{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:30:20Z","timestamp":1781332220590,"version":"3.54.1"},"reference-count":156,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1007\/s43032-025-01900-z","type":"journal-article","created":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T12:04:44Z","timestamp":1749816284000},"page":"2080-2097","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Phospholipases: Paving the Way for a New Life"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2454-7919","authenticated-orcid":false,"given":"Rohit","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preeti","family":"Vats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priti","family":"Panchal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudarshan","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"1900_CR1","doi-asserted-by":"publisher","first-page":"26338","DOI":"10.1016\/S0021-9258(18)47198-0","volume":"269","author":"M Inada","year":"1994","unstructured":"Inada M, Crowl RM, Bekkers ACAPA, Verheij H, Weiss J. Determinants of the inhibitory action of purified 14-kDa phospholipases A2 on cell-free prothrombinase complex. J Biol Chem. 1994;269:26338\u201343.","journal-title":"J Biol Chem"},{"key":"1900_CR2","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1053\/gast.2001.23254","volume":"120","author":"BL Richmond","year":"2001","unstructured":"Richmond BL, et al. Compensatory phospholipid digestion is required for cholesterol absorption in pancreatic phospholipase A2\u2013Deficient mice. Gastroenterology. 2001;120:1193\u2013202.","journal-title":"Gastroenterology"},{"key":"1900_CR3","doi-asserted-by":"crossref","unstructured":"Murakami M, Hara N, Kudo I, Inoue K. Triggering of degranulation in mast cells by exogenous type II phospholipase A2. J Immunol. 1993;151.","DOI":"10.4049\/jimmunol.151.10.5675"},{"key":"1900_CR4","doi-asserted-by":"publisher","first-page":"4007","DOI":"10.4049\/jimmunol.165.7.4007","volume":"165","author":"A Enomoto","year":"2000","unstructured":"Enomoto A, et al. Redundant and segregated functions of granule-associated heparin-binding group II subfamily of secretory phospholipases A2 in the regulation of degranulation and prostaglandin D2 synthesis in mast cells. J Immunol. 2000;165:4007\u201314.","journal-title":"J Immunol"},{"key":"1900_CR5","doi-asserted-by":"publisher","first-page":"26331","DOI":"10.1016\/S0021-9258(18)47197-9","volume":"269","author":"J Weiss","year":"1994","unstructured":"Weiss J, Inada M, Elsbach P, Crowl RM. Structural determinants of the action against Escherichia coli of a human inflammatory fluid phospholipase A2 in concert with polymorphonuclear leukocytes. J Biol Chem. 1994;269:26331\u20137.","journal-title":"J Biol Chem"},{"key":"1900_CR6","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/bs.ai.2016.05.001","volume":"132","author":"M Murakami","year":"2016","unstructured":"Murakami M, et al. The roles of the secreted phospholipase A2 gene family in immunology. Adv Immunol. 2016;132:91\u2013134.","journal-title":"Adv Immunol"},{"key":"1900_CR7","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1097\/MED.0000000000000138","volume":"22","author":"PP Robichaud","year":"2015","unstructured":"Robichaud PP, Surette ME. Polyunsaturated fatty acid-phospholipid remodeling and inflammation. Curr Opin Endocrinol Diabetes Obes. 2015;22:112\u20138.","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"1900_CR8","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1194\/jlr.R058123","volume":"56","author":"M Murakami","year":"2015","unstructured":"Murakami M, Sato H, Miki Y, Yamamoto K, Taketomi Y. A new era of secreted phospholipase A2. J Lipid Res. 2015;56:1248\u201361.","journal-title":"J Lipid Res"},{"key":"1900_CR9","doi-asserted-by":"publisher","first-page":"S237","DOI":"10.1194\/jlr.R800033-JLR200","volume":"50","author":"JE Burke","year":"2009","unstructured":"Burke JE, Dennis EA. Phospholipase A2 structure\/function, mechanism, and signaling. J Lipid Res. 2009;50:S237.","journal-title":"J Lipid Res"},{"key":"1900_CR10","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.biochi.2010.03.015","volume":"92","author":"M Murakami","year":"2010","unstructured":"Murakami M, Taketomi Y, Girard C, Yamamoto K, Lambeau G. Emerging roles of secreted phospholipase A2 enzymes: lessons from Transgenic and knockout mice. Biochimie. 2010;92:561\u201382.","journal-title":"Biochimie"},{"key":"1900_CR11","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1194\/jlr.R057984","volume":"56","author":"L Cocco","year":"2015","unstructured":"Cocco L, Follo MY, Manzoli L, Suh PG. Phosphoinositide-specific phospholipase C in health and disease. J Lipid Res. 2015;56:1853\u201360.","journal-title":"J Lipid Res"},{"key":"1900_CR12","doi-asserted-by":"crossref","unstructured":"Rugema NY et al. Structure of phospholipase C\u03b5 reveals an integrated RA1 domain and previously unidentified regulatory elements. Commun Biol. 2020;31(3):1\u201310.","DOI":"10.1038\/s42003-020-01178-8"},{"key":"1900_CR13","doi-asserted-by":"publisher","first-page":"29640","DOI":"10.1074\/jbc.270.50.29640","volume":"270","author":"SM Hammond","year":"1995","unstructured":"Hammond SM, et al. Human ADP-ribosylation Factor-activated Phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family. J Biol Chem. 1995;270:29640\u20133.","journal-title":"J Biol Chem"},{"key":"1900_CR14","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0960-9822(97)70090-3","volume":"7","author":"WC Colley","year":"1997","unstructured":"Colley WC, et al. Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. Curr Biol. 1997;7:191\u2013201.","journal-title":"Curr Biol"},{"key":"1900_CR15","doi-asserted-by":"crossref","unstructured":"Brandenburg LO, Pufe T, Koch T. Role of phospholipase D in G-protein coupled receptor function. Membr. 2014;4:302\u2013318.","DOI":"10.3390\/membranes4030302"},{"key":"1900_CR16","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/S0960-9822(02)00545-6","volume":"6","author":"MJ Cross","year":"1996","unstructured":"Cross MJ, et al. Stimulation of actin stress fibre formation mediated by activation of phospholipase D. Curr Biol. 1996;6:588\u201397.","journal-title":"Curr Biol"},{"key":"1900_CR17","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1084\/jem.184.2.585","volume":"184","author":"DJ Kusner","year":"1996","unstructured":"Kusner DJ, Hall CF, Schlesinger LS. Activation of phospholipase D is tightly coupled to the phagocytosis of Mycobacterium tuberculosis or opsonized zymosan by human macrophages. J Exp Med. 1996;184:585\u201395.","journal-title":"J Exp Med"},{"key":"1900_CR18","doi-asserted-by":"publisher","first-page":"12023","DOI":"10.1074\/jbc.275.16.12023","volume":"275","author":"A Siddhanta","year":"2000","unstructured":"Siddhanta A, Backer JM, Shields D. Inhibition of phosphatidic acid synthesis alters the structure of the golgi apparatus and inhibits secretion in endocrine cells. J Biol Chem. 2000;275:12023\u201331.","journal-title":"J Biol Chem"},{"key":"1900_CR19","first-page":"2746","volume":"2719 27","author":"A Toschi","year":"2007","unstructured":"Toschi A, Edelstein J, Rockwell P, Ohh M, Foster DA. HIF\u03b1 expression in VHL-deficient renal cancer cells is dependent on phospholipase D. Oncogene. 