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The\n                    <jats:italic>CYP2E1<\/jats:italic>\n                    C-1054T variant was linked to an elevated risk of PE according to the dominant, genotype, and allele genetic models (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05). The genotype TT\u2009+\u2009CT remained a significant predictor of PE in the logistic regression model including age, gestational age, and body mass index at delivery (OR\u2009=\u20091.606, 95% CI: 1.137\u20132.286;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.007). Moreover, the combined genotype TT\u2009+\u2009CT\/II\u2009+\u2009ID of the C-1054T and 96-bp I\/D variants further heightened the risk of PE, with the combined genotype DD\/CC serving as the reference category (OR\u2009=\u20092.383, 95% CI: 1.381\u20134.106,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.002). Furthermore, patients with the -1054T allele had lower serum albumin levels and total antioxidant capacity, and more severe proteinuria than those with the CC genotype (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05), and patients with the 96-bp I allele had a relatively higher atherosclerosis index than those with the DD genotype (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.057). No significant differences in genotype frequencies of PE with severe features, platelet count, serum hepatic enzyme activities and creatinine levels were observed according to the different genotypes (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&gt;\u20090.05). We conclude that the T allele of the C-1054T variant and its integration with the I allele of the 96-bp I\/D variant in\n                    <jats:italic>CYP2E1<\/jats:italic>\n                    are linked to an elevated risk of PE in Chinese women.\n                  <\/jats:p>","DOI":"10.1007\/s43032-025-01890-y","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T11:46:11Z","timestamp":1749642371000},"page":"3419-3428","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of xenobiotic-metabolizing gene cytochrome P450 2E1 variants with preeclampsia in Chinese women"],"prefix":"10.1007","volume":"32","author":[{"given":"Kaifeng","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7366-0825","authenticated-orcid":false,"given":"Xinghui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-021X","authenticated-orcid":false,"given":"Huai","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-5858","authenticated-orcid":false,"given":"Ping","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"key":"1890_CR1","doi-asserted-by":"publisher","unstructured":"Gestational hypertension and preeclampsia: ACOG practice bulletin, number 222. 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The study was approved by the Institutional Review Committee of West China Second Hospital of Sichuan University (No. 2020\u2013036 to Ping Fan) and informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}