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The rats in the PCOS\u2009+\u2009AVE group were orally administered AVE (50\u00a0mg\/100\u00a0g bw\/day) for 35\u00a0days. Systemic blood pressure, vascular endothelial function, ovarian morphology, and endocrine biomarker levels were measured at the end of the experiment. TNF-\u03b1 levels were also evaluated in the thoracic aorta and ovaries. Hormonal imbalances, ovarian morphological changes, and endothelial dysfunction were observed in the PCOS group, which returned to the controls after AVE treatment. Furthermore, AVE attenuated the aortic and ovarian levels of TNF-\u03b1 in the PCOS group. Our study suggests that AVE may have beneficial effects in the treatment of PCOS due to its anti-inflammatory and vasculoprotective properties.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1007\/s43032-025-01885-9","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T14:51:23Z","timestamp":1750690283000},"page":"2453-2466","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Beneficial Effects of Alchemilla vulgaris in DHEA-Induced Rat Model of Polycystic Ovary Syndrome"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1595-569X","authenticated-orcid":false,"given":"Zeynep Ece Utkan","family":"Korun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7341-4907","authenticated-orcid":false,"given":"Semil Selcen","family":"Gocmez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0501-1679","authenticated-orcid":false,"given":"Selenay","family":"Furat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9973-8619","authenticated-orcid":false,"given":"Kubra Kavram","family":"Sarihan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9410-8554","authenticated-orcid":false,"given":"Fatma Ceyla","family":"Eraldemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8394-2746","authenticated-orcid":false,"given":"Huseyin Askin","family":"Akpulat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6752-0065","authenticated-orcid":false,"given":"Deniz","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4803-7043","authenticated-orcid":false,"given":"Sule","family":"Yildiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"1885_CR1","doi-asserted-by":"publisher","first-page":"117439","DOI":"10.1016\/j.jep.2023.117439","volume":"320","author":"K Jakimiuk","year":"2024","unstructured":"Jakimiuk K, Tomczyk M. 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