2007;27:2746\u201353.","journal-title":"Oncogene 2008"},{"key":"1900_CR20","doi-asserted-by":"publisher","first-page":"3564","DOI":"10.1182\/blood-2006-02-005959","volume":"108","author":"N Lehman","year":"2006","unstructured":"Lehman N, et al. Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2. Blood. 2006;108:3564\u201372.","journal-title":"Blood"},{"key":"1900_CR21","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1007\/BF00133618","volume":"132 13","author":"R Reich","year":"1995","unstructured":"Reich R, Blumenthal M, Liscovitch M. Role of phospholipase D in laminin-induced production of gelatinase A (MMP-2) in metastatic cells. Clin Exp Metastasis 1995. 1995;132 13:134\u201340.","journal-title":"Clin Exp Metastasis 1995"},{"key":"1900_CR22","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/S0960-9822(98)70326-4","volume":"8","author":"FD Brown","year":"1998","unstructured":"Brown FD, et al. Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation. Curr Biol. 1998;8:835\u20138.","journal-title":"Curr Biol"},{"key":"1900_CR23","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.ejmech.2018.02.055","volume":"149","author":"JR Almeida","year":"2018","unstructured":"Almeida JR, et al. A novel synthetic peptide inspired on Lys49 phospholipase A2 from Crotalus oreganus abyssus snake venom active against multidrug-resistant clinical isolates. Eur J Med Chem. 2018;149:248\u201356.","journal-title":"Eur J Med Chem"},{"issue":"11","key":"1900_CR24","first-page":"1","volume":"111","author":"IA Santos","year":"2021","unstructured":"Santos IA, et al. Chikungunya virus entry is strongly inhibited by phospholipase A2 isolated from the venom of Crotalus durissus terrificus. Sci Rep 2021. 2021;111(11):1\u201312.","journal-title":"Sci Rep 2021"},{"key":"1900_CR25","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1084\/jem.20070029","volume":"204","author":"WR Henderson","year":"2007","unstructured":"Henderson WR, et al. Importance of group X\u2013secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. J Exp Med. 2007;204:865\u201377.","journal-title":"J Exp Med"},{"key":"1900_CR26","first-page":"622","volume":"390","author":"JV Bonventre","year":"1997","unstructured":"Bonventre JV, et al. Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2. Nat 1997 3906660. 1997;390:622\u20135.","journal-title":"Nat 1997 3906660"},{"key":"1900_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40659-020-00294-3","volume":"53","author":"WC Hwang","year":"2020","unstructured":"Hwang WC, et al. Inhibition of phospholipase D2 augments histone deacetylase inhibitor-induced cell death in breast cancer cells. Biol Res. 2020;53:1\u201311.","journal-title":"Biol Res"},{"key":"1900_CR28","doi-asserted-by":"publisher","first-page":"8070","DOI":"10.1158\/1078-0432.CCR-08-0566","volume":"14","author":"MI Patel","year":"2008","unstructured":"Patel MI, et al. Cytosolic phospholipase A2-\u03b1: A potential therapeutic target for prostate cancer. Clin Cancer Res. 2008;14:8070\u20139.","journal-title":"Clin Cancer Res"},{"key":"1900_CR29","doi-asserted-by":"crossref","unstructured":"Goodson SG, Zhang Z, Tsuruta JK, Wang W, O\u2019Brien DA. Classification of mouse sperm motility patterns using an automated multiclass support vector machines model. Biol Reprod 2011;84.","DOI":"10.1095\/biolreprod.110.088989"},{"key":"1900_CR30","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.ydbio.2003.10.034","volume":"267","author":"G Cohen","year":"2004","unstructured":"Cohen G, Rubinstein S, Gur Y, Breitbart H. Crosstalk between protein kinase A and C regulates phospholipase D and F-actin formation during sperm capacitation. Dev Biol. 2004;267:230\u201341.","journal-title":"Dev Biol"},{"key":"1900_CR31","doi-asserted-by":"crossref","unstructured":"Hess KC et al. The \u2018soluble\u2019 adenylyl cyclase in sperm mediates multiple signaling cAMP-dependent pathway. Dev Cell. 2005;9.","DOI":"10.1016\/j.devcel.2005.06.007"},{"key":"1900_CR32","doi-asserted-by":"crossref","unstructured":"Garbi M, Rubinstein S, Lax Y, Breitbart H. Activation of protein kinase C\u03b1 in the lysophosphatidic acid-induced bovine sperm acrosome reaction and phospholipase D1 regulation. Biol Reprod 2000;63.","DOI":"10.1095\/biolreprod63.5.1271"},{"key":"1900_CR33","doi-asserted-by":"crossref","unstructured":"Visconti PE et al. Capacitation of mouse spermatozoa. II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway. Development. 1995;121.","DOI":"10.1242\/dev.121.4.1139"},{"key":"1900_CR34","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.ydbio.2011.12.002","volume":"362","author":"SBS Itach","year":"2012","unstructured":"Itach SBS, Finklestein M, Etkovitz N, Breitbart H. Hyper-activated motility in sperm capacitation is mediated by phospholipase D-dependent actin polymerization. Dev Biol. 2012;362:154\u201361.","journal-title":"Dev Biol"},{"key":"1900_CR35","doi-asserted-by":"crossref","unstructured":"Clarke GN, Clarke FM, Wilson S. Actin in human spermatozoa. Biol Reprod. 1982;26.","DOI":"10.1095\/biolreprod26.2.319"},{"key":"1900_CR36","doi-asserted-by":"crossref","unstructured":"Ochs D, Wolf DP. Actin in ejaculated human sperm cells. Biol Reprod. 1985;33.","DOI":"10.1095\/biolreprod33.5.1223"},{"key":"1900_CR37","doi-asserted-by":"crossref","unstructured":"Virtanen I, Badley RA, Paasivuo R, Lehto V. P. Distinct cytoskeletal domains revealed in sperm cells. J Cell Biol. 1984;99.","DOI":"10.1083\/jcb.99.3.1083"},{"key":"1900_CR38","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.ydbio.2013.11.006","volume":"386","author":"RC Bates","year":"2014","unstructured":"Bates RC, et al. Activation of Src and release of intracellular calcium by phosphatidic acid during Xenopus laevis fertilization. Dev Biol. 2014;386:165\u201380.","journal-title":"Dev Biol"},{"key":"1900_CR39","doi-asserted-by":"crossref","unstructured":"Lefi\u00e8vre L, Jha KN, De Lamirande E, Visconti PE, Gagnon C. Activation of protein kinase A during human sperm capacitation and acrosome reaction. J Androl. 2002;23.","DOI":"10.1002\/j.1939-4640.2002.tb02314.x"},{"key":"1900_CR40","doi-asserted-by":"publisher","first-page":"95","DOI":"10.4161\/spmg.1.2.16820","volume":"1","author":"G Berruti","year":"2011","unstructured":"Berruti G, Paiardi C. Acrosome biogenesis: revisiting old questions to yield new insights. Spermatogenesis. 