{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:11:04Z","timestamp":1793229064580,"version":"4.5.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["22JR5RA911"],"award-info":[{"award-number":["22JR5RA911"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Primary ovarian insufficiency (POI) has become a serious problem causing infertility and endocrine disorders in women of child-bearing age. There is an urgent demand for novel drugs or targets to address the apoptosis, autophagy and mitochondria damage associated with ovarian aging. This study focused on the regulation of zygote arrest 1 (ZAR1) in ovarian function and its potential role in POI. We collected clinical samples, established POI cell and mouse models using 4-vinylcyclohexene diepoxide (VCD), and investigated the effects of ZAR1 in KGN cells and POI mice. We found that ZAR1 expression was negatively associated with follicle-stimulating hormone (FSH) in POI women. ZAR1 overexpression inhibited apoptosis activation, cell cycle arrest and mitophagy, but the protection effects can be blocked by autophagy inhibitor. Mice with lower expression of ZAR1 exhibited more severe ovarian damages. These findings indicated that ZAR1 is a novel target for prevention and treatment of ovarian aging.<\/jats:p>","DOI":"10.1007\/s43032-025-01857-z","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T11:51:28Z","timestamp":1744372288000},"page":"3429-3441","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Regulation of ZAR1 on Apoptosis and Mitophagy in Ovarian Granular Cells and Primary Ovarian Insufficiency (POI) Mice"],"prefix":"10.1007","volume":"32","author":[{"given":"Xiaodong","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5498-1436","authenticated-orcid":false,"given":"Yongxiu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"issue":"5","key":"1857_CR1","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.fertnstert.2021.03.004","volume":"115","author":"EE Telfer","year":"2021","unstructured":"Telfer EE, Andersen CY. In vitro growth and maturation of primordial follicles and immature oocytes. Fertil Steril. 2021;115(5):1116\u201325. https:\/\/doi.org\/10.1016\/j.fertnstert.2021.03.004.","journal-title":"Fertil Steril"},{"issue":"6","key":"1857_CR2","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.fertnstert.2020.09.134","volume":"114","author":"M Pcotasfr","year":"2020","unstructured":"Pcotasfr M. Testing and interpreting measures of ovarian reserve: a committee opinion. Fertil Steril. 2020;114(6):1151\u20137. https:\/\/doi.org\/10.1016\/j.fertnstert.2020.09.134.","journal-title":"Fertil Steril"},{"issue":"5","key":"1857_CR3","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1093\/humrep\/dew027","volume":"31","author":"L Webber","year":"2016","unstructured":"Webber L, et al. ESHRE guideline: management of women with premature ovarian insufficiency. Hum Reprod. 2016;31(5):926\u201337. https:\/\/doi.org\/10.1093\/humrep\/dew027.","journal-title":"Hum Reprod"},{"key":"1857_CR4","doi-asserted-by":"publisher","unstructured":"Ayesha, et al. Premature ovarian failure: an association with autoimmune diseases. J Clin Diagn Res. 2016;10(10). https:\/\/doi.org\/10.7860\/jcdr\/2016\/22027.8671. Qc10-qc12.","DOI":"10.7860\/jcdr\/2016\/22027.8671"},{"key":"1857_CR5","doi-asserted-by":"publisher","first-page":"999440","DOI":"10.3389\/fmed.2022.999440","volume":"9","author":"X Bai","year":"2022","unstructured":"Bai X, Wang S. Signaling pathway intervention in premature ovarian failure. Front Med (Lausanne). 2022;9:999440. https:\/\/doi.org\/10.3389\/fmed.2022.999440.","journal-title":"Front Med (Lausanne)"},{"key":"1857_CR6","doi-asserted-by":"publisher","first-page":"7279","DOI":"10.12659\/msm.910410","volume":"24","author":"Y Chang","year":"2018","unstructured":"Chang Y, et al. Egg quality and pregnancy outcome in young infertile women with diminished ovarian reserve. Med Sci Monit. 