{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T14:44:27Z","timestamp":1776177867923,"version":"3.50.1"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Reprod. Sci."],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s43032-025-01920-9","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T17:12:34Z","timestamp":1752513154000},"page":"2685-2691","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Implementation of a Program for Combined Intra-Gestational and Systemic Methotrexate Injection to Treat Non-Tubal Ectopic Pregnancy: A Report of Outcomes and Feasibility"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9784-889X","authenticated-orcid":false,"given":"Michael","family":"Strug","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent","family":"Monseur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben","family":"Alvero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lusine","family":"Aghajanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"1920_CR1","doi-asserted-by":"crossref","unstructured":"Panelli, DM, Phillips CH, Brady PC. Incidence, diagnosis and management of tubal and nontubal ectopic pregnancies: a review. Fertil Res Pract 2015;1:15.","DOI":"10.1186\/s40738-015-0008-z"},{"key":"1920_CR2","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/uog.974","volume":"23","author":"KM Seow","year":"2004","unstructured":"Seow KM, Huang LW, Lin YH, Lin MY, Tsai YL, Hwang JL. Cesarean scar pregnancy: issues in management. Ultrasound Obstet Gynecol. 2004;23:247\u201353.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"1920_CR3","doi-asserted-by":"crossref","unstructured":"Society for Maternal-Fetal Medicine . Electronic address, pso, Miller R, Timor-Tritsch IE, Gyamfi-Bannerman C. Society for Maternal-Fetal Medicine (SMFM) consult series #49: cesarean scar pregnancy. Am J Obstet Gynecol 2020;222:B2-B14.","DOI":"10.1016\/j.ajog.2020.01.030"},{"key":"1920_CR4","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.jmig.2019.03.016","volume":"27","author":"SB Gilbert","year":"2020","unstructured":"Gilbert SB, Alvero RJ, Roth L, Polotsky AJ. Direct methotrexate injection into the gestational sac for nontubal ectopic pregnancy: a review of efficacy and outcomes from a single institution. J Minim Invasive Gynecol. 2020;27:166\u201372.","journal-title":"J Minim Invasive Gynecol"},{"key":"1920_CR5","doi-asserted-by":"crossref","unstructured":"Dolinko, AV, Vrees RA, Frishman GN. Nontubal ectopic pregnancies: overview and treatment via local injection. J Minim Invasive Gynecol. 2017;25(2):287\u2013296.","DOI":"10.1016\/j.jmig.2017.07.008"},{"key":"1920_CR6","first-page":"3669","volume":"24","author":"TM Atkinson","year":"2016","unstructured":"Atkinson TM, Ryan SJ, Bennett AV, Stover AM, Saracino RM, Rogak LJ, et al. The association between clinician-based common terminology criteria for adverse events (CTCAE) and patient-reported outcomes (PRO): a systematic review. Support Care Cancer. 2016;24:3669\u201376.","journal-title":"Support Care Cancer"},{"key":"1920_CR7","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1111\/1471-0528.14752","volume":"125","author":"J Ramkrishna","year":"2018","unstructured":"Ramkrishna J, Kan GR, Reidy KL, Ang WC, Palma-Dias R. Comparison of management regimens following ultrasound diagnosis of nontubal ectopic pregnancies: a retrospective cohort study. BJOG. 2018;125:567\u201375.","journal-title":"BJOG"},{"issue":"44","key":"1920_CR8","first-page":"e41","volume":"207","author":"IE Timor-Tritsch","year":"2012","unstructured":"Timor-Tritsch IE, Monteagudo A, Santos R, Tsymbal T, Pineda G, Arslan AA. The diagnosis, treatment, and follow-up of cesarean scar pregnancy. Am J Obstet Gynecol. 2012;207(44):e41\u2013e13.","journal-title":"Am J Obstet Gynecol"},{"key":"1920_CR9","doi-asserted-by":"crossref","unstructured":"Ramkrishna, J, Kan GR, Reidy KL, Ang WC, Palma-Dias R. Comparison of management regimens following ultrasound diagnosis of nontubal ectopic pregnancies: a retrospective cohort study. Bjog 2017;125(5):567\u2013575.","DOI":"10.1111\/1471-0528.14752"},{"key":"1920_CR10","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1002\/jcu.22185","volume":"42","author":"M Framarino-dei-Malatesta","year":"2014","unstructured":"Framarino-dei-Malatesta M, Piccioni MG, Derme M, Polidori NF, Tibaldi V, Iannini I, et al. Transabdominal ultrasound-guided injection of methotrexate in the treatment of ectopic interstitial pregnancies. J Clin Ultrasound. 2014;42:522\u20136.","journal-title":"J Clin Ultrasound"},{"key":"1920_CR11","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1046\/j.1469-0705.1999.13020131.x","volume":"13","author":"T Hafner","year":"1999","unstructured":"Hafner T, Aslam N, Ross JA, Zosmer N, Jurkovic D. The effectiveness of non-surgical management of early interstitial pregnancy: a report of ten cases and review of the literature. Ultrasound Obstet Gynecol. 1999;13:131\u20136.","journal-title":"Ultrasound Obstet Gynecol"}],"container-title":["Reproductive Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-025-01920-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s43032-025-01920-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s43032-025-01920-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T09:18:51Z","timestamp":1757236731000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s43032-025-01920-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,14]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["1920"],"URL":"https:\/\/doi.org\/10.1007\/s43032-025-01920-9","relation":{},"ISSN":["1933-7191","1933-7205"],"issn-type":[{"value":"1933-7191","type":"print"},{"value":"1933-7205","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,14]]},"assertion":[{"value":"30 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This research study was conducted retrospectively from data obtained for clinical purposes\u00a0and was approved by the Stanford University Institutional Review Board (IRB-56127).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}