2011;1:95.","journal-title":"Spermatogenesis"},{"key":"1900_CR41","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1126\/science.1059042","volume":"292","author":"K Fukami","year":"2001","unstructured":"Fukami K, et al. Requirement of phospholipase C\u03b44 for the Zona pellucida-induced acrosome reaction. Sci. 2001;292:920\u20133.","journal-title":"Sci"},{"key":"1900_CR42","doi-asserted-by":"crossref","unstructured":"Arnoult C, Cardullo RA, Lemos JR, Florman HM. Activation of mouse sperm T-type Ca2\u2009+\u2009channels by adhesion to the egg zona pellucida. Proc Natl Acad Sci. 1996;93:13004\u201313009.","DOI":"10.1073\/pnas.93.23.13004"},{"key":"1900_CR43","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.ydbio.2003.09.032","volume":"265","author":"CN Tomes","year":"2004","unstructured":"Tomes CN, Roggero CM, De Blas G, Saling PM, Mayorga LS. Requirement of protein tyrosine kinase and phosphatase activities for human sperm exocytosis. Dev Biol. 2004;265:399\u2013415.","journal-title":"Dev Biol"},{"key":"1900_CR44","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1002\/jcp.20172","volume":"202","author":"SB Herrick","year":"2005","unstructured":"Herrick SB, et al. The acrosomal vesicle of mouse sperm is a calcium store. J Cell Physiol. 2005;202:663\u201371.","journal-title":"J Cell Physiol"},{"key":"1900_CR45","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1095\/biolreprod.102.011320","volume":"68","author":"HC Ho","year":"2003","unstructured":"Ho HC, Suarez SS. Characterization of the intracellular calcium store at the base of the sperm flagellum that regulates hyperactivated motility. Biol Reprod. 2003;68:1590\u20136.","journal-title":"Biol Reprod"},{"key":"1900_CR46","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1083\/jcb.200210057","volume":"161","author":"K Fukami","year":"2003","unstructured":"Fukami K, et al. Phospholipase C\u03b44 is required for Ca2\u2009+\u2009mobilization essential for acrosome reaction in sperm. J Cell Biol. 2003;161:79\u201388.","journal-title":"J Cell Biol"},{"key":"1900_CR47","doi-asserted-by":"crossref","unstructured":"Roldan E, Chemistry CF-J. of B. & 1993, undefined. Phospholipase A2 activation and subsequent exocytosis in the Ca2+\/ionophore-induced acrosome reaction of ram spermatozoa. ASBMB 1993;268:13962\u201313970.","DOI":"10.1016\/S0021-9258(19)85196-7"},{"key":"1900_CR48","doi-asserted-by":"crossref","unstructured":"Garde J, Roldan ER. Stimulation of Ca2+-dependent exocytosis of the sperm acrosome by cAMP acting downstream of phospholipase A2. J Reprod Fertil. 2000;118(1):57-68.","DOI":"10.1530\/reprod\/118.1.57"},{"key":"1900_CR49","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.ydbio.2004.01.031","volume":"269","author":"LL Runft","year":"2004","unstructured":"Runft LL, et al. Identification of a starfish egg PLC-\u03b3 that regulates Ca2\u2009+\u2009release at fertilization. Dev Biol. 2004;269:220\u201336.","journal-title":"Dev Biol"},{"key":"1900_CR50","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1006\/dbio.2000.9782","volume":"224","author":"KI Sato","year":"2000","unstructured":"Sato KI, Tokmakov AA, Iwasaki T, Fukami Y. Tyrosine kinase-dependent activation of phospholipase C\u03b3 is required for calcium transient in Xenopus egg fertilization. Dev Biol. 2000;224:453\u201369.","journal-title":"Dev Biol"},{"key":"1900_CR51","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1042\/BST20150221","volume":"44","author":"K Swann","year":"2016","unstructured":"Swann K, Lai FA. The sperm phospholipase C-\u03b6 and Ca2\u2009+\u2009signalling at fertilization in mammals. Biochem Soc Trans. 2016;44:267\u201372.","journal-title":"Biochem Soc Trans"},{"key":"1900_CR52","doi-asserted-by":"publisher","first-page":"3533","DOI":"10.1242\/dev.129.15.3533","volume":"129","author":"CM Saunders","year":"2002","unstructured":"Saunders CM, et al. PLC\u03b6: a sperm-specific trigger of Ca2\u2009+\u2009oscillations in eggs and embryo development. Development. 2002;129:3533\u201344.","journal-title":"Development"},{"key":"1900_CR53","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1006\/dbio.2001.0329","volume":"236","author":"LM Mehlmann","year":"2001","unstructured":"Mehlmann LM, Chattopadhyay A, Carpenter G, Jaffe LA. Evidence that phospholipase C from the sperm is not responsible for initiating Ca2\u2009+\u2009Release at fertilization in mouse eggs. Dev Biol. 2001;236:492\u2013501.","journal-title":"Dev Biol"},{"key":"1900_CR54","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ceca.2015.12.001","volume":"59","author":"HC Lee","year":"2016","unstructured":"Lee HC, Yoon SY, Lykke-Hartmann K, Fissore RA, Carvacho I. TRPV3 channels mediate Ca2\u2009+\u2009influx induced by 2-APB in mouse eggs. Cell Calcium. 2016;59:21\u201331.","journal-title":"Cell Calcium"},{"key":"1900_CR55","first-page":"315","volume":"161","author":"Y Nakamura","year":"2017","unstructured":"Nakamura Y, Fukami K. Regulation and physiological functions of mammalian phospholipase C. J BioChem. 2017;161:315\u201321.","journal-title":"J BioChem"},{"key":"1900_CR56","doi-asserted-by":"publisher","first-page":"e33496","DOI":"10.1371\/journal.pone.0033496","volume":"7","author":"M Aarabi","year":"2012","unstructured":"Aarabi M, et al. The testicular and epididymal expression profile of PLC\u03b6 in mouse and human does not support its role as a sperm-borne oocyte activating factor. PLoS ONE. 2012;7:e33496.","journal-title":"PLoS ONE"},{"key":"1900_CR57","doi-asserted-by":"publisher","first-page":"3671","DOI":"10.1172\/JCI36942","volume":"118","author":"SY Yoon","year":"2008","unstructured":"Yoon SY, et al. Human sperm devoid of PLC, zeta 1 fail to induce Ca2\u2009+\u2009release and are unable to initiate the first step of embryo development. J Clin Invest. 2008;118:3671\u201381.","journal-title":"J Clin Invest"},{"key":"1900_CR58","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1093\/humrep\/den280","volume":"23","author":"P Grasa","year":"2008","unstructured":"Grasa P, Coward K, Young C, Parrington J. The pattern of localization of the putative oocyte activation factor, phospholipase C\u03b6, in uncapacitated, capacitated, and ionophore-treated human spermatozoa. Hum Reprod. 2008;23:2513\u201322.","journal-title":"Hum Reprod"},{"key":"1900_CR59","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1093\/molehr\/gau098","volume":"21","author":"J Escoffier","year":"2015","unstructured":"Escoffier J, et al. Subcellular localization of phospholipase C\u03b6 in human sperm and its absence in DPY19L2-deficient sperm are consistent with its role in oocyte activation. Mol Hum Reprod. 2015;21:157\u201368.","journal-title":"Mol Hum Reprod"},{"key":"1900_CR60","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.fertnstert.2015.05.018","volume":"104","author":"S Yelumalai","year":"2015","unstructured":"Yelumalai S, et al. Total levels, localization patterns, and proportions of sperm exhibiting phospholipase C zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection. Fertil Steril. 