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Sci."],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lipopolysaccharide (LPS), a key component of Gram-negative bacterial cell walls, triggers strong inflammatory responses that can severely impair reproductive organs. The female genital tract\u2014including the ovaries, fallopian tubes, and uterus\u2014is particularly vulnerable to LPS-induced inflammation, oxidative stress, and apoptosis. This study investigated the protective effects of remifentanil (REMI), an ultra-short-acting opioid with anti-inflammatory and antioxidant properties, against LPS-induced injury in female Wistar albino rats. Thirty-two rats were divided into four groups: LPS, LPS\u2009+\u2009REMI, REMI, and Control. LPS (5\u00a0mg\/kg, i.p.) and REMI (0.04\u00a0mg\/kg, i.v.) were administered, followed by histopathological, immunohistochemical (TNF-\u03b1, NF-\u03baB, iNOS), and RT-qPCR analyses (Caspase-3, -9, -12, NRF2, HO-1) of the ovaries, uterus, and fallopian tubes. LPS exposure caused severe histological damage, increased inflammatory markers, and elevated caspase activity, particularly in the fallopian tubes and uterus. REMI treatment significantly reduced these pathological changes, restored NRF2 and HO-1 expression, and suppressed caspase activation. These findings indicate that REMI effectively protected against LPS-induced genital tract injury by modulating inflammation, reducing oxidative stress, and preventing apoptosis, highlighting its potential as a therapeutic agent for sepsis-related reproductive organ damage.<\/jats:p>","DOI":"10.1007\/s43032-025-01930-7","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T16:00:37Z","timestamp":1752595237000},"page":"2583-2594","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Remifentanil Attenuates LPS-Induced Genital Tract Injury by Modulating Inflammation, Oxidative Stress, and Mitochondrial Gene Expression in a Rat Sepsis Model"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1835-1082","authenticated-orcid":false,"given":"Ozlem","family":"Ozmen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1545-035X","authenticated-orcid":false,"given":"Halil","family":"Asci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4575-5653","authenticated-orcid":false,"given":"Senay","family":"Topsakal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2845-3744","authenticated-orcid":false,"given":"Rumeysa","family":"Taner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1478-6089","authenticated-orcid":false,"given":"Mert","family":"Oktem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5270-5630","authenticated-orcid":false,"given":"Kadriye Nilay","family":"Ozcan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2059-1074","authenticated-orcid":false,"given":"Bunyamin","family":"Aydin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"issue":"3","key":"1930_CR1","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.3390\/ijms26031204","volume":"26","author":"ME Kim","year":"2025","unstructured":"Kim ME, Lee JS. 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The Suleyman Demirel University local animal experimentation ethics committee gave its approval to the experimental protocol (No. 06.03.2025\/03-450).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Animal Research"}}]}}