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Rats in G2 (<jats:italic>n<\/jats:italic>\u2009=\u20097) were administered 30\u00a0IU pregnant mare serum gonadotropin for 4\u00a0days and OHSS was induced by administering 30\u00a0IU hCG on the fifth day. Rats in G3 (<jats:italic>n<\/jats:italic>\u2009=\u20097) were induced to have OHSS and were given 100\u00a0\u03bcg\/kg oral cabergoline, while rats in G4 (<jats:italic>n<\/jats:italic>\u2009=\u20097) were induced to have OHSS and were given 20\u00a0mg\/kg intraperitoneal nifedipine. On the fifth day, all rats were decapitated and VEGF, interleukin (IL)-1\u03b2, IL-6, tumor necrosis factor (TNF)-\u03b1, and hypoxia-inducible factor (HIF)-1\u03b1 levels were measured in their serum and tissues. TRPC1 gene expression and immunohistochemical analysis were performed in ovarian tissue. We showed that nifedipine inhibited VEGF and some inflammatory factor levels more than cabergoline. We showed that nifedipine may achieve these effects through TRPC1 blockade and suppression of inflammatory factors.<\/jats:p>","DOI":"10.1007\/s43032-025-01913-8","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T12:32:57Z","timestamp":1750249977000},"page":"2375-2387","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Nifedipine in Preventing Ovarian Hyperstimulation Syndrome through TRPC1 Ion Channel Inhibition"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5708-6733","authenticated-orcid":false,"given":"Emel","family":"Kocal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2635-7158","authenticated-orcid":false,"given":"Remzi","family":"Atilgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2376-4244","authenticated-orcid":false,"given":"\u015eehmus","family":"Pala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9787-4980","authenticated-orcid":false,"given":"Melike","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9874-3838","authenticated-orcid":false,"given":"Tuncay","family":"Kulo\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0208-8929","authenticated-orcid":false,"given":"Nevin","family":"Ilhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9968-8201","authenticated-orcid":false,"given":"Ebru Etem","family":"\u00d6nalan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3237-3672","authenticated-orcid":false,"given":"Serhat","family":"Han\u00e7er","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3756-2272","authenticated-orcid":false,"given":"Gizem Kaymaz","family":"Bircan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"1913_CR1","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1007\/s00404-020-05855-1","volume":"303","author":"I Hortu","year":"2021","unstructured":"Hortu I, Karadadas E, Ozceltik G, Tavmergen E, TavmergenGoker EN, Yigitturk G, Erbas O. 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