2015;104:561\u2013e5684.","journal-title":"Fertil Steril"},{"key":"1900_CR61","first-page":"178","volume":"18","author":"N Azad","year":"2018","unstructured":"Azad N, et al. Oligoasthenoteratozoospermic (OAT) men display altered phospholipase C \u03b6 (PLC\u03b6) localization and a lower percentage of sperm cells expressing PLC\u03b6 and post-acrosomal sheath WW domain-binding protein (PAWP). Bosn J Basic Med Sci. 2018;18:178\u201384.","journal-title":"Bosn J Basic Med Sci"},{"key":"1900_CR62","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1093\/humrep\/dep207","volume":"24","author":"E Heytens","year":"2009","unstructured":"Heytens E, et al. Reduced amounts and abnormal forms of phospholipase C zeta (PLC\u03b6) in spermatozoa from infertile men. Hum Reprod. 2009;24:2417\u201328.","journal-title":"Hum Reprod"},{"key":"1900_CR63","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1093\/humrep\/des092","volume":"27","author":"SY Yoon","year":"2012","unstructured":"Yoon SY, et al. Recombinant human phospholipase C zeta 1 induces intracellular calcium oscillations and oocyte activation in mouse and human oocytes. Hum Reprod. 2012;27:1768\u201380.","journal-title":"Hum Reprod"},{"key":"1900_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-213X-8-16","volume":"8","author":"PJ Ross","year":"2008","unstructured":"Ross PJ, et al. Parthenogenetic activation of bovine oocytes using bovine and murine phospholipase C zeta. BMC Dev Biol. 2008;8:1\u201312.","journal-title":"BMC Dev Biol"},{"key":"1900_CR65","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1093\/humrep\/der384","volume":"27","author":"J Kashir","year":"2012","unstructured":"Kashir J, et al. A maternally inherited autosomal point mutation in human phospholipase C zeta (PLC\u03b6) leads to male infertility. Hum Reprod. 2012;27:222\u201331.","journal-title":"Hum Reprod"},{"key":"1900_CR66","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.fertnstert.2012.05.002","volume":"98","author":"J Kashir","year":"2012","unstructured":"Kashir J, et al. Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLC\u03b6) from an infertile man by use of minisequencing of individual sperm and expression in somatic cells. Fertil Steril. 2012;98:423\u201331.","journal-title":"Fertil Steril"},{"key":"1900_CR67","doi-asserted-by":"crossref","unstructured":"Kashir J et al. Loss of activity mutations in phospholipase C zeta (PLC\u03b6) abolishes calcium oscillatory ability of human Recombinant protein in mouse oocytes. Hum Reprod 2011;26.","DOI":"10.1093\/humrep\/der336"},{"key":"1900_CR68","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.ajhg.2021.02.004","volume":"108","author":"J Dai","year":"2021","unstructured":"Dai J, et al. Homozygous pathogenic variants in ACTL9 cause fertilization failure and male infertility in humans and mice. Am J Hum Genet. 2021;108:469\u201381.","journal-title":"Am J Hum Genet"},{"key":"1900_CR69","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.fertnstert.2020.04.044","volume":"114","author":"S Cheung","year":"2020","unstructured":"Cheung S, et al. Identification and treatment of men with phospholipase C\u03b6\u2013defective spermatozoa. Fertil Steril. 2020;114:535\u201344.","journal-title":"Fertil Steril"},{"key":"1900_CR70","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1093\/humrep\/dez293","volume":"35","author":"P Yuan","year":"2020","unstructured":"Yuan P, et al. A novel homozygous mutation of phospholipase C zeta leading to defective human oocyte activation and fertilization failure. Hum Reprod. 2020;35:977\u201385.","journal-title":"Hum Reprod"},{"key":"1900_CR71","doi-asserted-by":"crossref","unstructured":"Zhu M et al. Human embryo polarization requires Plc signaling to mediate trophectoderm specification. Elife. 2021;10.","DOI":"10.7554\/eLife.65068"},{"key":"1900_CR72","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1095\/biolreprod.106.058347","volume":"78","author":"IK Gipson","year":"2008","unstructured":"Gipson IK, et al. MUC16 is lost from the uterodome (Pinopode) surface of the receptive human endometrium: in vitro evidence that MUC16 is a barrier to trophoblast adherence. Biol Reprod. 2008;78:134\u201342.","journal-title":"Biol Reprod"},{"key":"1900_CR73","first-page":"e137","volume":"5","author":"J-Y Zhu","year":"2012","unstructured":"Zhu J-Y, Pang Z-J, Yu Y. Regulation of trophoblast invasion: the role of matrix metalloproteinases. Rev Obstet Gynecol. 2012;5:e137.","journal-title":"Rev Obstet Gynecol"},{"key":"1900_CR74","doi-asserted-by":"publisher","first-page":"20140070","DOI":"10.1098\/rstb.2014.0070","volume":"370","author":"AM Carter","year":"2015","unstructured":"Carter AM, Enders AC, Pijnenborg R. The role of invasive trophoblast in implantation and placentation of primates. Philos Trans R Soc B Biol Sci. 2015;370:20140070.","journal-title":"Philos Trans R Soc B Biol Sci"},{"key":"1900_CR75","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1016\/j.bbamcr.2019.02.016","volume":"1866","author":"TA Stewart","year":"2019","unstructured":"Stewart TA, Davis FM. An element for development: calcium signaling in mammalian reproduction and development. Biochim Biophys Acta - Mol Cell Res. 2019;1866:1230\u20138.","journal-title":"Biochim Biophys Acta - Mol Cell Res"},{"key":"1900_CR76","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.devcel.2018.05.013","volume":"45","author":"MD White","year":"2018","unstructured":"White MD, Zenker J, Bissiere S, Plachta N. Instructions for assembling the early mammalian embryo. Dev Cell. 2018;45:667\u201379.","journal-title":"Dev Cell"},{"key":"1900_CR77","doi-asserted-by":"crossref","unstructured":"Kono K et al. Reconstruction of par-dependent Polarity in apolar cells reveals a dynamic process of cortical polarization. Elife 2019;8.","DOI":"10.7554\/eLife.45559"},{"key":"1900_CR78","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ceb.2017.10.007","volume":"51","author":"DS Johnston","year":"2018","unstructured":"Johnston DS. Establishing and transducing cell polarity: common themes and variations. Curr Opin Cell Biol. 2018;51:33\u201341.","journal-title":"Curr Opin Cell Biol"},{"key":"1900_CR79","doi-asserted-by":"crossref","unstructured":"Zhu M, Leung CY, Shahbazi MN, Zernicka-Goetz M. Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo. Nat Commun 8, (2017).","DOI":"10.1038\/s41467-017-00977-8"},{"key":"1900_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/genes12020198","volume":"12","author":"V Unnikrishnan","year":"2021","unstructured":"Unnikrishnan V, Kastelic J, Thundathil J. Intracytoplasmic sperm injection in cattle. Genes (Basel). 