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Women with endometriosis had a higher association of overall cancer (OR\u2009=\u20091.80, 95% CI: 1.19\u20142.72) and this was especially the case for ovarian cancer (OR\u2009=\u200911.40, 95% CI: 3.00\u201443.34). Subgroup and sensitivity analyses confirmed the robustness of these results. Kaplan\u2013Meier analysis indicated lower survival from all causes in women with endometriosis (p\u2009=\u20090.022) but no significant difference in cancer survival. MR analysis supported a positive relationship between endometriosis and ovarian cancer (OR\u2009=\u20091.203, 95% CI: 1.011\u20141.433). The history of endometriosis was positively associated with the history of overall and ovarian cancer. Women with a history of endometriosis should have access to enhanced cancer surveillance and proactive management. Further research is needed to confirm these associations and to give mechanistic insights.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1007\/s43032-025-01910-x","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T15:33:21Z","timestamp":1750692801000},"page":"2283-2294","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Endometriosis and Ovarian Cancer: Insights from NHANES and Mendelian Randomization Analysis"],"prefix":"10.1007","volume":"32","author":[{"given":"Dong","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuke","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6315-3176","authenticated-orcid":false,"given":"Kunyan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"issue":"1","key":"1910_CR1","doi-asserted-by":"publisher","first-page":"8028","DOI":"10.1038\/s41467-023-43913-9","volume":"14","author":"LC Giudice","year":"2023","unstructured":"Giudice LC, Horne AW, Missmer SA. 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Best Pract Res Clin Obstet Gynaecol. 2018;51:151\u201368.","journal-title":"Best Pract Res Clin Obstet Gynaecol"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-025-01910-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-025-01910-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-025-01910-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T23:50:46Z","timestamp":1757202646000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-025-01910-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,23]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["1910"],"URL":"https:\/\/doi.org\/10.1007\/s43032-025-01910-x","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,23]]},"assertion":[{"value":"6 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The current work used patient data in the public domain. \u200b\u200bAll analyses were conducted in accordance with NHANES guidelines () with written informed consent given by all participants and ethical approval granted by the NCHS research ethics review board ().","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}