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An additional ten adult female rats were included to assess changes in male sexual behavior. Feed restriction resulted in a marked increase in ghrelin levels and its gene expression in the examined tissues, with the most pronounced elevation observed in the 60% feed restricted group. Elevated ghrelin disrupted the HPG axis, leading to reduced levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone, while prolactin levels increased. These hormonal changes negatively impacted fertility, libido, semen quality, and overall sexual function. Additionally, feed restrictions caused histopathological alterations in the stomach and testes, along with reductions in both testicular and body weight. These findings suggest that increased ghrelin hormone, in response to energy deficiency, may inhibit the male reproductive axis, linking energy balance and reproductive function in male rats.<\/jats:p>","DOI":"10.1007\/s43032-025-01943-2","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T17:28:29Z","timestamp":1755019709000},"page":"3141-3153","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Linking Ghrelin Elevation to Reproductive Dysfunction: Insights from Feed-Restricted Male Rats"],"prefix":"10.1007","volume":"32","author":[{"given":"Marina M.","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Seifelnasr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-8379","authenticated-orcid":false,"given":"Marwa A.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman I.","family":"Hassanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa S.","family":"Morsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manal R.","family":"Bakeer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"issue":"1","key":"1943_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1515\/hmbci-2016-0018","volume":"26","author":"BN Alamri","year":"2016","unstructured":"Alamri BN, Shin K, Chappe V, Anini Y. 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