2021;12:1\u201318.","journal-title":"Genes (Basel)"},{"key":"1900_CR81","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1095\/biolreprod55.6.1292","volume":"55","author":"JJ Stachecki","year":"1996","unstructured":"Stachecki JJ, Armant DR. Regulation of blastocoele formation by intracellular calcium release is mediated through a phospholipase C-dependent pathway in mice. Biol Reprod. 1996;55:1292\u20138.","journal-title":"Biol Reprod"},{"key":"1900_CR82","doi-asserted-by":"publisher","unstructured":"Zhu M et al. Mechanism of cell polarisation and first lineage segregation in the human embryo.  bioRxiv. 2020. https:\/\/doi.org\/10.1101\/2020.09.23.310680","DOI":"10.1101\/2020.09.23.310680"},{"key":"1900_CR83","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1042\/BST20140291","volume":"43","author":"M Nomikos","year":"2015","unstructured":"Nomikos M. Novel signalling mechanism and clinical applications of sperm-specific PLC\u03b6. Biochem Soc Trans. 2015;43:371\u20136.","journal-title":"Biochem Soc Trans"},{"key":"1900_CR84","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcell.2020.00028","volume":"8","author":"A Saleh","year":"2020","unstructured":"Saleh A, et al. Essential role of sperm-specific PLC-Zeta in egg activation and male factor infertility: an update. Front Cell Dev Biol. 2020;8:1\u20139.","journal-title":"Front Cell Dev Biol"},{"key":"1900_CR85","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/978-1-4939-2480-6_5","volume":"843","author":"C O\u2019Neill","year":"2015","unstructured":"O\u2019Neill C, Li Y, Jin XL. Survival signalling in the preimplantation embryo. Adv Exp Med Biol. 2015;843:129\u201349.","journal-title":"Adv Exp Med Biol"},{"key":"1900_CR86","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1095\/biolreprod.107.060129","volume":"77","author":"Y Li","year":"2007","unstructured":"Li Y, Chandrakanthan V, Day ML, O\u2019Neill C. Direct evidence for the action of phosphatidylinositol (3,4,5)- trisphosphate-mediated signal transduction in the 2-cell mouse embryo. Biol Reprod. 2007;77:813\u201321.","journal-title":"Biol Reprod"},{"key":"1900_CR87","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/dvdy.24471","volume":"246","author":"S Menchero","year":"2017","unstructured":"Menchero S, Rayon T, Andreu MJ, Manzanares M. Signaling pathways in mammalian preimplantation development: linking cellular phenotypes to lineage decisions. Dev Dyn. 2017;246:245\u201361.","journal-title":"Dev Dyn"},{"key":"1900_CR88","doi-asserted-by":"publisher","first-page":"8387","DOI":"10.1074\/jbc.RA120.013666","volume":"295","author":"SC Hewitt","year":"2020","unstructured":"Hewitt SC, Grimm SA, Wu SP, DeMayo FJ, Korach KS. Estrogen receptor \u03b1 (ER\u03b1)-binding super-enhancers drive key mediators that control uterine Estrogen responses in mice. J Biol Chem. 2020;295:8387\u2013400.","journal-title":"J Biol Chem"},{"key":"1900_CR89","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1093\/molehr\/gau004","volume":"20","author":"K Saito","year":"2014","unstructured":"Saito K, et al. Degradation of estrogen receptor \u03b1 in activated blastocysts is associated with implantation in the delayed implantation mouse model. Mol Hum Reprod. 2014;20:384\u201391.","journal-title":"Mol Hum Reprod"},{"key":"1900_CR90","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1210\/me.2005-0140","volume":"20","author":"J Matthews","year":"2006","unstructured":"Matthews J, et al. Estrogen receptor (ER) \u03b2 modulates ER\u03b1-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen-responsive promoters. Mol Endocrinol. 2006;20:534\u201343.","journal-title":"Mol Endocrinol"},{"key":"1900_CR91","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1095\/biolreprod.110.087007","volume":"84","author":"XL Jin","year":"2011","unstructured":"Jin XL, O\u2019Neill C. Regulation of the expression of proto-oncogenes by autocrine embryotropins in the early mouse embryo. Biol Reprod. 2011;84:1216\u201324.","journal-title":"Biol Reprod"},{"key":"1900_CR92","doi-asserted-by":"publisher","first-page":"2629","DOI":"10.1210\/jcem.87.6.8532","volume":"87","author":"H Wang","year":"2002","unstructured":"Wang H, Wen Y, Mooney S, Behr B, Polan ML. Phospholipase A2 and cyclooxygenase gene expression in human preimplantation embryos. J Clin Endocrinol Metab. 2002;87:2629\u201334.","journal-title":"J Clin Endocrinol Metab"},{"key":"1900_CR93","doi-asserted-by":"crossref","unstructured":"Mayoral Andrade G et al. Molecules and prostaglandins related to embryo tolerance. Front Immunol 11, (2020).","DOI":"10.3389\/fimmu.2020.555414"},{"key":"1900_CR94","doi-asserted-by":"crossref","unstructured":"Wang H, Dey SK. Roadmap to embryo implantation: clues from mouse models. Nat Rev Genet. 2006;73(7):185\u2013199.","DOI":"10.1038\/nrg1808"},{"key":"1900_CR95","doi-asserted-by":"publisher","first-page":"3761","DOI":"10.1242\/dev.129.15.3761","volume":"129","author":"H Song","year":"2002","unstructured":"Song H, et al. Cytosolic phospholipase A2\u03b1 deficiency is crucial for \u2018on-time\u2019 embryo implantation that directs subsequent development. Development. 2002;129:3761\u20133761.","journal-title":"Development"},{"key":"1900_CR96","doi-asserted-by":"crossref","unstructured":"Niringiyumukiza JD, Cai H, Xiang W. Prostaglandin E2 involvement in mammalian female fertility: ovulation, fertilization, embryo development and early implantation. Reprod Biol Endocrinol. 2018;16(1):1\u201310.","DOI":"10.1186\/s12958-018-0359-5"},{"key":"1900_CR97","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.theriogenology.2019.09.046","volume":"142","author":"P Kaczynski","year":"2020","unstructured":"Kaczynski P, Goryszewska E, Baryla M, Waclawik A. Prostaglandin F2\u03b1 stimulates angiogenesis at the embryo-maternal interface during early pregnancy in the pig. Theriogenology. 2020;142:169\u201376.","journal-title":"Theriogenology"},{"key":"1900_CR98","doi-asserted-by":"publisher","first-page":"R55","DOI":"10.1530\/REP-18-0570","volume":"159","author":"JS Beltrame","year":"2020","unstructured":"Beltrame JS, Ca\u00f1umil VA, Sordelli MS, Ribeiro ML. Novel role for lysophosphatidic acid in vascular remodeling at the maternal\u2013fetal interface. Reproduction. 2020;159:R55\u201367.","journal-title":"Reproduction"},{"key":"1900_CR99","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13578-020-00495-z","volume":"10","author":"HK Park","year":"2020","unstructured":"Park HK, et al. Secretory phospholipase A2-X (Pla2g10) is a novel progesterone receptor target gene exclusively induced in uterine luminal epithelium for uterine receptivity in mice. Cell Biosci. 