2018;24:7279\u201384. https:\/\/doi.org\/10.12659\/msm.910410.","journal-title":"Med Sci Monit"},{"issue":"4","key":"1857_CR7","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.fertnstert.2019.11.014","volume":"113","author":"SJ Bunnewell","year":"2020","unstructured":"Bunnewell SJ, et al. Diminished ovarian reserve in recurrent pregnancy loss: a systematic review and meta-analysis. Fertil Steril. 2020;113(4):818\u2013e827813. https:\/\/doi.org\/10.1016\/j.fertnstert.2019.11.014.","journal-title":"Fertil Steril"},{"issue":"12","key":"1857_CR8","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1080\/09513590.2020.1750001","volume":"36","author":"KA Wald","year":"2020","unstructured":"Wald KA, et al. High incidence of diminished ovarian reserve in young unexplained recurrent pregnancy loss patients. Gynecol Endocrinol. 2020;36(12):1079\u201381. https:\/\/doi.org\/10.1080\/09513590.2020.1750001.","journal-title":"Gynecol Endocrinol"},{"issue":"5","key":"1857_CR9","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1530\/rep-09-0567","volume":"140","author":"AN Shelling","year":"2010","unstructured":"Shelling AN. Premature ovarian failure. Reproduction. 2010;140(5):633\u201341. https:\/\/doi.org\/10.1530\/rep-09-0567.","journal-title":"Reproduction"},{"issue":"2","key":"1857_CR10","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1258\/mi.2009.009020","volume":"15","author":"S Vujovic","year":"2009","unstructured":"Vujovic S. Aetiology of premature ovarian failure. Menopause Int. 2009;15(2):72\u20135. https:\/\/doi.org\/10.1258\/mi.2009.009020.","journal-title":"Menopause Int"},{"issue":"6","key":"1857_CR11","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1093\/humupd\/dmv036","volume":"21","author":"Y Qin","year":"2015","unstructured":"Qin Y, et al. Genetics of primary ovarian insufficiency: new developments and opportunities. Hum Reprod Update. 2015;21(6):787\u2013808. https:\/\/doi.org\/10.1093\/humupd\/dmv036.","journal-title":"Hum Reprod Update"},{"issue":"3","key":"1857_CR12","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1093\/biolre\/ioz084","volume":"101","author":"SA Yatsenko","year":"2019","unstructured":"Yatsenko SA, Rajkovic A. Genetics of human female infertility. Biol Reprod. 2019;101(3):549\u201366. https:\/\/doi.org\/10.1093\/biolre\/ioz084.","journal-title":"Biol Reprod"},{"issue":"6617","key":"1857_CR13","doi-asserted-by":"publisher","first-page":"eabq4835","DOI":"10.1126\/science.abq4835","volume":"378","author":"S Cheng","year":"2022","unstructured":"Cheng S, et al. Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment. Science. 2022;378(6617):eabq4835. https:\/\/doi.org\/10.1126\/science.abq4835.","journal-title":"Science"},{"issue":"21","key":"1857_CR14","doi-asserted-by":"publisher","first-page":"11387","DOI":"10.1093\/nar\/gkz863","volume":"47","author":"Y Rong","year":"2019","unstructured":"Rong Y, et al. ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation. Nucleic Acids Res. 2019;47(21):11387\u2013402. https:\/\/doi.org\/10.1093\/nar\/gkz863.","journal-title":"Nucleic Acids Res"},{"key":"1857_CR15","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s13148-017-0360-4","volume":"9","author":"AM Richter","year":"2017","unstructured":"Richter AM, et al. ZAR1 is a novel epigenetically inactivated tumour suppressor in lung cancer. Clin Epigenetics. 2017;9:60. https:\/\/doi.org\/10.1186\/s13148-017-0360-4.","journal-title":"Clin Epigenetics"},{"issue":"1","key":"1857_CR16","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1186\/s13148-019-0774-2","volume":"11","author":"V Deutschmeyer","year":"2019","unstructured":"Deutschmeyer V, et al. Epigenetic therapy of novel tumour suppressor ZAR1 and its cancer biomarker function. Clin Epigenetics. 2019;11(1):182. https:\/\/doi.org\/10.1186\/s13148-019-0774-2.","journal-title":"Clin Epigenetics"},{"issue":"1","key":"1857_CR17","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s12041-016-0721-3","volume":"96","author":"D Wang","year":"2017","unstructured":"Wang D, et al. Cloning and expression analysis of zygote arrest 1 (Zar1) in new Zealand white rabbits. J Genet. 