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At day 7, each female received oral treatment daily as follows; A (served as the control), B (received 3\u00a0mg\/kg CdCL<jats:sub>2<\/jats:sub>), C (received 100\u00a0mg\/kg PREOG), D (received 200\u00a0mg\/kg PREOG), E (received 100\u00a0mg\/kg PREOG\u2009+\u20093\u00a0mg\/kg CdCL<jats:sub>2<\/jats:sub>) and F (received 200\u00a0mg\/kg PREOG\u2009+\u20093\u00a0mg\/kg CdCL<jats:sub>2<\/jats:sub>) treatment continued to postnatal day 29 before weaning. The male pups separated from females continued to receive only food and water <jats:italic>ad lib<\/jats:italic> till postnatal ninety (PND90). At (PND 90) five males were selected from each group cohabited with the\u00a0untreated females at a\u00a0ratio of\u00a02:1 for a\u00a0fertility test, while six males from each were sacrificed, and\u00a0blood, semen, and testes were harvested for analysis. Our result indicated that PREOG enhanced semen quality, GSI\/EPI, SOD, GPx, and GST values at (PND90), also PREOG upregulates the expression of StAR, 3\u03b2-HSD, 17\u03b2-HSD genes, and testosterone value in (PND90), PREOG also upregulated the expression of PTMA, RSPH6A, DAAM1 genes, and the fertility outcome in (PND90) offspring. These findings validate the protective role of PREOG against cadmium-induced reprotoxcity in male offspring exposed during gestation and lactation and enhance reproductive performance.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1007\/s43032-025-01902-x","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T09:15:49Z","timestamp":1752138949000},"page":"2742-2762","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Complicity of DAAM1, PTMA, RSPH6A, and Steroidogenic Genes in the Fertility of Male Rats Exposed to Cadmium During Gestation and Lactation: Attenuation by PREOG"],"prefix":"10.1007","volume":"32","author":[{"given":"Ikokide Emmanuel","family":"Joseph","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaja Ishmael","family":"Festus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Temitayo Olabisi","family":"Ajibade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ademola Adetokunbo","family":"Oyagbemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathew Olugbenga","family":"Oyeyemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"1902_CR1","doi-asserted-by":"publisher","unstructured":"Sijo JP, Sandro CE, Ashok A. 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