{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:25:31Z","timestamp":1775561131097,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University","award":["No. YX202112"],"award-info":[{"award-number":["No. YX202112"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s43032-025-01918-3","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T13:12:30Z","timestamp":1750857150000},"page":"2574-2582","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Homeobox C6 is Up-Regulated and Affects the Pathogenesis of Endometriosis"],"prefix":"10.1007","volume":"32","author":[{"given":"Jianfa","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2765-5181","authenticated-orcid":false,"given":"Lijie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"1918_CR1","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1056\/NEJMra1810764","volume":"382","author":"KT Zondervan","year":"2020","unstructured":"Zondervan KT, Becker CM, Missmer SA. Endometriosis. N Engl J Med. 2020;382:1244\u201356.","journal-title":"N Engl J Med"},{"key":"1918_CR2","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1016\/j.cell.2021.04.041","volume":"184","author":"PTK Saunders","year":"2021","unstructured":"Saunders PTK, Horne AW. Endometriosis: Etiology, pathobiology, and therapeutic prospects. Cell. 2021;184:2807\u201324.","journal-title":"Cell"},{"key":"1918_CR3","doi-asserted-by":"publisher","first-page":"e070750","DOI":"10.1136\/bmj-2022-070750","volume":"379","author":"AW Horne","year":"2022","unstructured":"Horne AW, Missmer SA. Pathophysiology, diagnosis, and management of endometriosis. BMJ. 2022;379:e070750.","journal-title":"BMJ"},{"key":"1918_CR4","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/0925-4773(95)00494-7","volume":"55","author":"S Stein","year":"1996","unstructured":"Stein S, Fritsch R, Lemaire L, Kessel M. Checklist: vertebrate homeobox genes. Mech Dev. 1996;55:91\u2013108.","journal-title":"Mech Dev"},{"key":"1918_CR5","doi-asserted-by":"publisher","first-page":"a023002","DOI":"10.1101\/cshperspect.a023002","volume":"6","author":"H Du","year":"2015","unstructured":"Du H, Taylor HS. The role of HOX genes in female reproductive tract development, adult function, and fertility. Cold Spring Harb Perspect Med. 2015;6:a023002.","journal-title":"Cold Spring Harb Perspect Med"},{"key":"1918_CR6","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1007\/s10815-010-9471-y","volume":"27","author":"A Zanatta","year":"2010","unstructured":"Zanatta A, Rocha AM, Carvalho FM, Pereira RM, Taylor HS, Motta EL, et al. The role of the Hoxa10\/HOXA10 gene in the etiology of endometriosis and its related infertility: a review. J Assist Reprod Genet. 2010;27:701\u201310.","journal-title":"J Assist Reprod Genet"},{"key":"1918_CR7","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.fertnstert.2020.08.1398","volume":"115","author":"F Esfandiari","year":"2021","unstructured":"Esfandiari F, Favaedi R, Heidari-Khoei H, Chitsazian F, Yari S, Piryaei A, et al. Insight into epigenetics of human endometriosis organoids: DNA methylation analysis of HOX genes and their cofactors. Fertil Steril. 2021;115:125\u201337.","journal-title":"Fertil Steril"},{"key":"1918_CR8","doi-asserted-by":"crossref","unstructured":"Mihara Y, Maekawa R, Sato S, Shimizu N, Doi-Tanaka Y, Takagi H, et al. An integrated genomic approach identifies HOXC8 as an upstream regulator in ovarian endometrioma. J Clin Endocrinol Metab. 2020; 105(12).","DOI":"10.1210\/clinem\/dgaa618"},{"issue":"1","key":"1918_CR9","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/sj.onc.1207906","volume":"24","author":"S Ramachandran","year":"2005","unstructured":"Ramachandran S, Liu P, Young AN, Yin-Goen Q, Lim SD, Laycock N, et al. Loss of HOXC6 expression induces apoptosis in prostate cancer cells. Oncogene. 