2017;96(1):3\u20138. https:\/\/doi.org\/10.1007\/s12041-016-0721-3.","journal-title":"J Genet"},{"key":"1857_CR18","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1477-7827-4-12","volume":"4","author":"S Uzbekova","year":"2006","unstructured":"Uzbekova S, et al. Zygote arrest 1 gene in pig, cattle and human: evidence of different transcript variants in male and female germ cells. Reprod Biol Endocrinol. 2006;4:12. https:\/\/doi.org\/10.1186\/1477-7827-4-12.","journal-title":"Reprod Biol Endocrinol"},{"issue":"4","key":"1857_CR19","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1002\/mrd.20140","volume":"69","author":"TA Brevini","year":"2004","unstructured":"Brevini TA, et al. Expression pattern of the maternal factor zygote arrest 1 (Zar1) in bovine tissues, oocytes, and embryos. Mol Reprod Dev. 2004;69(4):375\u201380. https:\/\/doi.org\/10.1002\/mrd.20140.","journal-title":"Mol Reprod Dev"},{"issue":"2","key":"1857_CR20","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/ng1079","volume":"33","author":"X Wu","year":"2003","unstructured":"Wu X, et al. Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition. Nat Genet. 2003;33(2):187\u201391. https:\/\/doi.org\/10.1038\/ng1079.","journal-title":"Nat Genet"},{"issue":"Pt 2","key":"1857_CR21","doi-asserted-by":"publisher","first-page":"129632","DOI":"10.1016\/j.ijbiomac.2024.129632","volume":"260","author":"M Yu","year":"2024","unstructured":"Yu M, et al. Disruption of Zar1 leads to arrested oogenesis by regulating polyadenylation via Cpeb1 in tilapia (Oreochromis niloticus). Int J Biol Macromol. 2024;260(Pt 2):129632. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.129632.","journal-title":"Int J Biol Macromol"},{"key":"1857_CR22","doi-asserted-by":"publisher","first-page":"e17251","DOI":"10.7717\/peerj.17251","volume":"12","author":"Y Li","year":"2024","unstructured":"Li Y, et al. Transcriptome analysis during 4-vinylcyclohexene diepoxide exposure-induced premature ovarian insufficiency in mice. PeerJ. 2024;12:e17251. https:\/\/doi.org\/10.7717\/peerj.17251.","journal-title":"PeerJ"},{"key":"1857_CR23","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.reprotox.2018.06.071","volume":"80","author":"DN Tran","year":"2018","unstructured":"Tran DN, et al. Depletion of follicles accelerated by combined exposure to phthalates and 4-vinylcyclohexene diepoxide, leading to premature ovarian failure in rats. Reprod Toxicol. 2018;80:60\u20137. https:\/\/doi.org\/10.1016\/j.reprotox.2018.06.071.","journal-title":"Reprod Toxicol"},{"issue":"3","key":"1857_CR24","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1530\/jrf.0.0170555","volume":"17","author":"T Pedersen","year":"1968","unstructured":"Pedersen T, Peters H. Proposal for a classification of oocytes and follicles in the mouse ovary. J Reprod Fertil. 1968;17(3):555\u20137. https:\/\/doi.org\/10.1530\/jrf.0.0170555.","journal-title":"J Reprod Fertil"},{"issue":"1","key":"1857_CR25","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s13048-020-00724-6","volume":"13","author":"UC Sarma","year":"2020","unstructured":"Sarma UC, et al. Comparison of methods for quantifying primordial follicles in the mouse ovary. J Ovarian Res. 2020;13(1):121. https:\/\/doi.org\/10.1186\/s13048-020-00724-6.","journal-title":"J Ovarian Res"},{"issue":"2","key":"1857_CR26","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.3892\/mmr.2014.2281","volume":"10","author":"Z Xie","year":"2014","unstructured":"Xie Z, et al. Bafilomycin A1 inhibits autophagy and induces apoptosis in MG63 osteosarcoma cells. Mol Med Rep. 2014;10(2):1103\u20137. https:\/\/doi.org\/10.3892\/mmr.2014.2281.","journal-title":"Mol Med Rep"},{"key":"1857_CR27","doi-asserted-by":"publisher","unstructured":"Min DH et al. Bafilomycin A1 induces colon cancer cell death through impairment of the endolysosome system dependent on iron. Sci Rep. 2025;15(1):5148. https:\/\/doi.org\/10.1038\/s41598-025-89127-5.","DOI":"10.1038\/s41598-025-89127-5"},{"issue":"7","key":"1857_CR28","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1016\/j.fertnstert.2016.09.046","volume":"106","author":"SD Sullivan","year":"2016","unstructured":"Sullivan SD, et al. Hormone replacement therapy in young women with primary ovarian insufficiency and early menopause. Fertil Steril. 