2020;10:1\u201312.","journal-title":"Cell Biosci"},{"key":"1900_CR100","doi-asserted-by":"publisher","first-page":"23429","DOI":"10.1074\/jbc.C500168200","volume":"280","author":"Y Guo","year":"2005","unstructured":"Guo Y, et al. N-Acylphosphatidylethanolamine-hydrolyzing phospholipase D is an important determinant of uterine anandamide levels during implantation. J Biol Chem. 2005;280:23429\u201332.","journal-title":"J Biol Chem"},{"key":"1900_CR101","first-page":"135","volume":"38","author":"E Dirandeh","year":"2020","unstructured":"Dirandeh E, Ansari-Pirsaraei Z, Deldar H, Shohreh B, Ghaffar J. Endocannabinoid system and early embryonic loss in Holstein dairy cows. Anim Sci Pap Rep. 2020;38:135\u201344.","journal-title":"Anim Sci Pap Rep"},{"key":"1900_CR102","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.1210\/en.2009-0214","volume":"150","author":"P Filis","year":"2009","unstructured":"Filis P, et al. Phospholipase C-\u03b21 signaling affects reproductive behavior, ovulation, and implantation. Endocrinology. 2009;150:3259\u201366.","journal-title":"Endocrinology"},{"key":"1900_CR103","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1093\/molehr\/gas067","volume":"19","author":"P Filis","year":"2013","unstructured":"Filis P, Kind PC, Spears N. Implantation failure in mice with a disruption in phospholipase C beta 1 gene: lack of embryonic attachment, aberrant steroid hormone signalling and defective endocannabinoid metabolism. Mol Hum Reprod. 2013;19:290\u2013301.","journal-title":"Mol Hum Reprod"},{"key":"1900_CR104","doi-asserted-by":"publisher","first-page":"9335","DOI":"10.1074\/jbc.M109955200","volume":"277","author":"HJ Liao","year":"2002","unstructured":"Liao HJ, et al. Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice. J Biol Chem. 2002;277:9335\u201341.","journal-title":"J Biol Chem"},{"key":"1900_CR105","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1242\/jcs.041913","volume":"122","author":"R Bhattacharya","year":"2009","unstructured":"Bhattacharya R, et al. Distinct role of PLC\u03b23 in VEGF-mediated directional migration and vascular sprouting. J Cell Sci. 2009;122:1025\u201334.","journal-title":"J Cell Sci"},{"issue":"5","key":"1900_CR106","doi-asserted-by":"publisher","first-page":"e1215","DOI":"10.1038\/cddis.2014.181","volume":"55","author":"Y Nakamura","year":"2014","unstructured":"Nakamura Y, et al. Simultaneous loss of phospholipase C\u03b41 and phospholipase C\u03b43 causes cardiomyocyte apoptosis and cardiomyopathy. Cell Death Dis 2014. 2014;55(5):e1215\u20131215.","journal-title":"Cell Death Dis 2014"},{"key":"1900_CR107","doi-asserted-by":"publisher","first-page":"191","DOI":"10.5483\/BMBRep.2016.49.3.219","volume":"49","author":"CS Lee","year":"2016","unstructured":"Lee CS, Ghim J, Song P, Suh PG, Ryu SH. Loss of phospholipase D2 impairs VEGF-induced angiogenesis. BMB Rep. 2016;49:191.","journal-title":"BMB Rep"},{"key":"1900_CR108","first-page":"467","volume":"3","author":"F Sekiya","year":"2013","unstructured":"Sekiya F. Phospholipase C. Encycl Biol Chem Second Ed. 2013;3:467\u201371.","journal-title":"Encycl Biol Chem Second Ed"},{"key":"1900_CR109","doi-asserted-by":"publisher","first-page":"10979","DOI":"10.1128\/MCB.25.24.10979-10988.2005","volume":"25","author":"Y Nakamura","year":"2005","unstructured":"Nakamura Y, et al. Phospholipase C-\u03b41 and -\u03b43 are essential in the trophoblast for placental development. Mol Cell Biol. 2005;25:10979\u201388.","journal-title":"Mol Cell Biol"},{"key":"1900_CR110","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1242\/dev.025353","volume":"136","author":"H Ichise","year":"2009","unstructured":"Ichise H, Ichise T, Ohtani O, Yoshida N. Phospholipase C\u03b32 is necessary for separation of blood and lymphatic vasculature in mice. Development. 2009;136:191\u20135.","journal-title":"Development"},{"key":"1900_CR111","doi-asserted-by":"crossref","unstructured":"Schroeder JA, Jackson LF, Lee DC, Camenisch TD. Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling. J Mol Med. 2003;81(7):392\u2013403.","DOI":"10.1007\/s00109-003-0456-5"},{"key":"1900_CR112","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.neulet.2014.04.052","volume":"572","author":"U Burkhardt","year":"2014","unstructured":"Burkhardt U, et al. Impaired brain development and reduced cognitive function in phospholipase D-deficient mice. Neurosci Lett. 2014;572:48\u201352.","journal-title":"Neurosci Lett"},{"key":"1900_CR113","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuropharm.2013.11.002","volume":"79","author":"U Burkhardt","year":"2014","unstructured":"Burkhardt U, Wojcik B, Zimmermann M, Klein J. Phospholipase D is a target for Inhibition of astroglial proliferation by ethanol. Neuropharmacology. 2014;79:1\u20139.","journal-title":"Neuropharmacology"},{"key":"1900_CR114","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1007\/s12035-014-8773-y","volume":"51","author":"SY Park","year":"2015","unstructured":"Park SY, Ma W, Yoon SN, Kang MJ, Han JS. Phospholipase D1 increases Bcl-2 expression during neuronal differentiation of rat neural stem cells. Mol Neurobiol. 2015;51:1089\u2013102.","journal-title":"Mol Neurobiol"},{"key":"1900_CR115","doi-asserted-by":"publisher","first-page":"8459","DOI":"10.1074\/jbc.M110.171223","volume":"286","author":"Z Kouchi","year":"2011","unstructured":"Kouchi Z, et al. Phospholipase C\u03b43 regulates rhoa\/rho kinase signaling and neurite outgrowth. J Biol Chem. 2011;286:8459\u201371.","journal-title":"J Biol Chem"},{"key":"1900_CR116","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1002\/dvdy.182","volume":"249","author":"LW Runnels","year":"2020","unstructured":"Runnels LW, Komiya Y. TRPM6 and TRPM7: novel players in cell intercalation during vertebrate embryonic development. Dev Dyn. 2020;249:912\u201323.","journal-title":"Dev Dyn"},{"key":"1900_CR117","doi-asserted-by":"crossref","unstructured":"Broertjes J, Klarenbeek J, Habani Y, Langeslag M, Jalink K. TRPM7 residue S1269 mediates cAMP dependence of Ca2\u2009+\u2009influx. PLoS ONE. 2019;14.","DOI":"10.1101\/269688"},{"key":"1900_CR118","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.ijdevneu.2007.10.004","volume":"26","author":"T Nguyen","year":"2008","unstructured":"Nguyen T, Di Giovanni. NFAT signaling in neural development and axon growth. Int J Dev Neurosci. 2008;26:141.","journal-title":"Int J Dev Neurosci"},{"key":"1900_CR119","doi-asserted-by":"publisher","first-page":"55455","DOI":"10.1074\/jbc.M402905200","volume":"279","author":"S Puri","year":"2004","unstructured":"Puri S, et al. Polycystin-1 activates the calcineurin\/nfat (nuclear factor of activated T-cells) signaling pathway. J Biol Chem. 2004;279:55455\u201364.","journal-title":"J Biol Chem"},{"key":"1900_CR120","doi-asserted-by":"publisher","first-page":"5173","DOI":"10.1242\/dev.128.24.5173","volume":"128","author":"M Shirane","year":"2001","unstructured":"Shirane M, et al. Deficiency of phospholipase C-\u03b31 impairs renal development and hematopoiesis. Development. 