2005;24(1):188\u201398.","journal-title":"Oncogene"},{"key":"1918_CR10","doi-asserted-by":"crossref","unstructured":"Fujiki K, Duerr EM, Kikuchi H, Ng A, Xavier RJ, Mizukami Y, et al. HOXC6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth. Gastroenterology. 2008; 135(3): 907\u2013916, 916 e901\u2013902.","DOI":"10.1053\/j.gastro.2008.06.034"},{"key":"1918_CR11","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/s41419-021-03630-x","volume":"12","author":"L Qi","year":"2021","unstructured":"Qi L, Chen J, Zhou B, Xu K, Wang K, Fang Z, et al. HomeoboxC6 promotes metastasis by orchestrating the DKK1\/Wnt\/\u03b2-catenin axis in right-sided colon cancer. Cell Death Dis. 2021;12:337.","journal-title":"Cell Death Dis"},{"key":"1918_CR12","doi-asserted-by":"publisher","first-page":"8016102","DOI":"10.1155\/2022\/8016102","volume":"2022","author":"S Eryi","year":"2022","unstructured":"Eryi S, Zheng L, Honghua C, Su Z, Han X, Donggang P, et al. HOXC6 regulates the epithelial-mesenchymal transition through the TGF-\u03b2\/Smad signaling pathway and predicts a poor prognosis in glioblastoma. J Oncol. 2022;2022:8016102.","journal-title":"J Oncol"},{"key":"1918_CR13","first-page":"8656865","volume":"2022","author":"ZH Li","year":"2022","unstructured":"Li ZH, Ma Y, Zhou Y, Huang ZH. Expression profiles of HOXC6 predict the survival of glioblastoma patients and correlate with cell cycle. J Oncol. 2022;2022:8656865.","journal-title":"J Oncol"},{"key":"1918_CR14","doi-asserted-by":"crossref","unstructured":"Hamid AR, Hoogland AM, Smit F, Jannink S, van Rijt-van de Westerlo C, Jansen CF, et al. The role of HOXC6 in prostate cancer development. Prostate. 2015; 75: 1868\u20131876.","DOI":"10.1002\/pros.23065"},{"key":"1918_CR15","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1158\/0008-5472.CAN-07-5843","volume":"68","author":"CD McCabe","year":"2008","unstructured":"McCabe CD, Spyropoulos DD, Martin D, Moreno CS. Genome-wide analysis of the homeobox C6 transcriptional network in prostate cancer. Cancer Res. 2008;68:1988\u201396.","journal-title":"Cancer Res"},{"issue":"2","key":"1918_CR16","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s43032-021-00766-1","volume":"29","author":"Q Li","year":"2022","unstructured":"Li Q, Xi M, Shen F, Fu F, Wang J, Chen Y, et al. Identification of candidate gene signatures and regulatory networks in endometriosis and its related infertility by integrated analysis. Reprod Sci. 2022;29(2):411\u201326.","journal-title":"Reprod Sci"},{"key":"1918_CR17","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/S0002-9378(16)33500-1","volume":"122","author":"RW Noyes","year":"1975","unstructured":"Noyes RW, Hertig AT, Rock J. Dating the endometrial biopsy. Am J Obstet Gynecol. 1975;122:262\u20133.","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"1918_CR18","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.fertnstert.2013.04.041","volume":"100","author":"AA Delbandi","year":"2013","unstructured":"Delbandi AA, Mahmoudi M, Shervin A, Akbari E, Jeddi-Tehrani M, Sankian M, et al. Eutopic and ectopic stromal cells from patients with endometriosis exhibit differential invasive, adhesive, and proliferative behavior. Fertil Steril. 2013;100(3):761\u20139.","journal-title":"Fertil Steril"},{"key":"1918_CR19","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/s41420-022-01116-z","volume":"8","author":"J Zhao","year":"2022","unstructured":"Zhao J, Lin H, Huang K, Li S. Cancer-associated fibroblasts-derived extracellular vesicles carrying lncRNA SNHG3 facilitate colorectal cancer cell proliferation via the miR-34b-5p\/HuR\/HOXC6 axis. Cell Death Discov. 2022;8:346.","journal-title":"Cell Death Discov"},{"key":"1918_CR20","doi-asserted-by":"publisher","first-page":"2715","DOI":"10.1080\/21691401.2019.1635136","volume":"47","author":"J Zhou","year":"2019","unstructured":"Zhou J, Yang X, Song P, Wang H, Wang X. HOXC6 in the prognosis of prostate cancer. Artif Cells Nanomed Biotechnol. 