2016;106(7):1588\u201399. https:\/\/doi.org\/10.1016\/j.fertnstert.2016.09.046.","journal-title":"Fertil Steril"},{"issue":"1","key":"1857_CR29","doi-asserted-by":"publisher","first-page":"5871","DOI":"10.1038\/s41467-022-33323-8","volume":"13","author":"F Wang","year":"2022","unstructured":"Wang F, et al. BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency. Nat Commun. 2022;13(1):5871. https:\/\/doi.org\/10.1038\/s41467-022-33323-8.","journal-title":"Nat Commun"},{"issue":"1","key":"1857_CR30","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1038\/s41572-024-00547-5","volume":"10","author":"P Touraine","year":"2024","unstructured":"Touraine P, et al. Premature ovarian insufficiency. Nat Rev Dis Primers. 2024;10(1):63. https:\/\/doi.org\/10.1038\/s41572-024-00547-5.","journal-title":"Nat Rev Dis Primers"},{"issue":"2","key":"1857_CR31","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.tjog.2020.01.020","volume":"59","author":"F \u00d6zel","year":"2020","unstructured":"\u00d6zel F, et al. Protective effect of alpha lipoic acid on 4-vinylcyclohexene diepoxide induced primary ovarian failure in female rats. Taiwan J Obstet Gynecol. 2020;59(2):293\u2013300. https:\/\/doi.org\/10.1016\/j.tjog.2020.01.020.","journal-title":"Taiwan J Obstet Gynecol"},{"key":"1857_CR32","doi-asserted-by":"publisher","first-page":"1034832","DOI":"10.3389\/fgene.2022.1034832","volume":"13","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, et al. MiRNA-190a-5p promotes primordial follicle hyperactivation by targeting PHLPP1 in premature ovarian failure. Front Genet. 2022;13:1034832. https:\/\/doi.org\/10.3389\/fgene.2022.1034832.","journal-title":"Front Genet"},{"issue":"5","key":"1857_CR33","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1093\/oxfordjournals.humrep.a138602","volume":"9","author":"EY Adashi","year":"1994","unstructured":"Adashi EY. Endocrinology of the ovary. Hum Reprod. 1994;9(5):815\u201327. https:\/\/doi.org\/10.1093\/oxfordjournals.humrep.a138602.","journal-title":"Hum Reprod"},{"issue":"1","key":"1857_CR34","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1262\/jrd.2011-012","volume":"58","author":"F Matsuda","year":"2012","unstructured":"Matsuda F, et al. Follicular growth and Atresia in mammalian ovaries: regulation by survival and death of granulosa cells. J Reprod Dev. 2012;58(1):44\u201350. https:\/\/doi.org\/10.1262\/jrd.2011-012.","journal-title":"J Reprod Dev"},{"issue":"1","key":"1857_CR35","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/path.2697","volume":"221","author":"D Glick","year":"2010","unstructured":"Glick D, et al. Autophagy: cellular and molecular mechanisms. J Pathol. 2010;221(1):3\u201312. https:\/\/doi.org\/10.1002\/path.2697.","journal-title":"J Pathol"},{"key":"1857_CR36","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jare.2023.11.008","volume":"64","author":"L Zhang","year":"2024","unstructured":"Zhang L, et al. In pre-clinical study fetal hypoxia caused autophagy and mitochondrial impairment in ovary granulosa cells mitigated by melatonin supplement. J Adv Res. 2024;64:15\u201330. https:\/\/doi.org\/10.1016\/j.jare.2023.11.008.","journal-title":"J Adv Res"},{"issue":"6","key":"1857_CR37","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1042\/cs20220408","volume":"137","author":"J Xing","year":"2023","unstructured":"Xing J, et al. Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome. Clin Sci (Lond). 