year":"2020","unstructured":"Hu J, Tang T, Zeng Z, Wu J, Tan X, Yan J. The expression of small RNAs in exosomes of follicular fluid altered in human polycystic ovarian syndrome. PeerJ. 2020;8:e8640.","journal-title":"PeerJ"},{"issue":"2","key":"1854_CR162","first-page":"1380","volume":"10","author":"J Lu","year":"2017","unstructured":"Lu J, Zhang C, Gu B, et al. MicroRNA-182 inhibits rat ovarian granulosa cell apoptosis by targeting Smad7 in polycystic ovarian syndrome. Int J Clin Exp Pathol. 2017;10(2):1380\u20137.","journal-title":"Int J Clin Exp Pathol"},{"issue":"6","key":"1854_CR163","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1097\/AOG.0b013e3181a66843","volume":"113","author":"RW Rebar","year":"2009","unstructured":"Rebar RW. Premature ovarian failure. Obstet Gynecol. 2009;113(6):1355\u201363.","journal-title":"Obstet Gynecol"},{"issue":"4","key":"1854_CR164","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1093\/humupd\/dmi012","volume":"11","author":"D Goswami","year":"2005","unstructured":"Goswami D, Conway GS. Premature ovarian failure. Hum Reprod Update. 2005;11(4):391\u2013410.","journal-title":"Hum Reprod Update"},{"issue":"12","key":"1854_CR165","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1007\/s10815-015-0595-y","volume":"32","author":"J Cohen","year":"2015","unstructured":"Cohen J, Chabbert-Buffet N, Darai E. Diminished ovarian reserve, premature ovarian failure, poor ovarian responder\u2013a plea for universal definitions. J Assist Reprod Genet. 2015;32(12):1709\u201312.","journal-title":"J Assist Reprod Genet"},{"issue":"2","key":"1854_CR166","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1530\/REP-11-0371","volume":"144","author":"X Yang","year":"2012","unstructured":"Yang X, Zhou Y, Peng S, et al. Differentially expressed plasma microRNAs in premature ovarian failure patients and the potential regulatory function of mir-23a in granulosa cell apoptosis. Reproduction. 2012;144(2):235\u201344.","journal-title":"Reproduction"},{"issue":"5","key":"1854_CR167","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1093\/humrep\/dew027","volume":"31","author":"European Society for Human Reproduction and Embryology (ESHRE) Guideline Group on POI","year":"2016","unstructured":"European Society for Human Reproduction and Embryology (ESHRE) Guideline Group on POI. ESHRE guideline: management of women with premature ovarian insufficiency. Hum Reprod. 2016;31(5):926\u201337.","journal-title":"Hum Reprod"},{"issue":"4","key":"1854_CR168","doi-asserted-by":"publisher","first-page":"334","DOI":"10.3109\/09513590.2015.1116508","volume":"32","author":"SE Elizur","year":"2016","unstructured":"Elizur SE, Dratviman-Storobinsky O, Derech-Haim S, et al. FMR6 May play a role in the pathogenesis of fragile X-associated premature ovarian insufficiency. Gynecol Endocrinol. 2016;32(4):334\u20137.","journal-title":"Gynecol Endocrinol"},{"issue":"1","key":"1854_CR169","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s10815-017-1058-4","volume":"35","author":"LM Pastore","year":"2018","unstructured":"Pastore LM, Christianson MS, Stelling J, Kearns WG, Segars JH. Reproductive ovarian testing and the alphabet soup of diagnoses: DOR, POI, POF, POR, and FOR. J Assist Reprod Genet. 2018;35(1):17\u201323.","journal-title":"J Assist Reprod Genet"},{"issue":"4","key":"1854_CR170","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.fertnstert.2019.11.014","volume":"113","author":"SJ Bunnewell","year":"2020","unstructured":"Bunnewell SJ, Honess ER, Karia AM, Keay SD, Al Wattar BH, Quenby S. Diminished ovarian reserve in recurrent pregnancy loss: a systematic review and meta-analysis. Fertil Steril. 2020;113(4):818\u2013e8273.","journal-title":"Fertil Steril"},{"issue":"4","key":"1854_CR171","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1007\/s10815-024-03037-5","volume":"41","author":"Y Xie","year":"2024","unstructured":"Xie Y, Chen J, Liu K, et al. Differential expression of follicular fluid exosomal microRNA in women with diminished ovarian reserve. J Assist Reprod Genet. 2024;41(4):1087\u201396.","journal-title":"J Assist Reprod Genet"},{"issue":"1","key":"1854_CR172","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s13048-022-01053-6","volume":"15","author":"L Dong","year":"2022","unstructured":"Dong L, Xin X, Chang HM, et al. Expression of long noncoding RNAs in the ovarian granulosa cells of women with diminished ovarian reserve using high-throughput sequencing. J Ovarian Res. 2022;15(1):119.","journal-title":"J Ovarian Res"},{"key":"1854_CR173","doi-asserted-by":"publisher","first-page":"118174","DOI":"10.1016\/j.lfs.2020.118174","volume":"259","author":"M Abdalla","year":"2020","unstructured":"Abdalla M, Deshmukh H, Atkin SL, Sathyapalan T. MiRNAs as a novel clinical biomarker and therapeutic targets in polycystic ovary syndrome (PCOS): A review. Life Sci. 2020;259:118174.","journal-title":"Life Sci"},{"issue":"6","key":"1854_CR174","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1007\/s00404-023-07219-x","volume":"308","author":"Z Wang","year":"2023","unstructured":"Wang Z, Zheng Y, Zhong C, et al. Circular RNA as new serum metabolic biomarkers in patients with premature ovarian insufficiency. Arch Gynecol Obstet. 2023;308(6):1871\u20139.","journal-title":"Arch Gynecol Obstet"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-025-01854-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-025-01854-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-025-01854-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T13:49:13Z","timestamp":1757166553000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-025-01854-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,2]]},"references-count":174,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["1854"],"URL":"https:\/\/doi.org\/10.1007\/s43032-025-01854-2","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,2]]},"assertion":[{"value":"12 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None of the authors have any conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}