2001;128:5173\u201380.","journal-title":"Development"},{"key":"1900_CR121","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1152\/physiol.00031.2009","volume":"24","author":"Y Nakamura","year":"2009","unstructured":"Nakamura Y, Fukami K. Roles of phospholipase C isozymes in organogenesis and embryonic development. Physiology. 2009;24:332\u201341.","journal-title":"Physiology"},{"key":"1900_CR122","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1182\/blood-2005-06-2428","volume":"107","author":"A Caraux","year":"2006","unstructured":"Caraux A, et al. Phospholipase C-\u03b32 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells. Blood. 2006;107:994\u20131002.","journal-title":"Blood"},{"key":"1900_CR123","doi-asserted-by":"publisher","first-page":"4127","DOI":"10.4049\/jimmunol.170.8.4127","volume":"170","author":"AD Wells","year":"2003","unstructured":"Wells AD, et al. Regulation of T cell activation and tolerance by phospholipase C\u03b3-1-Dependent integrin avidity modulation. J Immunol. 2003;170:4127\u201333.","journal-title":"J Immunol"},{"key":"1900_CR124","doi-asserted-by":"crossref","unstructured":"Coolen NA, Schouten KCWM, Middelkoop E, Ulrich M. M. W. Comparison between human fetal and adult skin. Arch Dermatol Res. 2010;302.","DOI":"10.1007\/s00403-009-0989-8"},{"key":"1900_CR125","doi-asserted-by":"publisher","first-page":"8695","DOI":"10.1074\/jbc.M609135200","volume":"282","author":"Z Xie","year":"2007","unstructured":"Xie Z, Bikle DD. The recruitment of phosphatidylinositol 3-Kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C-\u03b31 activation and human keratinocyte differentiation. J Biol Chem. 2007;282:8695\u2013703.","journal-title":"J Biol Chem"},{"key":"1900_CR126","doi-asserted-by":"publisher","first-page":"8808","DOI":"10.1158\/0008-5472.CAN-04-3143","volume":"64","author":"Y Bai","year":"2004","unstructured":"Bai Y, et al. Crucial role of phospholipase C\u03b5 in chemical Carcinogen-Induced skin tumor development. Cancer Res. 2004;64:8808\u201310.","journal-title":"Cancer Res"},{"key":"1900_CR127","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1093\/emboj\/cdg302","volume":"22","author":"Y Nakamura","year":"2003","unstructured":"Nakamura Y, et al. Phospholipase C\u03b41 is required for skin stem cell lineage commitment. EMBO J. 2003;22:2981\u201391.","journal-title":"EMBO J"},{"key":"1900_CR128","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1126\/science.1251816","volume":"345","author":"R Romero","year":"2014","unstructured":"Romero R, Dey SK, Fisher SJ. Preterm labor: one syndrome, many causes. Sci (80-). 2014;345:760\u20135.","journal-title":"Sci (80-)"},{"key":"1900_CR129","doi-asserted-by":"crossref","unstructured":"Smith R. Parturition. 2009;356:271\u2013283. http:\/\/dx.doi.org\/10.1056\/NEJMra061360","DOI":"10.1056\/NEJMra061360"},{"key":"1900_CR130","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/0002-9378(84)90677-X","volume":"150","author":"AR Fuchs","year":"1984","unstructured":"Fuchs AR, Fuchs F, Husslein P, Soloff MS. Oxytocin receptors in the human uterus during pregnancy and parturition. Am J Obstet Gynecol. 1984;150:734\u201341.","journal-title":"Am J Obstet Gynecol"},{"key":"1900_CR131","first-page":"156","volume":"17","author":"F Petraglia","year":"1996","unstructured":"Petraglia F, Florio P, Nappi C, Genazzani AR. Peptide signaling in human placenta and membranes: autocrine, paracrine, and endocrine mechanisms. Endocr Rev. 1996;17:156\u201386.","journal-title":"Endocr Rev"},{"key":"1900_CR132","doi-asserted-by":"publisher","first-page":"6279","DOI":"10.1073\/pnas.0308742101","volume":"101","author":"E Isotani","year":"2004","unstructured":"Isotani E, et al. Real-time evaluation of myosin light chain kinase activation in smooth muscle tissues from a transgenic calmodulin-biosensor mouse. Proc Natl Acad Sci. 2004;101:6279\u201384.","journal-title":"Proc Natl Acad Sci"},{"key":"1900_CR133","doi-asserted-by":"crossref","unstructured":"Yu H, Chakravorty S, Song W, Ferenczi MA. Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives. Eur Biophys J. 2016;45(8):779\u2013805.","DOI":"10.1007\/s00249-016-1128-z"},{"key":"1900_CR134","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.ejogrb.2006.07.024","volume":"132","author":"SJ Choi","year":"2007","unstructured":"Choi SJ, Oh Syoung, Kim JH, Roh CR. Changes of nuclear factor kappa B (NF-\u03baB), cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9) in human myometrium before and during term labor. Eur J Obstet Gynecol Reprod Biol. 2007;132:182\u20138.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"1900_CR135","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1093\/oxfordjournals.humrep.a019090","volume":"11","author":"JJ Morrison","year":"1996","unstructured":"Morrison JJ, Deam SR, Smith SK, Ahmed A. Activation of protein kinase C is required for oxytocin-induced contractility in human pregnant myometrium. Hum Reprod. 1996;11:10\u20132285.","journal-title":"Hum Reprod"},{"key":"1900_CR136","doi-asserted-by":"publisher","first-page":"s51","DOI":"10.1111\/j.1469-445X.2000.tb00007.x","volume":"85","author":"MS Soloff","year":"2000","unstructured":"Soloff MS, Jeng YJ, Copland JA, Strakova Z, Hoare S. Signal pathways mediating Oxytocin stimulation of prostaglandin synthesis in select target cells. Exp Physiol. 2000;85:s51\u20138.","journal-title":"Exp Physiol"},{"key":"1900_CR137","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.plefa.2003.04.001","volume":"70","author":"M Lappas","year":"2004","unstructured":"Lappas M, Rice GE. Phospholipase A2 isozymes in pregnancy and parturition. Prostaglandins Leukot Essent Fat Acids. 2004;70:87\u2013100.","journal-title":"Prostaglandins Leukot Essent Fat Acids"},{"key":"1900_CR138","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1016\/S0002-9378(97)70614-8","volume":"176","author":"DG Skannal","year":"1997","unstructured":"Skannal DG, Eis ALW, Brockman D, Siddiqi TA, Myatt L. Immunohistochemical localization of phospholipase A2 isoforms in human myometrium during pregnancy and parturition. Am J Obstet Gynecol. 1997;176:878\u201382.","journal-title":"Am J Obstet Gynecol"},{"key":"1900_CR139","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1093\/molehr\/gah103","volume":"10","author":"DM Slater","year":"2004","unstructured":"Slater DM, Astle S, Bennett PR, Thornton S. Labour is associated with increased expression of type-IIA secretory phospholipase A2 but not type-IV cytosolic phospholipase A2 in human myometrium. Mol Hum Reprod. 2004;10:799\u2013805.","journal-title":"Mol Hum Reprod"},{"key":"1900_CR140","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S0002-9378(97)70459-9","volume":"177","author":"DG Skannal","year":"1997","unstructured":"Skannal DG, et al. Changes in activity of cytosolic phospholipase A2 in human Amnion at parturition. Am J Obstet Gynecol. 