2023;137(6):453\u201368. https:\/\/doi.org\/10.1042\/cs20220408.","journal-title":"Clin Sci (Lond)"},{"issue":"1","key":"1857_CR38","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.cell.2007.05.021","volume":"130","author":"H Nakatogawa","year":"2007","unstructured":"Nakatogawa H, et al. Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion. Cell. 2007;130(1):165\u201378. https:\/\/doi.org\/10.1016\/j.cell.2007.05.021.","journal-title":"Cell"},{"key":"1857_CR39","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ymeth.2014.11.021","volume":"75","author":"P Jiang","year":"2015","unstructured":"Jiang P, Mizushima N. LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells. Methods. 2015;75:13\u20138. https:\/\/doi.org\/10.1016\/j.ymeth.2014.11.021.","journal-title":"Methods"},{"key":"1857_CR40","doi-asserted-by":"publisher","first-page":"106431","DOI":"10.1016\/j.biocel.2023.106431","volume":"160","author":"P Melchinger","year":"2023","unstructured":"Melchinger P, Garcia BM. Mitochondria are midfield players in steroid synthesis. Int J Biochem Cell Biol. 2023;160:106431. https:\/\/doi.org\/10.1016\/j.biocel.2023.106431.","journal-title":"Int J Biochem Cell Biol"},{"issue":"7","key":"1857_CR41","doi-asserted-by":"publisher","first-page":"e21709","DOI":"10.1096\/fj.202100332R","volume":"35","author":"M Lv","year":"2021","unstructured":"Lv M, et al. Adipose-derived stem cells regulate metabolic homeostasis and delay aging by promoting mitophagy. Faseb J. 2021;35(7):e21709. https:\/\/doi.org\/10.1096\/fj.202100332R.","journal-title":"Faseb J"},{"key":"1857_CR42","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","volume":"4","author":"Sies H","year":"2015","unstructured":"Sies H. Oxidative stress: a concept in redox biology and medicine. Redox Biol. 2015;4:180\u20133. https:\/\/doi.org\/10.1016\/j.redox.2015.01.002.","journal-title":"Redox Biol"},{"issue":"Suppl 1","key":"1857_CR43","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1159\/000182753","volume":"39","author":"Y Okatani","year":"1993","unstructured":"Okatani Y, et al. Role of the free radical-scavenger system in aromatase activity of the human ovary. Horm Res. 1993;39(Suppl 1):22\u20137. https:\/\/doi.org\/10.1159\/000182753.","journal-title":"Horm Res"},{"issue":"9","key":"1857_CR44","doi-asserted-by":"publisher","first-page":"e0185045","DOI":"10.1371\/journal.pone.0185045","volume":"12","author":"GM Andrade","year":"2017","unstructured":"Andrade GM, et al. The role of the PI3K-Akt signaling pathway in the developmental competence of bovine oocytes. PLoS ONE. 2017;12(9):e0185045. https:\/\/doi.org\/10.1371\/journal.pone.0185045.","journal-title":"PLoS ONE"},{"issue":"6","key":"1857_CR45","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1071\/rd14212","volume":"28","author":"LQ Wang","year":"2016","unstructured":"Wang LQ, et al. Regulation of primordial follicle recruitment by cross-talk between the Notch and phosphatase and tensin homologue (PTEN)\/AKT pathways. Reprod Fertil Dev. 2016;28(6):700\u201312. https:\/\/doi.org\/10.1071\/rd14212.","journal-title":"Reprod Fertil Dev"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-025-01857-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-025-01857-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-025-01857-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:40:51Z","timestamp":1761154851000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-025-01857-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,11]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["1857"],"URL":"https:\/\/doi.org\/10.1007\/s43032-025-01857-z","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,11]]},"assertion":[{"value":"5 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of the First Hospital of Lanzhou University (IRB, including IACUC) (Approval Number: LDYYLL-2024-767).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors have no competing interests in this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}