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The study also observed increased activity of natural killer and T cells in affected tissues, pointing to an immune component in recurrent spontaneous abortion. Drug prediction analysis highlighted dexamethasone and menadione as potential treatments. These insights suggest that oxidative stress-induced senescence plays a critical role in recurrent spontaneous abortion, with UCP2 and GSR as promising biomarkers and therapeutic targets to improve endometrial health and reduce miscarriage risk. Further clinical studies are needed to validate these findings and explore their therapeutic applications.<\/jats:p>","DOI":"10.1007\/s43032-025-02023-1","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T17:32:59Z","timestamp":1765560779000},"page":"161-173","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endometrial Cell Senescence and Recurrent Spontaneous Abortion: Biomarker Potential of UCP2 and GSR"],"prefix":"10.1007","volume":"33","author":[{"given":"Zhumei","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuzhen","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5013-6166","authenticated-orcid":false,"given":"Jianhuang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"issue":"5","key":"2023_CR1","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1093\/humupd\/dmaa010","volume":"26","author":"NA Du Foss\u00e9","year":"2020","unstructured":"Du Foss\u00e9 NA, Van der Hoorn MP, van Lith JMM, et al. 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