2019;47:2715\u201320.","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"1918_CR21","doi-asserted-by":"publisher","first-page":"115","DOI":"10.18632\/aging.101363","volume":"10","author":"PD Li","year":"2018","unstructured":"Li PD, Chen P, Peng X, Ma C, Zhang WJ, Dai XF. HOXC6 predicts invasion and poor survival in hepatocellular carcinoma by driving epithelial-mesenchymal transition. Aging (Albany NY). 2018;10:115\u201330.","journal-title":"Aging (Albany NY)"},{"key":"1918_CR22","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/s41580-018-0080-4","volume":"20","author":"A Dongre","year":"2019","unstructured":"Dongre A, Weinberg RA. New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer. Nat Rev Mol Cell Biol. 2019;20:69\u201384.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1918_CR23","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.3390\/jcm9061915","volume":"9","author":"L Konrad","year":"2020","unstructured":"Konrad L, Dietze R, Riaz MA, Scheiner-Bobis G, Behnke J, Horn\u00e9 F, et al. Epithelial-mesenchymal transition in endometriosis-when does it happen? J Clin Med. 2020;9:1915.","journal-title":"J Clin Med"},{"key":"1918_CR24","doi-asserted-by":"publisher","first-page":"114909","DOI":"10.1016\/j.biopha.2023.114909","volume":"164","author":"M Zhang","year":"2023","unstructured":"Zhang M, Xu T, Tong D, Li S, Yu X, Liu B, et al. Research advances in endometriosis-related signaling pathways: A review. Biomed Pharmacother. 2023;164:114909.","journal-title":"Biomed Pharmacother"},{"key":"1918_CR25","doi-asserted-by":"publisher","first-page":"100697","DOI":"10.1016\/j.repbio.2022.100697","volume":"22","author":"T Gao","year":"2022","unstructured":"Gao T, Cao Y, Hu M, Du Y. The activation of TGF-\u03b2 signaling promotes cell migration and invasion of ectopic endometrium by targeting NRP2. Reprod Biol. 2022;22:100697.","journal-title":"Reprod Biol"},{"key":"1918_CR26","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12958-019-0512-9","volume":"17","author":"J Zhang","year":"2019","unstructured":"Zhang J, Li H, Yi D, Lai C, Wang H, Zou W, et al. Knockdown of vascular cell adhesion molecule 1 impedes transforming growth factor beta 1-mediated proliferation, migration, and invasion of endometriotic cyst stromal cells. Reprod Biol Endocrinol. 2019;17:69.","journal-title":"Reprod Biol Endocrinol"},{"key":"1918_CR27","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1093\/biolre\/iox140","volume":"97","author":"LB Shi","year":"2017","unstructured":"Shi LB, Zhou F, Zhu HY, Huang D, Jin XY, Li C, et al. Transforming growth factor beta1 from endometriomas promotes fibrosis in surrounding ovarian tissues via Smad2\/3 signaling. Biol Reprod. 2017;97:873\u201382.","journal-title":"Biol Reprod"},{"key":"1918_CR28","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/s12935-018-0680-2","volume":"18","author":"F Zhang","year":"2018","unstructured":"Zhang F, Ren CC, Liu L, Chen YN, Yang L, Zhang XA. HOXC6 gene silencing inhibits epithelial-mesenchymal transition and cell viability through the TGF-\u03b2\/smad signaling pathway in cervical carcinoma cells. Cancer Cell Int. 2018;18:204.","journal-title":"Cancer Cell Int"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-025-01918-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-025-01918-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-025-01918-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T22:50:03Z","timestamp":1757199003000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-025-01918-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["1918"],"URL":"https:\/\/doi.org\/10.1007\/s43032-025-01918-3","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,25]]},"assertion":[{"value":"8 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the institutional review board of the Third Xiangya Hospital of Central South University (No.E22250), and informed consent was obtained from all the patients.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}