1997;177:179\u201384.","journal-title":"Am J Obstet Gynecol"},{"key":"1900_CR141","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1530\/REP-07-0078","volume":"134","author":"MG Farina","year":"2007","unstructured":"Farina MG, et al. Secretory and cytosolic phospholipase A2 activities and expression are regulated by Oxytocin and estradiol during labor. Reproduction. 2007;134:355\u201364.","journal-title":"Reproduction"},{"key":"1900_CR142","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/S0090-6980(99)00057-X","volume":"60","author":"B Johansen","year":"2000","unstructured":"Johansen B, Rakkestad K, Balboa MA, Dennis EA. Expression of cytosolic and secreted forms of phospholipase A2 and cyclooxygenases in human placenta, fetal membranes, and chorionic cell lines. Prostaglandins Other Lipid Mediat. 2000;60:119\u201325.","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"1900_CR143","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1095\/biolreprod.109.079061","volume":"81","author":"N Brown","year":"2009","unstructured":"Brown N, Morrow JD, Slaughter JC, Paria BC, Reese J. Restoration of On-Time embryo implantation corrects the timing of parturition in cytosolic phospholipase A2 group IVA deficient mice. Biol Reprod. 2009;81:1131\u20138.","journal-title":"Biol Reprod"},{"issue":"133","key":"1900_CR144","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s00418-010-0695-9","volume":"1335","author":"AH Taylor","year":"2010","unstructured":"Taylor AH, Abbas MS, Habiba MA, Konje JC. Histomorphometric evaluation of cannabinoid receptor and Anandamide modulating enzyme expression in the human endometrium through the menstrual cycle. Histochem Cell Biol. 2010;1335(133):557\u201365. (2010).","journal-title":"Histochem Cell Biol"},{"key":"1900_CR145","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.placenta.2012.10.009","volume":"34","author":"C Ab\u00e1n","year":"2013","unstructured":"Ab\u00e1n C, et al. Differential expression of endocannabinoid system in normal and preeclamptic placentas: effects on nitric oxide synthesis. Placenta. 2013;34:67\u201374.","journal-title":"Placenta"},{"key":"1900_CR146","doi-asserted-by":"publisher","first-page":"5482","DOI":"10.1210\/jc.2004-0681","volume":"89","author":"OMH Habayeb","year":"2004","unstructured":"Habayeb OMH, et al. Plasma levels of the endocannabinoid Anandamide in Women\u2014A potential role in pregnancy maintenance and labor? J Clin Endocrinol Metab. 2004;89:5482\u20137.","journal-title":"J Clin Endocrinol Metab"},{"key":"1900_CR147","doi-asserted-by":"crossref","unstructured":"Accialini P et al. Anandamide exerts a differential effect on human placenta before and after the onset of labor. Front Physiol. 2021;12.","DOI":"10.3389\/fphys.2021.667367"},{"key":"1900_CR148","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.ejphar.2012.04.034","volume":"685","author":"MS Sordelli","year":"2012","unstructured":"Sordelli MS, Beltrame JS, Cella M, Franchi AM, Ribeiro ML. Cyclooxygenase-2 prostaglandins mediate anandamide-inhibitory action on nitric oxide synthase activity in the receptive rat uterus. Eur J Pharmacol. 2012;685:174\u20139.","journal-title":"Eur J Pharmacol"},{"key":"1900_CR149","unstructured":"Dirir A. The role of phospholipase C like 1 in the maintenance of uterine quiescence during human pregnancy. 2019."},{"key":"1900_CR150","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1113\/expphysiol.2013.072868","volume":"99","author":"YW Chan","year":"2014","unstructured":"Chan YW, Van den Berg HA, Moore JD, Quenby S, Blanks AM. Assessment of myometrial transcriptome changes associated with spontaneous human labour by high-throughput RNA-seq. Exp Physiol. 2014;99:510\u201324.","journal-title":"Exp Physiol"},{"key":"1900_CR151","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12916-016-0632-4","volume":"14","author":"R Migale","year":"2016","unstructured":"Migale R, et al. Modeling hormonal and inflammatory contributions to preterm and term labor using uterine Temporal transcriptomics. BMC Med. 2016;14:1\u201317.","journal-title":"BMC Med"},{"key":"1900_CR152","doi-asserted-by":"publisher","first-page":"e0250638","DOI":"10.1371\/journal.pone.0250638","volume":"16","author":"N Takahashi","year":"2021","unstructured":"Takahashi N, et al. Up-regulation of cytosolic prostaglandin E synthase in fetal-membrane and amniotic prostaglandin E2 accumulation in labor. PLoS ONE. 2021;16:e0250638.","journal-title":"PLoS ONE"},{"key":"1900_CR153","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1067\/mob.2000.107789","volume":"183","author":"M Koyama","year":"2000","unstructured":"Koyama M, et al. Elevations of group II phospholipase A2 concentrations in serum and amniotic fluid in association with preterm labor. Am J Obstet Gynecol. 2000;183:1537\u201343.","journal-title":"Am J Obstet Gynecol"},{"key":"1900_CR154","doi-asserted-by":"publisher","first-page":"L121","DOI":"10.1152\/ajplung.00516.2021","volume":"323","author":"D De Luca","year":"2022","unstructured":"De Luca D, et al. Secretory phospholipase A2 expression and activity in preterm clinical chorioamnionitis with fetal involvement. Am J Physiol Lung Cell Mol Physiol. 2022;323:L121\u20138.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"1900_CR155","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1053\/plac.1998.0376","volume":"20","author":"WR Hansen","year":"1999","unstructured":"Hansen WR, et al. Regulation of cytosolic phospholipase A2 expression by cytokines in human Amnion cells. Placenta. 1999;20:303\u20138.","journal-title":"Placenta"},{"key":"1900_CR156","doi-asserted-by":"publisher","DOI":"10.2478\/acb-2018-0023","author":"B Borowiec","year":"2018","unstructured":"Borowiec B, Hadada T, Kosi\u0144ska M. The role of prostaglandins and polymorphisms of A2 phospholipase genes in the occurrence of early uterine contractions during pregnancy. Med J Cell Biol. 2018. https:\/\/doi.org\/10.2478\/acb-2018-0023.","journal-title":"Med J Cell Biol"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-025-01900-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-025-01900-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-025-01900-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T19:25:12Z","timestamp":1757186712000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-025-01900-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,13]]},"references-count":156,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["1900"],"URL":"https:\/\/doi.org\/10.1007\/s43032-025-01900-z","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,13]]},"assertion":[{"value":"17 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional Review Board Statement"}},{"value":"The authors declare no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}